| Author | Title | Print-Published | Type | DOI@Sci-hub |
| CDK | | reference-entry | 10.1007/springerreference_92996 |
| Functions of CDK/cyclin Complexes in Endoreplication Regulation by the CDK Inhibitor SIAMESE | | dissertation | 10.31390/gradschool_dissertations.5173 |
| CDK | | reference-entry | 10.1007/springerreference_37256 |
| Pandit, J. | Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2 | 2009/9/8 | dataset | 10.2210/pdb3igg/pdb |
| Pandit, J. | Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2 | 2009/9/8 | dataset | 10.2210/pdb3ig7/pdb |
| Figure 4—figure supplement 1. CDK–phosphorylation of ORC intrinsically inhibits helicase loading. | | component | 10.7554/elife.33309.013 |
| CDK Inhibitor R547 | | reference-entry | 10.32388/iap5sl |
| Willighagen, Egon | 10000 CDK commits! | | posted-content | 10.59350/w1hpp-ks316 |
| Willighagen, Egon | CDK Literature #3 | | posted-content | 10.59350/rkkty-a3w29 |
| Willighagen, Egon | CDK News | | posted-content | 10.59350/xf9bq-44218 |
| Willighagen, Egon | CDK Literature #4 | | posted-content | 10.59350/es4e7-esh15 |
| Cermin Dunia Kedokteran | | journal | 10.55175/cdk |
| CDK | | book-chapter | 10.1007/3-540-30683-8_274 |
| CDK Inhibitor AT7519 | | reference-entry | 10.32388/286jz0 |
| Willighagen, Egon | CDK Literature #1 | | posted-content | 10.59350/g22fv-gtc07 |
| CDK Gene Mutation | | reference-entry | 10.32388/kf9klo |
| Willighagen, Egon | StatCVS on CDK | | posted-content | 10.59350/q7ehm-v1m81 |
| CDK | | book-chapter | 10.1007/978-3-540-47648-1_959 |
| Hu, X. | Cdc2: a monopotent or pluripotent CDK? | 2011/6 | journal-article | 10.1111/j.1365-2184.2011.00753.x |
| Willighagen, Egon | CDK Literature #2 | | posted-content | 10.59350/17nhx-htt54 |
| Supplementary file 1. CDK sequences used for phylogenetic analysis | | component | 10.7554/elife.10767.021 |
| Huang, Linda | Faculty Opinions recommendation of Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. | 2007/4/23 | dataset | 10.3410/f.1080804.533727 |
| Willighagen, Egon | Nightly CDK builds now available | | posted-content | 10.59350/s63wt-hbx56 |
| Apodaca, Richard L. | Updating Ruby CDK | | posted-content | 10.59350/yy9a2-wy148 |
| Willighagen, Egon | The CDK data model #1 | | posted-content | 10.59350/4xfms-7nn46 |
| Willighagen, Egon | CDK-Taverna fully recognized | | posted-content | 10.59350/pk40z-7z702 |
| CDK Inhibitor SNS-032 | | reference-entry | 10.32388/2sggcz |
| cdk | | book-chapter | 10.1007/3-540-29719-0_321 |
| Willighagen, Egon | CDK Workshop - Day #2 | | posted-content | 10.59350/f7vn0-kqz26 |
| cdk | | book-chapter | 10.1007/3-540-29832-0_321 |
| CDK | | book-chapter | 10.1007/978-3-540-38918-7_5357 |
| Willighagen, Egon | CDK Module dependencies #2 | | posted-content | 10.59350/e7qrk-ypg78 |
| Schreiner, S. | Kongenitale Kniegelenkluxation (CDK) | 2012/1 | journal-article | 10.1007/s00132-011-1874-7 |
| Carnero, A. | The INK4 Family of CDK Inhibitors | 1998 | book-chapter | 10.1007/978-3-642-71941-7_3 |
| CDK Inhibitors | | book-chapter | 10.1007/978-3-540-47648-1_963 |
| | | journal-issue | 10.55175/cdk.v48i6 |
| Valk, Ervin | CDK signaling via nonconventional CDK phosphorylation sites | 2023/11/1 | journal-article | 10.1091/mbc.e22-06-0196 |
| Grigoroudis, Asterios I. | Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_4 |
| Alvira, Daniel | Drug Delivery Strategies of Chemical CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_12 |
| Hu, Shanhu | Targeting anaphase catastrophe through CDK inhibition in lung cancer | | dissertation | 10.1349/ddlp.1623 |
| Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors | | component | 10.1021/acschembio.3c00616.s002 |
| | | journal-issue | 10.55175/cdk.v47i7 |
| Apodaca, Richard L. | Ruby CDK for Newbies | | posted-content | 10.59350/50ebs-4zq55 |
| Willighagen, Egon | Java Server Pages with CDK functionality | | posted-content | 10.59350/3kvks-pdb73 |
| Willighagen, Egon | Calculating geometrical properties with the CDK | | posted-content | 10.59350/sy6r5-pzw09 |
| Willighagen, Egon | Single PDFs for CDK News articles | | posted-content | 10.59350/rgdzb-bfe36 |
| Willighagen, Egon | Atom typing in the CDK | | posted-content | 10.59350/wm7aq-eqz10 |
| CDK Inhibitory Protein | | book-chapter | 10.1007/3-540-30683-8_276 |
| Apodaca, Richard L. | CDK, the Ruby Way | | posted-content | 10.59350/49w1p-2y164 |
| Willighagen, Egon | Jumbo 5.0 and the CDK | | posted-content | 10.59350/y0mte-4ns18 |
| Willighagen, Egon | CDK close to entering Debian | | posted-content | 10.59350/dmspa-wyb25 |
| CDK Inhibitors | 2011 | book-chapter | 10.1007/978-3-642-16483-5_963 |
| CDK | 2011 | book-chapter | 10.1007/978-3-642-16483-5_959 |
| | | journal-issue | 10.55175/cdk.v48i2 |
| | | journal-issue | 10.55175/cdk.v47i11 |
| CDK/JAK2/FLT3 Inhibitor TG02 Citrate | | reference-entry | 10.32388/xklmgh |
| Gortat, Anna | Analysis of CDK Inhibitor Action on Mitochondria-Mediated Apoptosis | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_9 |
| Willighagen, Egon | The CDK data classes and change notifications | | posted-content | 10.59350/3xsm0-bt478 |
| | | journal-issue | 10.55175/cdk.v49i0 |
| Apodaca, Richard L. | Scripting CDK with JRuby | | posted-content | 10.59350/sxxfq-shj88 |
| Willighagen, Egon | CDK Workshop - Days #3 and #4 | | posted-content | 10.59350/kvq10-snm07 |
| CDK-Activating Kinase Assembly Factor MAT1 | | reference-entry | 10.32388/6s4tbs |
| CDK | 2016 | book-chapter | 10.1007/978-3-662-46875-3_100468 |
| Willighagen, Egon | CDK Bug Squash Party - Day 2 | | posted-content | 10.59350/wzs4m-9ky43 |
| Willighagen, Egon | The CDK/Metabolomics/Chemometrics Unconference results | | posted-content | 10.59350/f2ajz-tmr63 |
| Willighagen, Egon | CDK Bug Squash Party - Day 5 | | posted-content | 10.59350/paxbm-rac78 |
| Willighagen, Egon | CDK and the Java 6 beta | | posted-content | 10.59350/6az21-1dt76 |
| Willighagen, Egon | Jumbo 5.0 and CML support in CDK | | posted-content | 10.59350/dzvnw-3b413 |
| | | journal-issue | 10.55175/cdk.v48i4 |
| Apodaca, Richard L. | Porting MX - CDK-Compatible VF Implementation | | posted-content | 10.59350/xat1r-hcs92 |
| Hirai, Hiroshi | Evaluating Chemical CDK Inhibitors as Cell Death Inducers | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_14 |
| Willighagen, Egon | UML diagram of CDK module dependencies | | posted-content | 10.59350/a3r1n-72841 |
| Upton, Jason W. | Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin | 2006/12/15 | journal-article | 10.1128/jvi.01722-06 |
| | | journal-issue | 10.55175/cdk.v47i8 |
| | | journal-issue | 10.55175/cdk.v47i10 |
| Willighagen, Egon | CDK Bug Squash Party - Day 1 | | posted-content | 10.59350/y5srm-hzx87 |
| | | journal-issue | 10.55175/cdk.v47i12 |
| Apodaca, Richard L. | Scripting Molecular Fingerprints with Ruby CDK | | posted-content | 10.59350/xgf37-ggz21 |
| Lacy, Susan | Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes | 1997/5/22 | journal-article | 10.1038/sj.onc.1201085 |
| | | grant | 10.55776/tai3266225 |
| | | journal-issue | 10.55175/cdk.v47i9 |
| | | journal-issue | 10.55175/cdk.v48i5 |
| | | journal-issue | 10.55175/cdk.v42i10 |
| Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors | | component | 10.1021/acschembio.3c00616.s001 |
| Ruiz, E. Josué | Meiotic Inactivation of Xenopus Myt1 by CDK/XRINGO, but Not CDK/Cyclin, via Site-Specific Phosphorylation | 2008/10 | journal-article | 10.1016/j.molcel.2008.08.029 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s002 |
| Guevara, Tatiana | Evaluating the Effects of CDK Inhibitors in Ischemia–Reperfusion Injury Models | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_10 |
| | | journal-issue | 10.55175/cdk.v48i1 |
| | | journal-issue | 10.55175/cdk.v48i3 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s003 |
| Lee, Young-Sam | Regulation of a Cyclin-CDK-CDK Inhibitor Complex by Inositol Pyrophosphates | 2007/4/6 | journal-article | 10.1126/science.1139080 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 1999/8/1 | report | 10.21236/ada378108 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 2000/9/1 | report | 10.21236/ada392485 |
| Apodaca, Richard L. | CDK, the Ruby Way: RCDK-0.2.0 | | posted-content | 10.59350/ev966-zz940 |
| Guha, Rajarshi | rcdk: Interface to the 'CDK' Libraries | 2006/10/4 | dataset | 10.32614/cran.package.rcdk |
| GROTH, A | High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27 Cdk-complexes | 2005/9 | journal-article | 10.1016/j.cellsig.2004.11.021 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s001 |
| Apodaca, Richard L. | Drawing 2-D Structures with Structure-CDK | | posted-content | 10.59350/qxc8d-c1w35 |
| Gallastegui, Edurne | Immunoprecipitation of Cdk–Cyclin Complexes for Determination of Kinase Activity | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_1 |
| Cyclin-dependent Kinase (CDK) Inhibitor | | book-chapter | 10.1007/3-540-30683-8_390 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s004 |
| Fisher, Robert P | Faculty Opinions recommendation of Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation. | 2008/11/11 | dataset | 10.3410/f.1125916.583024 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 1998/8/1 | report | 10.21236/ada359281 |
| Willighagen, Egon | CDK 1.0: a milestone after 7 year of development | | posted-content | 10.59350/qd21w-71g30 |
| lavarone, Antonio | Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15 | 1997/5 | journal-article | 10.1038/387417a0 |
| Willighagen, Egon | The molecular QSAR descriptors in the CDK | | posted-content | 10.59350/47rre-wwc20 |
| Gangopadhyay, Aditi | The Prospects of CDK Targeting and Clinical Application of CDK Inhibitors in Cancer | 2018/12/5 | book-chapter | 10.2174/9781681087016118090008 |
| Willighagen, Egon | Test results for the CDK 1.0.x branch | | posted-content | 10.59350/ry980-qya21 |
| Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk) | | component | 10.1021/acschembio.7b00972.s002 |
| Willighagen, Egon | InChI's in LaTex and CDK News | | posted-content | 10.59350/hysd0-wvc09 |
| Chiarelli, C | Cyclin D, CDK and CDK Inhibitors in Melanocytic Neoplasms. | 1997/8 | journal-article | 10.1097/00000372-199708000-00072 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v49i2.1746 |
| Synthesis of benzofuropyridine derivatives as CDK-5 inhibitors and anticancer agents | | dissertation | 10.58837/chula.the.2022.1218 |
| CDK | | other | 10.1002/0471684228.egp01945 |
| Guha, Rajarshi | rcdklibs: The CDK Libraries Packaged for R | 2009/1/8 | dataset | 10.32614/cran.package.rcdklibs |
| Pérez-Benavente, Beatriz | Cell Synchronization Techniques to Study the Action of CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_8 |
| Willighagen, Egon | CDK Debug classes and fixing the ModelBuilder3D bug | | posted-content | 10.59350/6p49t-sj396 |
| Multiplexed Profiling of CDK Kinase Activities in Tumor Biopsies with Fluorescent Peptide Biosensors | | component | 10.1021/acssensors.4c00139.s001 |
| Willighagen, Egon | CDK News 2.3 and InChI's | | posted-content | 10.59350/z97vw-87009 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v48i12.1586 |
| Willighagen, Egon | CDK Bug Squash Party - Day 3 and 4 | | posted-content | 10.59350/zwkym-aty79 |
| Figure 3: The efficiency of tumor markers in distinguish CDK patients from healthy control. | | component | 10.7717/peerj.19240/fig-3 |
| | | grant | 10.55776/t393 |
| Palomino-Schätzlein, Martina | Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_16 |
| Willighagen, Egon | R/CDK install fails on GCC 4.0 systems | | posted-content | 10.59350/b1vyj-0kd63 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v48i12.1589 |
| Futcher, A. B. | General Methods for Identifying G1-phase Substrates of Cdk Protein Kinases | 1999/6/1 | report | 10.21236/ada374137 |
| Many Hats for Cdk Inhibitor | 2006/1/10 | journal-article | 10.1126/stke.3172006tw468 |
| CDK | 2008 | book-chapter | 10.1007/978-1-4020-6754-9_2580 |
| | | grant | 10.35802/065956 |
| Tsutsui, Taiki | Identification of target genes for the CDK subunits of the Mediator complex | 2011/12 | journal-article | 10.1111/j.1365-2443.2011.01565.x |
| Willighagen, Egon | CDK is now available from your nearest Debian mirror | | posted-content | 10.59350/g5s78-zqk90 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v49i2.1745 |
| Willighagen, Egon | Janocchio: Jmol and CDK based 1H coupling constant prediction | | posted-content | 10.59350/rxzh8-9yr48 |
| Guidato, Sonia | Cyclin D2 Interacts with cdk‐5 and Modulates Cellular cdk‐5/p35 Activity | 1998/1 | journal-article | 10.1046/j.1471-4159.1998.70010335.x |
| -, - | Indeks Akhir Tahun | | journal-article | 10.55175/cdk.v48i12.1588 |
| CDK Inhibitors, Endocrine Therapy for Male Patients With Breast Cancer | 2019/3/8 | dataset | 10.1200/adn.19.190134 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v49i1.1648 |
| Nishizawa, Masafumi | Mouse Cyclin-dependent Kinase (Cdk) 5 Is a Functional Homologue of a Yeast Cdk, Pho85 Kinase | 1999/11 | journal-article | 10.1074/jbc.274.48.33859 |
| Dutto, Ilaria | Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_11 |
| Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk) | | component | 10.1021/acschembio.7b00972.s001 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v49i1.1647 |
| CELL CYCLE-REGULATION OF THE FANCD2 PROTEIN VIA CDK-MEDIATED S592 PHOSPHORYLATION | | dissertation | 10.23860/thesis-cantres-velez-juan-2020 |
| Apodaca, Richard L. | Source Code Documentation in Ruby: RDoc for Ruby CDK | | posted-content | 10.59350/jf1hb-6ev38 |
| Willighagen, Egon | Protein support in Bioclipse using Jmol and the CDK | | posted-content | 10.59350/23wn4-1nt07 |
| Willighagen, Egon | Comparing JUnit test results between CDK trunk/ and a branch | | posted-content | 10.59350/zs3tv-pp865 |
| Willighagen, Egon | Open Source Java tool chain: CDK compiles and JUnit tests run | | posted-content | 10.59350/933ah-c7f36 |
| Figure 7. Model of how meiotic cells inhibit DNA replication during the MI–MII transition. | | component | 10.7554/elife.33309.026 |
| Willighagen, Egon | Modern chemistry in the CDK: beyond the two-atom bond | | posted-content | 10.59350/h2ytc-6pt51 |
| Lone, Waseem | Silicon-tethered colchicine aryne cyclo-adduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases | | posted-content | 10.26434/chemrxiv-2024-rs3lh |
| Apodaca, Richard L. | From IUPAC Name to Molecular Formula with Ruby CDK | | posted-content | 10.59350/1nn38-3ef94 |
| Zettelmeyer, Florian | CDK Digital Marketing: Addressing Channel Conflict with Data Analytics | 2014 | reference-book | 10.4135/9781473969650 |
| Shimotohno, Akie | CDKPhosphorylation | | other | 10.1002/9781119312994.apr0336 |
| Apodaca, Richard L. | MX Performance Comparison #3: Substructure Search in MX and CDK | | posted-content | 10.59350/n4y52-t3a30 |
| Willighagen, Egon | Trouble running the CDK JUnit tests with Cacao and Kaffe | | posted-content | 10.59350/rn78z-r7j37 |
| Apodaca, Richard L. | Agile Chemical Informatics Development with CDK and Ruby: RCDK-0.3.0 | | posted-content | 10.59350/c8h7w-n4922 |
| Futcher, A. B. | General Methods for Identifying Gl-phase Substrates of Cdk Protein Kinases. | 1998/6/1 | report | 10.21236/ada366953 |
| Protein kinase (CDK/MAK) | | book-chapter | 10.1007/978-3-540-49756-1_63 |
| Purnamasari, Maretta Rosabella | Iktiosis Vulgaris | | journal-article | 10.55175/cdk.v47i10.1085 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/8/16 | peer-review | 10.1111/odi.13687/v1/review1 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/8/17 | peer-review | 10.1111/odi.13687/v1/review2 |
| Prasetya, Damar | Varisela Neonatal | | journal-article | 10.55175/cdk.v47i12.1239 |
| Cyclin-Dependent Kinase (CDK) Inhibitors: StructureActivity Relationships and Insights into the CDK2 Selectivity of 6Substituted 2Arylaminopurines | | component | 10.1021/acs.jmedchem.6b01254.s002 |
| Apodaca, Richard L. | From SMILES to InChI: Rino, CDK, and Ruby Java Bridge | | posted-content | 10.59350/hra9n-qry69 |
| Ringer, Lymor | Role of p53 in cdk Inhibitor VMY-1-103-induced Apoptosis in Prostate Cancer | 2013/11/1 | report | 10.21236/ada592440 |
| Anurogo, Dito | Cancer Stem Cells | | journal-article | 10.55175/cdk.v48i11.1549 |
| Pohl, M. | GWK/CDK-Bank | 1994/1/1 | book-chapter | 10.4337/9781781954218.00152 |
| Cyclin-Dependent Kinase (CDK) Inhibitors: StructureActivity Relationships and Insights into the CDK2 Selectivity of 6Substituted 2Arylaminopurines | | component | 10.1021/acs.jmedchem.6b01254.s001 |
| EMPIAR dataset | | | 10.6019/empiar-10438 |
| Shimotohno, Akie | CDK Phosphorylation | | book-chapter | 10.1002/9780470988923.ch5 |
| Dutta, Anindya | Action of the p53 Effector, p2l, on its Targets: Cyclin cdk and PCNA | 1998/10/1 | report | 10.21236/ada368460 |
| Apodaca, Richard L. | Easily Calculate TPSA Descriptors from SMILES Strings Using Ruby CDK | | posted-content | 10.59350/8xxp3-b8077 |
| Roovers, Kristin | Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis | 2002/5/1 | report | 10.21236/ada407447 |
| Apodaca, Richard L. | MX Performance Comparison #2: Exhaustive Ring Perception in MX and CDK | | posted-content | 10.59350/tv70e-5c238 |
| Rusli, Richardo | Retinitis Pigmentosa | | journal-article | 10.55175/cdk.v47i7.597 |
| Durandau, Eric | Cross-regulation between CDK and MAPK control cellular fate | | posted-content | 10.1101/274787 |
| Ringer, Lymor | Role of p53 in cdk Inhibitor VMY-1-103-Induced Apoptosis in Prostate Cancer | 2012/9/1 | report | 10.21236/ada567635 |
| Kawauchi, Takeshi | Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders | 2013/3 | journal-article | 10.1111/gtc.12029 |
| Yu, Bo | Downregulation of Cyclin D1 Alters cdk 4- and cdk 2-Specific Phosphorylation of Retinoblastoma Protein | 2000/6 | journal-article | 10.1006/mcbr.2000.0238 |
| Cheng, Weiyan | Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures | 2019/2 | journal-article | 10.1016/j.ejmech.2019.01.003 |
| ., Sukamto | Penanganan Ketoasidosis Diabetik pada Anak | | journal-article | 10.55175/cdk.v49i9.2039 |
| Nishizawa, Masafumi | Phosphorylation of Sic1, a Cyclin-dependent Kinase (Cdk) Inhibitor, by Cdk Including Pho85 Kinase Is Required for Its Prompt Degradation | 1998/9 | journal-article | 10.1091/mbc.9.9.2393 |
| Cyclin dependent kinase (CDK) | 2010/11 | journal-article | 10.1038/scibx.2010.1319 |
| Cyclin-Dependent Protein Kinases (CDK) | 2008 | book-chapter | 10.1007/978-1-4020-6754-9_3981 |
| CDK | 2006 | book-chapter | 10.1007/3-540-29623-9_10003 |
| Wysocki, Robert | CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage | 2006/10 | journal-article | 10.1038/nsmb1139 |
| Mahendra, Cipta | Peutz-Jeghers Syndrome | | journal-article | 10.55175/cdk.v48i12.1574 |
| Katz, Max | RichFaces CDK: Building Custom Components | 2011 | book-chapter | 10.1007/978-1-4302-3450-0_14 |
| Lawrenti, Hastarita | Hemofilia dan Perkembangan Terapinya | | journal-article | 10.55175/cdk.v48i9.1496 |
| Figure 4: The efficiency of tumor markers in distinguish CDK patients with normal serum creatinine from healthy controls. | | component | 10.7717/peerj.19240/fig-4 |
| Apodaca, Richard L. | Open Benchmarks for Cheminformatics: First Performance Comparison Between CDK and MX | | posted-content | 10.59350/7nc6k-w4216 |
| Cyclin‐Dependent Protein Kinase (
CDK
) | | other | 10.1002/0471684228.egp02997 |
| Srivastava, Mansi | Lineage-specific CDK activity dynamics characterize early mammalian development | | posted-content | 10.1242/prelights.38013 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/10/7 | peer-review | 10.1111/odi.13687/v2/review1 |
| Apodaca, Richard L. | Cheminformatics for the Web: Convert SD Files to HTML with Ruby CDK | | posted-content | 10.59350/gvwgq-b0x50 |
| Yuliana, Jeni | Aspek Klinis Ambliopia | | journal-article | 10.55175/cdk.v49i1.1639 |
| Sanchez-Diaz, Alberto | The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth | 2012/8/29 | journal-article | 10.1038/emboj.2012.224 |
| Pérez-Hidalgo, Livia | CDK Inhibitors | 2013 | book-chapter | 10.1007/978-1-4419-9863-7_12 |
| Apodaca, Richard L. | From InChI to Image with Ruby Open Babel and Ruby CDK | | posted-content | 10.59350/r891p-vmx14 |
| Chandra, Rudi | Tatalaksana Melanoma Maligna Kutaneus | | journal-article | 10.55175/cdk.v48i7.1453 |
| Turner, N. | Targeting the CDK 4-6 pathway | 2019/3 | journal-article | 10.1016/s0960-9776(19)30078-5 |
| Fig. 1. Ovarian enlargement and lack of blood flow in the CDK regimen with a full bladder | | component | 10.17816/psaic575-154 |
| Teo, Gloria | Diagnosis dan Tatalaksana Kegawatdaruratan Hiperkalemia | | journal-article | 10.55175/cdk.v48i8.1447 |
| Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor | | component | 10.1021/acs.oprd.1c00255.s001 |
| Lawrensia, Sherly | Diagnosis dan Tatalaksana Artritis Tuberkulosis | | journal-article | 10.55175/cdk.v47i8.773 |
| Ogata, Ryohei | Resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors confers cross-resistance to other CDK inhibitors but not to chemotherapeutic agents in breast cancer cells | 2021/1 | journal-article | 10.1007/s12282-020-01150-8 |
| RAYNAL, S | DIFFERENTIAL-EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA-1 ON PROTEIN-LEVELS OF P21 WAF AND CDK-2 AND ON CDK-2 KINASE-ACTIVITY IN HUMAN RD AND CCL64 MINK LUNG-CELLS | | journal-article | 10.3892/ijo.7.2.337 |
| Aprelikova, Olga | Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase | 1995/8 | journal-article | 10.1074/jbc.270.31.18195 |
| Lawrensia, Sherly | Lung Abscess: Diagnosis and Treatment | | journal-article | 10.55175/cdk.v48i5.1373 |
| p27
Kip1−/−
Strain 3 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg10 |
| Nitiyoso, Nugroho | Aspek Imunitas pada COVID-19 | | journal-article | 10.55175/cdk.v48i9.1497 |
| ., Suharto | Fisioterapi Kasus Cerebral Palsy Kuadriplegia Spastik | | journal-article | 10.55175/cdk.v49i9.2036 |
| | | grant | 10.55776/p19894 |
| Febriana, Lydia | Suplemen untuk Terapi Obesitas | | journal-article | 10.55175/cdk.v49i0.1964 |
| When a CDK Is Really a Transcription Factor | 2005/1/11 | journal-article | 10.1126/stke.2662005tw14 |
| Prasetio, Adrian | Gangguan Psikiatri Terkait Kafein | | journal-article | 10.55175/cdk.v47i7.603 |
| EMPIAR dataset | | | 10.6019/empiar-10561 |
| Dai, Yun | CDK Inhibitors in Multiple Myeloma | 2008 | book-chapter | 10.1007/978-1-59745-564-0_22 |
| Nitiyoso, Nugroho | Pilihan Pengobatan Sistemik pada Psoriasis | | journal-article | 10.55175/cdk.v49i3.1775 |
| Lone, Waseem Iqbal | Discovery of Colchicine Aryne Cyclo-Adduct as a Potent Molecule for the Abrogation of Epithelial to Mesenchymal Transition Via Modulating Cell Cycle Regulatory Cdk-2 and Cdk-4 Kinases | | posted-content | 10.2139/ssrn.4814175 |
| Fauzi, Ahmad | Haglund Deformity: Diagnosis and Treatment | | journal-article | 10.55175/cdk.v49i10.2067 |
| Yahya, Willy | Retinopati Prematuritas : Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v47i10.1080 |
| Meijer, Laurent | CDK Inhibitors | 2002 | book-chapter | 10.1016/b978-012476249-7/50008-4 |
| Henri, P. | Psoriatic epidermis is associated with upregulation of
CDK
2 and inhibition of
CDK
4 activity | 2020/3 | journal-article | 10.1111/bjd.18178 |
| Cyclin dependent kinase (CDK) | 2010/3 | journal-article | 10.1038/scibx.2010.272 |
| Futcher, A. B. | General Methods for Identifying G1-Phase Substrates of Cdk Protein Kinases. | 1996/6/1 | report | 10.21236/ada323678 |
| Cyclin dependent kinase (CDK) | 2012/4 | journal-article | 10.1038/scibx.2012.385 |
| Karyadi, Erlinda | Cutaneous Mucormycosis | | journal-article | 10.55175/cdk.v49i2.1740 |
| Larochelle, Stéphane | CDK-Activating Kinases: Detection and Activity Measurements | | book-chapter | 10.1385/1-59259-857-9:279 |
| Bisbis, Badia | Cyclin-dependent Kinase (CDK) Inhibitors Regulate the CDK-Cyclin Complex Activities in Endoreduplicating Cells of Developing Tomato Fruit | 2006/3 | journal-article | 10.1074/jbc.m506587200 |
| Lukito, Johan Indra | Tinjauan atas Terapi Insulin | | journal-article | 10.55175/cdk.v47i9.917 |
| Dai, Yun | CDK Inhibitors in Leukemia and Lymphoma | 2019/9/17 | book-chapter | 10.1201/9780429114670-15 |
| Putri, Zanty Rakhmania | Bell’s Palsy: Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v49i8.1986 |
| Pricelda, Alicia | Tren Terapi Age-Related Macular Degeneration | | journal-article | 10.55175/cdk.v48i12.1584 |
| Cicenas, Jonas | CDK Inhibitors and FDA: Approved and Orphan | | journal-article | 10.3390/cancers16081555 |
| Müllers, Erik | Cdk activity drives senescence from G2 phase | | posted-content | 10.1101/041723 |
| Karyadi, Erlinda | Cutaneous Mucormycosis | | journal-article | 10.55175/cdk.v49i2.1726 |
| -, Tommy | Angina Prinzmetal - Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v48i6.1431 |
| p27
Kip1−/−
Strain 2 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg9 |
| Afifah Nurullah, Fitri | Tinjauan atas N-Nitrosodimethylamine (NDMA) | | journal-article | 10.55175/cdk.v47i12.1249 |
| Chandra, Rudi | Pilihan Pengobatan Dermatologis Penuaan Periorbital | | journal-article | 10.55175/cdk.v47i12.1241 |
| Morgan, David O. | Principles of CDK regulation | 1995/3 | journal-article | 10.1038/374131a0 |
| Mahendro, Della Sulamita | Penggunaan Antivirus untuk COVID-19 | | journal-article | 10.55175/cdk.v48i7.1459 |
| Kristiningrum, Esther | Penggunaan Hydroxychloroquine dalam Tatalaksana Covid-19 | | journal-article | 10.55175/cdk.v47i12.1246 |
| Suryani, Adelia | Faktor-Faktor yang Memengaruhi Pigmentasi Manusia | | journal-article | 10.55175/cdk.v47i11.1195 |
| Permasutha, Made Bayu | Tinjauan atas Kanker Rongga Mulut | | journal-article | 10.55175/cdk.v48i3.1327 |
| Apodaca, Richard L. | CampDepict: Building a Simple SMILES Depict Web Application With JRuby, Structure CDK, and Camping | | posted-content | 10.59350/d2m6v-tag27 |
| Johan, Michael | Evaluasi dan Tatalaksana Hipernatremia | | journal-article | 10.55175/cdk.v48i6.1441 |
| Palacios Blanco, Inés | CDK phospho-regulation of the Rad51-accessory factor Sfr1 and its role in meiotic recombination | | dissertation | 10.14201/gredos.161088 |
| -, Carlson | Tatalaksana Demam pada Anak | | journal-article | 10.55175/cdk.v47i11.1200 |
| Decision letter: CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading | 2016/12/19 | peer-review | 10.7554/elife.23352.021 |
| Kusumo, Inosensia Diajeng | Tinjauan Atas Pioderma | | journal-article | 10.55175/cdk.v49i4.1822 |
| CDK Inhibitor Triples PFS in Breast Cancer | 2013/1/1 | journal-article | 10.1158/2159-8290.cd-nb2012-149 |
| ASCO TAPUR, CDK Studies Endeavor to Fill Gaps in Personalized Cancer Care Research | 2024/12/1 | dataset | 10.1200/acon.24.00037 |
| EMPIAR dataset | | | 10.6019/empiar-10431 |
| Fanardy, Angeline | Toksin Botulinum untuk Kasus Urogenital | | journal-article | 10.55175/cdk.v48i3.1337 |
| Dinari, Nur Alfi | Miopia: Etiologi dan Terapi | | journal-article | 10.55175/cdk.v49i10.2069 |
| Ciatawi, Kartini | Patofisiologi Spinal Cord Injury | | journal-article | 10.55175/cdk.v49i5.1848 |
| Ciatawi, Kartini | Patofisiologi Spinal Cord Injury | | journal-article | 10.55175/cdk.v49i9.2032 |
| Stanley, Jone A. | Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors | 2011/7 | journal-article | 10.1016/j.reprotox.2011.05.007 |
| Renita Sanyasi, Rosa De Lima | Sindrom Mona Lisa | | journal-article | 10.55175/cdk.v48i1.1258 |
| Wijaya, Sandy | Diagnosis dan Tatalaksana Polisitemia Vera | | journal-article | 10.55175/cdk.v47i7.596 |
| Lawrenti, Hastarita | Penghambat Immune Checkpoint untuk Terapi Kanker | | journal-article | 10.55175/cdk.v49i0.1966 |
| Shamsi, Zahra | Concestor kinase activation mechanism uncovers the cyclin dependence of CDK family kinases | | posted-content | 10.1101/410902 |
| Cherub, Jane | Terapi Antikoagulan pada COVID-19 | | journal-article | 10.55175/cdk.v48i6.1436 |
| Lukito, Johan Indra | Gunakan Insulin dengan CERMAT | | journal-article | 10.55175/cdk.v47i10.1093 |
| Mueller, Daniel | Abstract 2821: Characterization of CDK inhibitors in a biochemical assay using a comprehensive panel of human CDK-cyclin complexes | 2016/7/15 | journal-article | 10.1158/1538-7445.am2016-2821 |
| Setiawan, Michael | Mielopati Non Kompresif: Pendekatan Diagnosis | | journal-article | 10.55175/cdk.v47i9.909 |
| Dewi, Nadia Puspa | Aspek Klinis Dermatitis Seboroik | | journal-article | 10.55175/cdk.v49i6.1881 |
| Irsyada Yusuf, Amry | Diagnosis dan Tatalaksana Kriptorkhismus | | journal-article | 10.55175/cdk.v48i3.1330 |
| Wijaya, Meiliyana | Meningitis Kriptokokus pada Penderita HIV | | journal-article | 10.55175/cdk.v48i1.1256 |
| Feinberg, Bruce A. | Prescribing preferences for hormone sensitive (HR+) metastatic breast cancer (mBC) in the CDK 4/6 inhibitor (CDK 4/6i) era. | 2020/5/20 | journal-article | 10.1200/jco.2020.38.15_suppl.e13058 |
| Ratna Sari, Ihda Zuyina | Gambaran Sistiserkosis dan Taeniasis | | journal-article | 10.55175/cdk.v49i3.1768 |
| Besser, Alexandra | CDK Inhibitors in Normal and Malignant Cells | 2023 | book-chapter | 10.1016/b978-0-12-821618-7.00221-2 |
| Mahendrakrisna, Daniel | Tatalaksana Epilepsi Refrakter | | journal-article | 10.55175/cdk.v47i9.911 |
| Dianky, Amanda | Peran Nutrigenomik pada Tata Laksana Obesitas | | journal-article | 10.55175/cdk.v49i0.1965 |
| Decision letter: CDK control pathways integrate cell size and ploidy information to control cell division | 2020/12/20 | peer-review | 10.7554/elife.64592.sa1 |
| Wijaya, Lupita | Tatalaksana Nyeri Neuropatik Perifer dengan Sediaan Patch | | journal-article | 10.55175/cdk.v48i9.1484 |
| 4-Arylazo-3, 5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects | | component | 10.1021/jm0605740.s001 |
| First CDK 4/6 Inhibitor Heads to Market | 2015/4/1 | journal-article | 10.1158/2159-8290.cd-nb2015-028 |
| p27
Kip1−/−
Strain 1 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg8 |
| Carrieri, Francesca Anna | CDK
1 and
CDK
2 regulate
NICD
1 turnover and the periodicity of the segmentation clock | 2019/7 | journal-article | 10.15252/embr.201846436 |
| Mahendra, Cipta | Terapi Berbasis Sel: Perkembangan Terkini | | journal-article | 10.55175/cdk.v49i3.1769 |
| Clinical Trial in Healthy Volunteers and Subjects With CDK | | journal-article | 10.31525/ct1-nct03893799 |
| Cyclin dependent kinase (CDK); p53 | 2012/10 | journal-article | 10.1038/scibx.2012.1028 |
| CRESCENZI, ELVIRA | Association of Bcl‐2 with Cyclin A/Cdk‐2 Complex and Its Effects on Cdk‐2 Activity | 2002/11 | journal-article | 10.1111/j.1749-6632.2002.tb04647.x |
| Tan, Christine | Trombosis pada Pasien COVID-19 | | journal-article | 10.55175/cdk.v48i12.1571 |
| Chandra, Rudi | Aspek Dermatologi Penuaan Kulit Periorbital | | journal-article | 10.55175/cdk.v47i9.920 |
| -, Cecile | Diagnosis dan Tatalaksana Paroxysmal Nocturnal Hemoglobinuria | | journal-article | 10.55175/cdk.v48i7.1452 |
| Decker, T | Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27 | 2002/3/1 | journal-article | 10.1038/sj.leu.2402389 |
| Mostafa, Heba H. | Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons | 2015/5 | journal-article | 10.1128/jvi.00106-15 |
| Sondhi, Sham M. | Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases | 2006/6 | journal-article | 10.1016/j.bmc.2006.01.054 |
| Falco, Giulia De | Cdk Inhibitors: Background and Introduction | | book-chapter | 10.1385/1-59259-401-8:01 |
| -, Filberto | Diagnosis dan Tatalaksana Congenital Talipes Equino Varus (CTEV) | | journal-article | 10.55175/cdk.v48i1.1270 |
| Grant, Steven | CDK inhibitors and immune responses | 2009/8/15 | journal-article | 10.4161/cc.8.16.9346 |
| Kumala, Marcia | Suplementasi Vitamin B1 untuk Pasien Sepsis | | journal-article | 10.55175/cdk.v47i8.783 |
| Bird, R.Curtis | The Cyclin/Cyclin-Dependent Kinase (cdk) Complex | 1997 | book-chapter | 10.1016/b978-012100160-5/50006-3 |
| A novel and robust molecular switch actuating the quantitative model of eukaryotic Cdk control | | proceedings-article | 10.18699/sbb-2022-104 |
| Luminturahardjo, Winarko | Peranan Probiotik dalam Penanganan Infeksi COVID-19 | | journal-article | 10.55175/cdk.v48i5.1371 |
| Supit, Brigita | Infeksi TORCH Maternal dan Kongenital | | journal-article | 10.55175/cdk.v48i9.1499 |
| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| Linea Dorada | Tracklist: 1. El numero uno 2. La camioneta gris 3. La bronco negra 4. Chico Fuentes 5. Setecientas libras 6. Doctor Fonseca 7. Juan Ramos 8. Rosita la morena 9. Crimen en Chihuahua 10. La entallada 11. Gumaro Vazquez 12. Candido Rodriguez 13. El culichi 14. Esperanza Valero 15. Pedro Paez 16. Los traficantes 17. La ley del contrabandista 18. Los dos contrabandistas 19. El aguila real 20. El corrido de Gabino | 2002 | 2024-11-21T12:12:01Z |
| Musica Para La Raza, Vol.9 | Tracklist: 1. Carinito de Mi Vida 2. Sabiendo Quien Era Yo 3. Dijiste y Juraste 4. Te Aplacas o Te Aplaco 5. Tuve Una Novia 6. Tu Delirio 7. Dos Mujeres 8. Vamonos 9. Alta y Delgadita 10. La Fe Perdida 11. No Me Vuelvo A Enamorar 12. Que Sabes Tu | 2001 | 2024-11-26T05:52:03Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| CIA Reading Room cia-rdp84b00148r000100370001-5: OEXA RECORDS MANAGEMENT | Charles E. Wilson Chief, Public Affairs Division OEXA Records Management 1. Action Requested: Transfer primary PAD records management responsibility to OEXA Registry. 2. Background: Since PA ceased to exist as an Independent Office and became a Division in OEXA, PAD has nevertheless retained a Records Management Officer (RMO) and primary responsibility for this function. Since this is normally a Registry function, we are probably overdue in transferring it. I understand the OEXA Registry is already RMO for LLD. It seems to me that in a perfect world PAD would retain day-to-day maintenance of its decentralized files, but the Registry would assume responsi- bility for such things as reporting annual volume surveys, maintaining file retirement schedules, file renumbering projects, and the like. 3. Recommendation: Request OEXA Administrative Officer's assistance in establishing the Chief, OEXA Registry as RMO for all of OEXA and in transferring PAD's responsibility. We are prepared to assi; | 1982 | 2025-02-19T12:51:25Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| Vicki Winans | Tracklist: 1. Work It Out 2. Prelude: We Shall Overcome 3. Precious Lord (A Tribute To Dr. Martin Luther King) 4. Stand Up and Praise Him 5. We Shall Behold Him (New Rendition) 6. The Only One 7. Suddenly 8. I Remember When 9. You Never Left Me 10. Believing Is Seeing 11. Mary Did You Know | 1994 | 2017-10-20T11:51:56Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| DTIC ADB240661: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from GL phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the GL phase cyclin dependent kinases (cdk), cdk4 and cdk6. Cyclin dependent kinase 4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle-from GL into S phase in the osteosarcoma cell line, U2OS. Understanding differential regulation of these two kinases and their potentially different ; | 1998 | 2018-03-03T10:06:08Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| Phunky Phetes ep2 | Phunky Phetes ep2 created by fourstones (victor) Put together this show while (literally) on the road in Hollywood. Sorry about the quality of bumper, clearly the quality of phunk makes up for all. Track List: coast to coast-DU-remix by: deutscheunschuld -- (cc) Sampling Plus Vroum,vroum (remix) by: stefsax -- (cc) Attribution Noncommercial Life of Luxury (Shout Out mix) by: duckett -- (cc) Attribution Noncommercial Share-Alike (3.0) Tupelo by: Minus Kelvin -- (cc) Noncommercial Sampling Plus NYC-OLD SCHOOL Bootleg MIX. by: J.Lang -- (cc) Noncommercial Sampling Plus Deep In Ya Self (Faith Mix) by: DoKashiteru -- (cc) Attribution Noncommercial (3.0) Dream Of You by: Alex -- (cc) Attribution Noncommercial (3.0) Official (Ex-centric mix) by: cdk -- (cc) Attribution Noncommercial from ccMixter Bumpers: phunky phetes intro by: fourstones -- (cc) Noncommercial Sampling Plus Songboy3 CCMixter.org Promo 02 by: Songboy3 -- (cc) Attribution Noncommercial Share-Alike phphout ep.2 by: fourstones -; | | 2009-07-28T13:15:00Z |
| Clave Azul | Tracklist: 1. Lamberto Quintero 2. Pedro Aviles 3. Los Gallos de Sinaloa 4. El Corrido de Guasave 5. Ruben Cabada 6. Catarino y los Rurales 7. El Prieto "Crispin" 8. Cornelio Vage 9. El Contrabando de Nogales 10. Rosendo G. Castro | 2001 | 2024-12-13T11:33:31Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| CDK Global, LLC al v. Tulley Automotive Group, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2017-07-24T21:20:07Z |
| Boleros | Tracklist: 1. El Reloj/Perfidia/Mira Gue Eres Linda/Maria Elena/Aquellos Ojos Verdes/El Reloj/Te Quiero Dijiste/La Barca/Historia De Un Amor/El Reloj/Siboney/Sabor A Mi/Quiereme Mucho/El Reloj/Amapola/Angelitos Negros/Solamente Un Vez/Besame Mucho/El Reloj/Vamos A La Cama/La Conga 2. Me Lo Dijo Adela/Mi Vaca Lechera/Maria Christina Me Quiere Governar/Tequila/La Conga/Salud, Dinero Y Amor/Cielito Lindo/La Pachanga/La Gallina Papanatas/La Conga/La Bamba/La Raspa/La Cucaracha/La Conga/Se Va El Caiman/Todos Queremos Mas/Baio De Ana/La Conga/Vamos A La Cama | 1988 | 2024-07-11T07:14:09Z |
| The Future of Public Access TV and The Internet | Mark Cooper of the Consumer Federation of America speaks with local independent radio host John Grebe about current bills in Congress affecting the future of Public Access Television and the Internet. We also hear from Jason Crow, Access Coordinator of Cambridge Community Television and Michael Eisenmenger of Manhattan Neighborhood Network about how pending legislation in Congress takes away local control of media and places more power in the hands of Big Cable and Telephone companies. Click here to listen to the ACMEBoston Podcast February 11, 2006. Also discussed is the issue of Network Neutrality which Free Press , the national media reform organization, describes as "the guiding principle of the Internet that fosters open competition and innovation, while preserving the independence and accessibility of the World Wide Web" - Free Press, Net Freedom Now . To take a closer look at these issues, we'll hear John Grebe's interview from his program, "Sounds of Dissent" broadcast live on ; | 2006 | 2006-07-27T08:21:29Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| github.com-debezium-debezium_-_2021-12-10_11-35-09 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-10T12:09:39Z |
| DTIC ADA382749: Resistance to Tamoxifen: A Consequence of Altered p27Kipl Regulation During Breast Cancer Progression | This grant addresses the molecular mechanisms of resistance to the anti-estrogen, Tamoxifen, in breast cancers. Both estrogens and antiestrogens influence the cell cycle during the GI phase. In breast tumors, loss of the cdk inhibitor, p27, is associated with a poor prognosis and with steroid resistance. We postulate that altered p27 degradation in breast cancer may contribute to resistance to antiestrogen therapy. In the last year, we have assayed cell cycle effects of estradiol in the ER+ breast cancer cell line, MCF-7. MCF-7 arrests in G1 upon removal of estradiol or on addition of Tamoxifen. Upon re-addition of estradiol, cells re-enter the cell cycle with onset of S phase by 12 hours and loss of both p21 and p27 proteins. Cyclin D1 associated kinase activity rose transiently in early G1. Activation of cyclin E/cdk2 kinase in mid-late G1 was accompanied by loss of cyclin E-associated p21 and p27. The requirement for p27 in the quiescence induced by estradiol depletion was investiga; | 1999 | 2018-04-29T17:57:19Z |
| DTIC ADA398199: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal Tumorigenic Human Breast Cells | Ubiquitin-mediated proteolysis of cyclins, cyclin-dependent kinase inhibitors and certain other substrates, including proteins whose degradation is necessary for progression through mitosis, provide a molecular basis for unidirectional progression through the eukaryotic cell cycle. Aberrations in the ubiquitin-mediated destruction pathways, and particularly in the destruction of the Dl cyclin, have been implicated in human breast cancer. A cascade of enzymes leads to ubiquitination of substrate: El enzyme (ubiquitin activating); E2 enzyme (ubiquitin conjugating), and E3 enzyme (ubiquitin ligase). This last class of enzyme is large, and it performs the functions of targeting substrate and catalyzing formation of the polvubiquitin chains that mark substrate for destruction. We have found that all three members of the yeast cullin family are capable of performing the ubiquitination activity of E3 enzyme. All three yeast cullins undergo covalent modification with Rub1 protein, presumably t; | 2001 | 2018-05-05T21:00:08Z |
| DTIC ADA386459: Action of the p53 Effector, p21, on its Targets: Cyclin-CDK & PCNA | Our aim is to dissect the interactions of p21 (a downstream effector of the tumor suppressor protein p53) with its targets, cyclin-cdks and PCNA. In year 2 we have focused on the cyclin-cdks. We have quantitated the contribution of the cyclin-cdks binding Cy motif (on cdk substrates) to their interaction with the cyclin-cdks. We find that a Cy motif improves the Km of a substrate by 5OO-1000 fold without any effect on the Vmax of the peptide or the Km of ATP. Such a large contribution of the Cy motif to substrate recognition explains why a peptide based on the Cy motif of p21 inhibits phosphorylation by cdk. A small chemical that mimics the structure of the Cy motif would be a specific inhibitor of cdks and suppress breast cancer cell growth. Towards this end, site directed mutagenesis has been used to generate a library of mutants in the Cy motif of p21. Using this library we find that the first arginine (R1) and the third leucine (L3) of the Cy motif (RRLFG) are critical for docking ; | 1999 | 2018-04-30T22:37:50Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| the secrets of studying english | | 1980 | 2023-07-21T01:18:46Z |
| github.com-dabit3-awesome-aws-amplify_-_2021-02-13_23-48-59 | Curated list of AWS Amplify Resources Awesome AWS Amplify curates the best AWS Amplify, tools, tutorials, articles and more. PRs are welcome! Check out the Amplify Discord server Getting Started Github Documentation Workshops Serverless GraphQL API with AppSync and DynamoDB AWS Amplify Photo Sharing Workshop Next.js AWS Amplify Workshop Building real-time applications with React, GraphQL & AWS AppSync Building Mobile Applications with React Native & AWS Amplify AWS Amplify UnicornFlix Workshop (Video on Demand) AWS Amplify UnicornTrivia Workshop (Live streaming video) Tutorials - Blogs & tutorials General blogs & tutorials Full Stack Cloud Development with AWS Amplify TensorFlow.js + AWS Amplify 10 Minute Tutorial: Creating a Serverless Express Web Server & API ⚡️ 10 Ways to Use Serverless Functions Real quick GraphQL service with AWS Amplify & Appsync Visualizing Focus with Neurosity's Notion and AWS Amplify Build a Music Sharing App with Amazon S3 and AWS Amplify Introducing Conf; | 2021 | 2021-02-22T13:28:20Z |
| cuu-dinh-ky | | | 2024-04-09T14:17:26Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T21:59:48Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| The influence of negative training set size on machine learning-based virtual screening. | This article is from Journal of Cheminformatics , volume 6 . Abstract Background: The paper presents a thorough analysis of the influence of the number of negative training examples on the performance of machine learning methods. Results: The impact of this rather neglected aspect of machine learning methods application was examined for sets containing a fixed number of positive and a varying number of negative examples randomly selected from the ZINC database. An increase in the ratio of positive to negative training instances was found to greatly influence most of the investigated evaluating parameters of ML methods in simulated virtual screening experiments. In a majority of cases, substantial increases in precision and MCC were observed in conjunction with some decreases in hit recall. The analysis of dynamics of those variations let us recommend an optimal composition of training data. The study was performed on several protein targets, 5 machine learning algorithms (SMO, Naïve B; | 2014 | 2014-10-19T07:35:32Z |
| Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. | This article is from Breast Cancer : Targets and Therapy , volume 6 . Abstract Cellular proliferation, growth, and division following DNA (deoxyribonucleic acid) damage are tightly controlled by the cell-cycle regulatory machinery. This machinery includes cyclin-dependent kinases (CDKs) which complex with their cyclin partners, allowing the cell cycle to progress. The cell-cycle regulatory process plays a critical role in oncogenesis and in the development of therapeutic resistance; it is frequently disrupted in breast cancer, providing a rational target for therapeutic development. Palbociclib is a potent and selective inhibitor of CDK4 and -6 with significant activity in breast cancer models. Furthermore, it has been shown to significantly prolong progression-free survival when combined with letrozole in the management of estrogen receptor-positive metastatic breast cancer. In this article we review the cell cycle and its regulatory processes, their role in breast cancer, and the rat; | 2014 | 2014-10-06T01:38:18Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| github.com-sindresorhus-awesome_-_2023-10-26_11-42-32 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-26T13:33:54Z |
| Cierra la Puerta | Tracklist: 1. Cierra la Puerta 2. Una Copa Mas 3. Paloma Begra 4. Ahora Por Idea 5. Mi Sufrir 6. Anselma 7. Mi Dia de Suerte 8. Imelda 9. Que Dolor 10. El Ronquidito | 2001 | 2024-07-11T12:56:48Z |
| DTIC ADA385811: The Regulation of Human Cyclin E Protein Levels by the Ubiquitin Proteolytic Pathway | Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome-dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380. We pursued the first of these pathways by using a two-hybrid screen to identify proteins that could bind only to free cyclin E. This resulted in the isolation of human Cul-3, a member of the cullin family of E3 ubiquitin-protein ligases. We found that Cul-3 was bound to cyclin E but not to cyclin E-Cdk2 complexes in mammalian cells, and that overexpression of Cul-3 increased ubiquitination of cyclin E but not other cyclins. Conversely, deletion of the Cul-3 gene in mice caused increased accumulation of cyclin E protein, and had cell-type specific effects on S phase regulation. In the extraembryonic ectoderm, where cells undergo a standard mitotic cycle, there was a greatly increased number of cells in S phase. In the trophectoderm, where cells go throu; | 1999 | 2018-04-30T11:20:49Z |
| The Stormy Petrel (Large Print Edition) | | 1991 | 2023-07-25T00:30:17Z |
| DTIC ADA389310: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | The periodicity of CDK activity provides the molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins has been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with another multigene family of evolutionarily conserved proteins, the ROC/APC11 family, to form a complex that contains E3 ubiquitin ligase activity. We have show; | 2000 | 2018-05-01T22:46:59Z |
| Dante the Central Man of All the World | | 1922 | 2023-08-10T02:07:56Z |
| Chroniques syndicales internationalistes - CNT | La prochaine émission radio des Chroniques syndicales internationalistes sera demain, samedi 24 décembre 2022, à 11H30 sur Radio libertaire (89.4fm ou en ligne en direct sur http://media.radio-libertaire.org:8080/radiolib.mp3 , en podcast également), et animée par le secrétariat international de la CNT. Nous dédions cette émission aux camarades du Conseil Démocratique des Kurdes en France (CDK-F) en diffusant l'intégralité de leur conférence de presse qui a eu lieu le vendredi 23 décembre à 18h30 à Paris, suite à l'attaque sanglante ciblant des camarades Kurdes, faisant 3 morts et 4 blessés graves. Nous appelons à rejoindre massivement la manifestation appelée par le CDK-F ce samedi 24 décembre à 12H Place de la République à Paris. Tout notre soutien aux camarades Kurdes, Un coup porté contre l'un-e d'entre nous est un coup porté contre nous tous.toutes ! La solidarité sera toujours notre arme ! Le Secrétariat International de la CNT | 2022 | 2022-12-27T17:10:55Z |
| coderedfm27062020 | your weekly drum&bass radioshow outta stuttgart / germany | | 2020-06-28T15:02:26Z |
| DTIC ADA392349: Action of the p53 Effector, p21, on its Targets: Cyclin-cdk and PCNA | Cy or RXL motifs have been previously shown to be cyclin binding motifs found in a wide range of cyclin-cdk interacting proteins. For both cyclin A/cdk2 and cyclin E/cdk2, the presence of a Cy motif decreased the Km(sup peptide! 75 to 120-fold while the kcat remained unchanged. Changes in the length of the linker between the Cy motif and the phosphoacceptor serine suggest that both sites are engaged simultaneously to the cyclin and the cdk, respectively. PS100, a peptide containing a Cy motif, acts as a competitive inhibitor of cyclin/cdk complexes with a 15-fold lower Ki for cyclin E/cdk2 than for cyclin A/cdk2. These results provide kinetic proof that a Cy motif located at a minimal distance from the SPXK is essential for optimal phosphorylation by cdks and suggest that small chemicals that mimic the Cy motif would be specific inhibitors of substrate recognition by cyclin-dependent kinases. In addition, a detailed mutagenesis approach to define what sequence serves as a Cy motif reve; | 2000 | 2018-05-03T14:38:06Z |
| CDK-120 | | | 2021-04-17T01:59:16Z |