| Author | Title | Print-Published | Type | DOI@Sci-hub |
| CDK | | reference-entry | 10.1007/springerreference_92996 |
| Functions of CDK/cyclin Complexes in Endoreplication Regulation by the CDK Inhibitor SIAMESE | | dissertation | 10.31390/gradschool_dissertations.5173 |
| CDK | | reference-entry | 10.1007/springerreference_37256 |
| Pandit, J. | Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2 | 2009/9/8 | dataset | 10.2210/pdb3igg/pdb |
| Pandit, J. | Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2 | 2009/9/8 | dataset | 10.2210/pdb3ig7/pdb |
| Figure 4—figure supplement 1. CDK–phosphorylation of ORC intrinsically inhibits helicase loading. | | component | 10.7554/elife.33309.013 |
| CDK Inhibitor R547 | | reference-entry | 10.32388/iap5sl |
| Willighagen, Egon | 10000 CDK commits! | | posted-content | 10.59350/w1hpp-ks316 |
| Willighagen, Egon | CDK Literature #3 | | posted-content | 10.59350/rkkty-a3w29 |
| Willighagen, Egon | CDK News | | posted-content | 10.59350/xf9bq-44218 |
| Willighagen, Egon | CDK Literature #4 | | posted-content | 10.59350/es4e7-esh15 |
| CDK | | book-chapter | 10.1007/3-540-30683-8_274 |
| Cermin Dunia Kedokteran | | journal | 10.55175/cdk |
| CDK Gene Mutation | | reference-entry | 10.32388/kf9klo |
| CDK Inhibitor AT7519 | | reference-entry | 10.32388/286jz0 |
| Willighagen, Egon | StatCVS on CDK | | posted-content | 10.59350/q7ehm-v1m81 |
| Willighagen, Egon | CDK Literature #1 | | posted-content | 10.59350/g22fv-gtc07 |
| CDK | | book-chapter | 10.1007/978-3-540-47648-1_959 |
| Hu, X. | Cdc2: a monopotent or pluripotent CDK? | 2011/6 | journal-article | 10.1111/j.1365-2184.2011.00753.x |
| Willighagen, Egon | CDK Literature #2 | | posted-content | 10.59350/17nhx-htt54 |
| Supplementary file 1. CDK sequences used for phylogenetic analysis | | component | 10.7554/elife.10767.021 |
| Huang, Linda | Faculty Opinions recommendation of Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates. | 2007/4/23 | dataset | 10.3410/f.1080804.533727 |
| Willighagen, Egon | Nightly CDK builds now available | | posted-content | 10.59350/s63wt-hbx56 |
| Apodaca, Richard L. | Updating Ruby CDK | | posted-content | 10.59350/yy9a2-wy148 |
| Willighagen, Egon | The CDK data model #1 | | posted-content | 10.59350/4xfms-7nn46 |
| CDK Inhibitor SNS-032 | | reference-entry | 10.32388/2sggcz |
| Willighagen, Egon | CDK-Taverna fully recognized | | posted-content | 10.59350/pk40z-7z702 |
| cdk | | book-chapter | 10.1007/3-540-29832-0_321 |
| CDK | | book-chapter | 10.1007/978-3-540-38918-7_5357 |
| Willighagen, Egon | CDK Module dependencies #2 | | posted-content | 10.59350/e7qrk-ypg78 |
| Schreiner, S. | Kongenitale Kniegelenkluxation (CDK) | 2012/1 | journal-article | 10.1007/s00132-011-1874-7 |
| cdk | | book-chapter | 10.1007/3-540-29719-0_321 |
| Willighagen, Egon | CDK Workshop - Day #2 | | posted-content | 10.59350/f7vn0-kqz26 |
| Carnero, A. | The INK4 Family of CDK Inhibitors | 1998 | book-chapter | 10.1007/978-3-642-71941-7_3 |
| CDK Inhibitors | | book-chapter | 10.1007/978-3-540-47648-1_963 |
| | | journal-issue | 10.55175/cdk.v48i6 |
| Valk, Ervin | CDK signaling via nonconventional CDK phosphorylation sites | 2023/11/1 | journal-article | 10.1091/mbc.e22-06-0196 |
| Grigoroudis, Asterios I. | Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_4 |
| Alvira, Daniel | Drug Delivery Strategies of Chemical CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_12 |
| Hu, Shanhu | Targeting anaphase catastrophe through CDK inhibition in lung cancer | | dissertation | 10.1349/ddlp.1623 |
| Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors | | component | 10.1021/acschembio.3c00616.s002 |
| | | journal-issue | 10.55175/cdk.v47i7 |
| Apodaca, Richard L. | Ruby CDK for Newbies | | posted-content | 10.59350/50ebs-4zq55 |
| Willighagen, Egon | Single PDFs for CDK News articles | | posted-content | 10.59350/rgdzb-bfe36 |
| Willighagen, Egon | Java Server Pages with CDK functionality | | posted-content | 10.59350/3kvks-pdb73 |
| Willighagen, Egon | Atom typing in the CDK | | posted-content | 10.59350/wm7aq-eqz10 |
| Willighagen, Egon | Calculating geometrical properties with the CDK | | posted-content | 10.59350/sy6r5-pzw09 |
| Apodaca, Richard L. | CDK, the Ruby Way | | posted-content | 10.59350/49w1p-2y164 |
| Willighagen, Egon | Jumbo 5.0 and the CDK | | posted-content | 10.59350/y0mte-4ns18 |
| Willighagen, Egon | CDK close to entering Debian | | posted-content | 10.59350/dmspa-wyb25 |
| CDK Inhibitory Protein | | book-chapter | 10.1007/3-540-30683-8_276 |
| CDK | 2011 | book-chapter | 10.1007/978-3-642-16483-5_959 |
| CDK Inhibitors | 2011 | book-chapter | 10.1007/978-3-642-16483-5_963 |
| | | journal-issue | 10.55175/cdk.v48i2 |
| | | journal-issue | 10.55175/cdk.v47i11 |
| CDK/JAK2/FLT3 Inhibitor TG02 Citrate | | reference-entry | 10.32388/xklmgh |
| Gortat, Anna | Analysis of CDK Inhibitor Action on Mitochondria-Mediated Apoptosis | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_9 |
| Willighagen, Egon | The CDK data classes and change notifications | | posted-content | 10.59350/3xsm0-bt478 |
| | | journal-issue | 10.55175/cdk.v49i0 |
| Apodaca, Richard L. | Scripting CDK with JRuby | | posted-content | 10.59350/sxxfq-shj88 |
| Willighagen, Egon | CDK Workshop - Days #3 and #4 | | posted-content | 10.59350/kvq10-snm07 |
| CDK-Activating Kinase Assembly Factor MAT1 | | reference-entry | 10.32388/6s4tbs |
| CDK | 2016 | book-chapter | 10.1007/978-3-662-46875-3_100468 |
| Willighagen, Egon | CDK Bug Squash Party - Day 5 | | posted-content | 10.59350/paxbm-rac78 |
| Willighagen, Egon | CDK Bug Squash Party - Day 2 | | posted-content | 10.59350/wzs4m-9ky43 |
| Willighagen, Egon | The CDK/Metabolomics/Chemometrics Unconference results | | posted-content | 10.59350/f2ajz-tmr63 |
| Willighagen, Egon | CDK and the Java 6 beta | | posted-content | 10.59350/6az21-1dt76 |
| Willighagen, Egon | Jumbo 5.0 and CML support in CDK | | posted-content | 10.59350/dzvnw-3b413 |
| Hirai, Hiroshi | Evaluating Chemical CDK Inhibitors as Cell Death Inducers | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_14 |
| | | journal-issue | 10.55175/cdk.v48i4 |
| Willighagen, Egon | UML diagram of CDK module dependencies | | posted-content | 10.59350/a3r1n-72841 |
| Apodaca, Richard L. | Porting MX - CDK-Compatible VF Implementation | | posted-content | 10.59350/xat1r-hcs92 |
| | | journal-issue | 10.55175/cdk.v47i10 |
| Willighagen, Egon | CDK Bug Squash Party - Day 1 | | posted-content | 10.59350/y5srm-hzx87 |
| Lacy, Susan | Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes | 1997/5/22 | journal-article | 10.1038/sj.onc.1201085 |
| | | journal-issue | 10.55175/cdk.v47i8 |
| Upton, Jason W. | Evidence for CDK-Dependent and CDK-Independent Functions of the Murine Gammaherpesvirus 68 v-Cyclin | 2006/12/15 | journal-article | 10.1128/jvi.01722-06 |
| | | journal-issue | 10.55175/cdk.v47i12 |
| Apodaca, Richard L. | Scripting Molecular Fingerprints with Ruby CDK | | posted-content | 10.59350/xgf37-ggz21 |
| | | grant | 10.55776/tai3266225 |
| | | journal-issue | 10.55175/cdk.v42i10 |
| | | journal-issue | 10.55175/cdk.v47i9 |
| | | journal-issue | 10.55175/cdk.v48i5 |
| | | journal-issue | 10.55175/cdk.v48i1 |
| | | journal-issue | 10.55175/cdk.v48i3 |
| Ruiz, E. Josué | Meiotic Inactivation of Xenopus Myt1 by CDK/XRINGO, but Not CDK/Cyclin, via Site-Specific Phosphorylation | 2008/10 | journal-article | 10.1016/j.molcel.2008.08.029 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s002 |
| Guevara, Tatiana | Evaluating the Effects of CDK Inhibitors in Ischemia–Reperfusion Injury Models | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_10 |
| Degradation by Design: New Cyclin K Degraders from Old CDK Inhibitors | | component | 10.1021/acschembio.3c00616.s001 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 1999/8/1 | report | 10.21236/ada378108 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s003 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 2000/9/1 | report | 10.21236/ada392485 |
| Apodaca, Richard L. | CDK, the Ruby Way: RCDK-0.2.0 | | posted-content | 10.59350/ev966-zz940 |
| Guha, Rajarshi | rcdk: Interface to the 'CDK' Libraries | 2006/10/4 | dataset | 10.32614/cran.package.rcdk |
| Lee, Young-Sam | Regulation of a Cyclin-CDK-CDK Inhibitor Complex by Inositol Pyrophosphates | 2007/4/6 | journal-article | 10.1126/science.1139080 |
| GROTH, A | High-density growth arrest in Ras-transformed cells: low Cdk kinase activities in spite of absence of p27 Cdk-complexes | 2005/9 | journal-article | 10.1016/j.cellsig.2004.11.021 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s001 |
| Gallastegui, Edurne | Immunoprecipitation of Cdk–Cyclin Complexes for Determination of Kinase Activity | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_1 |
| Design, Synthesis, and Biological Evaluation for First GPX4 and CDK Dual Inhibitors | | component | 10.1021/acs.jmedchem.3c01890.s004 |
| Apodaca, Richard L. | Drawing 2-D Structures with Structure-CDK | | posted-content | 10.59350/qxc8d-c1w35 |
| Cyclin-dependent Kinase (CDK) Inhibitor | | book-chapter | 10.1007/3-540-30683-8_390 |
| Fisher, Robert P | Faculty Opinions recommendation of Meiotic inactivation of Xenopus Myt1 by CDK/XRINGO, but not CDK/cyclin, via site-specific phosphorylation. | 2008/11/11 | dataset | 10.3410/f.1125916.583024 |
| Willighagen, Egon | CDK 1.0: a milestone after 7 year of development | | posted-content | 10.59350/qd21w-71g30 |
| lavarone, Antonio | Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15 | 1997/5 | journal-article | 10.1038/387417a0 |
| Willighagen, Egon | The molecular QSAR descriptors in the CDK | | posted-content | 10.59350/47rre-wwc20 |
| Gangopadhyay, Aditi | The Prospects of CDK Targeting and Clinical Application of CDK Inhibitors in Cancer | 2018/12/5 | book-chapter | 10.2174/9781681087016118090008 |
| Schneider, Brandt | Role of the Cdk Inhibitor Sic 1 in Start | 1998/8/1 | report | 10.21236/ada359281 |
| Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk) | | component | 10.1021/acschembio.7b00972.s002 |
| Chiarelli, C | Cyclin D, CDK and CDK Inhibitors in Melanocytic Neoplasms. | 1997/8 | journal-article | 10.1097/00000372-199708000-00072 |
| Willighagen, Egon | InChI's in LaTex and CDK News | | posted-content | 10.59350/hysd0-wvc09 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v49i2.1746 |
| Willighagen, Egon | Test results for the CDK 1.0.x branch | | posted-content | 10.59350/ry980-qya21 |
| Pérez-Benavente, Beatriz | Cell Synchronization Techniques to Study the Action of CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_8 |
| Synthesis of benzofuropyridine derivatives as CDK-5 inhibitors and anticancer agents | | dissertation | 10.58837/chula.the.2022.1218 |
| CDK | | other | 10.1002/0471684228.egp01945 |
| Guha, Rajarshi | rcdklibs: The CDK Libraries Packaged for R | 2009/1/8 | dataset | 10.32614/cran.package.rcdklibs |
| Willighagen, Egon | CDK Debug classes and fixing the ModelBuilder3D bug | | posted-content | 10.59350/6p49t-sj396 |
| Willighagen, Egon | CDK News 2.3 and InChI's | | posted-content | 10.59350/z97vw-87009 |
| Multiplexed Profiling of CDK Kinase Activities in Tumor Biopsies with Fluorescent Peptide Biosensors | | component | 10.1021/acssensors.4c00139.s001 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v48i12.1586 |
| Willighagen, Egon | CDK Bug Squash Party - Day 3 and 4 | | posted-content | 10.59350/zwkym-aty79 |
| Figure 3: The efficiency of tumor markers in distinguish CDK patients from healthy control. | | component | 10.7717/peerj.19240/fig-3 |
| | | grant | 10.55776/t393 |
| Palomino-Schätzlein, Martina | Metabolomic Applications to the Characterization of the Mode-of-Action of CDK Inhibitors | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_16 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v48i12.1589 |
| Willighagen, Egon | R/CDK install fails on GCC 4.0 systems | | posted-content | 10.59350/b1vyj-0kd63 |
| CDK | 2008 | book-chapter | 10.1007/978-1-4020-6754-9_2580 |
| Many Hats for Cdk Inhibitor | 2006/1/10 | journal-article | 10.1126/stke.3172006tw468 |
| Futcher, A. B. | General Methods for Identifying G1-phase Substrates of Cdk Protein Kinases | 1999/6/1 | report | 10.21236/ada374137 |
| | | grant | 10.35802/065956 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v49i2.1745 |
| Willighagen, Egon | Janocchio: Jmol and CDK based 1H coupling constant prediction | | posted-content | 10.59350/rxzh8-9yr48 |
| Willighagen, Egon | CDK is now available from your nearest Debian mirror | | posted-content | 10.59350/g5s78-zqk90 |
| Tsutsui, Taiki | Identification of target genes for the CDK subunits of the Mediator complex | 2011/12 | journal-article | 10.1111/j.1365-2443.2011.01565.x |
| Guidato, Sonia | Cyclin D2 Interacts with cdk‐5 and Modulates Cellular cdk‐5/p35 Activity | 1998/1 | journal-article | 10.1046/j.1471-4159.1998.70010335.x |
| CDK Inhibitors, Endocrine Therapy for Male Patients With Breast Cancer | 2019/3/8 | dataset | 10.1200/adn.19.190134 |
| -, - | Indeks Akhir Tahun | | journal-article | 10.55175/cdk.v48i12.1588 |
| -, - | Indeks Subjek | | journal-article | 10.55175/cdk.v49i1.1648 |
| Dutto, Ilaria | Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair | 2016 | book-chapter | 10.1007/978-1-4939-2926-9_11 |
| Direct Substrate Identification with an Analog Sensitive (AS) Viral Cyclin-Dependent Kinase (v-Cdk) | | component | 10.1021/acschembio.7b00972.s001 |
| -, - | Indeks Penulis | | journal-article | 10.55175/cdk.v49i1.1647 |
| Nishizawa, Masafumi | Mouse Cyclin-dependent Kinase (Cdk) 5 Is a Functional Homologue of a Yeast Cdk, Pho85 Kinase | 1999/11 | journal-article | 10.1074/jbc.274.48.33859 |
| CELL CYCLE-REGULATION OF THE FANCD2 PROTEIN VIA CDK-MEDIATED S592 PHOSPHORYLATION | | dissertation | 10.23860/thesis-cantres-velez-juan-2020 |
| Willighagen, Egon | Protein support in Bioclipse using Jmol and the CDK | | posted-content | 10.59350/23wn4-1nt07 |
| Willighagen, Egon | Comparing JUnit test results between CDK trunk/ and a branch | | posted-content | 10.59350/zs3tv-pp865 |
| Willighagen, Egon | Open Source Java tool chain: CDK compiles and JUnit tests run | | posted-content | 10.59350/933ah-c7f36 |
| Figure 7. Model of how meiotic cells inhibit DNA replication during the MI–MII transition. | | component | 10.7554/elife.33309.026 |
| Apodaca, Richard L. | Source Code Documentation in Ruby: RDoc for Ruby CDK | | posted-content | 10.59350/jf1hb-6ev38 |
| Willighagen, Egon | Modern chemistry in the CDK: beyond the two-atom bond | | posted-content | 10.59350/h2ytc-6pt51 |
| Lone, Waseem | Silicon-tethered colchicine aryne cyclo-adduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases | | posted-content | 10.26434/chemrxiv-2024-rs3lh |
| Apodaca, Richard L. | From IUPAC Name to Molecular Formula with Ruby CDK | | posted-content | 10.59350/1nn38-3ef94 |
| Zettelmeyer, Florian | CDK Digital Marketing: Addressing Channel Conflict with Data Analytics | 2014 | reference-book | 10.4135/9781473969650 |
| Shimotohno, Akie | CDKPhosphorylation | | other | 10.1002/9781119312994.apr0336 |
| Apodaca, Richard L. | MX Performance Comparison #3: Substructure Search in MX and CDK | | posted-content | 10.59350/n4y52-t3a30 |
| Willighagen, Egon | Trouble running the CDK JUnit tests with Cacao and Kaffe | | posted-content | 10.59350/rn78z-r7j37 |
| Apodaca, Richard L. | Agile Chemical Informatics Development with CDK and Ruby: RCDK-0.3.0 | | posted-content | 10.59350/c8h7w-n4922 |
| Protein kinase (CDK/MAK) | | book-chapter | 10.1007/978-3-540-49756-1_63 |
| Purnamasari, Maretta Rosabella | Iktiosis Vulgaris | | journal-article | 10.55175/cdk.v47i10.1085 |
| Futcher, A. B. | General Methods for Identifying Gl-phase Substrates of Cdk Protein Kinases. | 1998/6/1 | report | 10.21236/ada366953 |
| Pohl, M. | GWK/CDK-Bank | 1994/1/1 | book-chapter | 10.4337/9781781954218.00152 |
| Ringer, Lymor | Role of p53 in cdk Inhibitor VMY-1-103-induced Apoptosis in Prostate Cancer | 2013/11/1 | report | 10.21236/ada592440 |
| Anurogo, Dito | Cancer Stem Cells | | journal-article | 10.55175/cdk.v48i11.1549 |
| Prasetya, Damar | Varisela Neonatal | | journal-article | 10.55175/cdk.v47i12.1239 |
| Cyclin-Dependent Kinase (CDK) Inhibitors: StructureActivity Relationships and Insights into the CDK2 Selectivity of 6Substituted 2Arylaminopurines | | component | 10.1021/acs.jmedchem.6b01254.s002 |
| Apodaca, Richard L. | From SMILES to InChI: Rino, CDK, and Ruby Java Bridge | | posted-content | 10.59350/hra9n-qry69 |
| Cyclin-Dependent Kinase (CDK) Inhibitors: StructureActivity Relationships and Insights into the CDK2 Selectivity of 6Substituted 2Arylaminopurines | | component | 10.1021/acs.jmedchem.6b01254.s001 |
| EMPIAR dataset | | | 10.6019/empiar-10438 |
| Shimotohno, Akie | CDK Phosphorylation | | book-chapter | 10.1002/9780470988923.ch5 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/8/16 | peer-review | 10.1111/odi.13687/v1/review1 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/8/17 | peer-review | 10.1111/odi.13687/v1/review2 |
| Dutta, Anindya | Action of the p53 Effector, p2l, on its Targets: Cyclin cdk and PCNA | 1998/10/1 | report | 10.21236/ada368460 |
| Apodaca, Richard L. | Easily Calculate TPSA Descriptors from SMILES Strings Using Ruby CDK | | posted-content | 10.59350/8xxp3-b8077 |
| Roovers, Kristin | Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis | 2002/5/1 | report | 10.21236/ada407447 |
| Apodaca, Richard L. | MX Performance Comparison #2: Exhaustive Ring Perception in MX and CDK | | posted-content | 10.59350/tv70e-5c238 |
| Ringer, Lymor | Role of p53 in cdk Inhibitor VMY-1-103-Induced Apoptosis in Prostate Cancer | 2012/9/1 | report | 10.21236/ada567635 |
| Kawauchi, Takeshi | Extra‐cell cycle regulatory functions of cyclin‐dependent kinases (CDK) and CDK inhibitor proteins contribute to brain development and neurological disorders | 2013/3 | journal-article | 10.1111/gtc.12029 |
| Rusli, Richardo | Retinitis Pigmentosa | | journal-article | 10.55175/cdk.v47i7.597 |
| Durandau, Eric | Cross-regulation between CDK and MAPK control cellular fate | | posted-content | 10.1101/274787 |
| Yu, Bo | Downregulation of Cyclin D1 Alters cdk 4- and cdk 2-Specific Phosphorylation of Retinoblastoma Protein | 2000/6 | journal-article | 10.1006/mcbr.2000.0238 |
| Cheng, Weiyan | Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures | 2019/2 | journal-article | 10.1016/j.ejmech.2019.01.003 |
| ., Sukamto | Penanganan Ketoasidosis Diabetik pada Anak | | journal-article | 10.55175/cdk.v49i9.2039 |
| Nishizawa, Masafumi | Phosphorylation of Sic1, a Cyclin-dependent Kinase (Cdk) Inhibitor, by Cdk Including Pho85 Kinase Is Required for Its Prompt Degradation | 1998/9 | journal-article | 10.1091/mbc.9.9.2393 |
| Cyclin dependent kinase (CDK) | 2010/11 | journal-article | 10.1038/scibx.2010.1319 |
| Cyclin-Dependent Protein Kinases (CDK) | 2008 | book-chapter | 10.1007/978-1-4020-6754-9_3981 |
| CDK | 2006 | book-chapter | 10.1007/3-540-29623-9_10003 |
| Wysocki, Robert | CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage | 2006/10 | journal-article | 10.1038/nsmb1139 |
| Katz, Max | RichFaces CDK: Building Custom Components | 2011 | book-chapter | 10.1007/978-1-4302-3450-0_14 |
| Lawrenti, Hastarita | Hemofilia dan Perkembangan Terapinya | | journal-article | 10.55175/cdk.v48i9.1496 |
| Figure 4: The efficiency of tumor markers in distinguish CDK patients with normal serum creatinine from healthy controls. | | component | 10.7717/peerj.19240/fig-4 |
| Apodaca, Richard L. | Open Benchmarks for Cheminformatics: First Performance Comparison Between CDK and MX | | posted-content | 10.59350/7nc6k-w4216 |
| Cyclin‐Dependent Protein Kinase (
CDK
) | | other | 10.1002/0471684228.egp02997 |
| Srivastava, Mansi | Lineage-specific CDK activity dynamics characterize early mammalian development | | posted-content | 10.1242/prelights.38013 |
| Mahendra, Cipta | Peutz-Jeghers Syndrome | | journal-article | 10.55175/cdk.v48i12.1574 |
| Review for "ALG3 contributes to the malignant properties of OSCC cells by regulating CDK‐Cyclin pathway" | 2020/10/7 | peer-review | 10.1111/odi.13687/v2/review1 |
| Apodaca, Richard L. | Cheminformatics for the Web: Convert SD Files to HTML with Ruby CDK | | posted-content | 10.59350/gvwgq-b0x50 |
| Yuliana, Jeni | Aspek Klinis Ambliopia | | journal-article | 10.55175/cdk.v49i1.1639 |
| Pérez-Hidalgo, Livia | CDK Inhibitors | 2013 | book-chapter | 10.1007/978-1-4419-9863-7_12 |
| Apodaca, Richard L. | From InChI to Image with Ruby Open Babel and Ruby CDK | | posted-content | 10.59350/r891p-vmx14 |
| Sanchez-Diaz, Alberto | The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth | 2012/8/29 | journal-article | 10.1038/emboj.2012.224 |
| Chandra, Rudi | Tatalaksana Melanoma Maligna Kutaneus | | journal-article | 10.55175/cdk.v48i7.1453 |
| Turner, N. | Targeting the CDK 4-6 pathway | 2019/3 | journal-article | 10.1016/s0960-9776(19)30078-5 |
| Application of Biocatalytic Reductive Amination for the Synthesis of a Key Intermediate to a CDK 2/4/6 Inhibitor | | component | 10.1021/acs.oprd.1c00255.s001 |
| Lawrensia, Sherly | Diagnosis dan Tatalaksana Artritis Tuberkulosis | | journal-article | 10.55175/cdk.v47i8.773 |
| Fig. 1. Ovarian enlargement and lack of blood flow in the CDK regimen with a full bladder | | component | 10.17816/psaic575-154 |
| Teo, Gloria | Diagnosis dan Tatalaksana Kegawatdaruratan Hiperkalemia | | journal-article | 10.55175/cdk.v48i8.1447 |
| Ogata, Ryohei | Resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors confers cross-resistance to other CDK inhibitors but not to chemotherapeutic agents in breast cancer cells | 2021/1 | journal-article | 10.1007/s12282-020-01150-8 |
| RAYNAL, S | DIFFERENTIAL-EFFECTS OF TRANSFORMING GROWTH-FACTOR-BETA-1 ON PROTEIN-LEVELS OF P21 WAF AND CDK-2 AND ON CDK-2 KINASE-ACTIVITY IN HUMAN RD AND CCL64 MINK LUNG-CELLS | | journal-article | 10.3892/ijo.7.2.337 |
| Aprelikova, Olga | Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase | 1995/8 | journal-article | 10.1074/jbc.270.31.18195 |
| Lawrensia, Sherly | Lung Abscess: Diagnosis and Treatment | | journal-article | 10.55175/cdk.v48i5.1373 |
| Nitiyoso, Nugroho | Aspek Imunitas pada COVID-19 | | journal-article | 10.55175/cdk.v48i9.1497 |
| ., Suharto | Fisioterapi Kasus Cerebral Palsy Kuadriplegia Spastik | | journal-article | 10.55175/cdk.v49i9.2036 |
| | | grant | 10.55776/p19894 |
| Febriana, Lydia | Suplemen untuk Terapi Obesitas | | journal-article | 10.55175/cdk.v49i0.1964 |
| When a CDK Is Really a Transcription Factor | 2005/1/11 | journal-article | 10.1126/stke.2662005tw14 |
| Prasetio, Adrian | Gangguan Psikiatri Terkait Kafein | | journal-article | 10.55175/cdk.v47i7.603 |
| p27
Kip1−/−
Strain 3 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg10 |
| Nitiyoso, Nugroho | Pilihan Pengobatan Sistemik pada Psoriasis | | journal-article | 10.55175/cdk.v49i3.1775 |
| Meijer, Laurent | CDK Inhibitors | 2002 | book-chapter | 10.1016/b978-012476249-7/50008-4 |
| Lone, Waseem Iqbal | Discovery of Colchicine Aryne Cyclo-Adduct as a Potent Molecule for the Abrogation of Epithelial to Mesenchymal Transition Via Modulating Cell Cycle Regulatory Cdk-2 and Cdk-4 Kinases | | posted-content | 10.2139/ssrn.4814175 |
| Fauzi, Ahmad | Haglund Deformity: Diagnosis and Treatment | | journal-article | 10.55175/cdk.v49i10.2067 |
| Yahya, Willy | Retinopati Prematuritas : Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v47i10.1080 |
| EMPIAR dataset | | | 10.6019/empiar-10561 |
| Dai, Yun | CDK Inhibitors in Multiple Myeloma | 2008 | book-chapter | 10.1007/978-1-59745-564-0_22 |
| Henri, P. | Psoriatic epidermis is associated with upregulation of
CDK
2 and inhibition of
CDK
4 activity | 2020/3 | journal-article | 10.1111/bjd.18178 |
| Cyclin dependent kinase (CDK) | 2010/3 | journal-article | 10.1038/scibx.2010.272 |
| Futcher, A. B. | General Methods for Identifying G1-Phase Substrates of Cdk Protein Kinases. | 1996/6/1 | report | 10.21236/ada323678 |
| Cyclin dependent kinase (CDK) | 2012/4 | journal-article | 10.1038/scibx.2012.385 |
| Bisbis, Badia | Cyclin-dependent Kinase (CDK) Inhibitors Regulate the CDK-Cyclin Complex Activities in Endoreduplicating Cells of Developing Tomato Fruit | 2006/3 | journal-article | 10.1074/jbc.m506587200 |
| Karyadi, Erlinda | Cutaneous Mucormycosis | | journal-article | 10.55175/cdk.v49i2.1740 |
| Larochelle, Stéphane | CDK-Activating Kinases: Detection and Activity Measurements | | book-chapter | 10.1385/1-59259-857-9:279 |
| Lukito, Johan Indra | Tinjauan atas Terapi Insulin | | journal-article | 10.55175/cdk.v47i9.917 |
| Dai, Yun | CDK Inhibitors in Leukemia and Lymphoma | 2019/9/17 | book-chapter | 10.1201/9780429114670-15 |
| Putri, Zanty Rakhmania | Bell’s Palsy: Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v49i8.1986 |
| Pricelda, Alicia | Tren Terapi Age-Related Macular Degeneration | | journal-article | 10.55175/cdk.v48i12.1584 |
| Karyadi, Erlinda | Cutaneous Mucormycosis | | journal-article | 10.55175/cdk.v49i2.1726 |
| Cicenas, Jonas | CDK Inhibitors and FDA: Approved and Orphan | | journal-article | 10.3390/cancers16081555 |
| Müllers, Erik | Cdk activity drives senescence from G2 phase | | posted-content | 10.1101/041723 |
| p27
Kip1−/−
Strain 2 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg9 |
| Afifah Nurullah, Fitri | Tinjauan atas N-Nitrosodimethylamine (NDMA) | | journal-article | 10.55175/cdk.v47i12.1249 |
| Chandra, Rudi | Pilihan Pengobatan Dermatologis Penuaan Periorbital | | journal-article | 10.55175/cdk.v47i12.1241 |
| Morgan, David O. | Principles of CDK regulation | 1995/3 | journal-article | 10.1038/374131a0 |
| Mahendro, Della Sulamita | Penggunaan Antivirus untuk COVID-19 | | journal-article | 10.55175/cdk.v48i7.1459 |
| Kristiningrum, Esther | Penggunaan Hydroxychloroquine dalam Tatalaksana Covid-19 | | journal-article | 10.55175/cdk.v47i12.1246 |
| Suryani, Adelia | Faktor-Faktor yang Memengaruhi Pigmentasi Manusia | | journal-article | 10.55175/cdk.v47i11.1195 |
| Permasutha, Made Bayu | Tinjauan atas Kanker Rongga Mulut | | journal-article | 10.55175/cdk.v48i3.1327 |
| Johan, Michael | Evaluasi dan Tatalaksana Hipernatremia | | journal-article | 10.55175/cdk.v48i6.1441 |
| Palacios Blanco, Inés | CDK phospho-regulation of the Rad51-accessory factor Sfr1 and its role in meiotic recombination | | dissertation | 10.14201/gredos.161088 |
| -, Tommy | Angina Prinzmetal - Diagnosis dan Tatalaksana | | journal-article | 10.55175/cdk.v48i6.1431 |
| Decision letter: CDK-regulated dimerization of M18BP1 on a Mis18 hexamer is necessary for CENP-A loading | 2016/12/19 | peer-review | 10.7554/elife.23352.021 |
| EMPIAR dataset | | | 10.6019/empiar-10431 |
| Kusumo, Inosensia Diajeng | Tinjauan Atas Pioderma | | journal-article | 10.55175/cdk.v49i4.1822 |
| CDK Inhibitor Triples PFS in Breast Cancer | 2013/1/1 | journal-article | 10.1158/2159-8290.cd-nb2012-149 |
| ASCO TAPUR, CDK Studies Endeavor to Fill Gaps in Personalized Cancer Care Research | 2024/12/1 | dataset | 10.1200/acon.24.00037 |
| -, Carlson | Tatalaksana Demam pada Anak | | journal-article | 10.55175/cdk.v47i11.1200 |
| Fanardy, Angeline | Toksin Botulinum untuk Kasus Urogenital | | journal-article | 10.55175/cdk.v48i3.1337 |
| Dinari, Nur Alfi | Miopia: Etiologi dan Terapi | | journal-article | 10.55175/cdk.v49i10.2069 |
| Ciatawi, Kartini | Patofisiologi Spinal Cord Injury | | journal-article | 10.55175/cdk.v49i5.1848 |
| Ciatawi, Kartini | Patofisiologi Spinal Cord Injury | | journal-article | 10.55175/cdk.v49i9.2032 |
| Stanley, Jone A. | Chromium-VI arrests cell cycle and decreases granulosa cell proliferation by down-regulating cyclin-dependent kinases (CDK) and cyclins and up-regulating CDK-inhibitors | 2011/7 | journal-article | 10.1016/j.reprotox.2011.05.007 |
| Apodaca, Richard L. | CampDepict: Building a Simple SMILES Depict Web Application With JRuby, Structure CDK, and Camping | | posted-content | 10.59350/d2m6v-tag27 |
| Renita Sanyasi, Rosa De Lima | Sindrom Mona Lisa | | journal-article | 10.55175/cdk.v48i1.1258 |
| Mueller, Daniel | Abstract 2821: Characterization of CDK inhibitors in a biochemical assay using a comprehensive panel of human CDK-cyclin complexes | 2016/7/15 | journal-article | 10.1158/1538-7445.am2016-2821 |
| Feinberg, Bruce A. | Prescribing preferences for hormone sensitive (HR+) metastatic breast cancer (mBC) in the CDK 4/6 inhibitor (CDK 4/6i) era. | 2020/5/20 | journal-article | 10.1200/jco.2020.38.15_suppl.e13058 |
| Irsyada Yusuf, Amry | Diagnosis dan Tatalaksana Kriptorkhismus | | journal-article | 10.55175/cdk.v48i3.1330 |
| Wijaya, Meiliyana | Meningitis Kriptokokus pada Penderita HIV | | journal-article | 10.55175/cdk.v48i1.1256 |
| Wijaya, Sandy | Diagnosis dan Tatalaksana Polisitemia Vera | | journal-article | 10.55175/cdk.v47i7.596 |
| Lawrenti, Hastarita | Penghambat Immune Checkpoint untuk Terapi Kanker | | journal-article | 10.55175/cdk.v49i0.1966 |
| Shamsi, Zahra | Concestor kinase activation mechanism uncovers the cyclin dependence of CDK family kinases | | posted-content | 10.1101/410902 |
| Cherub, Jane | Terapi Antikoagulan pada COVID-19 | | journal-article | 10.55175/cdk.v48i6.1436 |
| Lukito, Johan Indra | Gunakan Insulin dengan CERMAT | | journal-article | 10.55175/cdk.v47i10.1093 |
| Setiawan, Michael | Mielopati Non Kompresif: Pendekatan Diagnosis | | journal-article | 10.55175/cdk.v47i9.909 |
| Dewi, Nadia Puspa | Aspek Klinis Dermatitis Seboroik | | journal-article | 10.55175/cdk.v49i6.1881 |
| p27
Kip1−/−
Strain 1 | 2001/10/3 | journal-article | 10.1126/sageke.2001.1.tg8 |
| Carrieri, Francesca Anna | CDK
1 and
CDK
2 regulate
NICD
1 turnover and the periodicity of the segmentation clock | 2019/7 | journal-article | 10.15252/embr.201846436 |
| Ratna Sari, Ihda Zuyina | Gambaran Sistiserkosis dan Taeniasis | | journal-article | 10.55175/cdk.v49i3.1768 |
| Besser, Alexandra | CDK Inhibitors in Normal and Malignant Cells | 2023 | book-chapter | 10.1016/b978-0-12-821618-7.00221-2 |
| Mahendrakrisna, Daniel | Tatalaksana Epilepsi Refrakter | | journal-article | 10.55175/cdk.v47i9.911 |
| Dianky, Amanda | Peran Nutrigenomik pada Tata Laksana Obesitas | | journal-article | 10.55175/cdk.v49i0.1965 |
| 4-Arylazo-3, 5-diamino-1H-pyrazole CDK Inhibitors: SAR Study, Crystal Structure in Complex with CDK2, Selectivity, and Cellular Effects | | component | 10.1021/jm0605740.s001 |
| Decision letter: CDK control pathways integrate cell size and ploidy information to control cell division | 2020/12/20 | peer-review | 10.7554/elife.64592.sa1 |
| Wijaya, Lupita | Tatalaksana Nyeri Neuropatik Perifer dengan Sediaan Patch | | journal-article | 10.55175/cdk.v48i9.1484 |
| Mahendra, Cipta | Terapi Berbasis Sel: Perkembangan Terkini | | journal-article | 10.55175/cdk.v49i3.1769 |
| Clinical Trial in Healthy Volunteers and Subjects With CDK | | journal-article | 10.31525/ct1-nct03893799 |
| Cyclin dependent kinase (CDK); p53 | 2012/10 | journal-article | 10.1038/scibx.2012.1028 |
| Tan, Christine | Trombosis pada Pasien COVID-19 | | journal-article | 10.55175/cdk.v48i12.1571 |
| CRESCENZI, ELVIRA | Association of Bcl‐2 with Cyclin A/Cdk‐2 Complex and Its Effects on Cdk‐2 Activity | 2002/11 | journal-article | 10.1111/j.1749-6632.2002.tb04647.x |
| First CDK 4/6 Inhibitor Heads to Market | 2015/4/1 | journal-article | 10.1158/2159-8290.cd-nb2015-028 |
| Decker, T | Cell cycle progression of chronic lymphocytic leukemia cells is controlled by cyclin D2, cyclin D3, cyclin-dependent kinase (cdk) 4 and the cdk inhibitor p27 | 2002/3/1 | journal-article | 10.1038/sj.leu.2402389 |
| Mostafa, Heba H. | Herpes Simplex Virus 1 Upregulates p35, Alters CDK-5 Localization, and Stimulates CDK-5 Kinase Activity during Acute Infection in Neurons | 2015/5 | journal-article | 10.1128/jvi.00106-15 |
| Sondhi, Sham M. | Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases | 2006/6 | journal-article | 10.1016/j.bmc.2006.01.054 |
| Falco, Giulia De | Cdk Inhibitors: Background and Introduction | | book-chapter | 10.1385/1-59259-401-8:01 |
| Grant, Steven | CDK inhibitors and immune responses | 2009/8/15 | journal-article | 10.4161/cc.8.16.9346 |
| Bird, R.Curtis | The Cyclin/Cyclin-Dependent Kinase (cdk) Complex | 1997 | book-chapter | 10.1016/b978-012100160-5/50006-3 |
| A novel and robust molecular switch actuating the quantitative model of eukaryotic Cdk control | | proceedings-article | 10.18699/sbb-2022-104 |
| Patterson, James O. | Synergistic CDK control pathways maintain cell size homeostasis | | posted-content | 10.1101/2020.11.25.397943 |
| Luminturahardjo, Winarko | Peranan Probiotik dalam Penanganan Infeksi COVID-19 | | journal-article | 10.55175/cdk.v48i5.1371 |
| Chandra, Rudi | Aspek Dermatologi Penuaan Kulit Periorbital | | journal-article | 10.55175/cdk.v47i9.920 |
| -, Cecile | Diagnosis dan Tatalaksana Paroxysmal Nocturnal Hemoglobinuria | | journal-article | 10.55175/cdk.v48i7.1452 |
| Kumala, Marcia | Suplementasi Vitamin B1 untuk Pasien Sepsis | | journal-article | 10.55175/cdk.v47i8.783 |
| Review for "Palbociclib-mediated cell cycle arrest can occur in the absence of the CDK inhibitors p21 and p27" | 2021/6/23 | peer-review | 10.1098/rsob.210125/v1/review2 |
| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| Linea Dorada | Tracklist: 1. El numero uno 2. La camioneta gris 3. La bronco negra 4. Chico Fuentes 5. Setecientas libras 6. Doctor Fonseca 7. Juan Ramos 8. Rosita la morena 9. Crimen en Chihuahua 10. La entallada 11. Gumaro Vazquez 12. Candido Rodriguez 13. El culichi 14. Esperanza Valero 15. Pedro Paez 16. Los traficantes 17. La ley del contrabandista 18. Los dos contrabandistas 19. El aguila real 20. El corrido de Gabino | 2002 | 2024-11-21T12:12:01Z |
| Musica Para La Raza, Vol.9 | Tracklist: 1. Carinito de Mi Vida 2. Sabiendo Quien Era Yo 3. Dijiste y Juraste 4. Te Aplacas o Te Aplaco 5. Tuve Una Novia 6. Tu Delirio 7. Dos Mujeres 8. Vamonos 9. Alta y Delgadita 10. La Fe Perdida 11. No Me Vuelvo A Enamorar 12. Que Sabes Tu | 2001 | 2024-11-26T05:52:03Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| CIA Reading Room cia-rdp84b00148r000100370001-5: OEXA RECORDS MANAGEMENT | Charles E. Wilson Chief, Public Affairs Division OEXA Records Management 1. Action Requested: Transfer primary PAD records management responsibility to OEXA Registry. 2. Background: Since PA ceased to exist as an Independent Office and became a Division in OEXA, PAD has nevertheless retained a Records Management Officer (RMO) and primary responsibility for this function. Since this is normally a Registry function, we are probably overdue in transferring it. I understand the OEXA Registry is already RMO for LLD. It seems to me that in a perfect world PAD would retain day-to-day maintenance of its decentralized files, but the Registry would assume responsi- bility for such things as reporting annual volume surveys, maintaining file retirement schedules, file renumbering projects, and the like. 3. Recommendation: Request OEXA Administrative Officer's assistance in establishing the Chief, OEXA Registry as RMO for all of OEXA and in transferring PAD's responsibility. We are prepared to assi; | 1982 | 2025-02-19T12:51:25Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| DTIC ADB240661: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from GL phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the GL phase cyclin dependent kinases (cdk), cdk4 and cdk6. Cyclin dependent kinase 4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle-from GL into S phase in the osteosarcoma cell line, U2OS. Understanding differential regulation of these two kinases and their potentially different ; | 1998 | 2018-03-03T10:06:08Z |
| Phunky Phetes ep2 | Phunky Phetes ep2 created by fourstones (victor) Put together this show while (literally) on the road in Hollywood. Sorry about the quality of bumper, clearly the quality of phunk makes up for all. Track List: coast to coast-DU-remix by: deutscheunschuld -- (cc) Sampling Plus Vroum,vroum (remix) by: stefsax -- (cc) Attribution Noncommercial Life of Luxury (Shout Out mix) by: duckett -- (cc) Attribution Noncommercial Share-Alike (3.0) Tupelo by: Minus Kelvin -- (cc) Noncommercial Sampling Plus NYC-OLD SCHOOL Bootleg MIX. by: J.Lang -- (cc) Noncommercial Sampling Plus Deep In Ya Self (Faith Mix) by: DoKashiteru -- (cc) Attribution Noncommercial (3.0) Dream Of You by: Alex -- (cc) Attribution Noncommercial (3.0) Official (Ex-centric mix) by: cdk -- (cc) Attribution Noncommercial from ccMixter Bumpers: phunky phetes intro by: fourstones -- (cc) Noncommercial Sampling Plus Songboy3 CCMixter.org Promo 02 by: Songboy3 -- (cc) Attribution Noncommercial Share-Alike phphout ep.2 by: fourstones -; | | 2009-07-28T13:15:00Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| Clave Azul | Tracklist: 1. Lamberto Quintero 2. Pedro Aviles 3. Los Gallos de Sinaloa 4. El Corrido de Guasave 5. Ruben Cabada 6. Catarino y los Rurales 7. El Prieto "Crispin" 8. Cornelio Vage 9. El Contrabando de Nogales 10. Rosendo G. Castro | 2001 | 2024-12-13T11:33:31Z |
| github.com-sindresorhus-awesome_-_2022-01-24_22-26-30 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-25T02:20:23Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| github.com-debezium-debezium_-_2021-12-10_11-35-09 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-10T12:09:39Z |
| the new testament in the original greek | | 1928 | 2025-06-16T23:17:47Z |
| github.com-dabit3-awesome-aws-amplify_-_2021-02-13_23-48-59 | Curated list of AWS Amplify Resources Awesome AWS Amplify curates the best AWS Amplify, tools, tutorials, articles and more. PRs are welcome! Check out the Amplify Discord server Getting Started Github Documentation Workshops Serverless GraphQL API with AppSync and DynamoDB AWS Amplify Photo Sharing Workshop Next.js AWS Amplify Workshop Building real-time applications with React, GraphQL & AWS AppSync Building Mobile Applications with React Native & AWS Amplify AWS Amplify UnicornFlix Workshop (Video on Demand) AWS Amplify UnicornTrivia Workshop (Live streaming video) Tutorials - Blogs & tutorials General blogs & tutorials Full Stack Cloud Development with AWS Amplify TensorFlow.js + AWS Amplify 10 Minute Tutorial: Creating a Serverless Express Web Server & API ⚡️ 10 Ways to Use Serverless Functions Real quick GraphQL service with AWS Amplify & Appsync Visualizing Focus with Neurosity's Notion and AWS Amplify Build a Music Sharing App with Amazon S3 and AWS Amplify Introducing Conf; | 2021 | 2021-02-22T13:28:20Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| Corridos De La Sierra | Tracklist: 1. Los Mas Manchas Al Tigre 2. Los Tres Verdes 3. La Negocio Cuajado 4. Directores de Bandas 5. La Imagen de Malverde 6. Brinque la Barda 7. El Seänor 8. Seirra Michoacana 9. La Dama de Negro 10. Carro Con Clavo 11. Victor Zamudio 12. Miguel Lopez | 2002 | 2025-04-12T11:59:30Z |
| Corridos Originales | Tracklist: 1. El Rayo de Sinaloa 2. Se Les Pelo Baltazar 3. 20 Mujeres de Negro 4. Candido Rodriguez 5. El Rey de Mil Coronas 6. Juan Ramos 7. Dados Cargados 8. El Capitan y el Teniente 9. Contrabando de Juarez 10. Anastacio Pacheco 11. El Alma Grande 12. Mi Huerfano Alazan 13. El Cartel de los Cielos 14. El Regalo Caro 15. Las Liebres 16. Panchito Palma 17. El Halcon 18. El Doctor Veterinario 19. El Guante 20. Corrido de Javier Barba | 2002 | 2025-04-11T04:55:18Z |
| The influence of negative training set size on machine learning-based virtual screening. | This article is from Journal of Cheminformatics , volume 6 . Abstract Background: The paper presents a thorough analysis of the influence of the number of negative training examples on the performance of machine learning methods. Results: The impact of this rather neglected aspect of machine learning methods application was examined for sets containing a fixed number of positive and a varying number of negative examples randomly selected from the ZINC database. An increase in the ratio of positive to negative training instances was found to greatly influence most of the investigated evaluating parameters of ML methods in simulated virtual screening experiments. In a majority of cases, substantial increases in precision and MCC were observed in conjunction with some decreases in hit recall. The analysis of dynamics of those variations let us recommend an optimal composition of training data. The study was performed on several protein targets, 5 machine learning algorithms (SMO, Naïve B; | 2014 | 2014-10-19T07:35:32Z |
| Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. | This article is from Breast Cancer : Targets and Therapy , volume 6 . Abstract Cellular proliferation, growth, and division following DNA (deoxyribonucleic acid) damage are tightly controlled by the cell-cycle regulatory machinery. This machinery includes cyclin-dependent kinases (CDKs) which complex with their cyclin partners, allowing the cell cycle to progress. The cell-cycle regulatory process plays a critical role in oncogenesis and in the development of therapeutic resistance; it is frequently disrupted in breast cancer, providing a rational target for therapeutic development. Palbociclib is a potent and selective inhibitor of CDK4 and -6 with significant activity in breast cancer models. Furthermore, it has been shown to significantly prolong progression-free survival when combined with letrozole in the management of estrogen receptor-positive metastatic breast cancer. In this article we review the cell cycle and its regulatory processes, their role in breast cancer, and the rat; | 2014 | 2014-10-06T01:38:18Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| Catherine Dumonteil Kremer | "Quand on est en train de blesser son enfant, on se dit "pourquoi je fais ça?" au moment même où on le fait. Quelquefois, on se voit faire et on n'arrive pas à arrêter. Donc en nous, il y a quelqu'un qui est super, merveilleux, coopératif, aimant, intelligent, etc. Tout le monde a ça en lui." Catherine Dumonteil-Kremer est l'invitée du 8ème épisode de La Force de la Non-violence. Pionnière dans la parentalité positive, ancienne travailleur social, elle devient ensuite consultante parentale, éducatrice Montessori et crée le Réseau Parents Conscients. Autrice à succès avec notamment "Élever son enfant autrement", elle invente le concept de parentalité créative qui regroupe ce qu'elle considère comme des éléments fondamentaux au bon développement des enfants comme le maternage proximal, l'écoute, le jeu, l'acceptation et l'affirmation de soi tout en donnant une grande liberté aux parents d'innover dans leur relation avec leurs enfants. Membre fondateur de l'OVEO ; | | 2021-01-25T10:40:44Z |
| DTIC ADA385811: The Regulation of Human Cyclin E Protein Levels by the Ubiquitin Proteolytic Pathway | Cyclin E is an unstable protein that is degraded in a ubiquitin- and proteasome-dependent pathway. Two factors stimulate cyclin E ubiquitination in vivo: when it is free of its CDK partner, and when it is phosphorylated on threonine 380. We pursued the first of these pathways by using a two-hybrid screen to identify proteins that could bind only to free cyclin E. This resulted in the isolation of human Cul-3, a member of the cullin family of E3 ubiquitin-protein ligases. We found that Cul-3 was bound to cyclin E but not to cyclin E-Cdk2 complexes in mammalian cells, and that overexpression of Cul-3 increased ubiquitination of cyclin E but not other cyclins. Conversely, deletion of the Cul-3 gene in mice caused increased accumulation of cyclin E protein, and had cell-type specific effects on S phase regulation. In the extraembryonic ectoderm, where cells undergo a standard mitotic cycle, there was a greatly increased number of cells in S phase. In the trophectoderm, where cells go throu; | 1999 | 2018-04-30T11:20:49Z |
| The Stormy Petrel (Large Print Edition) | | 1991 | 2023-07-25T00:30:17Z |
| DTIC ADA389310: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | The periodicity of CDK activity provides the molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins has been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with another multigene family of evolutionarily conserved proteins, the ROC/APC11 family, to form a complex that contains E3 ubiquitin ligase activity. We have show; | 2000 | 2018-05-01T22:46:59Z |
| Nortenas del Pueblo No. 1 | Tracklist: 1. Sabiendo Quien Era Yo - Los Incomparables de Tijuana 2. La Rubia y la Morena - Los Dinamicos del Norte 3. Mujer, Mujer - Los Hermanos Banda 4. Aquellos Ojitos Verdes - Los Remolinos de Fabián Gómez 5. Tu Desastre - Los Incomparables de Tijuana 6. Alta y Delgadita - Los Dinamicos del Norte 7. Palomita Donde Vas - Los Hermanos Banda de Salamanca 8. Las Llaves - Los Remolinos de Fabián Gómez 9. Te Ando Siguiend los Pasos - Los Incomparables de Tijuana 10. En las Cantinas - Los Dinamicos del Norte 11. Destino Cruel - Los Hermanos Banda de Salamanca 12. Dos Mujeres - Los Remolinos de Fabián Gómez | 2002 | 2025-03-31T06:47:58Z |
| CDK-120 | | | 2021-04-17T01:59:16Z |
| Laocoon Nathan the Wise Minna von Barnhelm | | 1967 | 2023-08-08T08:47:51Z |
| github.com-angular-components_-_2019-11-09_08-00-19 | Component infrastructure and Material Design components for Angular Components and Material Design for Angular This is the home for the Angular team's UI components built for and with Angular.These include Material Design components and the Angular Component Development Kit (CDK). Quick links Documentation, demos, and guides | Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if you're building your first project with Angular Material. Check out our directory of design documents for more insight into our process. If you'd like to contribute, you must follow our contributing guidelines .You can look through the GitHub issues (which should be up-to-date on who is working on which featuresand which pieces are blocked) and make a comment. Please see our help wanted label for a list of issues where we could use help from the community. High level stuff planned for Q4 2019 (Oct - Nov): Remove dependency on HammerJS Finish remaining test harnesses; | 2019 | 2019-11-09T10:02:31Z |
| Re-thinking cell cycle regulators: the cross-talk with metabolism. | This article is from Frontiers in Oncology , volume 3 . Abstract Analysis of genetically engineered mice deficient in cell cycle regulators, including E2F1, cdk4, and pRB, showed that the major phenotypes are metabolic perturbations. These key cell cycle regulators contribute to lipid synthesis, glucose production, insulin secretion, and glycolytic metabolism. It has been shown that deregulation of these pathways can lead to metabolic perturbations and related metabolic diseases, such as obesity and type II diabetes. The cyclin–cdk–Rb–E2F1 pathway regulates adipogenesis in addition to its well-described roles in cell cycle regulation and cancer. It was also shown that E2F1 directly participates in the regulation of pancreatic growth and function. Similarly, cyclin D3, cdk4, and cdk9 are also adipogenic factors with strong effects on whole organism metabolism. These examples support the emerging notion that cell cycle regulatory proteins also modulate metabolic processes. These ce; | 2013 | 2014-10-28T16:47:52Z |
| github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-15_19-09-44 | Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ; | 2021 | 2021-01-16T03:16:22Z |
| Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. | This article is from Biomolecules & Therapeutics , volume 20 . Abstract Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents. In recent years, a number of structurally diverse HDAC inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. However, the underlying molecular mechanisms remain unclear. This study aimed at investigating the anti-tumor activity of various HDAC inhibitors, IN-2001, using T47D human breast cancer cells. Moreover, the possible mechanism by which HDAC inhibitors exhibit anti-tumor activity was also explored. In estrogen receptor positive T47D cells, IN-2001, HDAC inhibitor showed anti-proliferative effects in dose-and time-dependent manner. In T47D human breast cancer; | 2011 | 2014-10-24T20:14:53Z |
| Het bericht ‘CdK haalt ongemeen fel uit naar de NAM’ | This document is issued on date 2015-05-27. | 2015 | 2018-03-14T20:02:09Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_17-00-30 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-06T00:37:52Z |
| Commissioner Sullivan message to Clatsop County April 22 | | 2020 | 2022-10-14T13:47:04Z |
| Hong Kong Birds | | 1967 | 2023-07-30T23:20:36Z |
| DTIC ADA392349: Action of the p53 Effector, p21, on its Targets: Cyclin-cdk and PCNA | Cy or RXL motifs have been previously shown to be cyclin binding motifs found in a wide range of cyclin-cdk interacting proteins. For both cyclin A/cdk2 and cyclin E/cdk2, the presence of a Cy motif decreased the Km(sup peptide! 75 to 120-fold while the kcat remained unchanged. Changes in the length of the linker between the Cy motif and the phosphoacceptor serine suggest that both sites are engaged simultaneously to the cyclin and the cdk, respectively. PS100, a peptide containing a Cy motif, acts as a competitive inhibitor of cyclin/cdk complexes with a 15-fold lower Ki for cyclin E/cdk2 than for cyclin A/cdk2. These results provide kinetic proof that a Cy motif located at a minimal distance from the SPXK is essential for optimal phosphorylation by cdks and suggest that small chemicals that mimic the Cy motif would be specific inhibitors of substrate recognition by cyclin-dependent kinases. In addition, a detailed mutagenesis approach to define what sequence serves as a Cy motif reve; | 2000 | 2018-05-03T14:38:06Z |
| CIA Reading Room cia-rdp80-00810a000600660006-7: RAILROAD COAL STOCKS AND STATUS OF RAILROAD CARS | 25X1 ApFrP 1 1t aXe amn~/j : CIA-RDP80-0081 OA0006006600 6-7 25I I CENTRAL I 25XIEPORT NO, L INFORMATION REPORT CD NO. COUNTRY Iket Cary SUBJECT Rail.rocd Cool Stockal and Statu?s of Railrord Coro 25X1 PLACE .CQU1'? ECG )ATE CF INFO. T a, OOCU!,-V 3T COOTASNS Ili POP.D1IT4OF1 A"ACTINOTHE NATIONAL lib FEN1R P.'' O8 T141 UHi 1ZD STATES, tIT:lmf1 THE HBANIUIG OF TITLE 28. SFr TIGHS 703 I! i -D 794. 0: THE U. S. CODE, A.3 ASSEH050. IT5 TAAHSIiISSION ~)4I Rd1:EL? I' OI> OF 415 C0RT01470 TD O:7 RECEIPT ay AH UNAUTHOTIIZED PE100.0 f TS ":' mUl GIT D DY AV THE REPRODU70-t OP ':'H1S FORA IS PR-IuIIIITED. 25X1 25X1 Coal stocks and ;onsurr Lion of coal :I: ca o pe ua ~,.- l' ti Date in Hard Coal Raw E oT>r Jam-ary Coal `iota::. 21 49,131 17,280 Stocks 22 48,028 17,191 46,668 18,043 }3 } 25 25X1 DA FE 16)),c-TW 9 April 3.953 NO. OF Fii=GES NJO.. OF G--'1 CLS, {LUSTED E..iL(1'r!} #3:+L1: `ENT y~ y.f REPORT NO. THIS IS UNEJ''ELUAliTD !1[,,i'OP Q 61\14Oii ;+ c$Z? ? ttc 3~ 76,6ci 78,0313 76,724, 2%::,; | 1953 | 2024-02-24T10:38:21Z |