Bookhound

Primary

Books

Journals

Old Books

Theses

Catalogs

Bazaars

Fileservers

Online Services

Bookstores

FullText

❌ ČDK❌ Archive.org⏬ Crossref❌ LibGen❌ CLEAR ALL

Česká digitální knihovna

DostupnostNázevAutorDatumTypID
🔓
PDF?
Výroční zpráva2025periodical/periodicalvolume/periodicalitem/pageuuid:4adb403f-b839-4d2d-91e2-cd3d9ac4e3bd
🔓
PDF?
Meziměstská telefonní ústředna v Praze1929monograph/pageuuid:e20a6970-253d-11ee-8650-005056827e51
🔓
PDF?
Francouzská revoluce : populární dějiny bojů francouzské společnosti na sklonku 18. století. Díl 1. Zápas s královstvím1929monograph/pageuuid:840ef410-0803-11ed-be35-5ef3fc9bb22f
🔓
PDF?
X. mezinárodní sjezd slavistů : Sofija 14. - 22. 9. 1988 : bibliografie1994monograph/monographunit/pageuuid:45d9d8e0-a20e-11ed-9ac7-5ef3fc9bb22f
🔓
PDF?
Veterinární medicína10.2010periodical/periodicalvolume/periodicalitem/pageuuid:6354c070-9632-11e8-b07a-5ef3fc9bb22f
🔓
PDF?
Galerie du Palais Royal gravée d'aprés les tableaux des différentes écoles qui la composent: avec un abrégé de la vie des peintres et une description historique de chaque tableau1786monograph/pageuuid:17fda895-f78f-4d9c-90ad-dca3cb9e3a75
🔓
PDF?
Eklogy a písně1916monograph/pageuuid:441044f0-f6f8-11e9-a329-005056827e51
🔓
PDF?
Starší literatura česká1910, 1911monograph/pageuuid:b4692cb0-bd01-11ea-b68c-005056827e52
🔓
PDF?
Mythy : básně Jaroslava Vrchlického : 1. cyklus (1874-1878)1915monograph/pageuuid:0998a060-f496-11e9-a329-005056827e51
🔓
PDF?
Stavební stroje: Seznam a výrobci1947monograph/pageuuid:0442b1d0-84ab-11e2-aa2b-005056827e51
🔓
PDF?
Základové měřictví pro nižší třídy gymnasií1886monograph/pageuuid:3c6e4dc0-d47b-11dc-b5f4-000d606f5dc6
🔓
PDF?
Katoličtí mučedníci doby husitské1927monograph/pageuuid:6de55980-a2be-11e3-b833-005056827e52
🔓
PDF?
Jan Slavík (1885-1978): a Czech historian of revolutions2009monograph/pageuuid:bdbc8db0-38cf-11ed-a118-5ef3fc9bb22f
🔓
PDF?
Základové měřictví pro nižší třídy gymnasií1893monograph/pageuuid:eca38890-36a8-11ee-9691-005056827e52
🔓
PDF?
Porovnávací tabulky měr a vah i příslušných cen ku snadnému užívání metrické soustavy v říši rakouské vůbec a v zemi české zvlášť1875monograph/pageuuid:34f65bc0-6d52-11de-9cc7-000d606f5dc6
🔓
PDF?
Beylage zur Brünner Zeitung29.10.1808periodical/periodicalvolume/supplement/pageuuid:40d23930-7bf1-11e2-b930-005056827e51
🔓
PDF?
Učebné listy jazyka anglického pro samouky1886monograph/monographunit/pageuuid:55367630-80c8-11dd-b860-000d606f5dc6
🔓
PDF?
Hospodář: týdenník věnovaný rolnictví, hospodářskému průmyslu a národnímu hospodářství : týdenník věnovaný rolnictví, hospodářskému průmyslu, národnímu hospodářství a veřejné správě vůbec9.4.1887periodical/periodicalvolume/periodicalitem/pageuuid:0c579719-c6f8-4a16-8a4f-c6b12e6d449b
🔓
PDF?
Fysika pro vyšší školy1870monograph/pageuuid:7141d2c0-e6f8-11dd-a324-000d606f5dc6
🔓
PDF?
Posledních dvě stě let v historii rajhradského kláštera2013monograph/pageuuid:fd326900-7245-11e9-b253-005056827e52

Archive (50)

TitleDescriptionPublishedAdded
Human Geography An Ecological Study of Society19482025-09-10T04:44:00Z
DR. IDA - THE INSPIRING STORY OF DR. IDA SCUDDER, FIFTY YEARS A MEDICAL MISSIONARY IN INDIA.19592023-12-29T19:48:32Z
MESSIAH: His Redemptive Career19352024-08-13T06:44:04Z
The pageant of Japanese history,19382023-07-28T12:19:13Z
A surgeon remembers19532023-12-22T18:53:56Z
Authenticom, Inc. v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2020-03-25T23:18:28Z
Northtown Automotive Companies Inc. v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2020-03-22T03:31:21Z
the new testament19372025-06-17T00:05:16Z
PS5 shipments up 400% from last year (in the US)PlayStation 5’s could be a lot easier to come by this holiday season, Saints row devs plan to fix over 200 bugs in the next major update, and Splatoon 3 made up %69 of retail games sold in Japan last month. These stories and more in today’s video This video is a clip out of a live recording which you can watch here: https://youtu.be/YjJhrhj_Cdk Buy our shirt! https://is.gd/u3xCtA OR follow us on Twitter! https://twitter.com/DarthBurrit0 http://twitter.com/InsideGaming SOURCES [IGN] PS5 shipments up 400% https://www.ign.com/articles/playstation-5-us-shipments-are-up-400-from-last-year [GamesIndustry.biz] Splatoon 3 is selling at an alarming rate in Japan https://www.gamesindustry.biz/splatoon-3-sold-27m-boxed-copies-in-three-weeks-japan-monthly-charts [VGC] Saints Row patch will fix over 200 bugs https://www.videogameschronicle.com/news/the-first-major-saints-row-update-promises-over-200-bug-fixes-in-november/ [The Verge] New Meta Quest Pro play tested, will be $1500 https://www.the;20222024-03-15T15:41:54Z
PAVILIONS PF PROTECTION20062025-08-21T02:47:59Z
Mannen Med Salgpiporna19602025-09-26T02:02:52Z
Anti-Cancer Effect of IN-2001 in MDA-MB-231 Human Breast Cancer.This article is from Biomolecules & Therapeutics , volume 20 . Abstract In recent years, inhibition of HDACs has emerged as a potential strategy to reverse aberrant epigenetic changes associated with cancer, and several classes of HDAC inhibitors have been found to have potent and specific anticancer activities in preclinical studies. But their precise mechanism of action has not been elucidated. In this study, a novel synthetic inhibitor of HDAC, 3-(4-dimethylamino phenyl)-N-hydroxy-2-propenamide [IN-2001] was examined for its antitumor activity and the underlying molecular mechanisms of any such activity on human breast cancer cell lines. IN-2001 effectively inhibited cellular HDAC activity (IC50 = 0.585 nM) in MDA-MB-231 human breast cancer cells. IN-2001 caused a significant dose-dependent inhibition of cell proliferation in estrogen receptor (ER) negative MDA-MB-231 human breast cancer cells. Cell cycle analysis revealed that the gowth inhibitory effects of IN-2001 might be attrib;20112014-10-24T18:12:19Z
The King of Fighters 2002: (BR) [CDK]-Shaka vs(BR) [KOFB]LUIZ - 2022-06-16 05:06:48(BR) [CDK]-Shaka vs (BR) [KOFB]LUIZ - 2022-06-16 05:06:48 Fightcade replay id: 1655356008548-4901 #fightcade #kof2002 #[KOFB]LUIZ #[CDK]-Shaka For more videos check out: https://fightcadevids.com2023-01-21T17:42:48Z
Education and society in modern Germany19492023-07-25T04:04:04Z
Research in physiology19712025-09-08T00:26:07Z
Scientists In Organizations19662025-09-11T18:21:23Z
De Racine Au Parthenon: Essais Sur La Litterature Et L'Art A L'age Classique19772025-09-04T14:43:38Z
George G. Manderbach, Inc. v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2024-07-16T09:08:36Z
Separation - Invuduation19712025-09-08T02:57:52Z
le bapteme et la confirmation19692025-06-16T09:29:09Z
the valaue theory of karl marx19762025-05-22T13:48:47Z
East McComb Body Shop v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2024-08-28T09:13:51Z
Matos v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2018-10-05T16:04:41Z
yahoo-groups-2018-07-21T22-47-06Z-4bbc23Yahoo! Groups API grab. Contains messages of the following groups: 1ahoahong 2009cmsc128 abajarcolesterol abqphilosophers aceng1-ib agentorangeveterans alumnisaba93 ap12thv1 apn_maamvanne aquascape-indonesia arabic_inside arkiyoliji1 artsbabes asteric_of_smpn4_bogor ba186_sad bch_tongdoan_2008_2010 beginnerbluegrassjam biblebeegurnee binjakon bits_dlpd_msss2009 blogbirudotcom bsa_bag bspe1-1_economist ca411-1m canoepolohunks0809 ccfcommittee_09_10 che_141_142_tqruv chem2a_woodland cict_itfnds-icb citihi85 contratoscinemauff cool_hood_babii cpi_2009_2010 csci12_tz curriculoseprogramas2009essb dbti_tarlac_faculty discretemath_it2nd dmt_people dnyandeepnews dpms_2010 ec102h eco101_09 eco11_0910 ecoprofessionals_nea edp111_addu elladerma emc_ss_dames encoreestate esjsem1admu0910 galeradoingles2008 genevaacademicfoundation glawenko h-383lpu hau_6comgrad hiltech_group homplantes hum1_thu1 iit-kgp-met75 imtak-05 infoamie ingenieria_gay inspirationaldesignsvoices irc-sbg ironbros-team_one it10;2018-07-21T22:47:14Z
Manufacturing industries in america19202025-09-08T07:57:29Z
A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation.This article is from PLoS ONE , volume 9 . Abstract Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic;20142014-10-22T18:28:08Z
github.com-aws-aws-cdk_-_2020-03-31_08-47-24The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d;20202020-03-31T09:11:59Z
Dante the Central Man of All the World19222023-08-10T02:07:56Z
Aktu 20.05.1Toute l'aKtualité de Kubernetes en français. https://github.com/p7t/actus https://github.com/goharbor/harbor/releases/tag/v2.0.0 https://github.com/kubernetes-sigs/kind/releases/tag/v0.8.0 https://cdk8s.io/ https://github.com/ahmetb/kubectx/releases/tag/v0.9.020202020-05-20T10:34:03Z
At-home dumbbell workout - Seated Curls20202022-08-11T20:02:13Z
Two Kinds of Time: Life in Provincial China During the Crucial Years 1940-1941, Revised and Abridged19672023-12-23T07:35:21Z
CIA Reading Room cia-rdp75-00149r000500450023-6: MR. KENNEDY AND THE CUBA BRIEFINGSTAT Sanitized Copy Approved for Release 2010/04/09: CIA-RDP75-00149R000500450023-6 25 YEAR RF. RFviFXnil Sanitized Copy Approved for Release 2010/04/09: CIA-RDP75-00149R000500450023-6 STAT F-a d STAT " Mr. Kennedy. and the CubaBriefin V~~r~ ql cdk Otl,ar MAK Sanitized Copy Approved for Release 2010/04/09: CIA-RDP75-00149R000500450023-6 i liu,b,2 Pres1&nt .Kennedy's con- tention that he was not, in- formed during the 1960 cam- paign that the Eisenhower administration was sponsor- ing training of Cubans for a possible later invasion to at- tempt to overthrow Castro is one of the most astonish- ing announcements to come ;role the White House under any President in many years. - The President contends that he was not told of the training of Cubans in the U.S. until after he was elect- ed. He carried out the in- vasion under. his own plan- ning after becoming Presi- dent -- in a, manner that Mr. Kennedy's contention was made public by his Chief Press Secretary, Pierre Sal- inger, in respon;19622025-05-16T03:48:08Z
github.com-sindresorhus-awesome_-_2023-05-14_15-35-37😎 Awesome lists about all kinds of interesting topics Check out my latest app Today Quickly view your schedule in the macOS menu bar My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Paperwork that makes the data work. Easy APIs for paperwork. PDF generation, e-signature and embeddable no-code webforms. The easiest way to build paperwork automation into your product. Paperwork that makes the data work. E;20232023-05-14T17:50:28Z
[CDK 063] The Tin Foil Hat Brigade - Serious MusicianUnrequited love, the frustrations of modern life, Scallies shouting abuse at women from cars - The Tin Foil Hat Brigade talks about these, and more - all within a ten-minute blast of furious Game Boy noise and raw, emotional vocals. Or something like that, anyway. All Music and Lyrics by The Tin Foil Hat Brigade. Recorded and Mastered by Lloyd Gabriel. Additional Vocals (on G.Y.R.O) by Simon Patrick Gabriel and Lloyd Gabriel. Artwork and Photography by Simon Thelwell - http://www.sixeightthree.com/20142020-01-09T22:58:35Z
Sodium Tanshinone IIA Silate Inhibits High Glucose-Induced Vascular Smooth Muscle Cell Proliferation and Migration through Activation of AMP-Activated Protein Kinase.This article is from PLoS ONE , volume 9 . Abstract The proliferation of vascular smooth muscle cells may perform a crucial role in the pathogenesis of diabetic vascular disease. AMPK additionally exerts several salutary effects on vascular function and improves vascular abnormalities. The current study sought to determine whether sodium tanshinone IIA silate (STS) has an inhibitory effect on vascular smooth muscle cell (VSMC) proliferation and migration under high glucose conditions mimicking diabetes without dyslipidemia, and establish the underlying mechanism. In this study, STS promoted the phosphorylation of AMP-activated protein kinase (AMPK) at T172 in VSMCs. VSMC proliferation was enhanced under high glucose (25 mM glucose, HG) versus normal glucose conditions (5.5 mM glucose, NG), and this increase was inhibited significantly by STS treatment. We utilized western blotting analysis to evaluate the effects of STS on cell-cycle regulatory proteins and found that STS increased the;20142014-10-23T07:02:40Z
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells.This article is from BMC Cancer , volume 14 . Abstract Background: Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent. Methods: PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed. Associated signaling changes were also analyzed by RT-PCR and Western blots. Results: Here, we reported that SAHA, a histone deacetylase inhibitor (HDACi), exerted significant inhibitory efficiency against pancreatic cancer cell survival, proliferation, migration and VM. SAHA dose-dependently inhibited PaTu8988 pancreatic cancer cell growth with the IC-50 of 3.4 ± 0. 7 μM. Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/;20142014-10-21T20:47:25Z
github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-16_06-32-09Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ;20212021-01-16T15:23:57Z
DTIC ADA316821: Cellular Proteins Interacting with the Tumor Suppressor Protein p53.Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand-DNA. We defined the domain of p53 that bound to RPA and constructed p53 mutants that failed to bind RPA, but still functioned as transcriptional activators. We found that while these mutants of p53 lost their ability to bind RPA; they still maintained the growth suppression function of p53. Growth suppression function of p53 is dependent on its transactivation activity, probably by inducing p21 and other cell cycle inhibitors. We have extended our study to the p2l protein, which is induced by p53 and interacts with both the cdk2 Icinase and a DNA replication factor PcNA. Here we have demonstrated the importance of PCNA-inhibitory domain of p21 in vivo. We have also shown that p21 has to interact directly with both cyclin subunit and cdk2 subunit of the cyclin-cdk complex in order to inhibit the kinase activity and suppress cell growth in vivo.19962018-04-03T17:57:56Z
Video Editing PcUltimate Editing & Rendering Workstation Engineered for professional video editors, content creators, and motion designers who demand smooth timelines, fast exports, and reliable rendering performance. This CDK build is optimized to handle 4K / 8K video workflows, complex timelines, and simultaneous editing + rendering without slowdowns. Supported Professional Software Adobe Premiere Pro | After Effects | DaVinci Resolve | Blender | Cinema 4D | Adobe Illustrator | Adobe Audition | Figma | Adobe XD Performance Advantages • Smooth playback for complex 4K / 8K timelines • Faster rendering and export performance • Stable operation during long editing sessions • Efficient multitasking for editing, compositing, and rendering Not just a PC. A workstation built for creative production pipelines. CDK — Powering Tomorrow’s Workstations. 📞 +91 92707 66589 🌐 www.designsbykira.in #CDKWorkstations   #VideoEditingPC   #ContentCreatorSetup2026-04-07T09:46:14Z
DTIC ADA359281: Role of the Cdk Inhibitor Sic 1 in StartMpst cells have four fundamental goals; they must replicate their DNA, segregate their chromosomes, double their mass, and divide. Coordination of these events is essential. I have used the budding yeast S. cerevisiae to dissect the molecular events that control cell cycle progression. I have shown that not only are G1 cyclin-CDK complexes highly unstable rate-limiting activators for cell cycle progression, but that their essential function is to regulate the initiation of DNA replication by phosphorylating and promoting the degradation of a key cell cycle inhibitor, Sic1 (1,2). In fact, cyclin-CDK-regulated proteolysis may constitute the major mechanism of cell cycle control (3). Moreover, Sic1 appears to be the analog of the RB tumor suppressor gene. I have shown that Sic1, like RB, controls the timing of S-phase, ensures genomic stability, and most significantly, sic1 deletions, like rb deletions, completely remove cell cycle dependence on G1 cyclins (1,22). Furthermore, Sic1 protei;19982018-04-21T20:11:43Z
CKD (28648)CDK logo20122021-04-02T02:54:24Z
IUMA: ballantine skuadraTodo Partio por el año 98', cuando se conocieron Knowman y Black Market. Paso el tiempo y fueron formando distintos grupos (BLG, AGS, CDK), hasta que el 2002 dieron en el clavo creando la BALLANTINE'SKUADRA (un poco en broma, un poco en realidad), con el tiempo fue tomando fuerza e integrando a mas personajes. Un "gancho" en esa creación fue God Killah quien tenia una larga amistad con Get Killah, y este con Dj Killah. Al mismo tiempo otra amistad de antaño es la de God Killah y Glace one, lo que facilito la union entre todos (God Killah conocio hace muchos años a Black Market jejeje.). Get Killah con God Killah, hicieron el primer tema con el respaldo de Dj Killah. Se fueron creando distintas formulas, muchas practicas, todo para obtener el sonido que tenemos. La BTS como cada uno tubo un "comenzar" diferente, tienen muchos estilos y muchas influencias, esta mescla es la que le da el "toque". Los estudios son Black Label Studios a cargo de Dj Killah y la colaboración de los demas;2012-05-16T19:45:45Z
DTIC ADA435854: The Role of Ubiquitin E3 Ligase SCFSKP2 in Prostate Cancer DevelopmentThe CDK inhibitor p27Kipl acts as a negative regulator in the cell cycle and in prostate tumorigenesis. Either the loss of p27 or over-expression of its key regulator ubiquitin E3 ligase SKP2 is associated with prostate cancer. Prostate-sepcific expression of SKP2 is sufficient to induce hyperplasia, displasia, and low grade carcinoma in the mouse prostate gland. We propose to examine whether SKP2 cooperates with or is regulated by tumor suppressors such as Pten or Nkx3.1 implicated in prostatic tumorigenesis. In the past year, we have initiated the experiments by breeding and expansion of the colonies, crossing the SKP2 transgenic mice into Pten +/- strains, and ordering Nkx3.1 mice. Compound mice of SKP2 transgene and Pten +/- were made. Our initial studies suggest that there i&. no substantial difference in tumor frequency and grade in the SKP2 and Pten +/- compound mice versus single genetic alterations. These results suggest that PTEN may act through SKP2 for tumorigenesis. Since ;20052018-05-27T08:46:56Z
DTIC ADA455296: Consequences of Cyclin D1/BRCA1 Interaction in Breast Cancer ProgressionThe inheritance of one defective BRCA1 or BRCA2 allele predisposes an individual to developing breast, ovarian and T-cell cancers. In addition, in breast cancers where BRCA1 is not mutated, it is often functionally inactivated. Furthermore, cyclin D1 has been shown to be overexpressed in many cancers including breast cancer and its associates with BRCA1. Because of the crucial role of both of these proteins in cancer, it is reasonable to expect that this interaction has a significant role in tumor cells. The understanding of when this interaction occurs during cell cycle progression will help to determine the role of cyclin D1/BRCA1 binding in breast cancer cells. Therefore, I hypothesize that the direct interaction of cyclin D1 with BRCA1 results in the cell cycle dependent regulation of the activity of BRCA1. In this study, I wish to identify and confirm the cell cycle dependent cyclin D1/BRCA1 interaction in breast cancer cells, determine the biochemical consequence of cyclin D1/BRC;20062018-06-07T00:13:22Z
DTIC ADA378108: Role of the Cdk Inhibitor Sic 1 in StartNearly 180,000 women will develop breast cancer in 1999 and 44,000 will die. Cancer is essentially a disease of inappropriate proliferation due to a loss of normal cell cycle controls. We study cell cycle controls in the budding yeast S. cerevisiae. We have shown that the formation of active G1-cyclin dependent kinase complexes (Cdks) is rate limiting for cell cycle progression. The activity of these complexes is regulated through their association with highly unstable G1 cyclins. G1 cyclins are constitutively unstable, and their only essential function is to phosphorylate the B-type Cdk inhibitor, Sic1, and target it for degradation. Sic1 is one of few known in vivo substrates of yeast G1-Cdks. The amount and phosphorylation state of Sic1 appears to determine the timing and size of cell division. Sic1 mutants lacking several phosphorylation sites are stabilized and completely block cell cycle progression. Thus, the phosphorylation and subsequent degradation of Sic1 appears to be the c;19992018-04-28T13:18:00Z
github.com-debezium-debezium_-_2021-12-08_20-36-19Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe;20212021-12-08T23:14:00Z
DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium CompoundThis work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a;20052018-06-15T10:53:58Z
[CDK 016] Flappiest BitsAwww hells yeah! Jellica, the UK’s answer to goto80 (and IMO, the most underrated chiptuner in the country) kindly gives CDKr his ‘Flappiest Bits’ – an album which is similar to a wedding. How come? As there’s something old, something new, something borrowed, and something blue! (Some old tracks, some new tracks, a few covers and Pull My Nipples Hard , fact fans) Anyway, away with the awful analogies, just kick back and enjoy some fantastic chiptunes ‘n’ VST tracks! And if you like it, purchase his forthcoming miniCD from RetinaScan! The artwork for this is from the supremely talented Raquel Meyers , who also did the fantastic video for Jellica’s “I wld di 4 u” cover . Jellica also runs the UK’s second best chiptune weblabel (after CDKr of course ^_^), Kittenrock ! It’s down at the moment, and more’s the pity. Kittenrock and CDKr are also releasing a split CD-R soon, hopefully before the year is out!20082019-12-06T23:30:08Z
[CDK 056] Steady C - He Started It[CDK 056] Steady C - He Started It20112020-01-05T21:08:08Z
[CDK 059] Cerebral Scars - Northern Dancing Town[CDK 059] Cerebral Scars - Northern Dancing Town20122020-01-05T21:30:32Z

LibGen

AuthorTitlePublishedmd5