| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Linea Dorada | Tracklist: 1. El numero uno 2. La camioneta gris 3. La bronco negra 4. Chico Fuentes 5. Setecientas libras 6. Doctor Fonseca 7. Juan Ramos 8. Rosita la morena 9. Crimen en Chihuahua 10. La entallada 11. Gumaro Vazquez 12. Candido Rodriguez 13. El culichi 14. Esperanza Valero 15. Pedro Paez 16. Los traficantes 17. La ley del contrabandista 18. Los dos contrabandistas 19. El aguila real 20. El corrido de Gabino | 2002 | 2024-11-21T12:12:01Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| Vicki Winans | Tracklist: 1. Work It Out 2. Prelude: We Shall Overcome 3. Precious Lord (A Tribute To Dr. Martin Luther King) 4. Stand Up and Praise Him 5. We Shall Behold Him (New Rendition) 6. The Only One 7. Suddenly 8. I Remember When 9. You Never Left Me 10. Believing Is Seeing 11. Mary Did You Know | 1994 | 2017-10-20T11:51:56Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| A high concentration of genistein down-regulates activin A, Smad3 and other TGF-? pathway genes in human uterine leiomyoma cells. | This article is from Experimental & Molecular Medicine , volume 44 . Abstract Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis™, we identified genes (up- or down-regulated, ≥ 1.5 fold, P ≤ 0.001), functions and signaling pathways that were altered following treatment with an inhibitory concentration of genistein (50 µg/ml) in UtLM cells. Downregulation of TGF-β signaling pathway genes, activin A, activin B, Smad3, TGF-β2 and genes related to cell cycle regulation, with the exception of the upregulation of the CDK inhibitor P15, were identified and validated by real-time RT-PCR studies. Western blot analysis further demonstrated decreased protein expression of activin A and Smad3 in genistein-treated UtLM cells. Moreover, we found that activin A stimulated the growth of UtLM cells, and the inhibitory effect of genistein was partiall; | 2012 | 2014-10-28T19:53:56Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| DTIC ADB240661: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from GL phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the GL phase cyclin dependent kinases (cdk), cdk4 and cdk6. Cyclin dependent kinase 4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle-from GL into S phase in the osteosarcoma cell line, U2OS. Understanding differential regulation of these two kinases and their potentially different ; | 1998 | 2018-03-03T10:06:08Z |
| Phunky Phetes ep2 | Phunky Phetes ep2 created by fourstones (victor) Put together this show while (literally) on the road in Hollywood. Sorry about the quality of bumper, clearly the quality of phunk makes up for all. Track List: coast to coast-DU-remix by: deutscheunschuld -- (cc) Sampling Plus Vroum,vroum (remix) by: stefsax -- (cc) Attribution Noncommercial Life of Luxury (Shout Out mix) by: duckett -- (cc) Attribution Noncommercial Share-Alike (3.0) Tupelo by: Minus Kelvin -- (cc) Noncommercial Sampling Plus NYC-OLD SCHOOL Bootleg MIX. by: J.Lang -- (cc) Noncommercial Sampling Plus Deep In Ya Self (Faith Mix) by: DoKashiteru -- (cc) Attribution Noncommercial (3.0) Dream Of You by: Alex -- (cc) Attribution Noncommercial (3.0) Official (Ex-centric mix) by: cdk -- (cc) Attribution Noncommercial from ccMixter Bumpers: phunky phetes intro by: fourstones -- (cc) Noncommercial Sampling Plus Songboy3 CCMixter.org Promo 02 by: Songboy3 -- (cc) Attribution Noncommercial Share-Alike phphout ep.2 by: fourstones -; | | 2009-07-28T13:15:00Z |
| Tumor-suppressing viruses, genes, and drugs : innovative cancer therapy approaches | 1 online resource (xv, 425 pages) : // Includes bibliographical references and index // Ch. 1. Oncolytic viruses: virotherapy for cancer -- Ch. 2. Reovirus therapy of Ras-associated cancers -- Ch. 3. Oncolytic herpes simplex virus (G207) therapy: from basic to clinical -- Ch. 4. p53 and its targets -- Ch. 5. Prospects for tumor suppressor gene therapy: RB as an example -- Ch. 6. CDK inhibitors: genes and drugs -- Ch. 7. CDK inhibitors: small molecular weight compounds -- Ch. 8. NF1 and other RAS-binding peptides -- Ch. 9. Cytoskeletal tumor suppressor genes -- Ch. 10. TGF-[beta] signaling and carcinogenesis -- Ch. 11. DAN gene -- Ch. 12. Design of hammerhead ribozymes and allosterically controllable maxizymes for cancer gene therapy -- Ch. 13. Inhibitors of angiogenesis -- Ch. 14. Geranylgeranylated RhoB mediates the apoptotic and antineoplastic effects of farnesyltransferase inhibitors: new insights into cancer cell suicide -- Ch. 15. RAS binding compounds -- Ch. 16. Actin-binding dru; | 2002 | 2020-05-15T01:03:07Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| Het Utrechts Archief 807733 | Het Utrechts Archief catalog number: 807733 Description (Dutch): Afbeelding van de CDk-bak van het ontspoorde electrische treinstel nr. 302 (mat. 1940) van de N.S. bij de spoorbrug over de Haven te Maassluis. | 1956 | 2021-02-26T01:03:42Z |
| CDK Global, LLC al v. Tulley Automotive Group, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2017-07-24T21:20:07Z |
| Boleros | Tracklist: 1. El Reloj/Perfidia/Mira Gue Eres Linda/Maria Elena/Aquellos Ojos Verdes/El Reloj/Te Quiero Dijiste/La Barca/Historia De Un Amor/El Reloj/Siboney/Sabor A Mi/Quiereme Mucho/El Reloj/Amapola/Angelitos Negros/Solamente Un Vez/Besame Mucho/El Reloj/Vamos A La Cama/La Conga 2. Me Lo Dijo Adela/Mi Vaca Lechera/Maria Christina Me Quiere Governar/Tequila/La Conga/Salud, Dinero Y Amor/Cielito Lindo/La Pachanga/La Gallina Papanatas/La Conga/La Bamba/La Raspa/La Cucaracha/La Conga/Se Va El Caiman/Todos Queremos Mas/Baio De Ana/La Conga/Vamos A La Cama | 1988 | 2024-07-11T07:14:09Z |
| Persuading science : the art of scientific rhetoric | xi, 212 p. : 24 cm // Includes bibliographical references and index | 1991 | 2023-12-23T17:00:10Z |
| github.com-debezium-debezium_-_2021-12-10_11-35-09 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-10T12:09:39Z |
| Pathfinders in Medicine. | | 1929 | 2023-12-22T15:43:03Z |
| github.com-duo-labs-cloudmapper_-_2019-12-18_01-58-27 | CloudMapper helps you analyze your Amazon Web Services (AWS) environments. CloudMapper CloudMapper helps you analyze your Amazon Web Services (AWS) environments. The original purpose was to generate network diagrams and display them in your browser. It now contains much more functionality, including auditing for security issues. Network mapping demo Report demo Intro post Post to show spotting misconfigurations in networks Post on performing continuous auditing Commands audit : Check for potential misconfigurations. collect : Collect metadata about an account. More details here . find_admins : Look at IAM policies to identify admin users and roles, or principals with specific privileges. More details here . find_unused : Look for unused resources in the account. Finds unused Security Groups, Elastic IPs, network interfaces, volumes and elastic load balancers. prepare / webserver : See Network Visualizations public : Find public hosts and port ranges. More details here . sg_ips : Get ge; | 2019 | 2019-12-29T21:52:58Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| The Future of Public Access TV and The Internet | Mark Cooper of the Consumer Federation of America speaks with local independent radio host John Grebe about current bills in Congress affecting the future of Public Access Television and the Internet. We also hear from Jason Crow, Access Coordinator of Cambridge Community Television and Michael Eisenmenger of Manhattan Neighborhood Network about how pending legislation in Congress takes away local control of media and places more power in the hands of Big Cable and Telephone companies. Click here to listen to the ACMEBoston Podcast February 11, 2006. Also discussed is the issue of Network Neutrality which Free Press , the national media reform organization, describes as "the guiding principle of the Internet that fosters open competition and innovation, while preserving the independence and accessibility of the World Wide Web" - Free Press, Net Freedom Now . To take a closer look at these issues, we'll hear John Grebe's interview from his program, "Sounds of Dissent" broadcast live on ; | 2006 | 2006-07-27T08:21:29Z |
| Lo Mejor De Los Hermanos Rosario | Tracklist: 1. Pecadora 2. Las Locas 3. Vengo Acabando 4. El Chicharron 5. El Palo 6. Maria 7. Nadie Me Brinda Na 8. Me Tiene Amarrao 9. El Lapiz 10. La Napa 11. Mirame 12. El Problema De Gisla 13. Mireya 14. Homenaje a Pepe 15. Cenizas | 1988 | 2024-04-17T07:11:08Z |
| github.com-sindresorhus-awesome_-_2023-06-23_22-54-41 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-24T23:56:50Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| github.com-dabit3-awesome-aws-amplify_-_2021-02-13_23-48-59 | Curated list of AWS Amplify Resources Awesome AWS Amplify curates the best AWS Amplify, tools, tutorials, articles and more. PRs are welcome! Check out the Amplify Discord server Getting Started Github Documentation Workshops Serverless GraphQL API with AppSync and DynamoDB AWS Amplify Photo Sharing Workshop Next.js AWS Amplify Workshop Building real-time applications with React, GraphQL & AWS AppSync Building Mobile Applications with React Native & AWS Amplify AWS Amplify UnicornFlix Workshop (Video on Demand) AWS Amplify UnicornTrivia Workshop (Live streaming video) Tutorials - Blogs & tutorials General blogs & tutorials Full Stack Cloud Development with AWS Amplify TensorFlow.js + AWS Amplify 10 Minute Tutorial: Creating a Serverless Express Web Server & API ⚡️ 10 Ways to Use Serverless Functions Real quick GraphQL service with AWS Amplify & Appsync Visualizing Focus with Neurosity's Notion and AWS Amplify Build a Music Sharing App with Amazon S3 and AWS Amplify Introducing Conf; | 2021 | 2021-02-22T13:28:20Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| DTRASH10 - Bastards United - Bastards United | This is a killer collection of breakneck headbanger digital thrash music. Bastards United have are a complete digicore band with guitarists, MCs and program thrashers. Straight from the Netherlands, BU collaborates on some slammin' tracks with Rabies/CDK and b57 from CPUWAR in the mix! | 1999 | 2008-04-19T16:24:14Z |
| Los Merengazos Del Año Vol.11 | Tracklist: 1. Que Buenas Son Las Fiestas - Pochy Y Su Cocoband 2. Algo Le Di Yo - Bonny Cepeda Y Su Orquesta 3. Baby Baby - Dimanchy 4. Volviendome Tu - Dioni Fernández Y El Equipo 5. Mambo - Los Hermanos Mercedes 6. La Chica Trueno - Yanko 7. Tu Eres Mi Hembra - Monchy Capricho 8. Macarena - Yarumba 9. El Macho - Nelson Gil 10. Ella Me Da - Grupo Karamba 11. A Fuego Lento - Feliz Cumbre 12. Noche De Luna - Lisandro Meza | 1994 | 2024-04-14T23:22:07Z |
| the secrets of studying english | | 1980 | 2023-07-21T01:18:46Z |
| github.com-debezium-debezium_-_2021-12-09_10-32-23 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-09T11:34:00Z |
| github.com-sottlmarek-DevSecOps_-_2022-01-15_03-45-55 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def; | 2022 | 2022-01-15T10:00:54Z |
| [CDK 023] Urban Bits | The second of CDKr’s Hip Hop themed compilations – this one is a covers filled release, with tracks from Combat Dave, Josstin Timberlake, Oxygenstar and more! Covers include tracks by Jay Z, KanYe West, Hurricane Chris and loads of others too. The artwork is by the supremely talented Sir Count Ville Von Konttinen III esq (AKA KeFF) – thanks for that mate! The full tracklist is after the jump! | 2008 | 2019-12-07T00:23:58Z |
| The reason you can't buy a car is the same reason that your health insurer let hackers dox you | This week on my podcast, I read The reason you can't buy a car is the same reason that your health insurer let hackers dox you , a column from one of last week's editions of my Pluralistic newsletter; it describes a monopoly pattern whereby companies execute a series of mergers to dominate a sector, leaving their IT systems brittle and tangled - and vital to the nation. Just like with Equifax, the 737 Max disasters tipped Boeing into a string of increasingly grim catastrophes. Each fresh disaster landed with the grim inevitability of your general contractor texting you that he's just opened up your ceiling and discovered that all your joists had rotted out – and that he won't be able to deal with that until he deals with the termites he found last week, and that they'll have to wait until he gets to the cracks in the foundation slab from the week before, and that those will have to wait until he gets to the asbestos he just discovered in the walls. Drip, drip, drip, as you realize th; | 2024 | 2024-06-30T21:51:55Z |
| FReeKS014: Make Rave Not Hate Stays Drum'n' Bass | Make Rave, not Hate stays Drum'n'Bass! In this show our Radio DJ Robb plays an one hour Drum'n'Bass-Set – strictly Open Music found on the Netaudio Platform ccMixter . In addition we also have some radio information for our German and Rhein-Neckar based listeners. Playlist Apoxode – Escape from Mars 180 Blake – Jack Frost Analog By Nature – Don't go (RumbleStep Mix) Analog By Nature – If God Was Sleeping (cdk Mix) Analog By Nature – Loveshadow - You Made It Up ^ (cdk Mix) Abstract Audio – Dorst Blake – I know your voice spinningmerkaba – Reusenoise (DNB Mix) Abstract Audio – CCMixter (We are not evil) Scott Altham – I got the rhymes (Electric Fish Mix) Alex – Dancing Like A Maniac bangcorrupt – Freedom Analog By Nature – Time (cdk Give Me Some Dubstep Extended Mix) Abstract Audio – Dinosaur Bones Apoxode – Crystal Clear 180 | 2020 | 2020-07-22T21:25:21Z |
| Open Licensed Music Podcast - Episode 39: Electronic | Episode 39 of the Open Licensed Music Podcast featuring electronic music. Hi, and welcome to the Open Licensed Music Podcast, the show where we highlight music from artists who let you share their music. I'm Ralph Wacksworth, and today's episode is featuring electronic music. Electron Stack (5:04 @ 0:11) - http://obtusemusic.bandcamp.com/album/cloudy-sky The silent force (5:30 @ 5:15) - http://zero-project.gr/ Midnight Mystery (4:07 @ 10:45) - https://soundcloud.com/diabolist/midnight-mystery starmann65_A Moment of Silence for Japan (3:35 @ 14:52) - http://www.jamendo.com/en/track/748775/starmann65-a-moment-of-silence-for-japan RnB Japan (3:47 @ 18:27) - http://www.jamendo.com/en/track/73231/rnb-japan That was Electron Stack by Obtuse, which is available from his website at obtusemusic.bandcamp.com and is licensed under an Attribution Noncommercial Share-Alike license. After that was The silent force by zero-project, which is available from zero-project.gr and is licensed under an Attr; | 2013 | 2013-02-17T14:25:23Z |
| Corridos De La Sierra | Tracklist: 1. Los Mas Manchas Al Tigre 2. Los Tres Verdes 3. La Negocio Cuajado 4. Directores de Bandas 5. La Imagen de Malverde 6. Brinque la Barda 7. El Seänor 8. Seirra Michoacana 9. La Dama de Negro 10. Carro Con Clavo 11. Victor Zamudio 12. Miguel Lopez | 2002 | 2025-04-12T11:59:30Z |
| Corridos Originales | Tracklist: 1. El Rayo de Sinaloa 2. Se Les Pelo Baltazar 3. 20 Mujeres de Negro 4. Candido Rodriguez 5. El Rey de Mil Coronas 6. Juan Ramos 7. Dados Cargados 8. El Capitan y el Teniente 9. Contrabando de Juarez 10. Anastacio Pacheco 11. El Alma Grande 12. Mi Huerfano Alazan 13. El Cartel de los Cielos 14. El Regalo Caro 15. Las Liebres 16. Panchito Palma 17. El Halcon 18. El Doctor Veterinario 19. El Guante 20. Corrido de Javier Barba | 2002 | 2025-04-11T04:55:18Z |
| Catherine Dumonteil Kremer | "Quand on est en train de blesser son enfant, on se dit "pourquoi je fais ça?" au moment même où on le fait. Quelquefois, on se voit faire et on n'arrive pas à arrêter. Donc en nous, il y a quelqu'un qui est super, merveilleux, coopératif, aimant, intelligent, etc. Tout le monde a ça en lui." Catherine Dumonteil-Kremer est l'invitée du 8ème épisode de La Force de la Non-violence. Pionnière dans la parentalité positive, ancienne travailleur social, elle devient ensuite consultante parentale, éducatrice Montessori et crée le Réseau Parents Conscients. Autrice à succès avec notamment "Élever son enfant autrement", elle invente le concept de parentalité créative qui regroupe ce qu'elle considère comme des éléments fondamentaux au bon développement des enfants comme le maternage proximal, l'écoute, le jeu, l'acceptation et l'affirmation de soi tout en donnant une grande liberté aux parents d'innover dans leur relation avec leurs enfants. Membre fondateur de l'OVEO ; | | 2021-01-25T10:40:44Z |
| Black Sweater, White Cat 1.27.2007 | Broadcast to Podcast devoted to Creative Commons music. | 2007 | 2007-01-28T12:40:05Z |
| [CDK 034] Natty - These Days I Expect The Worst | [CDK 034] Natty - These Days I Expect The Worst | 2009 | 2020-01-02T22:35:46Z |
| DTIC ADA410428: Development of Inhibitors That Selectively Disrupt Substrate Recognition by Cyclin-Dependent Kinases | Upregulation of cyclin/cdk activity and the resulting deregulation of the cell cycle is a common feature in the malignant transformation of breast epithelial cells and thus makes cyclin/cdks an attractive target for drug design. The long-term goal of our work is to develop inhibitors which inhibit cyclin/cdk activity by disrupting the interaction between cyclins and their substrates, an association that requires a sequence motif in the substrate termed a Cy motif. Cy or RXL motifs are general purpose motifs for the interaction of cellular factors with cyclins. Recent work in our laboratory has shown that these motifs are critical determinants of both substrate recognition and specificity and function by targeting molecules to particular cyclin/cdk complexes. During the first year of grant support, we have made significant advancements into understanding substrate recognition by cyclin-dependent kinases. This work provides the framework for the development of Cy motif-derived peptides a; | 2002 | 2018-05-11T22:33:13Z |
| DTIC ADA443026: Radiation Sensitization in Breast Cancer via Targeting Survivin Expression | We proposed to determine whether overexpression- of surviving results in radio resistance and the possible mechanisms; whether irradiation down regulates p34(CDC2) and its mechanism in vascular endothelium and whether CDK (cyclin dependent kinase) inhibitors sensitize it to radiation injury; the mechanism of surviving- deregulation in breast cancer and whether inhibition of surviving or its regulator, p34(CDC2) abolishes radio resistance. We found that overexpression of surviving leads to radiation resistance and CDK inhibitors result in radiosensitization. We also found that deregulation of surviving in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of surviving and Stat3 results in significantly increased sensitization of breast cancer. In the next two years, we will determine the biological significance of combining surviving inhibitors or CDK inhibitors with radiotherapy in xenograft models of breast cancer. The proposed study w; | 2005 | 2018-05-30T23:48:34Z |