| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| Linea Dorada | Tracklist: 1. El numero uno 2. La camioneta gris 3. La bronco negra 4. Chico Fuentes 5. Setecientas libras 6. Doctor Fonseca 7. Juan Ramos 8. Rosita la morena 9. Crimen en Chihuahua 10. La entallada 11. Gumaro Vazquez 12. Candido Rodriguez 13. El culichi 14. Esperanza Valero 15. Pedro Paez 16. Los traficantes 17. La ley del contrabandista 18. Los dos contrabandistas 19. El aguila real 20. El corrido de Gabino | 2002 | 2024-11-21T12:12:01Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| CIA Reading Room cia-rdp84b00148r000100370001-5: OEXA RECORDS MANAGEMENT | Charles E. Wilson Chief, Public Affairs Division OEXA Records Management 1. Action Requested: Transfer primary PAD records management responsibility to OEXA Registry. 2. Background: Since PA ceased to exist as an Independent Office and became a Division in OEXA, PAD has nevertheless retained a Records Management Officer (RMO) and primary responsibility for this function. Since this is normally a Registry function, we are probably overdue in transferring it. I understand the OEXA Registry is already RMO for LLD. It seems to me that in a perfect world PAD would retain day-to-day maintenance of its decentralized files, but the Registry would assume responsi- bility for such things as reporting annual volume surveys, maintaining file retirement schedules, file renumbering projects, and the like. 3. Recommendation: Request OEXA Administrative Officer's assistance in establishing the Chief, OEXA Registry as RMO for all of OEXA and in transferring PAD's responsibility. We are prepared to assi; | 1982 | 2025-02-19T12:51:25Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| Tumor-suppressing viruses, genes, and drugs : innovative cancer therapy approaches | 1 online resource (xv, 425 pages) : // Includes bibliographical references and index // Ch. 1. Oncolytic viruses: virotherapy for cancer -- Ch. 2. Reovirus therapy of Ras-associated cancers -- Ch. 3. Oncolytic herpes simplex virus (G207) therapy: from basic to clinical -- Ch. 4. p53 and its targets -- Ch. 5. Prospects for tumor suppressor gene therapy: RB as an example -- Ch. 6. CDK inhibitors: genes and drugs -- Ch. 7. CDK inhibitors: small molecular weight compounds -- Ch. 8. NF1 and other RAS-binding peptides -- Ch. 9. Cytoskeletal tumor suppressor genes -- Ch. 10. TGF-[beta] signaling and carcinogenesis -- Ch. 11. DAN gene -- Ch. 12. Design of hammerhead ribozymes and allosterically controllable maxizymes for cancer gene therapy -- Ch. 13. Inhibitors of angiogenesis -- Ch. 14. Geranylgeranylated RhoB mediates the apoptotic and antineoplastic effects of farnesyltransferase inhibitors: new insights into cancer cell suicide -- Ch. 15. RAS binding compounds -- Ch. 16. Actin-binding dru; | 2002 | 2020-05-15T01:03:07Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| DTIC ADB240661: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from GL phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the GL phase cyclin dependent kinases (cdk), cdk4 and cdk6. Cyclin dependent kinase 4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle-from GL into S phase in the osteosarcoma cell line, U2OS. Understanding differential regulation of these two kinases and their potentially different ; | 1998 | 2018-03-03T10:06:08Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| DTIC ADA382749: Resistance to Tamoxifen: A Consequence of Altered p27Kipl Regulation During Breast Cancer Progression | This grant addresses the molecular mechanisms of resistance to the anti-estrogen, Tamoxifen, in breast cancers. Both estrogens and antiestrogens influence the cell cycle during the GI phase. In breast tumors, loss of the cdk inhibitor, p27, is associated with a poor prognosis and with steroid resistance. We postulate that altered p27 degradation in breast cancer may contribute to resistance to antiestrogen therapy. In the last year, we have assayed cell cycle effects of estradiol in the ER+ breast cancer cell line, MCF-7. MCF-7 arrests in G1 upon removal of estradiol or on addition of Tamoxifen. Upon re-addition of estradiol, cells re-enter the cell cycle with onset of S phase by 12 hours and loss of both p21 and p27 proteins. Cyclin D1 associated kinase activity rose transiently in early G1. Activation of cyclin E/cdk2 kinase in mid-late G1 was accompanied by loss of cyclin E-associated p21 and p27. The requirement for p27 in the quiescence induced by estradiol depletion was investiga; | 1999 | 2018-04-29T17:57:19Z |
| DTIC ADA398199: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal Tumorigenic Human Breast Cells | Ubiquitin-mediated proteolysis of cyclins, cyclin-dependent kinase inhibitors and certain other substrates, including proteins whose degradation is necessary for progression through mitosis, provide a molecular basis for unidirectional progression through the eukaryotic cell cycle. Aberrations in the ubiquitin-mediated destruction pathways, and particularly in the destruction of the Dl cyclin, have been implicated in human breast cancer. A cascade of enzymes leads to ubiquitination of substrate: El enzyme (ubiquitin activating); E2 enzyme (ubiquitin conjugating), and E3 enzyme (ubiquitin ligase). This last class of enzyme is large, and it performs the functions of targeting substrate and catalyzing formation of the polvubiquitin chains that mark substrate for destruction. We have found that all three members of the yeast cullin family are capable of performing the ubiquitination activity of E3 enzyme. All three yeast cullins undergo covalent modification with Rub1 protein, presumably t; | 2001 | 2018-05-05T21:00:08Z |
| DTIC ADA386459: Action of the p53 Effector, p21, on its Targets: Cyclin-CDK & PCNA | Our aim is to dissect the interactions of p21 (a downstream effector of the tumor suppressor protein p53) with its targets, cyclin-cdks and PCNA. In year 2 we have focused on the cyclin-cdks. We have quantitated the contribution of the cyclin-cdks binding Cy motif (on cdk substrates) to their interaction with the cyclin-cdks. We find that a Cy motif improves the Km of a substrate by 5OO-1000 fold without any effect on the Vmax of the peptide or the Km of ATP. Such a large contribution of the Cy motif to substrate recognition explains why a peptide based on the Cy motif of p21 inhibits phosphorylation by cdk. A small chemical that mimics the structure of the Cy motif would be a specific inhibitor of cdks and suppress breast cancer cell growth. Towards this end, site directed mutagenesis has been used to generate a library of mutants in the Cy motif of p21. Using this library we find that the first arginine (R1) and the third leucine (L3) of the Cy motif (RRLFG) are critical for docking ; | 1999 | 2018-04-30T22:37:50Z |
| Dante the Central Man of All the World | | 1922 | 2023-08-10T02:07:56Z |
| coderedfm27062020 | your weekly drum&bass radioshow outta stuttgart / germany | | 2020-06-28T15:02:26Z |
| the new testament in the original greek | | 1928 | 2025-06-16T23:17:47Z |
| The influence of negative training set size on machine learning-based virtual screening. | This article is from Journal of Cheminformatics , volume 6 . Abstract Background: The paper presents a thorough analysis of the influence of the number of negative training examples on the performance of machine learning methods. Results: The impact of this rather neglected aspect of machine learning methods application was examined for sets containing a fixed number of positive and a varying number of negative examples randomly selected from the ZINC database. An increase in the ratio of positive to negative training instances was found to greatly influence most of the investigated evaluating parameters of ML methods in simulated virtual screening experiments. In a majority of cases, substantial increases in precision and MCC were observed in conjunction with some decreases in hit recall. The analysis of dynamics of those variations let us recommend an optimal composition of training data. The study was performed on several protein targets, 5 machine learning algorithms (SMO, Naïve B; | 2014 | 2014-10-19T07:35:32Z |
| Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. | This article is from Breast Cancer : Targets and Therapy , volume 6 . Abstract Cellular proliferation, growth, and division following DNA (deoxyribonucleic acid) damage are tightly controlled by the cell-cycle regulatory machinery. This machinery includes cyclin-dependent kinases (CDKs) which complex with their cyclin partners, allowing the cell cycle to progress. The cell-cycle regulatory process plays a critical role in oncogenesis and in the development of therapeutic resistance; it is frequently disrupted in breast cancer, providing a rational target for therapeutic development. Palbociclib is a potent and selective inhibitor of CDK4 and -6 with significant activity in breast cancer models. Furthermore, it has been shown to significantly prolong progression-free survival when combined with letrozole in the management of estrogen receptor-positive metastatic breast cancer. In this article we review the cell cycle and its regulatory processes, their role in breast cancer, and the rat; | 2014 | 2014-10-06T01:38:18Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| The Stormy Petrel (Large Print Edition) | | 1991 | 2023-07-25T00:30:17Z |
| DTIC ADA410428: Development of Inhibitors That Selectively Disrupt Substrate Recognition by Cyclin-Dependent Kinases | Upregulation of cyclin/cdk activity and the resulting deregulation of the cell cycle is a common feature in the malignant transformation of breast epithelial cells and thus makes cyclin/cdks an attractive target for drug design. The long-term goal of our work is to develop inhibitors which inhibit cyclin/cdk activity by disrupting the interaction between cyclins and their substrates, an association that requires a sequence motif in the substrate termed a Cy motif. Cy or RXL motifs are general purpose motifs for the interaction of cellular factors with cyclins. Recent work in our laboratory has shown that these motifs are critical determinants of both substrate recognition and specificity and function by targeting molecules to particular cyclin/cdk complexes. During the first year of grant support, we have made significant advancements into understanding substrate recognition by cyclin-dependent kinases. This work provides the framework for the development of Cy motif-derived peptides a; | 2002 | 2018-05-11T22:33:13Z |
| DTIC ADA443026: Radiation Sensitization in Breast Cancer via Targeting Survivin Expression | We proposed to determine whether overexpression- of surviving results in radio resistance and the possible mechanisms; whether irradiation down regulates p34(CDC2) and its mechanism in vascular endothelium and whether CDK (cyclin dependent kinase) inhibitors sensitize it to radiation injury; the mechanism of surviving- deregulation in breast cancer and whether inhibition of surviving or its regulator, p34(CDC2) abolishes radio resistance. We found that overexpression of surviving leads to radiation resistance and CDK inhibitors result in radiosensitization. We also found that deregulation of surviving in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of surviving and Stat3 results in significantly increased sensitization of breast cancer. In the next two years, we will determine the biological significance of combining surviving inhibitors or CDK inhibitors with radiotherapy in xenograft models of breast cancer. The proposed study w; | 2005 | 2018-05-30T23:48:34Z |
| Nortenas del Pueblo No. 1 | Tracklist: 1. Sabiendo Quien Era Yo - Los Incomparables de Tijuana 2. La Rubia y la Morena - Los Dinamicos del Norte 3. Mujer, Mujer - Los Hermanos Banda 4. Aquellos Ojitos Verdes - Los Remolinos de Fabián Gómez 5. Tu Desastre - Los Incomparables de Tijuana 6. Alta y Delgadita - Los Dinamicos del Norte 7. Palomita Donde Vas - Los Hermanos Banda de Salamanca 8. Las Llaves - Los Remolinos de Fabián Gómez 9. Te Ando Siguiend los Pasos - Los Incomparables de Tijuana 10. En las Cantinas - Los Dinamicos del Norte 11. Destino Cruel - Los Hermanos Banda de Salamanca 12. Dos Mujeres - Los Remolinos de Fabián Gómez | 2002 | 2025-03-31T06:47:58Z |
| CDK-120 | | | 2021-04-17T01:59:16Z |
| Laocoon Nathan the Wise Minna von Barnhelm | | 1967 | 2023-08-08T08:47:51Z |
| DTIC ADA438990: Activation of P13K/PKB Signaling in Breast Cancer may Inhibit TGFB-Induced G1 Arrest through Changes in p27 Function | TGF-Beta1 plays a pivotal role in maintaining homeostasis of normal tissues including mammary epithelial cell growth, in which TGF-Beta1 induces cell cycle arrest through activating cdk inhibitors including p15(exp INK4B) and p27(expKiP1). Loss of p27(exp KiP1), seminally described in breast cancers, has been found in a plethora of human malignancies. The Slingerland (my mentor) lab found that p27 is subject to complex post-translational regulation, e.g. phosphorylation. To elucidate the mechanisms underlying TGF-Beta resistance in breast cancer cells, this proposal set out to address the hypothesis that changes in phosphorylation serve to switch the cdk inhibitor p27 from an active state that binds avidly to cyclin E/cdk2 in TGF-beta arrest and in G0, to an inactive state in late G1 and mitogenic activation of the P13K/PKB pathways leads to phosphorylation of p27, reducing its affinity for cyclin E/cdk2 and abrogating its inhibitory function. We proposed 3 specific Aims to pursue this; | 2004 | 2018-05-28T04:15:18Z |
| github.com-angular-components_-_2019-11-09_08-00-19 | Component infrastructure and Material Design components for Angular Components and Material Design for Angular This is the home for the Angular team's UI components built for and with Angular.These include Material Design components and the Angular Component Development Kit (CDK). Quick links Documentation, demos, and guides | Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if you're building your first project with Angular Material. Check out our directory of design documents for more insight into our process. If you'd like to contribute, you must follow our contributing guidelines .You can look through the GitHub issues (which should be up-to-date on who is working on which featuresand which pieces are blocked) and make a comment. Please see our help wanted label for a list of issues where we could use help from the community. High level stuff planned for Q4 2019 (Oct - Nov): Remove dependency on HammerJS Finish remaining test harnesses; | 2019 | 2019-11-09T10:02:31Z |
| Jay Kay Collision Center, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-06-27T09:15:55Z |
| CDK Global, LLC v. Southeast Atlantic Peterbilt of North Carolina, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-30T20:14:22Z |
| Kulkarni v. CDK Global, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2023-06-01T09:14:33Z |
| Re-thinking cell cycle regulators: the cross-talk with metabolism. | This article is from Frontiers in Oncology , volume 3 . Abstract Analysis of genetically engineered mice deficient in cell cycle regulators, including E2F1, cdk4, and pRB, showed that the major phenotypes are metabolic perturbations. These key cell cycle regulators contribute to lipid synthesis, glucose production, insulin secretion, and glycolytic metabolism. It has been shown that deregulation of these pathways can lead to metabolic perturbations and related metabolic diseases, such as obesity and type II diabetes. The cyclin–cdk–Rb–E2F1 pathway regulates adipogenesis in addition to its well-described roles in cell cycle regulation and cancer. It was also shown that E2F1 directly participates in the regulation of pancreatic growth and function. Similarly, cyclin D3, cdk4, and cdk9 are also adipogenic factors with strong effects on whole organism metabolism. These examples support the emerging notion that cell cycle regulatory proteins also modulate metabolic processes. These ce; | 2013 | 2014-10-28T16:47:52Z |
| github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-15_19-09-44 | Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ; | 2021 | 2021-01-16T03:16:22Z |
| Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. | This article is from Biomolecules & Therapeutics , volume 20 . Abstract Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents. In recent years, a number of structurally diverse HDAC inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. However, the underlying molecular mechanisms remain unclear. This study aimed at investigating the anti-tumor activity of various HDAC inhibitors, IN-2001, using T47D human breast cancer cells. Moreover, the possible mechanism by which HDAC inhibitors exhibit anti-tumor activity was also explored. In estrogen receptor positive T47D cells, IN-2001, HDAC inhibitor showed anti-proliferative effects in dose-and time-dependent manner. In T47D human breast cancer; | 2011 | 2014-10-24T20:14:53Z |
| Het bericht ‘CdK haalt ongemeen fel uit naar de NAM’ | This document is issued on date 2015-05-27. | 2015 | 2018-03-14T20:02:09Z |
| Commissioner Sullivan message to Clatsop County April 22 | | 2020 | 2022-10-14T13:47:04Z |
| Hong Kong Birds | | 1967 | 2023-07-30T23:20:36Z |
| DTIC ADA392349: Action of the p53 Effector, p21, on its Targets: Cyclin-cdk and PCNA | Cy or RXL motifs have been previously shown to be cyclin binding motifs found in a wide range of cyclin-cdk interacting proteins. For both cyclin A/cdk2 and cyclin E/cdk2, the presence of a Cy motif decreased the Km(sup peptide! 75 to 120-fold while the kcat remained unchanged. Changes in the length of the linker between the Cy motif and the phosphoacceptor serine suggest that both sites are engaged simultaneously to the cyclin and the cdk, respectively. PS100, a peptide containing a Cy motif, acts as a competitive inhibitor of cyclin/cdk complexes with a 15-fold lower Ki for cyclin E/cdk2 than for cyclin A/cdk2. These results provide kinetic proof that a Cy motif located at a minimal distance from the SPXK is essential for optimal phosphorylation by cdks and suggest that small chemicals that mimic the Cy motif would be specific inhibitors of substrate recognition by cyclin-dependent kinases. In addition, a detailed mutagenesis approach to define what sequence serves as a Cy motif reve; | 2000 | 2018-05-03T14:38:06Z |