| Title | Description | Published | Added |
| John Gay, his place in the eighteenth century | | 1938 | 2023-12-27T15:46:10Z |
| CDK 01 20 | 01*200 | | 2023-03-23T13:43:39Z |
| I was a probationer | | 1937 | 2025-09-08T07:44:38Z |
| The King of Fighters 2002: (BR) Tosh-AM-666 vs(BR) [CDK]A.J.KOF - 2022-09-23 17:42:03 | (BR) Tosh-AM-666 vs (BR) [CDK]A.J.KOF - 2022-09-23 17:42:03 Fightcade replay id: 1663954923376-8072 #fightcade #kof2002 #[CDK]A.J.KOF #Tosh-AM-666 For more videos check out: https://fightcadevids.com | | 2022-09-24T00:59:37Z |
| Authenticom, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-03-25T23:18:28Z |
| DTIC ADA384004: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | Sequential activation and inactivation of cyclin dependent kinases (CDK) regulate eukaryotic cell cycle transitions. The periodicity of CDK activity provides a molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins have been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells, but they are poorly understood at present. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: El (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with ; | 1999 | 2018-04-30T00:33:35Z |
| A surgeon remembers | | 1953 | 2023-12-22T18:53:56Z |
| The Lost Americans | | 1968 | 2025-08-01T01:19:53Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Irradiation And The Nervous System | | 1963 | 2025-09-11T15:24:38Z |
| BRITANNICA WORLD LANGUAGE DICTIONARY | | 1959 | 2025-08-24T15:43:03Z |
| Periodic systems and their relation to the systematic analysis of molecular data | xxvi, 629 p., 8 p. of plates : 24 cm. + // Microfiches in pocket on front flyleaf // Includes bibliographies and index | 1989 | 2023-12-23T07:53:35Z |
| Flight Without Power | | 1940 | 2025-09-12T12:32:24Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| Continuum theory and dynamical systems : proceedings of the AMS-IMS-SIAM joint summer research conference held June 17-23, 1989, with support from the National Science Foundation and the Army Research Office | ix, 182 p. : 26 cm // "The AMS-IMS-SIAM Joint Summer Research Conference in the Mathematical Sciences on Relationships between Continuum Theory and the Theory of Dynamical Systems was held at Humboldt State University, Arcata, California, on June 17-23, 1989"--T.p. verso // Sponsored by the National Science Foundation // Includes bibliographical references | 1991 | 2024-01-10T13:03:37Z |
| From this day forward | | 1941 | 2023-07-29T05:57:44Z |
| Germinal | | 1951 | 2023-07-25T01:30:34Z |
| lomegvisual # 061 "pieces alife" | A short experimental voodle by bk featuring some almost forgotten left-over footage brought back to life not quite as it was captured in Beijing, China - 2008.09.24 at 09:31 hours. View how the simple inversion of 'pieces of life' (ccmixter's cdk)Â makes 'pieces alife', and thus another body and space morphology.b.k.: video 061 for lomeg-rom.blogspot.com - 3'56'' | | 2009-03-21T10:15:11Z |
| Aviles v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-06-28T09:07:16Z |
| DTIC ADA369304: Role of cdc25 Phosphatases in Cellular Immortalization. | The goal of this proposal is to study the potential role of tyrosine phosphorylation-dependent checkpoint and especially the cdc25 phosphatase family of cyclin dependent kinase (CDK) activators in cellular immortalization. We have shown that cdc25 phosphatases did in fact extend the normal mammary epithelial cells life span, but do not immortalize them. The effect was most prominent with cdc25A and cdc25B phosphatases. Cdc25C phosphatase' had less effect on HMEC life span. Experiments with catalytically inactive cdc25A mutant show that phosphatase activity of cdc25A is essential for the life span extension. Our experiments shows that telomerase is not activated by cdc25A expression in normal human cells, suggesting that cdc25 most likely affect Ml. but not M2 checkpoints. | 1999 | 2018-04-25T22:23:31Z |
| Houttuynia cordata Thunb extract modulates G0/G1 arrest and Fas/CD95-mediated death receptor apoptotic cell death in human lung cancer A549 cells. | This article is from Journal of Biomedical Science , volume 20 . Abstract Background: Houttuynia cordata Thunb (HCT) is commonly used in Taiwan and other Asian countries as an anti-inflammatory, antibacterial and antiviral herbal medicine. In this study, we investigated the anti-human lung cancer activity and growth inhibition mechanisms of HCT in human lung cancer A549 cells. Results: In order to investigate effects of HCT on A549 cells, MTT assay was used to evaluate cell viability. Flow cytometry was employed for cell cycle analysis, DAPI staining, and the Comet assay was used for DNA fragmentation and DNA condensation. Western blot analysis was used to analyze cell cycle and apoptotic related protein levels. HCT induced morphological changes including cell shrinkage and rounding. HCT increased the G0/G1 and Sub-G1 cell (apoptosis) populations and HCT increased DNA fragmentation and DNA condensation as revealed by DAPI staining and the Comet assay. HCT induced activation of caspase-; | 2013 | 2014-10-29T10:44:45Z |
| github.com-lloesche-valheim-server-docker_-_2021-03-15_23-08-06 | Valheim dedicated gameserver with automatic update, World backup and ValheimPlus mod support lloesche/valheim-server Docker image Valheim Server in a Docker Container (with ValheimPlus support) Table of contents Basic Docker Usage Environment Variables Log filters Event hooks Event hook examples Install extra packages Copy backups to another location Delay restarts by 1 minute and notify on Discord ValheimPlus config from Environment Variables System requirements Deployment Deploying with Docker and systemd Deploying with docker-compose Deploying to Kubernetes Deploying to AWS ECS Updates Backups Finding Your Server In-game Steam Server Browser Steam Server Favorites & LAN Play Admin Commands Supervisor Supervisor API Status web server ValheimPlus Updates Configuration Server data rate Disable server password Changing startup CMD in Portainer Synology Help First install Updating the container image to the latest version Error after download of new container image Basic Docker Usage The; | 2021 | 2021-03-16T07:10:56Z |
| Peaching in new york Diaries and papers | | 1924 | 2025-06-16T08:02:31Z |
| Shadow of Fu Manchu, | | 1948 | 2023-07-25T02:48:30Z |
| [CDK 009] Generate | Finnish chiptuner Nestroyer is going through somewhat of a music ‘purple patch’ at the moment, and CDK Records are honoured to host his latest set of tunes. A top collection of tunes, so good Timbaland might even nick ’em! Let’s hope not though. | 2008 | 2019-12-06T21:26:46Z |
| DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 | DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 DDT Iron Man Heavy Metal Title Match Toru Owashi (c) vs. Akito Pre-Show Ten Man Tag Team Match DISASTER BOX (Kazuki Hirata, Naomi Yoshimura & Toru Owashi), Saki Akai & Yuki Ishida vs. CDK (Chris Brookes & Masahiro Takanashi), Akito, Antonio Honda & Yusuke Okada Pre-Show Tag Team Hardcore Match Hideki Okatani & Yuya Koroku vs. The 37KAMIINA (Shunma Katsumata & Toi Kojima) Tag Team Match Daisuke Sasaki & MJ Paul vs. Mizuki Watase & Soma Takao Six Man Tag Team Match MAO, Yuji Hino & Yukio Naya vs. Pheromones (Danshoku Dino, Yuki Ino & Yumehito Imanari) D-Ou Grand Prix 2021 2 Block A Match Jun Akiyama vs. The Bodyguard D-Ou Grand Prix 2021 2 Block B Match HARASHIMA vs. Yuji Okabayashi D-Ou Grand Prix 2021 2 Block B Match Konosuke Takeshita vs. Kazusada Higuchi D-Ou Grand Prix 2021 2 Block A Match Tetsuya Endo vs. Yuki Ueno | 2021 | 2021-11-22T00:19:53Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| Jane Eyre | | 1960 | 2025-10-09T06:38:41Z |
| wezhq | wehou d uyudunu hndhiu fenonhyy "wezhq". shu enuhiudd h npendiu n uyeynhy h hhqnzuu ou feyuyip nqeezu hy npyohuiu. cdk hhohd nhu ueeuhiudd hy fnqiuuui eeq, h nyiu onoijdunn uuq, zun ndy uyduhpy uyeuyep dfeubhnuih yy dnnyuu. nhohd wehop hhzyu ndndyhhpu hy npuyiiiudd, euony zun nhu euoznnuehnuiu dn dnnhuh qeenzquuh, qnunepu uuiu huyhu. en qnue unhyu dpud hhuyeydhu uuqui hdunehi n hyj, wehou hy ohuiu, fnqu nhu nuhuhup hy noiiu n eeqh qhhze «buddquop n unyj uyeynhy», hufhduhhek hyqhu nuhnu muufhnhnu. | | 2025-02-09T08:43:09Z |
| github.com-sindresorhus-awesome_-_2022-11-23_17-40-35 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-24T01:59:00Z |
| github.com-sindresorhus-awesome_-_2023-06-23_22-54-41 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-24T23:56:50Z |
| github.com-infracost-infracost_-_2022-03-25_02-51-39 | Cloud cost estimates for Terraform in pull requests💰📉 Love your cloud bill! Infracost shows cloud cost estimates for Terraform. It enables DevOps, SRE and engineers to see a cost breakdown and understand costs before making changes , either in the terminal or pull requests. This provides your team with a safety net as people can discuss costs as part of the workflow. Quick start 1. Install Infracost Assuming Terraform is already installed, get the latest Infracost release: macOS Homebrew: shbrew install infracost Linux/macOS manual download:```sh Downloads the CLI based on your OS/arch and puts it in /usr/local/bin curl -fsSL https://raw.githubusercontent.com/infracost/infracost/master/scripts/install.sh | sh``` Docker and Windows users see here . 2. Get API key Register for a free API key, which is used by the CLI to retrieve prices from our Cloud Pricing API, e.g. get prices for instance types. No cloud credentials or secrets are sent to the API and you can also self-host it. s; | 2022 | 2022-03-25T08:35:07Z |
| github.com-localstack-localstack_-_2022-04-21_22-18-03 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-04-22T00:42:51Z |
| U3WM-LPAL: www.autonews.com | Perma.cc archive of https://www.autonews.com/dealers/cdk-reynolds-challenge-ariz-dealer-data-law created on 2021-11-14 00:51:55+00:00. | 2021 | 2021-11-15T02:08:09Z |
| The Early theory of equations : on their nature and constitution : translations of three treatises | 218 p. ; 23 cm // On the recognition of equations / by François Viète -- A new discovery in algebra / by Albert Girard -- On the nature and constitution of equations / by Florimond de Beaune | 1986 | 2023-12-22T11:17:45Z |
| ****Crown CDK-3300R Japan Digital Component System With CD Player | unsold item https://shopgoodwill.com/item/159727744 | | 2023-02-17T08:48:58Z |
| Ekoostik Hookah Live at Aggie Theater on 1999-07-23 | Disk 1 - Set1 1) Coming Back to Me 2) Day By Day 3) The Giant 4) Sugar Jam-> 5) Sister Sugar 6) Alexander II* 7) Silver Train 8) Springtime Again 9) The Streetbeater(Theme to Sanford & Son) Disc 2 - Set2 1) Ecstasy, 2) Pass the Cider, Pass the Rum, 3) Blow 'em Away, 4) Rollin in My Sweet Baby's Arms, 5) Somewhere Down the Line** 6) Crowd 7) E: Throwing Stones | 1999 | 2006-03-01T20:13:42Z |
| E2F Inhibition Synergizes with Paclitaxel in Lung Cancer Cell Lines. | This article is from PLoS ONE , volume 9 . Abstract The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and thus, it is predicted that blocking the E2F pathway would have therapeutic potential. To test this hypothesis, we have examined the activity of HLM006474 (a small molecule pan-E2F inhibitor) in lung cancer cell lines as a single agent and in combination with other compounds. HLM006474 reduces the viability of both SCLC and NSCLC lines with a biological IC50 that varies between 15 and 75 µM, but with no significant difference between the groups. Combination of HLM006474 with cisplatin and gemcitabine demonstrate little synergy; however, HLM006474 synergizes with paclitaxel. Surprisingly, we discovered that brief treatment of cells with HLM006474 led to an increase of E2F3 protein levels (due to de-repression of these promoter sites). Since paclitaxel sensitivity has been shown to correlate with E2F3 levels, we hypothesized that HLM006474 synergy with paclitaxel may be me; | 2014 | 2014-10-22T18:06:02Z |
| iodine metabolism and thyroid function | | 1973 | 2025-09-04T06:24:54Z |
| The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells. | This article is from Cell Division , volume 8 . Abstract Background: Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that β-adrenergic receptors (β-ARs) may play an important role in the pathogenesis of IH. Results: In the present study, we investigated the β-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both β1- and β2-ARs were expressed in HemECs. Stimulation of the β-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was a; | 2013 | 2014-10-29T13:12:50Z |
| AD #3840 - ONE Gets Lifeline from Foxconn; BYD Struggling in Japan; Rivian Slashes Manufacturing Costs | - Stellantis Warns It Could Abandon UK Market- ONE Gets Lifeline from Foxconn- Automakers Say No to High-Speed AEB- BYD Struggling to Sell EVs in Japan- XPeng Says 2025 is ChatGPT Moment for AVs- CDK Cyberattack Hurts Financials of Dealer Groups- BlackSuit is Hacker Group Behind CDK Hack- VW Updates Jetta- Rivian Slashes Manufacturing Costs- U.S. Consumers Want to Own Their Vehicle Data | 2024 | 2024-11-16T18:51:39Z |
| DTIC ADA374391: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from G1 phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the G1 phase cycling dependent kinases (cdk), cdk4 and cdk6. Cdk4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle from G1 into S phase in the osteosarcoma cell line, U2OS and in primary mouse astrocytes. Understanding differential regulation of these two kinases and their potentiall; | 1999 | 2018-04-27T16:45:34Z |
| DTIC ADA443026: Radiation Sensitization in Breast Cancer via Targeting Survivin Expression | We proposed to determine whether overexpression- of surviving results in radio resistance and the possible mechanisms; whether irradiation down regulates p34(CDC2) and its mechanism in vascular endothelium and whether CDK (cyclin dependent kinase) inhibitors sensitize it to radiation injury; the mechanism of surviving- deregulation in breast cancer and whether inhibition of surviving or its regulator, p34(CDC2) abolishes radio resistance. We found that overexpression of surviving leads to radiation resistance and CDK inhibitors result in radiosensitization. We also found that deregulation of surviving in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of surviving and Stat3 results in significantly increased sensitization of breast cancer. In the next two years, we will determine the biological significance of combining surviving inhibitors or CDK inhibitors with radiotherapy in xenograft models of breast cancer. The proposed study w; | 2005 | 2018-05-30T23:48:34Z |
| DTIC ADA311359: Factors that Effect Signal Transduction by the Estrogen Receptor. | This project examines the mechanism of signal transduction by the estrogen receptor (ER), a hormone dependent transcriptional regulator involved in many human breast tumors. We have found that ectopic expression of the cyclin A/cdk2 kinase complex increases hormone-dependent transcriptional activity by the estrogen receptor in vivo. This effect can be further enhanced by the concurrent expression of cyclin-dependent kinase activators, CAKs, and abolished by coexpression of the cdk inhibitor (CDI), p27. Likewise, ER-dependent transcriptional activation is reduced by the expression of a dominant negative cdk2 mutant in mammalian cells or by deletion of a potential cyclin A homologue, Clb4, in yeast. ER is also phosphorylated in vitro by cyclin A/cdk2 and incorporation of phosphate into ER is stimulated by the ectopic expression of cyclin A in vivo. Together, these results strongly suggest a role for cyclin-dependent kinases in the regulation of ER transcriptional enhancement. | 1995 | 2018-04-01T21:08:24Z |
| DTIC ADA317025: Interaction of the Tumor Suppressor p53 with Replication Protein A. | The DNA replication factor RPA physically associates with the tumor suppressor protein p53, an interaction that could be important for the function of both these proteins in normal and cancer cells. Using two mutant forms of p53 with the desired property of not binding RPA we have demonstrated that RPA binding is not required for growth suppression by p53. We have also made a deletion mutant of RPA which does not bind p53 to show that despite binding single-stranded DNA, this mutant of RPA fails to support DNA replication. Therefore the region of RPA which interacts with p53 is essential for the protein complex's activity. In contrast to RPA binding, transcription trans-activation by p53 is essential for growth suppression. One of targets of p53, p21/WAFl/CIPl, inhibits the cell-cycle by associating with cyclin-cdk kinases. It also inhibits DNA replication by interacting with a replication factor, Proliferating Cell Nuclear Antigen (PCNA). We have characterized a 39 amino acid fragment; | 1996 | 2018-04-03T21:40:04Z |
| CDK-US - O&O S.r.l. | | | 2021-04-07T20:38:29Z |
| MySpace Thesis Music Sample: Ma-Md | A compilation of music acquired from the MySpace Social Network platform in the 2007-2008 period by Ben Fields in the pursuit of his Ph.D. and social-network/music-network dissertation. Gathered for the purposes of analysis and calculation, the resulting tens of thousands of lower-quality MP3s sat on an external hard drive for a decade before being offered in this collection. The sampling was random and not based on any specific criteria. | 2008 | 2019-03-21T06:17:40Z |
| On The Development of Biophysical Models for Space Radiation Risk Assessment | Experimental techniques in molecular biology are being applied to study biological risks from space radiation. The use of molecular assays presents a challenge to biophysical models which in the past have relied on descriptions of energy deposition and phenomenological treatments of repair. We describe a biochemical kinetics model of cell cycle control and DNA damage response proteins in order to model cellular responses to radiation exposures. Using models of cyclin-cdk, pRB, E2F's, p53, and GI inhibitors we show that simulations of cell cycle populations and GI arrest can be described by our biochemical approach. We consider radiation damaged DNA as a substrate for signal transduction processes and consider a dose and dose-rate reduction effectiveness factor (DDREF) for protein expression. | 1999 | 2011-05-29T02:54:15Z |
| github.com-aws-aws-cdk_-_2022-09-20_16-52-21 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 14.15.0 ) We recommend using a version in Active LTS Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Go ( Go ≥ 1.16.4 ) Third-party Language Deprecation: language version is only supported until its EOL (End Of Life) shared by the vendor or commun; | 2022 | 2022-09-20T16:54:25Z |