| Title | Description | Published | Added |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Long Valley, The | | 1967 | 2023-02-23T18:38:22Z |
| Mahatma Gandhi | | 2012 | 2024-01-04T12:38:14Z |
| The Old Architecture of Quebec | | 1947 | 2025-05-22T17:20:02Z |
| Lawyer Says Bin Laden Did Not Orchestrate 9/11 | Al-Qaeda leader never claimed responsibility for attack, Van de Wiel tells Australian Supreme Court Paul Joseph Watson Prison Planet Thursday, February 28th, 2008 Skepticism towards the 9/11 official story reached the Australian Supreme Court this week after a lawyer asserted that the attacks were not orchestrated by Osama bin Laden during the trial of an alleged terror group in Melbourne. "To say that this was all orchestrated by Osama bin Laden is a silly thing to do. He's never claimed responsibility for it," Remy van de Wiel QC told the Australian jury. Full Story Here: http://prisonplanet.com/articles/february2008/022808_bin_laden.htm | 2008 | 2024-05-09T20:01:58Z |
| treatment of the patient past fifty | | 1941 | 2025-09-04T01:47:40Z |
| Everyday Things In American Life | | 1941 | 2025-09-09T13:08:10Z |
| Indian Oasis | | 1939 | 2025-08-24T05:44:54Z |
| Nov 04 2025 Town meeting | | 2025 | 2025-11-06T13:34:51Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| Not Every Workstation Is Built For Rendering. | Not Every Workstation Is Built For Rendering. Some Are Built To Create Experiences. This CDK Radiant Series System Was Developed For Real-time Unreal Engine Architectural Presentations, Enabling Real Estate Developers To Showcase Projects Through Smooth Interactive Walkthroughs. With The RTX 4090 At Its Core, The System Ensures Fluid Navigation Through Complex Environments, Delivering A Seamless And Immersive Experience For Clients And Stakeholders. Custom Built By CDK. 📞 +91 92707 66589 🌐 www.designsbykira.In #cdkworkstations #unrealengine #realtimevisualization #architecturevisualization | | 2026-04-09T09:41:51Z |
| The Hindu-Arabic numerals | | 1990 | 2024-01-10T08:39:12Z |
| Living embers: the life and writings of George William Griffith | | 1937 | 2023-12-28T00:31:16Z |
| Indian rubber man | | 1939 | 2025-09-09T22:39:54Z |
| Mannen Med Salgpiporna | | 1960 | 2025-09-26T02:02:52Z |
| Amarna in religion und kunst | | 1931 | 2025-05-22T20:55:21Z |
| Ebank Trademark Video 2 | Ebank ® company video music of song attributed to, Download the music in this video, this one song at, ccmixter.org/files/cdk/17432 To learn more about the creator and owner of this song go to the following link, this song used in Creative Commons License, "Silence Await" by cdk ccmixter.org/files/cdk/17432 | 2016 | 2016-09-30T21:51:44Z |
| CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITY | Approved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known; | 1981 | 2024-05-13T17:20:36Z |
| Stella Dysart of Ambrosia Lake | | 1959 | 2024-01-08T12:14:29Z |
| Graphs with Diameter $n-e$ Minimizing the Spectral Radius | The spectral radius $\rho(G)$ of a graph $G$ is the largest eigenvalue of its adjacency matrix $A(G)$. For a fixed integer $e\ge 1$, let $G^{min}_{n,n-e}$ be a graph with minimal spectral radius among all connected graphs on $n$ vertices with diameter $n-e$. Let $P_{n_1,n_2,...,n_t,p}^{m_1,m_2,...,m_t}$ be a tree obtained from a path of $p$ vertices ($0 \sim 1 \sim 2 \sim ... \sim (p-1)$) by linking one pendant path $P_{n_i}$ at $m_i$ for each $i\in\{1,2,...,t\}$. For $e=1,2,3,4,5$, $G^{min}_{n,n-e}$ were determined in the literature. Cioab\v{a}-van Dam-Koolen-Lee \cite{CDK} conjectured for fixed $e\geq 6$, $G^{min}_{n,n-e}$ is in the family ${\cal P}_{n,e}=\{P_{2,1,...1,2,n-e+1}^{2,m_2,...,m_{e-4},n-e-2}\mid 2 | 2011 | 2013-09-23T15:53:26Z |
| Analytical Geometry | | 1980 | 2023-12-22T12:13:27Z |
| DTIC ADA376126: Development and Use of Novel Tools to Directly Screen for Substrates of Cyclin Dependent Kinases. | The aim of this research is to gain further insights into the means by which cell proliferation is controlled by cyclin dependent kinases. To this end, a screen has been carried out for proteins that interact with the budding yeast cdk, Cdc28. 10 novel interacting proteins have been identified in a two-hybrid screen using a Ga14/Cdc28 fusion as the bait. Several of the putative interacting proteins have been shown to interact with specific cyclin-Cdc28 kinase complexes. For each of the 10 two-hybrid positives the nature of the Cdc28 interaction is currently being determined by biochemical means. The functional difference between cyclins in their abilities to induce and repress transcription has been investigated using the genomic technology of microarrays. In addition, the complete set of cell cycle regulated genes in yeast has been defined. This work has now been published (MBC 9:32?3-3297 1998), and a full description and complete data sets are available on a public website at http:/; | 1999 | 2018-04-27T17:44:26Z |
| DTIC ADA392320: Role of cdc25 Phosphatases in Cellular Immortalization | The goal of this proposal is to study the potential role of tyrosine phosphorylation-dependent checkpoint and especially the cdc25 phosphatase family of cyclin dependent kinase (CDK) activators in cellular immortalization. We have shown that cdc25 phosphatases did in fact extend the normal mammary epithelial cells (HMEC) life span, but did not immortalize them. The effect was most prominent with cdc25A and cdc25B phosphatases. Cdc25C phosphatase had less effect on HMEC life span. Experiments with catalytically inactive cdc25A mutant show that phosphatase activity of cdc2SA is essential for the life span extension. Our experiments show that telomerase is not activated by cdc25A expression in normal human cells, suggesting that cdc25 most likely affect Ml, but not M2 checkpoints. Retroviral cDNA libraries (sense and anti-sense) were introduced into HMEC together with cdc25 to assay for the potential 'enhancement' of cdc25 ability to expand the cellular life span. Among genes affected by ; | 2001 | 2018-05-03T14:21:00Z |
| DTIC ADA358053: The p16 Pathway In Breast Cancer and Senescence Control. | The p16INK4a protein, hereafter referred to as pl6, is a known negative regulator of cell cycle progression through its cyclin dependent kinase (CDK) inhibiting function (1). pl6 competes with the activating D type cyclins for association with CDK4 or CDK6, thereby preventing phosphorylation of proteins controlling Ol exit such as the retinoblastoma (Rb) protein (2). Inactivation of p16 has been observed in numerous tumor types (3-8), and lack or reduced expression of p16 has also been shown through a variety of technical approaches to occur in at least 50% of the breast cancer samples examined (9, 10). While these findings suggest that p16 may play an important role in breast tumorigenesis, the consequence of such abberrations of p16 are not yet clear. | 1998 | 2018-04-21T04:36:31Z |
| [CDK 009] Generate | Finnish chiptuner Nestroyer is going through somewhat of a music ‘purple patch’ at the moment, and CDK Records are honoured to host his latest set of tunes. A top collection of tunes, so good Timbaland might even nick ’em! Let’s hope not though. | 2008 | 2019-12-06T21:26:46Z |
| DTIC ADA455296: Consequences of Cyclin D1/BRCA1 Interaction in Breast Cancer Progression | The inheritance of one defective BRCA1 or BRCA2 allele predisposes an individual to developing breast, ovarian and T-cell cancers. In addition, in breast cancers where BRCA1 is not mutated, it is often functionally inactivated. Furthermore, cyclin D1 has been shown to be overexpressed in many cancers including breast cancer and its associates with BRCA1. Because of the crucial role of both of these proteins in cancer, it is reasonable to expect that this interaction has a significant role in tumor cells. The understanding of when this interaction occurs during cell cycle progression will help to determine the role of cyclin D1/BRCA1 binding in breast cancer cells. Therefore, I hypothesize that the direct interaction of cyclin D1 with BRCA1 results in the cell cycle dependent regulation of the activity of BRCA1. In this study, I wish to identify and confirm the cell cycle dependent cyclin D1/BRCA1 interaction in breast cancer cells, determine the biochemical consequence of cyclin D1/BRC; | 2006 | 2018-06-07T00:13:22Z |
| DTIC ADA378108: Role of the Cdk Inhibitor Sic 1 in Start | Nearly 180,000 women will develop breast cancer in 1999 and 44,000 will die. Cancer is essentially a disease of inappropriate proliferation due to a loss of normal cell cycle controls. We study cell cycle controls in the budding yeast S. cerevisiae. We have shown that the formation of active G1-cyclin dependent kinase complexes (Cdks) is rate limiting for cell cycle progression. The activity of these complexes is regulated through their association with highly unstable G1 cyclins. G1 cyclins are constitutively unstable, and their only essential function is to phosphorylate the B-type Cdk inhibitor, Sic1, and target it for degradation. Sic1 is one of few known in vivo substrates of yeast G1-Cdks. The amount and phosphorylation state of Sic1 appears to determine the timing and size of cell division. Sic1 mutants lacking several phosphorylation sites are stabilized and completely block cell cycle progression. Thus, the phosphorylation and subsequent degradation of Sic1 appears to be the c; | 1999 | 2018-04-28T13:18:00Z |
| DTIC ADB223090: Signalling Pathways of Cooperative Oncogenes and Their Effects on the Transcriptional Control of Cell Cycle Genes in Schwann Cell Transformation (Neurofibromatosis). | The co-operation between Ras/Raf and SV4O large T (LT) in the transformation of primary rat Schwann cells is a strikingly synergistic process. We have explored the signalling pathways and the molecular mechanisms involved. Either activated Ras or an inducible Raf onco-protein alone, induce a Gi-specific cell cyle arrest. This requires prolonged activation of MAP kinase activity followed by the inhibition of cyclin-dependent kinases (cdk) via induction of the cyclin/cdk inhibitory protein, p21 Cipi. In contrast, when Raf is activated in the presence of LT or dominant-negative (dn)-p53, the cell cycle arrest and p21CIPl induction are specifically abolished and the ability of Raf to increase the specific activity of cyclin-dependent kinases is revealed. Thus Raf-dependent Gi arrest and p2iCIPl induction require p53 function. This indicates that in this scenario p53 plays a key role in signal integration and determines the specificity of the cellular response to the Ras/Raf pathway indepen; | 1996 | 2018-02-26T07:37:05Z |
| DTIC ADA369304: Role of cdc25 Phosphatases in Cellular Immortalization. | The goal of this proposal is to study the potential role of tyrosine phosphorylation-dependent checkpoint and especially the cdc25 phosphatase family of cyclin dependent kinase (CDK) activators in cellular immortalization. We have shown that cdc25 phosphatases did in fact extend the normal mammary epithelial cells life span, but do not immortalize them. The effect was most prominent with cdc25A and cdc25B phosphatases. Cdc25C phosphatase' had less effect on HMEC life span. Experiments with catalytically inactive cdc25A mutant show that phosphatase activity of cdc25A is essential for the life span extension. Our experiments shows that telomerase is not activated by cdc25A expression in normal human cells, suggesting that cdc25 most likely affect Ml. but not M2 checkpoints. | 1999 | 2018-04-25T22:23:31Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| DTIC ADA470865: The Role of Ubiquitin E3 Ligase SCF-SKP2 in Prostate Cancer Development | Low or absent expression of CDK inhibitor p27Kip1 is associated with malignant prostatecarcinomas. Loss of tumor suppressors p53 and Pten is also associated with prostate cancers. We found that p27 is regulated by both SCF-SKP2 and a novel ubiquitin E3 ligase containing CUL4-DDB1-WD40-repeat proteins. In addition, we have identified that a specific CUL4A-DDB1-L2DTL/CDT2-PCNA ubiquitin E3 ligase binds and targets p53 polyubiquitination- dependentproteolysis in cooperation with MDM2. By interacting with a WD40-repeat proteins as asubstrate targeting subunit, the CUL4-DDB1 ubiquitin E3 ligase regulates a wide array of biological events including cell cycle regulation, genome stability, and histone methylation;alteration of these events have been shown to associate with the development of prostatecarcinogenesis. We in addition found that expression of SKP2 and Pten heterozygosity do notcooperate in the mouse prostate carcinoma models, suggesting that SKP2 may act downstream ofPten pathway.; | 2007 | 2018-06-13T23:39:03Z |
| DTIC ADA542782: Evaluating the Significance of CDK2-PELP1 Axis in Tumorigenesis and Hormone Therapy Resistance | Current endocrine therapy for ER+ve breast cancer involves Tamoxifen, and Aromatase inhibitors. De novoand/or acquired resistance to endocrine therapies however frequently occur. Interestingly, earlier studies have shown that activation of Cyclin Dependent Kinase 2 (CDK2) and deregulation of PELP1 (Proline, glutamic Acid and Leucine rich Protein), a novel ER coregulator is found associated with endocrine therapy resistance. The results of this study showed that PELP1 is a novel substrate of CDK2. Functional studies established PELP1 as a modulator of E2F transactivation function and PELP1 phosphorylation is needed for optimal activation of E2F target genes. Studies utilizing a novel PELP1 phospho antibody, model cell lines stably expressing the PELP1-shRNA or PELP1-CDK2 phosphosite mutants demonstrated that CDK phosphorylation of PELP1 is important for estrogen (E2) mediated cell cycle progression. Further, PELP1 phosphorylation by CDK is important for E2-mediated tumorigenesis in vivo; | 2011 | 2018-08-14T11:30:17Z |
| T74D-QGKJ: www.autonews.com | Perma.cc archive of https://www.autonews.com/dealers/cdk-reynolds-challenge-ariz-dealer-data-law created on 2021-11-16 18:25:17+00:00. | 2021 | 2021-11-17T19:11:54Z |
| DTIC ADA382540: Dominant-Active Alleles of Rb as Universal Tumor Suppressors of Mammary Carcinoma | The tumor suppressor Rb is a nuclear-phosphoprotein that controls cell proliferation, survival and differentiation and is thought to be either mutated or functionally inactivated by phosphorylation in virtually all human cancer including breast cancer. We developed transgenic mouse models to study the outcomes of upregulating the Rb pathway in the mammary gland and test whether Rb is a universal tumor suppressor. Unphosphorylatable alleles of Rb (RbDeltap34 and RbDeltaKl 1, with 8 and 11 CDK sites mutated) were targeted to the mammary epithelium under control of the MMTV-LTR (proliferating and differentiating mammary epithelium) and WAP (differentiating epithelial cells) promoters. Pre-pubertal MMTV-RbDeltap34 and MMTV-RbDeltaKl 1 transgenic female mice exhibited suppression of ductal growth and branching. During estrus, these transgenic females displayed enlargement of the alveolar compartment. Intriguingly, some MMTV-RbDeltap34 and MMTV- RbDeltaKl 1 transgenic females developed focal; | 1999 | 2018-04-29T18:11:53Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| DTIC ADA482640: Suppression of Prostate Tumors by INK4C and PTEN | Work during this entire funding period thoroughly characterized mutant mice in the cyclin-dependent kinase (CDK) inhibitor p18Ink4c, which causes hyperplastic cell growth in various tissues including the prostate and the lipid phosphatase Pten, which regulates cell growth and is highly associated with the development of human prostate cancer. The first two years of funding were highly productive and resulted in one manuscript publication supporting a functional collaboration between p18Ink4c and Pten in tumor suppression. Both the rate and spectrum of tumor development in the compound mutant mice were substantially accelerated and expanded. Combined genetic, histological, cellular, and biochemical analyses led to four major findings: (i) that p18 and PTEN each have previously unrecognized functions in tumor suppression, such as p18's function in the prostate and anterior lobe of the pituitary and PTEN's function in the pituitary, (ii) that the p18-Pten double mutant mice developed vari; | 2007 | 2018-06-22T04:53:07Z |
| sinceretheory.podcast_v1.3 | 01 I've switched to Mac, goodbye Windows. The Bluescreen is going through reorganization. What is Google Pack? 02 Louis Braille's birthday Download File List iPod with WiFi 03 Flickr: "2.5.8." by powerbooktrance (license) Music: CDK - Midnight Bliss (Green Dub Mix) (license) I'm a little upset about del.icio.us being swooped by Yahoo! | | 2006-01-05T18:47:03Z |
| Pride Flag Raised in Silver Spring | Montgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 995 | 2022 | 2022-06-02T01:32:19Z |
| Religion In Life - Season 6 Episode 4 | For more content and information about AppTV, visit www.watchapptv.com Religion in Life is a show that explores how faith and spirituality play an integral part in the world today. Ozzie Ostwalt, Ph.D., from the Department of Philosophy and Religion hosts the show and engages in discussion with panelists that range from professors, local religious leaders and spiritually engaged community members. | 2017 | 2023-03-30T17:28:36Z |
| [CDK 016] Flappiest Bits | Awww hells yeah! Jellica, the UK’s answer to goto80 (and IMO, the most underrated chiptuner in the country) kindly gives CDKr his ‘Flappiest Bits’ – an album which is similar to a wedding. How come? As there’s something old, something new, something borrowed, and something blue! (Some old tracks, some new tracks, a few covers and Pull My Nipples Hard , fact fans) Anyway, away with the awful analogies, just kick back and enjoy some fantastic chiptunes ‘n’ VST tracks! And if you like it, purchase his forthcoming miniCD from RetinaScan! The artwork for this is from the supremely talented Raquel Meyers , who also did the fantastic video for Jellica’s “I wld di 4 u” cover . Jellica also runs the UK’s second best chiptune weblabel (after CDKr of course ^_^), Kittenrock ! It’s down at the moment, and more’s the pity. Kittenrock and CDKr are also releasing a split CD-R soon, hopefully before the year is out! | 2008 | 2019-12-06T23:30:08Z |
| [CDK 059] Cerebral Scars - Northern Dancing Town | [CDK 059] Cerebral Scars - Northern Dancing Town | 2012 | 2020-01-05T21:30:32Z |
| ccMixter unwind (a chillout compilation) - vol. 2 | A studio DJ set featuring ambient, chill and downtempo remixes from ccMixter.org exclusively. All tracks are CC-licensed. DJ-mixed by s.c.mixer. ------------- http://ccmixter.org/ http://ccmixter.org/people/scmixer/ | | 2009-07-19T19:31:22Z |
| CDK-11A-M Manual () | | | 2021-03-04T12:02:56Z |
| [CDK 053] Various Artists - USK vs FIGHTER X | [CDK 053] USK vs FIGHTER X | 2011 | 2020-01-05T20:15:20Z |
| Colon cancer prevention : dietary modulation of cellular and molecular mechanisms | viii, 165 pages : 26 cm // This volume covers recent research on all aspects of colon cancer prevention, including normal and abnormal colonic development, chemoprevention of colon cancer, the role of dietary factors in prevention, experimental approaches and mechanisms in prevention, as well as whether cell proliferation and apoptosis is the link between relative risk and prevention. Topics include: transcriptional regulation in intestinal development; colonic cell proliferation, differentiation and apoptosis; defects in the regulation of beta-catenin in colorectal cancer; dietary lipids, inflammation, and colon cancer; sulindac sulfone-induced regression of rectal polyps in patients with familial adenomatous polyposis; prevention of colon cancer and modulation of aberrant crypt foci; cell proliferation and apoptosis by retinoids and NSAIDs; mechanisms by which energy restriction inhibits carcinogenesis; dietary intervention studies of colorectal cancer; the genetics of hereditary non; | 1999 | 2020-07-28T01:28:44Z |
| github.com-angular-components_-_2023-10-27_00-13-06 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2023 | 2023-10-27T14:09:27Z |
| github.com-localstack-localstack_-_2021-11-19_23-04-44 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Run • Configure • Play – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment.With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider!Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services,LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more!The Pro version of LocalStack supports additional APIs and advanced features.You c; | 2021 | 2021-11-20T02:26:30Z |
| E2F Inhibition Synergizes with Paclitaxel in Lung Cancer Cell Lines. | This article is from PLoS ONE , volume 9 . Abstract The CDK/Rb/E2F pathway is commonly disrupted in lung cancer, and thus, it is predicted that blocking the E2F pathway would have therapeutic potential. To test this hypothesis, we have examined the activity of HLM006474 (a small molecule pan-E2F inhibitor) in lung cancer cell lines as a single agent and in combination with other compounds. HLM006474 reduces the viability of both SCLC and NSCLC lines with a biological IC50 that varies between 15 and 75 µM, but with no significant difference between the groups. Combination of HLM006474 with cisplatin and gemcitabine demonstrate little synergy; however, HLM006474 synergizes with paclitaxel. Surprisingly, we discovered that brief treatment of cells with HLM006474 led to an increase of E2F3 protein levels (due to de-repression of these promoter sites). Since paclitaxel sensitivity has been shown to correlate with E2F3 levels, we hypothesized that HLM006474 synergy with paclitaxel may be me; | 2014 | 2014-10-22T18:06:02Z |
| github.com-sindresorhus-awesome_-_2021-11-30_06-23-08 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-11-30T06:30:59Z |
| github.com-sindresorhus-awesome_-_2022-11-14_11-14-47 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-14T21:57:22Z |