| Title | Description | Published | Added |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Irradiation And The Nervous System | | 1963 | 2025-09-11T15:24:38Z |
| A Little Extra Effort | | 2007 | 2023-07-25T22:15:33Z |
| Research in physiology | | 1971 | 2025-09-08T00:26:07Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| De Racine Au Parthenon: Essais Sur La Litterature Et L'Art A L'age Classique | | 1977 | 2025-09-04T14:43:38Z |
| John Gay, his place in the eighteenth century | | 1938 | 2023-12-27T15:46:10Z |
| Marine molluscan genera of western north america | | 1963 | 2025-09-08T08:50:24Z |
| AD #3850 - Lyriq Now #2 in Cadillac Sales; GM Backs Off 1 Million EV Goal by 2025; Chinese Suppliers Race Into Mexico | - GM Backs Off 1 Million EV Goal by 2025- Lyriq Now #2 in Cadillac Sales- Forecasts BEVs to Hit 50% U.S. Sales by 2030- Cyberattack Cost Dealers $1 Billion- Lucid Claims Most Efficient EV- Stellantis Sues Another Supplier- Stellantis To Sell Recycled Oil- TotalEnergies to Install 3,000 Chargers in UK- With New A5 Audi Has No Coupe or Convertible- Chinese Suppliers Race Into Mexico- Suddenly EREVs Make A Lot of Sense | 2024 | 2024-11-16T17:25:08Z |
| Education and society in modern Germany | | 1949 | 2023-07-25T04:04:04Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-07T09:45:28Z |
| github.com-sottlmarek-DevSecOps_-_2022-01-14_09-42-59 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def; | 2022 | 2022-01-14T21:43:52Z |
| The leverage of labor : managing the Cortés haciendas in Tehuantepec, 1588-1688 | xxv, 245 p. ; 24 cm // Includes bibliographical references | 1989 | 2023-10-02T02:39:59Z |
| le bapteme des enfants | | 1948 | 2025-06-17T08:26:27Z |
| Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. | This article is from The Journal of Cell Biology , volume 192 . Abstract Phosphorylation of Kvβ2 releases Kv1 channels from microtubules to control their specific distribution at the axonal membrane. | 2011 | 2014-10-24T23:30:53Z |
| Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina; | 2013 | 2014-10-28T15:40:11Z |
| An Antioxidant Extract of Tropical Lichen,Parmotrema reticulatum, Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cell Line MCF-7. | This article is from PLoS ONE , volume 8 . Abstract This report highlights the phytochemical analysis, antioxidant potential and anticancer activity against breast carcinoma of 70% methanolic extract of lichen, Parmotrema reticulatum (PRME). Phytochemical analysis of PRME confirms the presence of various phytoconstituents like alkaloids, carbohydrates, flavonoids, glycosides, phenols, saponins, tannins, anthraquinones, and ascorbic acid; among which alkaloids, phenols and flavonoids are found in abundant amount. High performance liquid chromatography (HPLC) analysis of PRME revealed the presence of catechin, purpurin, tannic acid and reserpine. Antioxidant activity was evaluated by nine separate methods. PRME showed excellent hydroxyl and hypochlorous radical scavenging as well as moderate DPPH, superoxide, singlet oxygen, nitric oxide and peroxynitrite scavenging activity. Cytotoxicity of PRME was tested against breast carcinoma (MCF-7), lung carcinoma (A549) and normal lung fibroblas; | 2013 | 2014-10-28T23:51:24Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |
| Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. | This article is from Experimental and Therapeutic Medicine , volume 5 . Abstract Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by the oncoprotein BCR-ABL, which exhibits a constitutive tyrosine kinase activity. Imatinib mesylate (IM), an inhibitor of the tyrosine kinase activity of BCR-ABL, has been used as a first-line therapy for CML. However, IM is less effective in the accelerated phase and blastic phases of CML and certain patients develop IM resistance due to the mutation and amplification of the BCR-ABL gene. Fangchinoline, an important chemical constituent from the dried roots of Stephaniae tetrandrae S. Moore, exhibits significant antitumor activity in various types of cancers, including breast, prostate and hepatocellular carcinoma. However, the effects and the underlying mechanisms of fangchinoline in CML remain unclear. In the present study, we identified that fangchinoline inhibits cell proliferation in a dose- and time-dependent manner in K562; | 2013 | 2014-10-29T06:42:29Z |
| Nathan The Caveman | | 2008 | 2025-09-09T14:18:04Z |
| Inseparable loyalty : a biography of William Bull | x, 232 p. : 24 cm // Includes bibliographical references (p. [213]-218) and index | 1991 | 2023-12-22T20:37:39Z |
| East McComb Body Shop, Individually and on behalf of all similarly situated persons v. CDK GLOBAL INC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:31:20Z |
| Lars Hartman Auf den namen desherrn jesus | | 1992 | 2025-06-20T04:18:02Z |
| Zentrum Paul Klee Bern | | 2006 | 2023-07-25T19:49:11Z |
| Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans. | This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract Although many critical roles of the RUNX family proteins have already been identified, little attention has been given to how these proteins interact with other factors. Elucidating RUNX protein interactions will help extend our understanding of their roles in normal development and tumorigenesis. In this study, we performed large-scale RNAi screening to identify genes that genetically interact with rnt-1, the sole homolog of RUNX protein in the nematode Caenorhabditis elegans. To this end, we took advantage of the fact that C. elegans can survive a severe loss of RNT-1 function with only mild phenotypes, and we looked for genes that caused a synthetic phenotype in the rnt-1 mutant background. We identified seven genes, three of which (cdk-8, cic-1, and sur-2) are involved in transcription, two of which (pgp-2 and cct-5) are involved in stress response, and two of which (D2045.7 and W09D10.4) are involved in signalin; | 2013 | 2014-10-28T00:42:20Z |
| ＦＲＩＧＨＴ ＮＩＧＨＴ ２[Visual Mixtape] | FRIGHT NIGHT 2 | Phonk Fridays ...𝔪𝔬𝔯𝔢 𝔱𝔥𝔞𝔫 𝔞 𝔰𝔢𝔮𝔲𝔢𝔩 𝔦𝔱'𝔰 𝔞 𝖘𝖈𝖗𝖊𝖆𝖒... FOR US, BY US VOL 666: Curated/mixed by iNFMS Full tape: https://soundcloud.com/iaminfms/fright-night-part-2 --------------------------------------------------------------------------------- T r a c k l i s t 00:20 : iNFMS - SPIT YO GAME [https://soundcloud.com/iaminfms] 02:13 : LORDKADO - MIDNIGHT SHOOTOUT w/ ABO [https://soundcloud.com/lordkado // https://soundcloud.com/mahatmaganja420] 04:37 : NIGHTINGALE - RED DROP [https://soundcloud.com/itsnightingale] 06:58 : otto22 - TAKE WHAT YOU WANT [https://soundcloud.com/otto22beats] 09:36 : WOBVSE - Hunter [https://soundcloud.com/wobase] 12:15 : DEISHIN - San [https://soundcloud.com/deishin] 14:40 : PXSSXSSXD - COLDEST [https://soundcloud.com/pxssxssxd] 18:05 : BEXFIELD - THOUGHT YOU KNEW [https://soundcloud.com/yaboibex] 20:15 : OG Marv - Water w/ RXIMV [https://soundcloud.com/ogmarv // https://; | 2019 | 2024-02-12T20:23:57Z |
| THE DON CHRONICLES: VOLUME THREE | The best of 2024 PHONK TAPES | iNFMS presents THE DON CHRONICLES: VOLUME THREE produced by iNFMS // Visuals by AnalogByNature respect this thing of ours... Volume 1: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 Volume 2: https://soundcloud.com/iaminfms/don-chronicles-2 Purchase: https://infms495.bandcamp.com/album/the-don-chronicles-volume-3 - dedicated to all the Fallen Soldiers, Hustlers, Macks, Pimps and Dons. Rest in power, gone but never forgotten. Shout Outs: STVSHBOI, Justillionaire, CDK, BADRADIO, SWAY, Flat Sprite, POSS PLAYA, SKINNYKID, Camyo, SHELTR. and LORDKADO - [00:00] H8 ME [03:29] TAKE NOTE$ [06:04] DOLLAZ N SENSE [08:16] HALF A MILL [10:42] WHY NOW? [13:53] PIMPIN HARD [16:46] INHALEXHALE [18:52] EARNERZ - linktr.ee/official_infms www.analogbynature.tv www.badradio.nz merch and stuff ; http://STORE.RYANCELSIUS.COM Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: Ryan.Celsius@gmail.com ---100% F; | 2024 | 2024-08-11T21:38:21Z |
| linuxbrew cdk | linuxbrew cdk | | 2021-04-07T20:55:45Z |
| Psychology of Personal Adjustment Student's Introduction to Mental Hygience | | 1949 | 2025-09-10T00:53:02Z |
| Pride Flag Raised in Silver Spring | Montgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 995 | 2022 | 2022-06-02T01:32:19Z |
| odp-cdk-example | This is an archive of the project's publicly available source code and (where available) wiki repositories in bare git format, as well as related issues, pull requests and similar data from Github in JSON format, created on 2025-03-06. Project 'odp-cdk-example' from agency 'GSA', organization 'GSA'. Original project description: A serverless demonstration of the AWS CDK using Lambda, API Gateway, and Amazon S3 :rocket: | 2025 | 2025-03-12T18:53:16Z |
| IUMA: cdk Dashiell | Started like 6 months ago, now dominating the arts of sampling and sythetizing, I've decided to become a house dj, even got myself a couple of Gemini XL-400 II Turntables and a Gemini PMX 40 Mixer to start practicing for what I've greatly planned is my first presentation in a couple of years. That doesn't means that i've stopped producing! Actually I'm working with the Mirage corporation, a producing crew from Orlando, and another producer from Wisconsin, Da Corster. With both these influences I've learned a lot more and have applied it on this two new songs I got...Enjoy! :) | | 2012-05-18T17:23:07Z |
| yahoo-groups-2018-08-30T08-13-01Z-d5b6d2 | Yahoo! Groups API grab. Contains messages of the following groups: 08cecmcafriends 10thyec_documentations 10thyec_hrd 212sl_10 67_council_10-11 67_excom_10-11 aartedecompartilhar10 aborock accountantsworld advancedpca aggregator_game alcorp alyssamilanofansforever ambersdream api_2010 aulagelso_ceis aw88 basketball_ac beyondcircle bfpdatabasedevelopmentgroup bio11_lab_guzman blpholcimyli blueridgebirdexchange brandceo bsn2bnsginfo campusrecruitment cb7grupo252 cbhadventures ccih_aquiraz cdk_java cdpclub1011 cepe2000 clanrad_duty5 cmbe_ecrouves comissao_oab_se computer_lingap_1011 coolathawles cphic1994 csspvc daks_friends dapi_ii_2010a datasys_oracle_dba daytonactivitybagswap defensoriayplanmedico dhbn dimboola djjmatematika ec_azad_kermanshah_group economics_9a elenproj_ee energetica_iasi_1990 epdtributario-p04028 epmfam ex_smkbp feua2001 fkrkaceh fpik_umpgroup fumclovelandseniorhigh gangland2010 giusti12 houstonrubies h-v-v ibecbotucatu ibm379 ihrm_bertelsmann ipmiub iptn_2010 ipwija; | | 2018-08-30T08:13:09Z |
| madame de sevigne her letters and her world | | 1946 | 2025-09-04T07:44:29Z |
| Cell cycle control : mechanisms and protocols | Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle / Anna Philpott and P. Renee Yew -- The mammalian cell cycle / Jane Vera Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane Vera Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and virus infection / Steven Emmett ... [et al.] --^ // Methods fo; | 2005 | 2012-05-22T14:15:36Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T23:53:12Z |
| Finite element methods for Navier-Stokes equations : theory and algorithms | x, 374 p. : 24 cm // Extended version of: Finite element approximation of the Navier-Stokes equations. 1979 // Bibliography: p. [368]-371 // Includes indexes | 1986 | 2023-12-22T11:10:09Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| die mikromorphologie der menschlichen zahnpulpa | | 1970 | 2025-09-04T05:39:32Z |
| The Life of Jonathan M. Bennett- A Study of the Virginias In Transition | | 1943 | 2023-12-22T16:18:38Z |
| Twinning And Diffusionless Transformations In Metals | | 1954 | 2025-09-12T13:34:58Z |
| the new testament | | 1937 | 2025-06-17T00:05:16Z |
| Shoreline City Council Regular Meeting - December 2, 2024 | # Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern; | 2024 | 2026-09-03T10:16:24Z |
| The life of Edward, Earl of Clarendon, Lord High Chancellor of England | | 1911 | 2024-01-12T08:38:15Z |
| High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. | This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co; | 2012 | 2014-10-28T23:41:32Z |
| The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm. | This article is from Nucleic Acids Research , volume 42 . Abstract Robustness and completion of DNA replication rely on redundant DNA replication origins. Reduced efficiency of origin licensing is proposed to contribute to chromosome instability in CDK-deregulated cell cycles, a frequent alteration in oncogenesis. However, the mechanism by which this instability occurs is largely unknown. Current models suggest that limited origin numbers would reduce fork density favouring chromosome rearrangements, but experimental support in CDK-deregulated cells is lacking. We have investigated the pattern of origin firing efficiency in budding yeast cells lacking the CDK regulators Cdh1 and Sic1. We show that each regulator is required for efficient origin activity, and that both cooperate non-redundantly. Notably, origins are differentially sensitive to CDK deregulation. Origin sensitivity is independent on normal origin efficiency, firing timing or chromosomal location. Interestingly, at a chrom; | 2014 | 2014-10-21T00:10:14Z |
| AD #3841 - Rivian Hits Paydirt With Massive VW Investment; Revealed The Last Pontiac Concept Car; CATL Flies 4-Ton Electric Plane | - Rivian Hits Paydirt With Massive VW Investment- Rivian Hints At 5 Future Models- Tesla Drops Under 50% U.S. EV Market Share- CDK Cyberattack Lasts Longer Than Expected- U.S. June Sales At 16.2 Million SAAR- Revealed The Last Pontiac Concept Car- GM-SAIC Use Robots for Car Testing- Bentley Unleashes Most Powerful Model Ever- CATL Flies 4-Ton Electric Plane | 2024 | 2024-11-16T18:41:55Z |
| Indole-3-Carbinol Inhibits Nasopharyngeal Carcinoma Growth through Cell Cycle Arrest In Vivo and In Vitro. | This article is from PLoS ONE , volume 8 . Abstract Nasopharyngeal carcinoma is a common malignant tumor in the head and neck. Because of frequent recurrence and distant metastasis which are the main causes of death, better treatment is needed. Indole-3-carbinol (I3C), a natural phytochemical found in the vegetables of the cruciferous family, shows anticancer effect through various signal pathways. I3C induces G1 arrest in NPC cell line with downregulation of cell cycle-related proteins, such as CDK4, CDK6, cyclin D1 and pRb. In vivo, nude mice receiving I3C protectively or therapeutically exhibited smaller tumors than control group after they were inoculated with nasopharyngeal carcinoma cells. The expression of CDK4, CDK6, cyclin D1 and pRb in preventive treatment group and drug treatment group both decreased compared with the control group. We conclude that I3C can inhibit the growth of NPC in vitro and in vivo by suppressing the expression of CDK and cyclin families. The drug was s; | 2013 | 2014-10-27T03:53:00Z |
| Applications of the InChI in cheminformatics with the CDK and Bioclipse. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. Results: We here describe how the InChI library is used in the Bioclipse workbench and the Chemistry Development Kit (CDK) cheminformatics library. To make this possible, a JNI bridge to the InChI library was developed, JNI-InChI, allowing Java software to access the InChI algorithms. By using this bridge, the CDK project packages the InChI binaries in a module and offers easy access from Java using the CDK API. The Bioclipse project packages and offers InChI as a dynamic OSGi bundle that can easily be used by any OSGi-compliant software, in addition to the regular Java Archive and Maven bundles. Bioclipse itself uses the InChI as a key component and calculates it on the fly whe; | 2013 | 2014-10-27T02:14:25Z |