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❌ ČDK❌ Archive.org⏬ Crossref⏬ LibGen❌ CLEAR ALL

Česká digitální knihovna

DostupnostNázevAutorDatumTypID
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Výroční zpráva2025periodical/periodicalvolume/periodicalitem/pageuuid:4adb403f-b839-4d2d-91e2-cd3d9ac4e3bd
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Meziměstská telefonní ústředna v Praze1929monograph/pageuuid:e20a6970-253d-11ee-8650-005056827e51
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Francouzská revoluce : populární dějiny bojů francouzské společnosti na sklonku 18. století. Díl 1. Zápas s královstvím1929monograph/pageuuid:840ef410-0803-11ed-be35-5ef3fc9bb22f
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X. mezinárodní sjezd slavistů : Sofija 14. - 22. 9. 1988 : bibliografie1994monograph/monographunit/pageuuid:45d9d8e0-a20e-11ed-9ac7-5ef3fc9bb22f
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Knižní novinky : časopis pro knihkupce, knihovny, nakladatele a čtenáře14.07.2003periodical/periodicalvolume/periodicalitem/pageuuid:88d3e6d0-1da5-11eb-9146-005056825209
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Veterinární medicína10.2010periodical/periodicalvolume/periodicalitem/pageuuid:6354c070-9632-11e8-b07a-5ef3fc9bb22f
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Galerie du Palais Royal gravée d'aprés les tableaux des différentes écoles qui la composent: avec un abrégé de la vie des peintres et une description historique de chaque tableau1786monograph/pageuuid:17fda895-f78f-4d9c-90ad-dca3cb9e3a75
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Eklogy a písně1916monograph/pageuuid:441044f0-f6f8-11e9-a329-005056827e51
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Starší literatura česká1910, 1911monograph/pageuuid:b4692cb0-bd01-11ea-b68c-005056827e52
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Mythy : básně Jaroslava Vrchlického : 1. cyklus (1874-1878)1915monograph/pageuuid:0998a060-f496-11e9-a329-005056827e51
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Stavební stroje: Seznam a výrobci1947monograph/pageuuid:0442b1d0-84ab-11e2-aa2b-005056827e51
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Základové měřictví pro nižší třídy gymnasií1886monograph/pageuuid:3c6e4dc0-d47b-11dc-b5f4-000d606f5dc6
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Katoličtí mučedníci doby husitské1927monograph/pageuuid:6de55980-a2be-11e3-b833-005056827e52
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Jan Slavík (1885-1978): a Czech historian of revolutions2009monograph/pageuuid:bdbc8db0-38cf-11ed-a118-5ef3fc9bb22f
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Základové měřictví pro nižší třídy gymnasií1893monograph/pageuuid:eca38890-36a8-11ee-9691-005056827e52
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Porovnávací tabulky měr a vah i příslušných cen ku snadnému užívání metrické soustavy v říši rakouské vůbec a v zemi české zvlášť1875monograph/pageuuid:34f65bc0-6d52-11de-9cc7-000d606f5dc6
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Beylage zur Brünner Zeitung29.10.1808periodical/periodicalvolume/supplement/pageuuid:40d23930-7bf1-11e2-b930-005056827e51
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Učebné listy jazyka anglického pro samouky1886monograph/monographunit/pageuuid:55367630-80c8-11dd-b860-000d606f5dc6
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Hospodář: týdenník věnovaný rolnictví, hospodářskému průmyslu a národnímu hospodářství : týdenník věnovaný rolnictví, hospodářskému průmyslu, národnímu hospodářství a veřejné správě vůbec9.4.1887periodical/periodicalvolume/periodicalitem/pageuuid:0c579719-c6f8-4a16-8a4f-c6b12e6d449b
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Fysika pro vyšší školy1870monograph/pageuuid:7141d2c0-e6f8-11dd-a324-000d606f5dc6

Archive (50)

TitleDescriptionPublishedAdded
The three Jameses19622025-05-22T16:21:27Z
Second international meeting of the international society for neurochemistry19692025-09-08T04:17:18Z
Irradiation And The Nervous System19632025-09-11T15:24:38Z
The civil war centennial: A report to the congress19682025-07-30T19:58:01Z
Regional neurochemistry19612025-09-08T03:28:35Z
Research in physiology19712025-09-08T00:26:07Z
Scientists In Organizations19662025-09-11T18:21:23Z
De Racine Au Parthenon: Essais Sur La Litterature Et L'Art A L'age Classique19772025-09-04T14:43:38Z
Marine molluscan genera of western north america19632025-09-08T08:50:24Z
Cell cycle control : mechanisms and controlxii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v;20052020-05-25T21:59:48Z
AD #3850 - Lyriq Now #2 in Cadillac Sales; GM Backs Off 1 Million EV Goal by 2025; Chinese Suppliers Race Into Mexico- GM Backs Off 1 Million EV Goal by 2025- Lyriq Now #2 in Cadillac Sales- Forecasts BEVs to Hit 50% U.S. Sales by 2030- Cyberattack Cost Dealers $1 Billion- Lucid Claims Most Efficient EV- Stellantis Sues Another Supplier- Stellantis To Sell Recycled Oil- TotalEnergies to Install 3,000 Chargers in UK- With New A5 Audi Has No Coupe or Convertible- Chinese Suppliers Race Into Mexico- Suddenly EREVs Make A Lot of Sense20242024-11-16T17:25:08Z
Education and society in modern Germany19492023-07-25T04:04:04Z
github.com-infracost-infracost_-_2022-03-24_17-01-48Cloud cost estimates for Terraform in pull requests💰📉 Love your cloud bill! Infracost shows cloud cost estimates for Terraform. It enables DevOps, SRE and engineers to see a cost breakdown and understand costs before making changes , either in the terminal or pull requests. This provides your team with a safety net as people can discuss costs as part of the workflow. Quick start 1. Install Infracost Assuming Terraform is already installed, get the latest Infracost release: macOS Homebrew: shbrew install infracost Linux/macOS manual download:```sh Downloads the CLI based on your OS/arch and puts it in /usr/local/bin curl -fsSL https://raw.githubusercontent.com/infracost/infracost/master/scripts/install.sh | sh``` Docker and Windows users see here . 2. Get API key Register for a free API key, which is used by the CLI to retrieve prices from our Cloud Pricing API, e.g. get prices for instance types. No cloud credentials or secrets are sent to the API and you can also self-host it. s;20222022-03-24T20:04:58Z
github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ;20222022-02-07T09:45:28Z
github.com-sottlmarek-DevSecOps_-_2022-01-14_09-42-59Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def;20222022-01-14T21:43:52Z
github.com-debezium-debezium_-_2021-12-10_11-35-09Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe;20212021-12-10T12:09:39Z
John O'Neil Johnson Toyota, LLC v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2018-09-16T15:37:44Z
Dante the Central Man of All the World19222023-08-10T02:07:56Z
The King of Fighters 2002: (BR) PPSh-41 vs(BR) [CDK]-Shaka - 2023-01-27 13:30:18(BR) PPSh-41 vs (BR) [CDK]-Shaka - 2023-01-27 13:30:18 Fightcade replay id: 1674826218824-5406 #fightcade #kof2002 #[CDK]-Shaka #PPSh-41 For more videos check out: https://fightcadevids.com2023-01-27T18:11:11Z
Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting.This article is from The Journal of Cell Biology , volume 192 . Abstract Phosphorylation of Kvβ2 releases Kv1 channels from microtubules to control their specific distribution at the axonal membrane.20112014-10-24T23:30:53Z
Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases.This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina;20132014-10-28T15:40:11Z
github.com-MoonsetJS-Moonset_-_2023-01-06_06-49-49A data processing framework on top of AWS. Moonset Moonset is a data processing framework on top of AWS. It provides both batchprocessing and stream processing. Try command: npx moonset --help For example, to run some hive tasks on AWS EMR. Try to following command. ```bash config the credentials npx moonset config run a job npx moonset run \ --plugin '@moonset/plugin-platform-emr' \ --plugin '@moonset/plugin-data-glue' \ --job '{ "input": [{ "glue": { "db": "foo", "table": "apple", "partition": {"region id": "1", "snapshot date": "2020-01-01"}} }], "task": [{ "hive": {"sql": "insert overwrite table foo.pineapple partition (region id=1, snapshot date=\"2020-01-01\") select foo from foo.apple;"} }], "output": [{ "glue": { "db": "foo", "table": "pineapple", "partition": {"region id": "1", "snapshot date": "2020-01-01"}} }]}'``` All resources are managed by AWS CDK so there is minimum effort forinfrastructure setup. You can run it in a brand new account. The EMR is created in a VPC's priv;20232024-09-01T18:51:25Z
github.com-angular-components_-_2021-09-03_07-07-40Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo;20212021-09-03T10:45:19Z
github.com-apache-incubator-apisix_-_2019-11-01_09-03-27Cloud-Native Microservices API Gateway 中文 APISIX QQ group : 552030619 APISIX is a cloud-native microservices API gateway, delivering the ultimate performance, security, open source and scalable platform for all your APIs and microservices. APISIX is based on OpenResty and etcd. Compared with traditional API gateways, APISIX has dynamic routing and plug-in hot loading, which is especially suitable for API management under micro-service system. Installation | Documentation | Development ENV | FAQ Why APISIX? If you are building a website, mobile device or IoT (Internet of Things) application, you may need to use an API gateway to handle interface traffic. APISIX is a cloud-based microservices API gateway that handles traditional north-south traffic and handles east-west traffic between services. APISIX provides dynamic load balancing, authentication, rate limiting, and other plugins through plugin mechanisms, and supports plugins you develop yourself. For more detailed information, s;20192019-11-01T09:09:58Z
github.com-sindresorhus-awesome_-_2021-04-05_11-52-56😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list?     Contribution guide     Creating a list     Twitter     Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru;20212021-04-05T13:17:05Z
github.com-sindresorhus-awesome_-_2022-01-22_21-24-15😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab;20222022-01-23T01:20:47Z
[CDK 017] NSF FileCalifornian badass TristEndo is a Famitrackin’ motherfucker – and this album is CDK’s first all NSF release! A very rock influenced release, it’s a surefire way to get your fists pumping, and TristEndo doesn’t even need to resort to excessive unce! I’m especially loving the song ‘Destination’ – TristEndo is an artist to look out for in 2008/2009! There are two downloads, one with the MP3s and NSFs of the album, and a NSF only version! For those not in the know, a NSF (or NES Sound File) file is a chiptune only file, which (even though it has a tiny size) is less compressed than the mp3! So download a NSF player (I recommend VirtuaNSF (go to “Other program / data”) , whack this in and enjoy!) Or you could, y’know, just put the mp3s in your media player and enjoy them that way.20082019-12-06T23:51:18Z
[CDK 035] Josstin Timberlake - eatfuck[CDK 035] Josstin Timberlake - eatfuck20092020-01-03T02:21:31Z
[CDK 012] Spurs Of A Dead RangerYEEE-HAW! Sparkyboy , possibly South Africa’s only chipartist, has unleashed this heaven for us – It’s one of the more unique releases out there, utilising everything from Game Boys to his toy guitar collection! I’m loving it all at the moment, especially ‘Gloom’ – what an opener!20082019-12-06T22:32:39Z
coderedfm27062020your weekly drum&bass radioshow outta stuttgart / germany2020-06-28T15:02:26Z
The fury out of time19652023-08-09T07:48:05Z
DTIC ADA303157: Role of Changes in the Expression of Cyclins and Retinoblastoma Protein in the Development of Breast Cancer.In the initial year of the grant, we have carried out the bulk of the studies to characterize breast cancer cell lines with respect to overexpression of cyclin Dl protein and the presence of Rb (retinoblastoma) protein (Specific Aim No. 1). In addition, we have begun examination of surgically obtained breast cancer tissue samples for cyclin Dl protein overexpression and Rb protein content (Specific Aim No. 6). Since the original grant proposal was submitted, advances in our understanding of cell cycle regulation, and in particular advances in our understanding of the importance of defects in cell cycle regulation to the development of cancer, have proceeded at a rapid pace( )( ). In order to incorporate these advances into our investigation of cell cycle regulatory defects in breast cancer, we have expanded and reoriented some aspects of our approach. This has included a detailed assessment of the levels of cyclin dependent kinase (cdk) 4 and cdk 6, and of the cdk4/cdk6-specific cdk in;19952018-03-26T00:06:56Z
Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans.This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract Although many critical roles of the RUNX family proteins have already been identified, little attention has been given to how these proteins interact with other factors. Elucidating RUNX protein interactions will help extend our understanding of their roles in normal development and tumorigenesis. In this study, we performed large-scale RNAi screening to identify genes that genetically interact with rnt-1, the sole homolog of RUNX protein in the nematode Caenorhabditis elegans. To this end, we took advantage of the fact that C. elegans can survive a severe loss of RNT-1 function with only mild phenotypes, and we looked for genes that caused a synthetic phenotype in the rnt-1 mutant background. We identified seven genes, three of which (cdk-8, cic-1, and sur-2) are involved in transcription, two of which (pgp-2 and cct-5) are involved in stress response, and two of which (D2045.7 and W09D10.4) are involved in signalin;20132014-10-28T00:42:20Z
Periodic systems and their relation to the systematic analysis of molecular dataxxvi, 629 p., 8 p. of plates : 24 cm. + // Microfiches in pocket on front flyleaf // Includes bibliographies and index19892023-12-23T07:53:35Z
The saintmaker's Christmas Eve19552023-08-11T09:11:11Z
Jay Kay Collision Center, Inc. v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2024-06-27T09:15:55Z
CDK Global, LLC v. Southeast Atlantic Peterbilt of North Carolina, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2018-09-30T20:14:22Z
Kulkarni v. CDK Global, Inc.This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2023-06-01T09:14:33Z
the civilizations of ancient america19512025-06-17T02:55:30Z
linuxbrew cdklinuxbrew cdk2021-04-07T20:55:45Z
Built By CDK For Server-Grade ReliabilityMost Servers Can Run. This One Doesn’t Stop. Built By CDK For Server-Grade Reliability, This Server Is Configured For Continuous Operation—Where Uptime, Data Stability, And Consistent Throughput Are Non-Negotiable. From Optimized Storage Architecture To Balanced Memory Configuration, Clean Power Delivery, And Carefully Matched Components, Every Element Is Tuned To Work In Sync—Reducing Fail Points And Delivering Stable Performance For Years To Come. The Result? Uninterrupted 24x7 Operation. Reliable Data Handling At Scale. Consistent Performance Under Sustained Load. Long-Term Reliability You Can Depend On. Because In Server Environments, Stopping Isn’t An Option. Engineered By CDK. 📞 +91 92707 66589 🌐 www.designsbykira.in #cdkserver #serversolutions #datacenter #enterprisesystems #highavailability2026-04-22T12:28:58Z
Psychology of Personal Adjustment Student's Introduction to Mental Hygience19492025-09-10T00:53:02Z
Pride Flag Raised in Silver SpringMontgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 99520222022-06-02T01:32:19Z
yahoo-groups-2018-08-30T08-13-01Z-d5b6d2Yahoo! Groups API grab. Contains messages of the following groups: 08cecmcafriends 10thyec_documentations 10thyec_hrd 212sl_10 67_council_10-11 67_excom_10-11 aartedecompartilhar10 aborock accountantsworld advancedpca aggregator_game alcorp alyssamilanofansforever ambersdream api_2010 aulagelso_ceis aw88 basketball_ac beyondcircle bfpdatabasedevelopmentgroup bio11_lab_guzman blpholcimyli blueridgebirdexchange brandceo bsn2bnsginfo campusrecruitment cb7grupo252 cbhadventures ccih_aquiraz cdk_java cdpclub1011 cepe2000 clanrad_duty5 cmbe_ecrouves comissao_oab_se computer_lingap_1011 coolathawles cphic1994 csspvc daks_friends dapi_ii_2010a datasys_oracle_dba daytonactivitybagswap defensoriayplanmedico dhbn dimboola djjmatematika ec_azad_kermanshah_group economics_9a elenproj_ee energetica_iasi_1990 epdtributario-p04028 epmfam ex_smkbp feua2001 fkrkaceh fpik_umpgroup fumclovelandseniorhigh gangland2010 giusti12 houstonrubies h-v-v ibecbotucatu ibm379 ihrm_bertelsmann ipmiub iptn_2010 ipwija;2018-08-30T08:13:09Z
die mikromorphologie der menschlichen zahnpulpa19702025-09-04T05:39:32Z
The United States and civilization19432023-12-27T14:40:37Z
Various Artists * 33,333 Steps To A Power Ov The Darkness LeaguesVarious Artists * 33,333 Steps to a Power ov the Darkness Leagues   (Disc one)   01. DJ R3V3R3ND MURD3R * !33,333 STEPS TO A POWER OV THE DARKNESS LEAGUES!  02. sOuL_sCientiSt * More Fiyah Mix   03. FIGURATIVE THEATRE * MEGAMARKET UTOPIA   04. Hel.Razor * Slave 2 The System  05. dreDDup * We Fuck Until Dawn  06. Moray Eel * Hellish Adoption   07. Cryogenic Implosion * Delete Humanity   08. The Apocryphal Order * Beyond The Depraved Scope Of Salvation  09. Come To My Rise * Play A Game  10. The Rinn * Voices  11. Crimson Blue * L.M.A.  12. Severed Fifth * Blackening   13. Spiritual Dissection * Across A Frozen Hell  14. Returning We Hear the Larks * Nascence in the Caverns of Mount Olympus  15. Cuntworm * Seduced By Damnation  16. Earslaughter * Roka Smrti   (Disc two)     01. DiSloCaTed * Megazord  02. Cyber Snake * War  03. Circlerun * 13  04. Obsidian Shell * Misanthropia  05. Dawn Of Tears * Since They're Gone   06. Operación Mutante * Matanza  0;20132013-11-26T13:29:39Z
High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a.This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co;20122014-10-28T23:41:32Z
The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm.This article is from Nucleic Acids Research , volume 42 . Abstract Robustness and completion of DNA replication rely on redundant DNA replication origins. Reduced efficiency of origin licensing is proposed to contribute to chromosome instability in CDK-deregulated cell cycles, a frequent alteration in oncogenesis. However, the mechanism by which this instability occurs is largely unknown. Current models suggest that limited origin numbers would reduce fork density favouring chromosome rearrangements, but experimental support in CDK-deregulated cells is lacking. We have investigated the pattern of origin firing efficiency in budding yeast cells lacking the CDK regulators Cdh1 and Sic1. We show that each regulator is required for efficient origin activity, and that both cooperate non-redundantly. Notably, origins are differentially sensitive to CDK deregulation. Origin sensitivity is independent on normal origin efficiency, firing timing or chromosomal location. Interestingly, at a chrom;20142014-10-21T00:10:14Z
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