| Title | Description | Published | Added |
| The Old Architecture of Quebec | | 1947 | 2025-05-22T17:20:02Z |
| github.com-tiantianGPU-reg-factory_-_2026-06-04_06-12-01 | None # 🏭 reg-factory### Outlook · ChatGPT · Grok · Claude 全自动注册机**自动批量注册 Outlook 邮箱 → 用它在 ChatGPT / Grok / Claude 上注册账号 → 导出可直登 cookie** reg-factory 是一套全自动注册流水线：先自注册 Outlook 邮箱，再用同一邮箱在 ChatGPT / Grok / Claude 上批量注册账号，并导出可直登的 cookie。底层用 比特浏览器(BitBrowser) 做指纹隔离、 Clash Verge 做节点切换绕区域封锁与 Cloudflare 风控、接码/打码平台过手机号与验证码。 ⚠️ 仅供学习与授权测试使用。所有密钥通过环境变量提供，仓库内不含任何明文凭据。 1. 前置条件 ① 比特浏览器 BitBrowser 安装并 启动 比特浏览器客户端，确保本地 API 在线（默认 http://127.0.0.1:54345 ）。 客户端要保持运行——脚本通过该 API 创建/打开/关闭浏览器窗口。 ② Clash Verge（开启 API 权限） 安装 Clash Verge 并导入你的机场; | 2026 | 2026-06-04T22:05:03Z |
| Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. | This article is from Molecular Cell , volume 54 . Abstract The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1. During S phase, Cdk-mediated phosphorylation of Yen1 promotes its nuclear exclusion and inhibits catalytic activity by reducing the efficiency of DNA binding. Later in the cell cycle, at anaphase, Cdc14 drives Yen1 dephosphorylation, leading to its nuclear relocalization and enzymatic activation. Using a constitutively activated form of Yen1, we show that uncontrolled Yen1 activity is detrimental to the cell: spatial and temporal restriction of Yen1 protects against g; | 2014 | 2014-10-23T07:40:09Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| [CDK 024] Dextroid | Dexter is a Game Boy musician straight outta Southampton, and he’s decided to grace CDKr with his debut album – a pretty intense 15 tracks of musical fun! He’s definitely a chipmusician going places, don’t be surprised to see this guy making it MASSEEV in chiptune, fo sho. | 2008 | 2019-12-07T00:28:52Z |
| Y 2mate.com Exotic Wyvern Speed Paint CDK 8t FNl BL 4 1080p | Mm m mm | | 2020-09-07T16:43:56Z |
| 10 Microsserviços na prática: IaC com CDK e deploy na AWS | /home/alex/Downloads/cursos alura/Desenvolvimento Back-End Java/Nível 2 - APIs Seguras, Microsserviços e CI CD/1 Programação/10 Microsserviços na prática: IaC com CDK e deploy na AWS | | 2026-07-02T21:54:27Z |
| DTIC AD1007359: A Genetically Engineered Mouse Model of Neuroblastoma Driven by Mutated ALK and MYCN | During the past year, we have made significant progress towards meeting the goals of the funded grant proposal. We have identified a novel therapeutic strategy for MYCN-amplified neuroblastoma using a novel first-in-class inhibitor of cyclin dependent kinase 7 and have demonstrated selective potent activity against these tumors without general toxicity. Additionally, we have determined that in tumors expressing mutated ALK but without MYCN amplification, the combination of an ALK inhibitor and a transcriptional CDK inhibitor is synergistic. Both these strategies are ripe for clinical development and testing. Finally, our collection of tumors and sympathetic ganglia during different developmental stages will enable us to delineate the genetic and epigenetic changes that occur during tumorigenesis. | 2015 | 2020-01-15T23:19:28Z |
| DTIC ADA392324: Isolation of Proteins Interacting With the Cyclin D1-CDK6 Complex From Normal and Tumorigenic Human Breast Cells Using a Novel Yeast Three-Hybrid System | The eukaryotic cell division cycle is primary controlled by a family of protein serine/threonine kinases, the cyclin-dependent-kinases (CDKs). Activation of CDKs is dependent upon the interaction with an activating cyclin subunit. Presumably, these kinases progress the cell cycle by phosphorylation of critical cellular proteins. The detection of these transient kinase-substrate protein-protein interactions using conventional methods presents a major technical challenge, and is primarily responsible for our poor understanding of CDK substrates. The yeast two-hybrid system is a method for detecting protein-protein interactions. A major limitation of this method is the fact that only binary interactions can be detected. Using a modified version of the two-hybrid system, I am able to detect the interaction of ternary protein complexes. Using the cyclin D1-CDK6 protein complex as bait, I have identified the interaction of this complex with the tumor suppressor protein tuberin. Tuberin inter; | 1999 | 2018-05-03T14:23:38Z |
| DTIC ADA354074: Cell Cycle in Normal and Malignant Breast Epithelial Cells. | Breast cancer is a disease where breast epithelial cells become refractory to appropriate growth and differentiation signals. It is likely that numerous genetic changes can contribute to malignant transformation, including mutations that alter the cell cycle regulatory machinery. We have therefore sought to characterize the function of both positive and negative cell cycle regulatory elements in normal and malignant breast epithelial cells. In particular, we have focused on cyclin E, a positive cell cycle regulators element already implicated in some breast malignancies and on a class of negative regulators of cyclin-dependent kinases (Cdks). Preliminary data indicate that both cylin E and Cdk inhibitors are important in breast malignancy. | 1998 | 2018-04-19T20:58:06Z |
| CIA Reading Room cia-rdp90-00552r000100550040-8: PANEL FINDS CASEY NOT UNFIT FOR JOB | Sanitized Copy Approved for Release 2010/07/29: CIA-RDP90-00552R000100550040-8 NEW YORK TIES E, i' i CLE AIPPEA D 2 DECEMBER 1981 C )IN, PAGE' PANEL ~ , "mg a~ ~t~t tbar~rt the public at saon WadDeKI&Y. r. Noyaiban MW the delay wos.d ernmit ? flies UNFIT I$ the m ;" r of tld c xx* atte,e?a 13 members .rno crula not attend today's s tasks aboutbair v3ee-s on the pane 's eaneiusiom, erxd we+ald Per=ft; Mr. Caaay tozs+3ew them, But 'Whole. Situation is Not rroE,a Moynihan mW uttering,' Senator Sa M. a tthhet: ?o"'di of intelligence Director$ ~- ,to on o`r 1he added ;w 1e ji vse,.a, a sms~ ' used to ref 4Z931JAl3331R33i~ grtoi Josepb R BiBea Jr., Demoemt of Deiawere, said in an WASB1NGTa f,13ee. I -The Se stet iota view aZter the m eetin, that be disa.. Select C ommit ee en bMH*mm will geed with the etanmittee's ~? that and has no ham roe William J. Cawy is "mat to aeey-e as m 0'1 bare a very dirfermt V3tw iron rectorof Caatr*i;atailia,estca,seco~rdins that of nay cdk~e es m the ~iZer,'? t; | 1981 | 2025-06-03T23:01:26Z |
| Indian rubber man | | 1939 | 2025-09-09T22:39:54Z |
| DTIC ADA392349: Action of the p53 Effector, p21, on its Targets: Cyclin-cdk and PCNA | Cy or RXL motifs have been previously shown to be cyclin binding motifs found in a wide range of cyclin-cdk interacting proteins. For both cyclin A/cdk2 and cyclin E/cdk2, the presence of a Cy motif decreased the Km(sup peptide! 75 to 120-fold while the kcat remained unchanged. Changes in the length of the linker between the Cy motif and the phosphoacceptor serine suggest that both sites are engaged simultaneously to the cyclin and the cdk, respectively. PS100, a peptide containing a Cy motif, acts as a competitive inhibitor of cyclin/cdk complexes with a 15-fold lower Ki for cyclin E/cdk2 than for cyclin A/cdk2. These results provide kinetic proof that a Cy motif located at a minimal distance from the SPXK is essential for optimal phosphorylation by cdks and suggest that small chemicals that mimic the Cy motif would be specific inhibitors of substrate recognition by cyclin-dependent kinases. In addition, a detailed mutagenesis approach to define what sequence serves as a Cy motif reve; | 2000 | 2018-05-03T14:38:06Z |
| Life in ponds and streams | | 1911 | 2023-12-22T12:27:19Z |
| Soil and freshwater niematodes | | 1951 | 2025-09-08T04:35:20Z |
| die mikromorphologie der menschlichen zahnpulpa | | 1970 | 2025-09-04T05:39:32Z |
| His Dog | | 1922 | 2025-08-24T14:33:51Z |
| Formula Sports Cars, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-09-22T09:05:29Z |
| github.com-neargle-my-re0-k8s-security_-_2022-05-25_13-14-52 | :atom: [WIP] 整理过去的分享，从零开始的Kubernetes攻防 ... 从零开始的Kubernetes攻防 本材料基于我原先在腾讯发表的博客 《红蓝对抗中的云原生漏洞挖掘及利用实录》 进行持续更新和完善，用于解决公众号无法及时勘误和调整的局限性；且由于Kubernetes安全特性、容器安全等场景的攻防技术在不断发展和改变，文章的内容也会持续不断的进行调整；并在后续会补充从零开始的实验环境搭建、Kubernetes安全特性对抗、完整红蓝对抗案例、EBPF安全等相关的内容。希望整理和囊括我在Kubecon、CloudNativeCon、HITB、BlackHat、WHC、CIS等会议上分享的云原生安全相关的议题，以及此前写过的所有相关文章；希望重新构建和整理自己的在 Kubernetes 上的知识体系。👁 盼望能多积累勘误，沉淀一些真正有质量的内容。 文件包括[WIP]：1. SLIDE - 近期发表的议题材料2. PAPER - 近期; | 2022 | 2022-05-25T19:46:33Z |
| github.com-sindresorhus-awesome_-_2021-10-02_04-49-15 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2021 | 2021-10-02T15:21:09Z |
| github.com-sindresorhus-awesome_-_2022-01-23_12-29-31 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-23T13:31:49Z |
| github.com-sindresorhus-awesome_-_2023-10-26_15-42-21 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-27T01:55:02Z |
| github.com-sindresorhus-awesome_-_2026-03-09_07-59-57 | 😎 Awesome lists about all kinds of interesting topics Check out my macOS app Supercharge Elevate your Mac experience My open source work is supported by the community Special thanks to: Effortless backends with infrastructure from code An open-source framework that supports any programming language, cloud provider, or deployment automation tool. Wispr Flow Talk to code, stay in the Flow. Flow is built for devs who live in their tools. Speak and give more context, get better results. Fast remote container builds and GitHub Actions runners. What is an awesome list? Contribution guide Creating a list Twitter Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentrali; | 2026 | 2026-03-11T17:33:52Z |
| bdiod cwswco | d – daavv jvsbv. mwcvavcdh, wvs l davskcld kdaclav «oel-1», cwqdav k dwkwaww sdilk cd kwipdw swilacow adcdecow cala, cw l qdscivkcwd cwskdcidcld k walc la svwob cadsklecob skwilacob kdawk. xwawwecw, dkw-kw sdvedk, akw svwwawadd la wdavlccww qdwio avcmkp calawkwd wdskw k swadkcwkvclmb kvdwsw divssv cw wcadadidcln cd skdklk. tw dwsav kkww cvskvkcld – wvskda dbvckw adkkdakwsw dadsv, v kkwaww dalkdip l kwksd qwdh kcd dvkdswalw, d kdqm cdk cavkv cv cawlsaoq. xwk l m cd cvwdadkvnsp wkskdcvkp. adw qwidd akw wkskdcvkp-kw wcd kdcdap l cdddav. | | 2025-02-27T18:46:48Z |
| Modulated Expression of Genes Encoding Estrogen Metabolizing Enzymes by G1-Phase Cyclin-Dependent Kinases 6 and 4 in Human Breast Cancer Cells. | This article is from PLoS ONE , volume 9 . Abstract G1-phase cell cycle defects, such as alterations in cyclin D1 or cyclin-dependent kinase (cdk) levels, are seen in most tumors. For example, increased cyclin D1 and decreased cdk6 levels are seen in many human breast tumors. Overexpression of cdk6 in breast tumor cells in culture has been shown to suppress proliferation, unlike the growth stimulating effects of its close homolog, cdk4. In addition to directly affecting proliferation, alterations in cdk6 or cdk4 levels in breast tumor cells also differentially influence levels of numerous steroid metabolic enzymes (SMEs), including those involved in estrogen metabolism. Overexpression of cdk6 in tumor cell lines having low cdk6 resulted in decreased levels of mRNAs encoding aldo-keto reductase (AKR)1C1, AKR1C2 and AKR1C3, which are hydroxysteroid dehydrogenases (HSDs) involved in steroid hormone metabolism. In contrast, increasing cdk4 dramatically increased these transcript levels, es; | 2014 | 2014-10-21T22:27:31Z |
| Do replication forks control late origin firing in Saccharomyces cerevisiae? | This article is from Nucleic Acids Research , volume 40 . Abstract Recent studies of eukaryotic DNA replication timing profiles suggest that the time-dependent rate of origin firing, I(t), has a universal shape, which ensures a reproducible replication completion time. However, measurements of I(t) are based on population averages, which may bias the shape of the I(t) because of imperfect cell synchrony and cell-to-cell variability. Here, we measure the population-averaged I(t) profile from synchronized Saccharomyces cerevisiae cells using DNA combing and we extract the single-cell I(t) profile using numerical deconvolution. The single cell I(t) and the population-averaged I(t) extracted from DNA combing and replication timing profiles are similar, indicating a genome scale invariance of the replication process, and excluding cell-to-cell variability in replication time as an explanation for the shape of I(t). The single cell I(t) correlates with fork density in wild-type cells, which ; | 2011 | 2014-10-25T01:07:14Z |
| Regulation of T Cell Differentiation and Alloimmunity by the Cyclin-Dependent Kinase Inhibitor p18ink4c. | This article is from PLoS ONE , volume 9 . Abstract Cellular proliferation in response to mitogenic stimuli is negatively regulated by the Cip/Kip and the Ink4 families of cyclin-dependent kinase (CDK) inhibitors. Several of these proteins are elevated in anergic T cells, suggesting a potential role in the induction or maintenance of tolerance. Our previous studies showed that p27kip1 is required for the induction of T cell anergy and transplantation tolerance by costimulatory blockade, but a role for Ink4 proteins in these processes has not been established. Here we show that CD4+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals. However, this gain of proliferative function was accompanied by a moderate increase in the rate of cell death, and was accompanied by an overall defect in the generation of alloreactive IFNγ-producing effector cells. Consistent with this, p18ink4c-d; | 2014 | 2014-10-24T00:58:58Z |
| Loop LLC v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-10-07T16:05:38Z |
| Motor Vehicle Software Corporation v. CDK Global, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2018-12-27T22:05:46Z |
| 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. | This article is from Cell Death & Disease , volume 5 . Abstract The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase (Pfk-1). PFKFB3 is overexpressed in human cancers, regulated by HIF-1α, Akt and PTEN, and required for the survival and growth of multiple cancer types. Although most functional studies of the role of PFKFB3 in cancer progression have invoked its well-recognized function in the regulation of glycolysis, recent observations have established that PFKFB3 also traffics to the nucleus and that its product, F2,6BP, activates cyclin-dependent kinases (Cdks). In particular, F2,6BP stimulates the Cdk-mediated phospho; | 2014 | 2014-10-08T05:47:42Z |
| Deadgar's Dark Coffin Classics presents Incredible Melting Man | For use on The Vortexx The Horror Host Network All Hosts! All the Time! www.horrorhost.net | | 2021-12-21T22:36:24Z |
| DTIC ADA384004: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | Sequential activation and inactivation of cyclin dependent kinases (CDK) regulate eukaryotic cell cycle transitions. The periodicity of CDK activity provides a molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins have been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells, but they are poorly understood at present. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: El (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with ; | 1999 | 2018-04-30T00:33:35Z |
| Chroniques syndicales internationalistes - CNT | La prochaine émission radio des Chroniques syndicales internationalistes sera demain, samedi 24 décembre 2022, à 11H30 sur Radio libertaire (89.4fm ou en ligne en direct sur http://media.radio-libertaire.org:8080/radiolib.mp3 , en podcast également), et animée par le secrétariat international de la CNT. Nous dédions cette émission aux camarades du Conseil Démocratique des Kurdes en France (CDK-F) en diffusant l'intégralité de leur conférence de presse qui a eu lieu le vendredi 23 décembre à 18h30 à Paris, suite à l'attaque sanglante ciblant des camarades Kurdes, faisant 3 morts et 4 blessés graves. Nous appelons à rejoindre massivement la manifestation appelée par le CDK-F ce samedi 24 décembre à 12H Place de la République à Paris. Tout notre soutien aux camarades Kurdes, Un coup porté contre l'un-e d'entre nous est un coup porté contre nous tous.toutes ! La solidarité sera toujours notre arme ! Le Secrétariat International de la CNT | 2022 | 2022-12-27T17:10:55Z |
| Partial hepatectomy in rats results in immediate down-regulation of p27Kip1 in residual liver tissue by transcriptional and post-translational processes. | This article is from Frontiers in Physiology , volume 4 . Abstract Purpose: The cyclin-dependent kinase (Cdk) inhibitor p27Kip1 may be involved in regulating re-entry of residual hepatocytes into the cell cycle upon loss of liver tissue by partial hepatectomy (PH). As yet, changes in Kip1 expression during the initial period following PH are not well-characterized. We investigated immediate changes in Kip1 mRNA and protein levels as well as changes in Kip1 phosphorylation in liver tissue within the relevant time window between surgery and the onset of DNA synthesis at 10–12 h.Methods: We used real-time PCR, quantitative Western blotting, and immune histochemistry on tissue samples of adult rats obtained during or between 2 and 10 h after surgical removal of two thirds of the liver to analyze Kip1 mRNA or protein levels, respectively, or to quantify nuclear expression of Kip1.Results: Kip1 mRNA was down-regulated within 4 h after PH by 60% and remained unchanged thereafter up to 10 h.; | 2013 | 2014-10-28T05:43:28Z |
| A systematic screen reveals new elements acting at the G2/M cell cycle control. | This article is from Genome Biology , volume 13 . Abstract Background: The major cell cycle control acting at the G2 to mitosis transition is triggered in all eukaryotes by cyclin-dependent kinases (CDKs). In the fission yeast Schizosaccharomyces pombe the activation of the G2/M CDK is regulated primarily by dephosphorylation of the conserved residue Tyr15 in response to the stress-nutritional response and cell geometry sensing pathways. To obtain a more complete view of the G2/M control we have screened systematically for gene deletions that advance cells prematurely into mitosis. Results: A screen of 82% of fission yeast non-essential genes, comprising approximately 3,000 gene deletion mutants, identified 18 genes that act negatively at mitotic entry, 7 of which have not been previously described as cell cycle regulators. Eleven of the 18 genes function through the stress response and cell geometry sensing pathways, both of which act through CDK Tyr15 phosphorylation, and 4 of the re; | 2012 | 2014-10-24T16:07:32Z |
| DTIC ADA386852: Role of cdc25 Phosphatases in Cellular Immortalization | The goal of this proposal is to study the potential role of tyrosine phosphorylation-dependent checkpoint and especially the cdc25 phosphatase family of cyclin dependent kinase (CDK) activators in cellular immortalization. We have shown that cdc25 phosphatases did in fact extend the normal mammary epithelial cells (HMEC) life span, but do not immortalize them. The effect was most prominent with cdc25A and cdc25B phosphatases. Cdc25C phosphatase had less effect on HMEC life span. Experiments with catalytically inactive cdc25A mutant show that phosphatase activity of cdc25A is essential for the life span extension. Our experiments show that telomerase is not activated by cdc25A expression in normal human cells, suggesting that cdc25 most likely affect Ml, but not M2 checkpoints. Retroviral cDNA libraries (sense and anti-sense) were introduced into HMEC together with cdc25 to assay for the potential enhancement of cdc25 ability to expand the cellular life span. Work is underway to identif; | 2000 | 2018-04-30T22:25:18Z |
| DTIC ADB265310: Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis | Extensive molecular, biochemical, cell biological, and cytogenetic studies of breast cancer cell lines and breast cancer biopsies have indicated that overexpression of cyclin Dl plays an important role in breast tumor oncogenesis. Particularly, D-type cyclins are fundamental to cell cycle regulation of the tumor suppressor protein, Rb. However, cyclin Dl has been reported being overexpressed to the same degree in both the early and late stages of breast cancer. Therefore, cyclin Dl overexpression alone may not be a good indicator of breast cancer. Preliminary data from our laboratory suggest that the cdk inhibitor p21(cipl) can be upregulated bycyclin Dl overexpression in NIH3T3. Also, we are examining the role of PI3K pathway in cell cycle progression given its relevance in cyclin Dl expression and its correlation with the tumor supressor gene, PTEN. We show in MEFs that LY294OO2 (LY), a PI3K inhibitor, is able to reduce cyclin Dl expression level and to block entry in S phase with li; | 2000 | 2018-03-11T00:30:27Z |
| DTIC ADB281573: Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis | PI3K signaling is involved in many aspects of cell cycle progression and is often deregulated in malignant cells. Akt, a downstream kinase effector of PI3K, stabilizes cyclin Dl protein and phosphorylates the cdk inhibitor p21 preventing its anti-proliferative effects in breast cancer cells. In this report we attempt to identify PI3K- dependent molecules necessary to rescue cyclin A expression. We examined if loss of p27 together with forced expression of cyclin Dl was sufficient to rescue cyclin A expression in p27-null MEFs and demonstrated that S phase entry could not be restored by forced cyclin Dl expression. As it has been reported that the cyclin A promoter contains a cyclic AMP responsive element and that Akt phosphorylates Ser-133 of CREB in response to mitogens, we examined the phosphorylation state of CREB in the presence or absence of LY. No significant differences in CREB activation were observed suggesting additional transcription factors are required for PI3K effects on ; | 2001 | 2018-03-19T02:29:50Z |
| github.com-sindresorhus-awesome_-_2021-02-15_13-23-24 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript runtime built on Chrome's V8 JavaScript engine. Cross-Platform - Writing cross-platform code on Node.js. Frontend Development iOS - Mobile operating system for Apple phones and tablets. Android - Mobile ; | 2021 | 2021-02-16T11:42:48Z |
| github.com-sindresorhus-awesome_-_2021-09-29_09-07-55 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2021 | 2021-10-02T03:15:21Z |
| Exome sequencing reveals a potential mutational trajectory and treatments for a specific pancreatic cancer patient. | This article is from OncoTargets and therapy , volume 7 . Abstract Pancreatic cancer is the fourth biggest killer, and has one of the worst prognoses, of any cancer type. Approximately 95% of patients diagnosed with pancreatic cancer will not survive beyond 5 years post diagnosis, and these statistics have barely improved in over 40 years. Here, genomic changes in one particular patient with stage IV metastatic pancreatic cancer were explored to suggest a potential personalized treatment. In particular, exome sequencing of genomic DNA extracted from blood and the cancer biopsy was utilized with the aim of identifying mutational drivers of the cancer. This analysis revealed a splice site mutation in RBCK1 as the most promising driver of the cancer and a therapy based on a pan-cyclin-dependent kinase (pan-CDK) inhibitor, flavopiridol. This study suggests that drugs whose effectiveness is unclear for general populations of cancer sufferers should possibly be reconsidered for specific pati; | 2014 | 2014-10-22T18:42:34Z |
| Natural selection and social theory : selected papers of Robert L. Trivers | viii, 345 pages ; 25 cm // A collection of 10 papers, 5 published in scholarly journals between 1971-1976 and 5 between 1982-2000 // Reciprocal altruism -- Parental investment and reproductive success -- The Trivers-Willard effect -- Parent-offspring conflict -- Haplodiploidy and the social insects -- Size and reproductive success in a lizard -- Selecting good genes for daughters -- Self-deception in service of deceit -- Genomic imprinting -- Fluctuating asymmmetry and 2nd:4th digit ratio in children // Includes bibliographical references and index | 2002 | 2023-12-22T14:56:18Z |
| CDK Ventures, LLC v. Performance Shading Systems Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2017-07-18T21:40:09Z |
| github.com-localstack-localstack_-_2021-11-18_13-41-48 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Run • Configure • Play – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment.With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider!Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services,LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more!The Pro version of LocalStack supports additional APIs and advanced features.You c; | 2021 | 2021-11-18T13:56:44Z |
| github.com-ComposioHQ-awesome-claude-skills_-_2026-02-19_06-22-06 | A curated list of awesome Claude Skills, resources, and tools for customizing Claude AI workflows Awesome Claude Skills A curated list of practical Claude Skills for enhancing productivity across Claude.ai, Claude Code, and the Claude API. Want skills that do more than generate text? Claude can send emails, create issues, post to Slack, and take actions across 1000+ apps. See how → Quickstart: Connect Claude to 500+ Apps The connect-apps plugin lets Claude perform real actions - send emails, create issues, post to Slack. It handles auth and connects to 500+ apps using Composio under the hood. 1. Install the Plugin bashclaude --plugin-dir ./connect-apps-plugin 2. Run Setup /connect-apps:setup Paste your API key when asked. (Get a free key at platform.composio.dev ) 3. Restart & Try It bashexitclaude Want skills that do more than generate text? Claude can send emails, create issues, post to Slack, and take actions across 1000+ apps. See how → If you receive the email, Claude is now c; | 2026 | 2026-03-11T19:51:45Z |
| github.com-Threekiii-Awesome-Redteam_-_2022-06-02_02-30-23 | 一个红队知识仓库 Awesome-Redteam 【免责声明】本仓库所涉及的技术、思路和工具仅供学习，任何人不得将其用于非法用途和盈利，否则后果自行承担。 轻量化红队知识仓库，不定期更新。markdown文档与Linux alias命令或Windows doskey命令联动，可实现终端快捷查询。 近期在复现免杀（涵盖msf、evasion、veil、venom、shellter等）： Click Here 攻防渗透中的常用命令（涵盖信息收集/漏洞挖掘/内网穿透/msf/cs等知识点）： Click Here 长期维护一个综合漏洞知识库（涵盖Vulhub、Peiqi、Edge、0sec、Wooyun等开源漏洞库）： Threekiii/Vulnerability-Wiki 长期维护一个漏洞利用工具库（涵盖Vulhub、Peiqi等开源漏洞库）： Threekiii/Awesome-Exploit 目录 Awesome-Redteam 目录 漏洞知识库 项目导航 速查文档-CheatSheets 一些代码-Scripts 攻防知识-Tips 服务搭建-Docs 开源导航 编解码/加解密 实用工具 威胁情报 ; | 2022 | 2022-06-02T22:34:09Z |
| github.com-duo-labs-cloudmapper_-_2019-12-18_01-58-27 | CloudMapper helps you analyze your Amazon Web Services (AWS) environments. CloudMapper CloudMapper helps you analyze your Amazon Web Services (AWS) environments. The original purpose was to generate network diagrams and display them in your browser. It now contains much more functionality, including auditing for security issues. Network mapping demo Report demo Intro post Post to show spotting misconfigurations in networks Post on performing continuous auditing Commands audit : Check for potential misconfigurations. collect : Collect metadata about an account. More details here . find_admins : Look at IAM policies to identify admin users and roles, or principals with specific privileges. More details here . find_unused : Look for unused resources in the account. Finds unused Security Groups, Elastic IPs, network interfaces, volumes and elastic load balancers. prepare / webserver : See Network Visualizations public : Find public hosts and port ranges. More details here . sg_ips : Get ge; | 2019 | 2019-12-29T21:52:58Z |
| Morgan v. CDK Global, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2022-05-06T09:17:56Z |
| Palace Diary: Authorized Account of the crowded days of Queen Elizabeth's Life from the time of her twenty-first birthday on April 21, 1947 | | 1958 | 2023-08-09T08:44:55Z |
| github.com-aws-aws-cdk_-_2020-06-17_09-03-52 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.13.0 ) We recommend using a version in Active LTS ⚠️ versions 13.0.0 to 13.6.0 are not supported due to compatibility issues with our dependencies. Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Start; | 2020 | 2020-06-17T09:23:13Z |