| Title | Description | Published | Added |
| DTIC ADA412793: Chemotherapy of Late Stage Breast Cancer Targeted Towards Cell Cycle Regulatory Components | Our original goal was to target cell cycle regulatory components as a potential therapy for breast cancer. The target p16 is a tumor suppressor and a CDK inhibitor and is inactivated by gene methylation. The drug 5-aza-2'deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, is targeted for reexpression of a repressed p16 in late stage breast cancer patients. Re-activation of the p16 gene in cells in which the gene is methylated will restore normal growth control and be efficacious in treatment of breast cancer. A mouse model for the action of the drug was developed and used to test the efficacy of the drug. | 2002 | 2018-05-12T16:53:07Z |
| Redacting PII data at The Very Group with Amazon Comprehend | This three-part series demonstrates how to use graph neural networks (GNNs) and Amazon Neptune to generate movie recommendations using the IMDb and Box Office Mojo Movies/TV/OTT licensable data package, which provides a wide range of entertainment metadata, including over 1 billion user ratings; credits for more than 11 million cast and crew members; 9 million movie, TV, and entertainment titles; and global box office reporting data from more than 60 countries. Many AWS media and entertainment customers license IMDb data through AWS Data Exchange to improve content discovery and increase customer engagement and retention. The following diagram illustrates the complete architecture implemented as part of this series. To demonstrate the OOC search functionality with a simple example, we split the IMDb knowledge graph into customer-catalog and out-of-customer-catalog. We mark the titles that contain \"Toy Story\" as an out-of-customer catalog resource and the rest of the IMDb knowledge gr; | 2023 | 2023-01-29T23:46:41Z |
| DTIC ADA360338: Development and Use of Novel Tools to Directly Screen for Substrates of Cyclin Dependent Kinases | Cell division is a central and primary biological function. Many problems in biology and medicine center around cell division, but without a knowledge of the mechanism by which division is controlled, these problems are difficult to attack. The major transitions of the cell cycle are is controlled by a protein called a cyclin dependent kinase, or Cdk. The cell cycles of both yeast and human cells are controlled by a Cdk. Using the yeast two hybrid system I have isolated many novel Cdk interacting proteins in yeast, and these may be instrumental in controlling cell cycle progression. I have also isolate two exciting proteins which can only interact with a substrate trapping mutant of a yeast Cdk. These may be Cdk new substrates. I have also used the genomic technology of Gene Chips, to define the complete set of cell cycle regulated genes in yeast, and to characterize their controlling promoter elements. These two projects have yielded novel and exciting results, of interest to both the; | 1998 | 2018-04-22T05:07:32Z |
| Bob Baker Volkswagen v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-16T22:44:00Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| github.com-angular-components_-_2021-09-03_22-25-54 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-09-03T22:51:37Z |
| Berlioz: Symphonie Fantastique / Symphony No.5 / Prometheus Overture | Tracklist: 1. Die Geschöpfe des Prometheus Op.43 - Overture - Ludwig van Beethoven 2. Symphony No.5 in Bb major D485 - I. Allegro - Franz Schubert 3. Symphony No.5 in Bb major D485 - II. Andante con moto - Franz Schubert 4. Symphony No.5 in Bb major D485 - III. Menuetto: Allegro molto - Trio - Franz Schubert 5. Symphony No.5 in Bb major D485 - IV. Allegro vivace - Franz Schubert 6. Symphonie Fantastique Op.14 - I. Rêveries. Passions (Largo - Allegro agitato ed appassionato assai) - Hector Berlioz 7. Symphonie Fantastique Op.14 - II. Un bal (Valse: Allegro non troppo) - Hector Berlioz 8. Symphonie Fantastique Op.14 - III. Scène aux champs (Adagio) - Hector Berlioz 9. Symphonie Fantastique Op.14 - IV. Marche au supplice (Allegretto non troppo) - Hector Berlioz 10. Symphonie Fantastique Op.14 - V. Songe d'une nuit du Sabbat (Larghetto - Allegro) - Ronde du Sabbat (Poco meno mosso) - Hector Berlioz | 2000 | 2024-03-29T01:08:00Z |
| DTIC ADA411262: Targeting the AP-1 Transcription Factor for the Treatment of Breast Cancer | The AP-l transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-l by over-expressing a dominant negative form - of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that- inhibition of AP-l blocks the cell cycle, reverses TAM-resistance of breast cancer cells, and suppression of AP-l in vivo causes regression of existing breast tumors. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-l blockade inhibits breast cancer growth. Our studies suggested that TAM67 inhibits breast cancer growth predominantly by inducing CDK inhibitors (such as P27), suppressing GI cyclins expression and reducing CDKs activity, thus inducing a cell cycle block. We also showed that TAM67 induces apoptosis in serum-free condition in breast cancer cells. We are currently investigating the molecular mechanism by which TAM67 causes a cell cy; | 2002 | 2018-05-12T03:54:47Z |
| Asian economy ppt CDK | Spoken text for ppt asian economy CDK | | 2011-04-03T16:27:54Z |
| The King of Fighters 2002: (BR) LZO//GOIANO CAPOEIRA vs(BR) [CDK]-Shaka - 2022-12-26 14:01:27 | (BR) LZO//GOIANO CAPOEIRA vs (BR) [CDK]-Shaka - 2022-12-26 14:01:27 Fightcade replay id: 1672063287929-7484 #fightcade #kof2002 #LZO//GOIANOCAPOEIRA #[CDK]-Shaka For more videos check out: https://fightcadevids.com | | 2022-12-28T21:17:04Z |
| DTIC ADA369304: Role of cdc25 Phosphatases in Cellular Immortalization. | The goal of this proposal is to study the potential role of tyrosine phosphorylation-dependent checkpoint and especially the cdc25 phosphatase family of cyclin dependent kinase (CDK) activators in cellular immortalization. We have shown that cdc25 phosphatases did in fact extend the normal mammary epithelial cells life span, but do not immortalize them. The effect was most prominent with cdc25A and cdc25B phosphatases. Cdc25C phosphatase' had less effect on HMEC life span. Experiments with catalytically inactive cdc25A mutant show that phosphatase activity of cdc25A is essential for the life span extension. Our experiments shows that telomerase is not activated by cdc25A expression in normal human cells, suggesting that cdc25 most likely affect Ml. but not M2 checkpoints. | 1999 | 2018-04-25T22:23:31Z |
| Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. | This article is from Cell Cycle , volume 11 . Abstract The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with its enhanced potency previously observed in a variety of human cancer cell lines. More importantly, in vivo MRI and single voxel proton MR-Spectroscopy further established that VMY-1-103 ; | 2012 | 2014-10-26T21:07:18Z |
| Immunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma. | This article is from Journal of Oral and Maxillofacial Pathology : JOMFP , volume 18 . Abstract Background:: Cyclin dependent kinase-4 (CDK4) encoded by CDK gene, is a heterodimer protein of cell cycle in G1-S transition. This study aimed to characterize the CDK4 immunoreactivity in different histological grades of oral leukoplakias (OLs) and oral squamous cell carcinomas (OSCCs) and also aims to discuss its probable role in the tumor biogenesis. Materials and Methods:: Expression of CDK4 was investigated in total of 52 samples including OL (15), OSCCs (30) and normal oral tissues (07). A labeled Streptavidin-Biotin immunohistochemistry assay was performed and staining intensity was evaluated. Results:: The staining pattern was similar in all tissues and was located in both nuclei and cytoplasm. Dysplastic epithelium displayed a progressive increase in nuclear expression of CDK4 when compared to normal tissues. Also, positive staining cytoplasm was highly evident in OSCC with loss of d; | 2014 | 2014-10-21T00:20:34Z |
| Herpes Simplex Virus 1 (HSV-1) ICP22 Protein Directly Interacts with Cyclin-Dependent Kinase (CDK)9 to Inhibit RNA Polymerase II Transcription Elongation. | This article is from PLoS ONE , volume 9 . Abstract The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral infection and affects expression of host cell genes. ICP22 is known to reduce the global level of serine (Ser)2 phosphorylation of the Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 heptapeptide repeats comprising the carboxy-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II. Accordingly, ICP22 is thought to associate with and inhibit the activity of the positive-transcription elongation factor b (P-TEFb) pol II CTD Ser2 kinase. We show here that ICP22 causes loss of CTD Ser2 phosphorylation from pol II engaged in transcription of protein-coding genes following ectopic expression in HeLa cells and that recombinant ICP22 interacts with the CDK9 subunit of recombinant P-TEFb. ICP22 also interacts with pol II in vitro. Residues 193 to 256 of ICP22 are sufficient for interaction with CDK9 and inhibition of pol II CTD Ser2 phosphorylation but do not; | 2014 | 2014-10-01T20:40:34Z |
| Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans. | This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract Although many critical roles of the RUNX family proteins have already been identified, little attention has been given to how these proteins interact with other factors. Elucidating RUNX protein interactions will help extend our understanding of their roles in normal development and tumorigenesis. In this study, we performed large-scale RNAi screening to identify genes that genetically interact with rnt-1, the sole homolog of RUNX protein in the nematode Caenorhabditis elegans. To this end, we took advantage of the fact that C. elegans can survive a severe loss of RNT-1 function with only mild phenotypes, and we looked for genes that caused a synthetic phenotype in the rnt-1 mutant background. We identified seven genes, three of which (cdk-8, cic-1, and sur-2) are involved in transcription, two of which (pgp-2 and cct-5) are involved in stress response, and two of which (D2045.7 and W09D10.4) are involved in signalin; | 2013 | 2014-10-28T00:42:20Z |
| Boleros | Tracklist: 1. El Reloj/Perfidia/Mira Gue Eres Linda/Maria Elena/Aquellos Ojos Verdes/El Reloj/Te Quiero Dijiste/La Barca/Historia De Un Amor/El Reloj/Siboney/Sabor A Mi/Quiereme Mucho/El Reloj/Amapola/Angelitos Negros/Solamente Un Vez/Besame Mucho/El Reloj/Vamos A La Cama/La Conga 2. Me Lo Dijo Adela/Mi Vaca Lechera/Maria Christina Me Quiere Governar/Tequila/La Conga/Salud, Dinero Y Amor/Cielito Lindo/La Pachanga/La Gallina Papanatas/La Conga/La Bamba/La Raspa/La Cucaracha/La Conga/Se Va El Caiman/Todos Queremos Mas/Baio De Ana/La Conga/Vamos A La Cama | 1988 | 2024-07-11T07:14:09Z |
| Corridos del Pueblo Con Banda | Tracklist: 1. Carga ladeada - Paulino Vargas 2. El michoacano - Federico Villa 3. El tamal - Joel Elizalde 4. Terrible cuerno de chivo - Los Tahures 5. El contrabando de Nogales - Lalo Elizalde 6. Los dos hermanos - Federico Villa 7. Las parcelas de Mendoza - Joel Elizalde 8. El cabo de Michoacâan - Los Tahures 9. El gallo de San Juan - Lalo Elizalde 10. Sucediâo en la barranca - Federico Villa 11. El moro y la mora - Joel Elizalde 12. La bronco negra - Los Tahures | 2002 | 2025-03-31T06:01:33Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| Mahatma Gandhi | | 2012 | 2024-01-04T12:38:14Z |
| Corridos de a Kilo | Tracklist: 1. Pacas de a Kilo 2. El Comandante 3. Rodrigo Lopez 4. Roberto Alvarado 5. Reyes Ruiz 6. La Tragedia del Puente 7. El Corrido de Baltazar 8. El Corrido del Remojado 9. Las 13 Toneladas 10. El Corrido Pepito | 2001 | 2024-07-24T00:51:29Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| CDK Ventures, LLC v. Performance Shading Systems Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2017-07-18T21:40:09Z |
| github.com-aws-aws-cdk_-_2022-09-21_02-53-56 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 14.15.0 ) We recommend using a version in Active LTS Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Go ( Go ≥ 1.16.4 ) Third-party Language Deprecation: language version is only supported until its EOL (End Of Life) shared by the vendor or commun; | 2022 | 2022-09-21T05:05:30Z |
| DTIC ADA430444: Targeting the AP-1 Transcription Factor for the Treatment of Breast Cancer | The AP-1 transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-1 by over-expressing a dominant negative form of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that inhibition of AP-1 blocks the cell cycle, suppression of AP-1 in vivo inhibits the development of breast tumors, the cjun-DN protein binds and inactivates important growth regulatory proteins present in breast cancer cells, these proteins include Jun and Fos family members as well as coactivators that bind cJun. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-1 blockade inhibits breast cancer growth. Our studies suggested that TAM67 inhibits breast cancer growth predominantly by inducing CDK inhibitors ?such as P27), suppressing G1 cyclins expression and reducing CDKs activity, thus inducing a cell cycle block. We also showed that TAM67 binds al; | 2004 | 2018-05-23T22:15:58Z |
| 14 Exitos, Vol. 2 | Tracklist: 1. Mi Pueblo / Fernando Villalona 2. Mi Vida Eres Tu / Fernando Villalona 3. Armonicemos / Fernando Villalona 4. Dejame Volver / Fernando Villalona 5. Coco de Agua / Fernando Villalona 6. Cumbia Merenguera / Fernando Villalona 7. Celos / Fernando Villalona 8. Santiago / Fernando Villalona 9. Sonâambulo / Fernando Villalona 10. Lo Que Tengo / Fernando Villalona 11. El Polvorete / Fernando Villalona 12. Cancavo y Convexo / Fernando Villalona 13. Sere / Fernando Villalona 14. Cantando / Fernando Villalona | 1989 | 2023-05-13T13:29:02Z |
| [CDK 014] Assault | An assault on the senses? An assault on modern society? An assault on South Arctic (I and II)? An assault on old video gaming equipment? Whatever the Assault, it’s gonna assault your ears – in the best way possible! Goatslacker is a Floridian chiptuner who also uses the occasional keyboards ‘n’ drums for his music. He has a GSOH, likes walks in the parks and cinema and WLTM a person with similar interests in phat basslines and tight drums. | 2008 | 2019-12-06T22:45:14Z |
| Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells. | This article is from Vascular Cell , volume 3 . Abstract Objective: Vascular smooth muscle cell (VSMC) hypertrophy and proliferation occur in response to strain-induced local and systemic inflammatory cytokines and growth factors which may contribute to hypertension, atherosclerosis, and restenosis. We hypothesize VSMC strain, modeling normotensive arterial pressure waveforms in vitro, results in attenuated proliferative and increased hypertrophic responses 48 hrs post-strain. Methods: Using Flexcell Bioflex Systems we determined the morphological, hyperplastic and hypertrophic responses of non-strained and biomechanically strained cultured rat A7R5 VSMC. We measured secretion of nitric oxide, key cytokine/growth factors and intracellular mediators involved in VSMC proliferation via fluorescence spectroscopy and protein microarrays. We also investigated the potential roles of VEGF on VSMC strain-induced proliferation. Results: Protein microarrays revealed significant increases in VEGF ; | 2011 | 2014-10-27T22:12:00Z |
| Ayer, Hoy y Siempre, Vol. 1 | Tracklist: 1. La Canelera 2. Sin Rencor 3. Morenita Encantadora 4. Rosalito 5. La Mala Sombra 6. Cruz de Madera 7. Se Que No Eres Libre 8. Morenita Querida 9. Sin Rivales 10. Ya No Sufras 11. Seras Para Mi 12. Que Nos Perdone Dios 13. Porque La Quiero 14. Porque Probaste El Fruto 15. No Soy Feliz 16. Tus Quince Años 17. Tu Eres 18. Traicion Por Amor 19. Mil Promesas 20. Pilares de Cristal | 2002 | 2025-04-24T00:24:25Z |
| The Key to Classics: Chopin | Tracklist: 1. Chopin: Impromptu #4 In C Sharp Minor, Op. 66, CT 46, "Fantaisie-Impromptu" - Andrea Lucchesini 2. Etude in E (Tristesse) - Andrei Gavrilov 3. Chopin: Nocturne #2 In E Flat, Op. 9 - Tzimon Barto 4. Grande Valse Brillante in B-flat - Dmitri Alexeev 5. Chopin: Polonaise #6 In A Flat, Op. 53 - Maurizio Pollini 6. Valse in A Minor - Agustín Anievas 7. Etude in C Minor (Revolutionary) - Andrei Gavrilov 8. Chopin: Piano Concerto #1 In E Minor, Op. 11 - 2.Romance: Larghetto - Maurizio Pollini; Paul Kletzki: Philharmonia Orchestra 9. Etude in A-flat (Aeolian Harp) - Andrei Gavrilov 10. Chopin: Nocturne #13 In C Minor, Op. 48/1 - André Watts 11. Prelude in D-flat (Sostenuto) - Dmitri Alexeev 12. Prelude in B-flat Minor (Presto con fuoco) - Dmitri Alexeev 13. Chopin: Mazurka #13 In A Minor, Op. 17/4, CT 63 - Leif Ove Andsnes 14. Chopin: Ballade #1 In G Minor, Op. 23 - Maurizio Pollini | 1993 | 2019-08-17T02:46:12Z |
| github.com-localstack-localstack_-_2022-11-12_23-39-58 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-13T09:19:09Z |
| Timely Activation of Budding Yeast APCCdh1 Involves Degradation of Its Inhibitor, Acm1, by an Unconventional Proteolytic Mechanism. | This article is from PLoS ONE , volume 9 . Abstract Regulated proteolysis mediated by the ubiquitin proteasome system is a fundamental and essential feature of the eukaryotic cell division cycle. Most proteins with cell cycle-regulated stability are targeted for degradation by one of two related ubiquitin ligases, the Skp1-cullin-F box protein (SCF) complex or the anaphase-promoting complex (APC). Here we describe an unconventional cell cycle-regulated proteolytic mechanism that acts on the Acm1 protein, an inhibitor of the APC activator Cdh1 in budding yeast. Although Acm1 can be recognized as a substrate by the Cdc20-activated APC (APCCdc20) in anaphase, APCCdc20 is neither necessary nor sufficient for complete Acm1 degradation at the end of mitosis. An APC-independent, but 26S proteasome-dependent, mechanism is sufficient for complete Acm1 clearance from late mitotic and G1 cells. Surprisingly, this mechanism appears distinct from the canonical ubiquitin targeting pathway, exhibitin; | 2014 | 2014-10-11T23:56:58Z |
| DTIC ADA435854: The Role of Ubiquitin E3 Ligase SCFSKP2 in Prostate Cancer Development | The CDK inhibitor p27Kipl acts as a negative regulator in the cell cycle and in prostate tumorigenesis. Either the loss of p27 or over-expression of its key regulator ubiquitin E3 ligase SKP2 is associated with prostate cancer. Prostate-sepcific expression of SKP2 is sufficient to induce hyperplasia, displasia, and low grade carcinoma in the mouse prostate gland. We propose to examine whether SKP2 cooperates with or is regulated by tumor suppressors such as Pten or Nkx3.1 implicated in prostatic tumorigenesis. In the past year, we have initiated the experiments by breeding and expansion of the colonies, crossing the SKP2 transgenic mice into Pten +/- strains, and ordering Nkx3.1 mice. Compound mice of SKP2 transgene and Pten +/- were made. Our initial studies suggest that there i&. no substantial difference in tumor frequency and grade in the SKP2 and Pten +/- compound mice versus single genetic alterations. These results suggest that PTEN may act through SKP2 for tumorigenesis. Since ; | 2005 | 2018-05-27T08:46:56Z |
| github.com-sindresorhus-awesome_-_2023-10-26_11-42-32 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-26T13:33:54Z |
| Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina; | 2013 | 2014-10-28T15:40:11Z |
| The ironic temper: Anatole France and his time | | 1932 | 2024-01-12T07:23:21Z |
| Cierra la Puerta | Tracklist: 1. Cierra la Puerta 2. Una Copa Mas 3. Paloma Begra 4. Ahora Por Idea 5. Mi Sufrir 6. Anselma 7. Mi Dia de Suerte 8. Imelda 9. Que Dolor 10. El Ronquidito | 2001 | 2024-07-11T12:56:48Z |
| [CDK 024] Dextroid | Dexter is a Game Boy musician straight outta Southampton, and he’s decided to grace CDKr with his debut album – a pretty intense 15 tracks of musical fun! He’s definitely a chipmusician going places, don’t be surprised to see this guy making it MASSEEV in chiptune, fo sho. | 2008 | 2019-12-07T00:28:52Z |
| tajvdkhih. joa 4 | aitk codkit dkd vdahk aodahrittkv dxah. ja, haj ajanada bkti, vracir rinav aot. ro jajaa dk ahxaqtka ta dkdo axicajanatai, k ray xarto qyd j cida. jiaixk ati axicahokdo octo an adoktivqak aaakhatav cdk dkdolo aala – axotajtvhk r jtincorki, ahodjtvhkak ao raiaa rxakiajaaa xaaaaa a tavha r olxoatoa loxoci octolo aaditkjolo tidorija. w iada dk ati axicahokdo hodkjo pho, ray dkdo dk taatolo axoni… | | 2024-09-27T15:49:27Z |
| DTIC ADA429736: TGF-Beta Resistance in Breast Cancer | Transforming growth factor-Beta (TGF-Beta) potently inhibits cell proliferation by causing cell cycle arrest at the Gl phase. Smad proteins mediate the TGF-Beta antiproliferative responses by regulating the expression of several cell cycle components. We have recently discovered that Smad3, a key Smad protein for the TGF-Beta antiproliferative responses, is a major physiological substrate for cyclin-dependent kinases CDK4 and cDK2. Except for the Rb family members, Smad3 is the only cDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function. Since cyclin Dl that activates CDK4 and the related cDK6 is amplified or overexpressed in a high percentage of human breast cancers, we examined whether Smad3 is highly phosphorylated by CDK in breast cancers. Using primary human breast cancer tissue microarrays and a phosphopeptide antibody against a CDK phosphorylation site in Smad3, we have found that overexpression of cy; | 2004 | 2018-05-22T14:32:34Z |
| Capillary Gas Chromatography in Essential Oil Analysis | | 1987 | 2023-12-22T14:00:41Z |
| West Hollywood Movers.pdf (PDFy mirror) | This public document was automatically mirrored from PDFy . Original filename: West Hollywood Movers.pdf URL: https://pdf.yt/d/M2VcwciF_cdk_IN4 Upload date: November 18, 2014 09:52:26 | 2014 | 2014-11-18T10:00:35Z |
| Check-List of Birds of the World. Volume IV | | 1940 | 2023-07-29T08:55:41Z |
| The Early theory of equations : on their nature and constitution : translations of three treatises | 218 p. ; 23 cm // On the recognition of equations / by François Viète -- A new discovery in algebra / by Albert Girard -- On the nature and constitution of equations / by Florimond de Beaune | 1986 | 2023-12-22T11:17:45Z |
| Loadholt v. CDK Enterprises, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2022-09-27T09:25:51Z |
| Morgan v. CDK Global, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2022-05-06T09:17:56Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells. | This article is from Cell Division , volume 8 . Abstract Background: Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that β-adrenergic receptors (β-ARs) may play an important role in the pathogenesis of IH. Results: In the present study, we investigated the β-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both β1- and β2-ARs were expressed in HemECs. Stimulation of the β-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was a; | 2013 | 2014-10-29T13:12:50Z |
| Graphs with Diameter $n-e$ Minimizing the Spectral Radius | The spectral radius $\rho(G)$ of a graph $G$ is the largest eigenvalue of its adjacency matrix $A(G)$. For a fixed integer $e\ge 1$, let $G^{min}_{n,n-e}$ be a graph with minimal spectral radius among all connected graphs on $n$ vertices with diameter $n-e$. Let $P_{n_1,n_2,...,n_t,p}^{m_1,m_2,...,m_t}$ be a tree obtained from a path of $p$ vertices ($0 \sim 1 \sim 2 \sim ... \sim (p-1)$) by linking one pendant path $P_{n_i}$ at $m_i$ for each $i\in\{1,2,...,t\}$. For $e=1,2,3,4,5$, $G^{min}_{n,n-e}$ were determined in the literature. Cioab\v{a}-van Dam-Koolen-Lee \cite{CDK} conjectured for fixed $e\geq 6$, $G^{min}_{n,n-e}$ is in the family ${\cal P}_{n,e}=\{P_{2,1,...1,2,n-e+1}^{2,m_2,...,m_{e-4},n-e-2}\mid 2 | 2011 | 2013-09-23T15:53:26Z |
| Commissioner Sullivan message to Clatsop County April 22 | | 2020 | 2022-10-14T13:47:04Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_02-24-10 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-05T12:18:54Z |