| Title | Description | Published | Added |
| github.com-DovAmir-awesome-design-patterns_-_2022-12-08_10-37-12 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage DevOps & containers Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalo; | 2022 | 2022-12-15T12:47:03Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| BRITANNICA WORLD LANGUAGE DICTIONARY | | 1959 | 2025-08-24T15:43:03Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| CIA Reading Room cia-rdp91-00403r000200380008-6: FR:IZSO L TO:BAGER G | Traffic Organization and Preparation of Tim Tableofor Pusenger Shippliig on the Balaton.MMGARIANI perk Kozlekedese KozIony) 24 may 1970.,PP 384-387.DTA LN 1328-70Ju1Y 71The Plans and Tasks of Mobart for the Year 1970.RMARIM., per. KozIekedesi Kbzlony, No 16,19 April 1970, p 285.DTA rX 114g-7oJ'AlY 71Trends In Transportmbion and Postal Output Devicing1969.MMGMIM~ perk Kozelekedsi lCozIony, No 153April 12, 1970, p~ M7-2',11.DIA LN 1148-70May 71The Twerity-Five Years of Hungarian Shipping.UMMIM, per, I-a-ziekedesi KoziMp .4 April 1970sPp 248-250-DiA Lw 1147-70State PAIUVWU# IM Task* MftbWobyWay &*Wlo 9 pp.HUWARW Paogo 90 IYAOr 0ins 50417RF,NungaryF400&F ?0 407j,346V^aq;mBow&r 70 4020445NW& 7111 lans for I~ailroad Containerization wotexi.by Laszlo Izao, k~yorgy ionyrd, 9 pp,10WARIAW, por, Xozlq)cedAk 1~q pnv, lWapust,30 I'~ov 1969. pp W~Z~d- L4 _-i ei~s 49688U~ImngaryBconi-eb 70 40o,6o,6-laticnal aid i iiaij)our L,; 40I )ILL.14lUji"'It"L.'j, ~ILEi2!L~ 17 ~.;,),vo, 1'J69Ilil.,\ 1~~ U48-69(D; | 1983 | 2026-03-31T13:43:14Z |
| github.com-lloesche-valheim-server-docker_-_2021-03-15_23-08-06 | Valheim dedicated gameserver with automatic update, World backup and ValheimPlus mod support lloesche/valheim-server Docker image Valheim Server in a Docker Container (with ValheimPlus support) Table of contents Basic Docker Usage Environment Variables Log filters Event hooks Event hook examples Install extra packages Copy backups to another location Delay restarts by 1 minute and notify on Discord ValheimPlus config from Environment Variables System requirements Deployment Deploying with Docker and systemd Deploying with docker-compose Deploying to Kubernetes Deploying to AWS ECS Updates Backups Finding Your Server In-game Steam Server Browser Steam Server Favorites & LAN Play Admin Commands Supervisor Supervisor API Status web server ValheimPlus Updates Configuration Server data rate Disable server password Changing startup CMD in Portainer Synology Help First install Updating the container image to the latest version Error after download of new container image Basic Docker Usage The; | 2021 | 2021-03-16T07:10:56Z |
| Predict shipment ETA with no-code machine learning using Amazon SageMaker Canvas | Over the last few years, online education platforms have seen an increase in adoption of and an uptick in demand for video-based learnings because it offers an effective medium to engage learners. To expand to international markets and address a culturally and linguistically diverse population, businesses are also looking at diversifying their learning offerings by localizing content into multiple languages. These businesses are looking for reliable and cost-effective ways to solve their localization use cases. Localizing content mainly includes translating original voices into new languages and adding visual aids such as subtitles. Traditionally, this process is cost-prohibitive, manual, and takes a lot of time, including working with localization specialists. With the power of AWS machine learning (ML) services such as Amazon Transcribe , Amazon Translate , and Amazon Polly , you can create a viable and a cost-effective localization solution. You can use Amazon Transcribe to create a; | 2022 | 2022-08-10T05:07:03Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| yahoo-groups-2018-06-30T23-49-20Z-213b6b | Yahoo! Groups API grab. Contains messages of the following groups: abass_t92 adaevi adeala agec424group almostfamous-bvds apurv_heavymetal arch_ugm_05 asd-trainees-0809 avrilavigneavlav aw_groups backlanebizneskl baeeunice bazket_sport besmart_group biotechresearchers bscs_1b_prog_cdk bsn_4a_frieslovers c3_noticeboard cagarencuclillas camobutts ccsflitjournal cfne_22008 chatters cheap-pet-supplies cicstcollege cisco_ghana clubfiatecuador cmpe274_business_intelligence_fall2008 coa08_iiu conexaoamsterda coolfriends_ngp cool_raj1989_hot copi_nijmegen cosbuc2008_12r1 cpa-world csc_8 cscst-argaocampusmis-ict darla_fux52a_livecams darvazeh dc_metro_angels dhrumil88 digitaldial_diversidial_online ds112grouppapergk dyala eca_maniez efbalicobacoba entreprisemichite fierydemon2008 filmstadensickla fina6335_uh2008 flat4677 fuad_online ga-fesc garciamendozafamilytree gay60plus gcet_cs2012 gdc-organic gherti-entertainment ghp_group gkm_2k8 grandmas-recipe-box grupoutp113 gw78 het_tien_roi_89 hottes; | | 2018-06-30T23:49:27Z |
| MySpace Thesis Music Sample: Ma-Md | A compilation of music acquired from the MySpace Social Network platform in the 2007-2008 period by Ben Fields in the pursuit of his Ph.D. and social-network/music-network dissertation. Gathered for the purposes of analysis and calculation, the resulting tens of thousands of lower-quality MP3s sat on an external hard drive for a decade before being offered in this collection. The sampling was random and not based on any specific criteria. | 2008 | 2019-03-21T06:17:40Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-04_23-17-10 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-05T09:01:59Z |
| github.com-sindresorhus-awesome_-_2021-12-29_16-51-20 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-29T23:33:05Z |
| github.com-sindresorhus-awesome_-_2022-01-23_19-01-28 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-24T01:48:28Z |
| github.com-sindresorhus-awesome_-_2022-11-12_16-07-31 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-13T21:28:57Z |
| github.com-sindresorhus-awesome_-_2023-06-26_15-20-26 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-27T00:52:07Z |
| github.com-sottlmarek-DevSecOps_-_2021-11-26_17-57-22 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this Library of knowledge please create proper PR (Pull request) with description what you are adding following these set of rules: Clear description of PR Keep it simple Fact over feelings or personal opinions Add source and follow the Library style Note: Currently this is early version of the library. I recommend PR after first official release. DevSecOps Library info: This library contains list of tools and methodologies accompanied with resources. The main goal is provide to the engineers guide trough opensource DevSecOps tooling. This repository covers only cyber security in cloud and DevSecOps scope. Table of Contents Defintition Tooling Precommit and threat modeling SAST DAST Supply chain and dependencies Infrastructure as code Containers security Kubernetes Cloud Chaos engineering Policy as code Methodologies Other License What is DevSecOps DevSecOps fosuses on security automat; | 2021 | 2021-11-27T17:37:25Z |
| github.com-italiaremote-awesome-italia-remote_-_2023-09-07_16-15-21 | A list of remote-friendly or full-remote companies that targets Italian talents. Awesome Italia Remote A list of 324 remote-friendly or full-remote companies that targets Italian talents. Companies can be both based in Italy or around the world but with operations in Italy. Please read the contribution guidelines before opening a pull request or contributing to this repository. Web View https://italiaremote.com/companies Built and maintained by Alessandro Marino Edoardo Costantini Legenda Remote Policies Label | Meaning--- | ---Full | Company doesn't have physical offices, so you'll always work remotely.Hybrid | Company allows remote but only for some days.Optional | Company allows you to choose when work remotely or in office, but can ask you to go sometimes. Hiring Policies Label | Meaning--- | ---Direct | Company is hiring directly with a legal entity in Italy.Contract | Company is hiring contractors in Italy, VAT Number is required.Intermediary | Company is hiring using a payroll i; | 2023 | 2023-09-07T20:17:29Z |
| Behind The Scenes and Updates On Each Case | In this episode, I take you behind-the-scenes of each case I covered in the Court Junkie podcast, as well as go over the latest updates. You'll also hear from Pravin Varughese's mom and family friend, as well as other Court Junkies. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter; | 2017 | 2023-07-08T12:41:02Z |
| github.com-T-head-Semi-wujian100_open_-_2019-10-24_06-20-55 | IC design and development should be faster，simpler and more reliable wujian100_open wujian100_open is a MCU base SoC. We can simulate by EDA tools and emulate by FPGA. Also we can develop the IPs and software in this platform. We wish more and more developers building the open MCU ecosystem with T-Head. IC design and development should be faster simpler and more reliableDirectory Structure|--Project //open source project work directory |--riscv_toolchain //tool chain install directory download from t-head.cn |--wujian100_open //wujian100_open project get from github |--case //test case example for simulation |--doc //wujian100_open user guide |--fpga //FPGA script |--lib //compile script for simulation |--regress //regression result |--sdk //software design kit |--soc //Soc RTL source code |--tb //test bench |--tools //simulation script and setup file |--workdir //simulation directory |--LICENSE |--README.md Get Start 1. prepare a project work directory just like 'Project'2. cd Proje; | 2019 | 2019-10-24T09:00:18Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| Het Utrechts Archief 846446 | Het Utrechts Archief catalog number: 846446 Description (Dutch): Interieur van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-27T20:18:20Z |
| Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families. | This article is from Journal of Carcinogenesis , volume 10 . Abstract Background:: Cisplatin (CDDP) is a drug used for treatment of many types of malignancy but pancreatic cancer is relatively resistant to it. This study aims to determine whether and how cyclin D1 (D1) and c-Myc influence the response of pancreatic cancer cells to CDDP. Materials and Methods:: Ela-mycPT mouse pancreatic cancer cells were transfected with D1 or c-myc cDNA and treated with CDDP alone or together with NPCD, an inhibitor of cyclin dependent ckinase (CDK) 4 and 6. Reverse transcription followed by polymerase chain reaction (RT-PCR) and western blot assays were used to determine the mRNA and protein levels of interested genes. Cell viability was determined using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results:: Treatment of Ela-mycPT1 cells with CDDP caused an increase in c-myc expression but a slightly latent decrease in D1 expression, whereas D1 and c-Myc proteins repres; | 2011 | 2014-10-28T18:52:34Z |
| Overtures Of Biology | | 1964 | 2025-09-11T12:55:51Z |
| DTIC ADA453395: Suppression of Prostate Cancer by PTEN and p18INK4c | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (exp Ink4c) and the lipid phosphatase PTEN, which regulates cell growth and survival. The p18(exp -/-) ; PTEN (exp +/-) double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C-cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in PTEN (exp +/-) cells, and further activated and accumulated in the nucleus in p18 (exp -/-) ; PTEN (exp +/-) tumor cells, suggesting a tissue- and genetic background-dependent haploinsufficiency of Pten in tum; | 2006 | 2018-06-05T18:22:11Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| github.com-sindresorhus-awesome_-_2022-01-22_21-24-15 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-23T01:20:47Z |
| github.com-apache-incubator-apisix_-_2019-11-01_09-03-27 | Cloud-Native Microservices API Gateway 中文 APISIX QQ group : 552030619 APISIX is a cloud-native microservices API gateway, delivering the ultimate performance, security, open source and scalable platform for all your APIs and microservices. APISIX is based on OpenResty and etcd. Compared with traditional API gateways, APISIX has dynamic routing and plug-in hot loading, which is especially suitable for API management under micro-service system. Installation | Documentation | Development ENV | FAQ Why APISIX? If you are building a website, mobile device or IoT (Internet of Things) application, you may need to use an API gateway to handle interface traffic. APISIX is a cloud-based microservices API gateway that handles traditional north-south traffic and handles east-west traffic between services. APISIX provides dynamic load balancing, authentication, rate limiting, and other plugins through plugin mechanisms, and supports plugins you develop yourself. For more detailed information, s; | 2019 | 2019-11-01T09:09:58Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. | This article is from Molecular Cell , volume 54 . Abstract The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1. During S phase, Cdk-mediated phosphorylation of Yen1 promotes its nuclear exclusion and inhibits catalytic activity by reducing the efficiency of DNA binding. Later in the cell cycle, at anaphase, Cdc14 drives Yen1 dephosphorylation, leading to its nuclear relocalization and enzymatic activation. Using a constitutively activated form of Yen1, we show that uncontrolled Yen1 activity is detrimental to the cell: spatial and temporal restriction of Yen1 protects against g; | 2014 | 2014-10-23T07:40:09Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-06_04-11-10 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-06T21:32:41Z |
| github.com-sindresorhus-awesome_-_2021-04-02_19-51-59 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-03T12:50:55Z |
| github.com-sindresorhus-awesome_-_2021-04-05_16-07-23 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-06T01:27:34Z |
| github.com-sindresorhus-awesome_-_2021-11-26_04-57-42 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-11-28T17:59:53Z |
| github.com-localstack-localstack_-_2022-11-12_20-26-32 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-12T20:48:32Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |
| Remarkable women of france ( from 1431 to 1749 ) | | 1914 | 2025-09-08T04:07:29Z |
| CIA Reading Room cia-rdp85m00364r002204280136-7: LETTER TO (SANITIZED) | Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 CENTRAL INTELLIGENCE AGENCY PUBLIC AFFAIRS Phone: (703) 351-7676 18 April 1983 STAT Thank you for writing Mr. Casey for whom I am responding. I am sorry but the Central Intelligence Agency is in no position to help you. Thank you for writing our Agency. I am sorry we cannot be of assistance to you. Sincerely, STAT OEXA/PAD/KJH/cdk/18 Apr 83/7676 Di strib..a.. __ C/e Pd Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 _ STAT | 1983 | 2025-02-20T13:56:07Z |
| CIA Reading Room cia-rdp83m00914r002900060005-4: I AM PLEASED TO INVITE YOU TO A ONE-DAY SPECIAL SECURITY PRESENTATION | Approved For Release 2006/0 Y2rY A`TR _ 83M00914R002900060005-4 Washington. D. C 20505 31 MAR 1982 ER 82-4708/1 I am pleased to invite you to a one-day-special security pres- entation sponsored by the White House and hosted by the Central Intelligence Agency at n Thursday, 25X1 13 May 1982. This session w i l l give those o you who were unable to attend last year the chance to do so. The schedule is enclosed. This highly-selective session has been designed to meet your special needs as an official Government spokes- person. I promise you it will be interesting and informative. The day is intended to broaden your knowledge and enhance your effective- ness throughout your period of Government service. If my schedule holds, I plan to be with you for at least a portion of the day. Kindly direct your response to CIA's Public Affairs office, telephone 351-7676. I hope to see you there. Sincerely, I g ail William J. Casey Director of Central Intelligence Enclosure UNCLASSIFIED WHEN SEPARATED ; | 1982 | 2024-07-15T20:22:12Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. | This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co; | 2012 | 2014-10-28T23:41:32Z |
| Applications of the InChI in cheminformatics with the CDK and Bioclipse. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. Results: We here describe how the InChI library is used in the Bioclipse workbench and the Chemistry Development Kit (CDK) cheminformatics library. To make this possible, a JNI bridge to the InChI library was developed, JNI-InChI, allowing Java software to access the InChI algorithms. By using this bridge, the CDK project packages the InChI binaries in a module and offers easy access from Java using the CDK API. The Bioclipse project packages and offers InChI as a dynamic OSGi bundle that can easily be used by any OSGi-compliant software, in addition to the regular Java Archive and Maven bundles. Bioclipse itself uses the InChI as a key component and calculates it on the fly whe; | 2013 | 2014-10-27T02:14:25Z |
| 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. | This article is from Cell Death & Disease , volume 5 . Abstract The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase (Pfk-1). PFKFB3 is overexpressed in human cancers, regulated by HIF-1α, Akt and PTEN, and required for the survival and growth of multiple cancer types. Although most functional studies of the role of PFKFB3 in cancer progression have invoked its well-recognized function in the regulation of glycolysis, recent observations have established that PFKFB3 also traffics to the nucleus and that its product, F2,6BP, activates cyclin-dependent kinases (Cdks). In particular, F2,6BP stimulates the Cdk-mediated phospho; | 2014 | 2014-10-08T05:47:42Z |
| CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITY | Approved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known; | 1981 | 2024-05-13T17:20:36Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. | This article is from eLife , volume 3 . Abstract During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here that PP2A-B55 is the enzyme responsible for dephosphorylating pEndos during M phase exit. The kinetic parameters for PP2A-B55’s action on pEndos are orders of magnitude lower than those for CDK-phosphorylated substrates, suggesting a simple model for PP2A-B55 regulation that we call inhibition by unfair competition. As the name suggests, during M phase PP2A-B55’s attention is diverted to pEndos, which binds much more avidly and is dephosphorylated more slowly than other substrates. When Gwl is inactivated during the M phase-to-interphase transition, the dynamic balance changes: pEndos dephosphorylated by PP2A-B55 cannot be replaced, so the phosphatase can refocus its attention on CDK-phospho; | 2014 | 2014-10-23T20:21:36Z |
| Pathway of Programmed Cell Death and Oxidative Stress Induced by ?-Hydroxybutyrate in Dairy Cow Abomasum Smooth Muscle Cells and in Mouse Gastric Smooth Muscle. | This article is from PLoS ONE , volume 9 . Abstract The administration of exogenous β-hydroxybutyrate (β-HB), as well as fasting and caloric restriction, is a condition associated with β-HB abundance and decreased appetite in animals. Increased β-HB and decreased appetite exist simultaneously in some diseases, such as bovine left displaced abomasums (LDA) and human chronic gastritis. However, the effects of β-HB on stomach injuries have not been explored. To elucidate the possible effects of exogenous β-HB on the stomach, mice were injected intraperitoneally with β-HB, and bovine abomasum smooth muscle cells (BSMCs) were treated with different concentrations of β-HB. We found that β-HB induced BSMCs endoplasmic reticulum- and mitochondria-mediated apoptotic cell death. β-HB promoted Bax expression and caspase-12, -9, and -3 activation while blocking Bcl-2 expression. β-HB also promoted AIF, EndoG release and p53 expression. β-HB acted on key molecules in the apoptotic cell ; | 2014 | 2014-10-22T19:40:13Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| Protein kinase C signaling and cell cycle regulation. | This article is from Frontiers in Immunology , volume 3 . Abstract A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about 30 years. However, despite the wealth of information on PKC-mediated control of, T cell activation, understanding of the effects of PKCs on the cell cycle machinery in this cell type remains limited. Studies in other systems have revealed important cell cycle-specific effects of PKC signaling that can either positively or negatively impact proliferation. The outcome of PKC activation is highly context-dependent, with the precise cell cycle target(s) and overall effects determined by the specific isozyme involved, the timing of PKC activation, the cell type, and the signaling environment. Although PKCs can regulate all stages of the cell cycle, they appear to predominantly affect G0/G1 and G2. PKCs can modulate multiple cell cycle regulatory molecules, including cyclins, cyclin-dependent kin; | 2013 | 2014-10-28T20:08:08Z |