| Title | Description | Published | Added |
| DTIC ADA412793: Chemotherapy of Late Stage Breast Cancer Targeted Towards Cell Cycle Regulatory Components | Our original goal was to target cell cycle regulatory components as a potential therapy for breast cancer. The target p16 is a tumor suppressor and a CDK inhibitor and is inactivated by gene methylation. The drug 5-aza-2'deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, is targeted for reexpression of a repressed p16 in late stage breast cancer patients. Re-activation of the p16 gene in cells in which the gene is methylated will restore normal growth control and be efficacious in treatment of breast cancer. A mouse model for the action of the drug was developed and used to test the efficacy of the drug. | 2002 | 2018-05-12T16:53:07Z |
| Redacting PII data at The Very Group with Amazon Comprehend | This three-part series demonstrates how to use graph neural networks (GNNs) and Amazon Neptune to generate movie recommendations using the IMDb and Box Office Mojo Movies/TV/OTT licensable data package, which provides a wide range of entertainment metadata, including over 1 billion user ratings; credits for more than 11 million cast and crew members; 9 million movie, TV, and entertainment titles; and global box office reporting data from more than 60 countries. Many AWS media and entertainment customers license IMDb data through AWS Data Exchange to improve content discovery and increase customer engagement and retention. The following diagram illustrates the complete architecture implemented as part of this series. To demonstrate the OOC search functionality with a simple example, we split the IMDb knowledge graph into customer-catalog and out-of-customer-catalog. We mark the titles that contain \"Toy Story\" as an out-of-customer catalog resource and the rest of the IMDb knowledge gr; | 2023 | 2023-01-29T23:46:41Z |
| DTIC ADA360338: Development and Use of Novel Tools to Directly Screen for Substrates of Cyclin Dependent Kinases | Cell division is a central and primary biological function. Many problems in biology and medicine center around cell division, but without a knowledge of the mechanism by which division is controlled, these problems are difficult to attack. The major transitions of the cell cycle are is controlled by a protein called a cyclin dependent kinase, or Cdk. The cell cycles of both yeast and human cells are controlled by a Cdk. Using the yeast two hybrid system I have isolated many novel Cdk interacting proteins in yeast, and these may be instrumental in controlling cell cycle progression. I have also isolate two exciting proteins which can only interact with a substrate trapping mutant of a yeast Cdk. These may be Cdk new substrates. I have also used the genomic technology of Gene Chips, to define the complete set of cell cycle regulated genes in yeast, and to characterize their controlling promoter elements. These two projects have yielded novel and exciting results, of interest to both the; | 1998 | 2018-04-22T05:07:32Z |
| In re: Dealer Management Systems Antitrust Litig. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-03-22T17:58:37Z |
| Bob Baker Volkswagen v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-16T22:44:00Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_17-00-30 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-06T00:37:52Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| DTIC ADA411262: Targeting the AP-1 Transcription Factor for the Treatment of Breast Cancer | The AP-l transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-l by over-expressing a dominant negative form - of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that- inhibition of AP-l blocks the cell cycle, reverses TAM-resistance of breast cancer cells, and suppression of AP-l in vivo causes regression of existing breast tumors. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-l blockade inhibits breast cancer growth. Our studies suggested that TAM67 inhibits breast cancer growth predominantly by inducing CDK inhibitors (such as P27), suppressing GI cyclins expression and reducing CDKs activity, thus inducing a cell cycle block. We also showed that TAM67 induces apoptosis in serum-free condition in breast cancer cells. We are currently investigating the molecular mechanism by which TAM67 causes a cell cy; | 2002 | 2018-05-12T03:54:47Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| Reaganautas III | Olvidemos lo no grabado y lo no publicado y centrémonos en lo que sà podemos escuchar. En esta ocasión, y siguiendo nuestra absurda costumbre de colgar programa sÃ, programa no, tenemos la tercera muestra audible de la mayor locura de las ondas herzianas. John Randall Hoth analiza la victoria de los Republicanos en las elecciones legislativas estadounidenses y toda la actualidad sobre la senadora zombie, Jerry Conway nos acerca a un mito del rock underground, CDK Pichafrita, con la visita de Lucas, uno de los que fueran componentes del grupo y Jimmy Weaver se adentrará en las redes de nuestro querido Tea Party. Acontecimiento: se produce la primera llamada telefónica al programa y todo ello tras la irrupción de la policia en el estudio buscando un perro kamikaze enviado desde Grecia. | | 2010-11-04T23:12:52Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| On & On | Tracklist: 1. Let Jesus Love You 2. I'll Praise His Name 3. To Teach Me 4. On & On 5. In Spite Of It All 6. Show Some Sign 7. Healing Hands 8. It Is Well With My Soul 9. Hallelujah, Amen! | 1994 | 2025-03-20T07:54:14Z |
| Boleros | Tracklist: 1. El Reloj/Perfidia/Mira Gue Eres Linda/Maria Elena/Aquellos Ojos Verdes/El Reloj/Te Quiero Dijiste/La Barca/Historia De Un Amor/El Reloj/Siboney/Sabor A Mi/Quiereme Mucho/El Reloj/Amapola/Angelitos Negros/Solamente Un Vez/Besame Mucho/El Reloj/Vamos A La Cama/La Conga 2. Me Lo Dijo Adela/Mi Vaca Lechera/Maria Christina Me Quiere Governar/Tequila/La Conga/Salud, Dinero Y Amor/Cielito Lindo/La Pachanga/La Gallina Papanatas/La Conga/La Bamba/La Raspa/La Cucaracha/La Conga/Se Va El Caiman/Todos Queremos Mas/Baio De Ana/La Conga/Vamos A La Cama | 1988 | 2024-07-11T07:14:09Z |
| Mahatma Gandhi | | 2012 | 2024-01-04T12:38:14Z |
| Corridos del Pueblo Con Banda | Tracklist: 1. Carga ladeada - Paulino Vargas 2. El michoacano - Federico Villa 3. El tamal - Joel Elizalde 4. Terrible cuerno de chivo - Los Tahures 5. El contrabando de Nogales - Lalo Elizalde 6. Los dos hermanos - Federico Villa 7. Las parcelas de Mendoza - Joel Elizalde 8. El cabo de Michoacâan - Los Tahures 9. El gallo de San Juan - Lalo Elizalde 10. Sucediâo en la barranca - Federico Villa 11. El moro y la mora - Joel Elizalde 12. La bronco negra - Los Tahures | 2002 | 2025-03-31T06:01:33Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| github.com-aws-aws-cdk_-_2022-09-21_02-53-56 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 14.15.0 ) We recommend using a version in Active LTS Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Go ( Go ≥ 1.16.4 ) Third-party Language Deprecation: language version is only supported until its EOL (End Of Life) shared by the vendor or commun; | 2022 | 2022-09-21T05:05:30Z |
| DTIC ADA430444: Targeting the AP-1 Transcription Factor for the Treatment of Breast Cancer | The AP-1 transcription factor is a central component of many signal transduction pathways. We have shown that blocking AP-1 by over-expressing a dominant negative form of cJun (cjun-DN, Tam67) inhibits breast cancer cell growth. We hypothesize that inhibition of AP-1 blocks the cell cycle, suppression of AP-1 in vivo inhibits the development of breast tumors, the cjun-DN protein binds and inactivates important growth regulatory proteins present in breast cancer cells, these proteins include Jun and Fos family members as well as coactivators that bind cJun. In the present study, we demonstrated that TAM67 inhibits breast cancer growth both in vitro and in vivo. We determined the mechanism by which AP-1 blockade inhibits breast cancer growth. Our studies suggested that TAM67 inhibits breast cancer growth predominantly by inducing CDK inhibitors ?such as P27), suppressing G1 cyclins expression and reducing CDKs activity, thus inducing a cell cycle block. We also showed that TAM67 binds al; | 2004 | 2018-05-23T22:15:58Z |
| [CDK 014] Assault | An assault on the senses? An assault on modern society? An assault on South Arctic (I and II)? An assault on old video gaming equipment? Whatever the Assault, it’s gonna assault your ears – in the best way possible! Goatslacker is a Floridian chiptuner who also uses the occasional keyboards ‘n’ drums for his music. He has a GSOH, likes walks in the parks and cinema and WLTM a person with similar interests in phat basslines and tight drums. | 2008 | 2019-12-06T22:45:14Z |
| An Essay on Marxian Economics | | 1942 | 2023-07-25T08:51:27Z |
| Ayer, Hoy y Siempre, Vol. 1 | Tracklist: 1. La Canelera 2. Sin Rencor 3. Morenita Encantadora 4. Rosalito 5. La Mala Sombra 6. Cruz de Madera 7. Se Que No Eres Libre 8. Morenita Querida 9. Sin Rivales 10. Ya No Sufras 11. Seras Para Mi 12. Que Nos Perdone Dios 13. Porque La Quiero 14. Porque Probaste El Fruto 15. No Soy Feliz 16. Tus Quince Años 17. Tu Eres 18. Traicion Por Amor 19. Mil Promesas 20. Pilares de Cristal | 2002 | 2025-04-24T00:24:25Z |
| Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells. | This article is from BMC Cancer , volume 14 . Abstract Background: Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent. Methods: PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed. Associated signaling changes were also analyzed by RT-PCR and Western blots. Results: Here, we reported that SAHA, a histone deacetylase inhibitor (HDACi), exerted significant inhibitory efficiency against pancreatic cancer cell survival, proliferation, migration and VM. SAHA dose-dependently inhibited PaTu8988 pancreatic cancer cell growth with the IC-50 of 3.4 ± 0. 7 μM. Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/; | 2014 | 2014-10-21T20:47:25Z |
| DTIC ADA415783: Regulated Transformation of Mammary Epithelial Cells by Transforming Growth Factor Beta 1 | We report that MMTV-DNIIR female mice have accelerated mammary gland differentiation during early pregnancy with impaired development during late pregnancy and lactation followed by delayed post-lactational involution. Mammary tumors, mostly carcinoma in situ, developed spontaneously in the MMTV-DNIIR mice with a long median latency (27.5 months). Invading carcinoma cells in MMTV-DNIIR animals showed loss of DNIIR transgene expression as determined by in situ hybridization. The data indicate that signaling from endogenous TGF-Betas not only plays an important role in normal mammary gland physiology but also can also suppress the early stage of tumor formation and contribute to tumor invasion once carcinomas have developed. The ability of the TGF-beta signaling pathways to inhibit proliferation of many epithelial cells while stimulating proliferation fibroblasts remains a conundrum. We found that the absence of RhoA and p160(ROCK) activity in fibroblastic NIH3T3 cells and its presence i; | 2003 | 2018-05-13T18:21:14Z |
| Timely Activation of Budding Yeast APCCdh1 Involves Degradation of Its Inhibitor, Acm1, by an Unconventional Proteolytic Mechanism. | This article is from PLoS ONE , volume 9 . Abstract Regulated proteolysis mediated by the ubiquitin proteasome system is a fundamental and essential feature of the eukaryotic cell division cycle. Most proteins with cell cycle-regulated stability are targeted for degradation by one of two related ubiquitin ligases, the Skp1-cullin-F box protein (SCF) complex or the anaphase-promoting complex (APC). Here we describe an unconventional cell cycle-regulated proteolytic mechanism that acts on the Acm1 protein, an inhibitor of the APC activator Cdh1 in budding yeast. Although Acm1 can be recognized as a substrate by the Cdc20-activated APC (APCCdc20) in anaphase, APCCdc20 is neither necessary nor sufficient for complete Acm1 degradation at the end of mitosis. An APC-independent, but 26S proteasome-dependent, mechanism is sufficient for complete Acm1 clearance from late mitotic and G1 cells. Surprisingly, this mechanism appears distinct from the canonical ubiquitin targeting pathway, exhibitin; | 2014 | 2014-10-11T23:56:58Z |
| github.com-sindresorhus-awesome_-_2023-10-26_11-42-32 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-26T13:33:54Z |
| ajcvvg | cp, bgv j! fyefjkye wvmefv, jjg wvlgoc yvkwljyg, wvwe v fvfvgj wvqlpjvgg!f gv rgv qgweggvj bgvkegvj wkwjwegvwe kjgl gebvgejg gjkgvcv gewwlcegg. fvjjg, qlpjse b ajcvvgj vmsebvg kjgl vg jcv… cdk… sjlgfwjcjwjc? cwlgg jj, bjlvbvj qkvye jqgg ypfe wwvkjgvgg! bjfg, fpwebgj fvljgv qgwefegg!debwvle gej meyvgbvl tyvlpdebwvle b ajcvvg bqgpwvl… | | 2024-05-26T13:59:51Z |
| The ironic temper: Anatole France and his time | | 1932 | 2024-01-12T07:23:21Z |
| Cierra la Puerta | Tracklist: 1. Cierra la Puerta 2. Una Copa Mas 3. Paloma Begra 4. Ahora Por Idea 5. Mi Sufrir 6. Anselma 7. Mi Dia de Suerte 8. Imelda 9. Que Dolor 10. El Ronquidito | 2001 | 2024-07-11T12:56:48Z |
| Faust : drame fantastique en cinq actes, quatorze tableaux | 25 p. ; 31 cm // "Représenté pour la première fois, à Paris, sur le Théâtre de la Porte-Saint-Martin, le 27 septembre 1856." | 1912 | 2023-08-09T19:28:32Z |
| github.com-sindresorhus-awesome_-_2021-12-29_16-51-20 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-29T23:33:05Z |
| [CDK 024] Dextroid | Dexter is a Game Boy musician straight outta Southampton, and he’s decided to grace CDKr with his debut album – a pretty intense 15 tracks of musical fun! He’s definitely a chipmusician going places, don’t be surprised to see this guy making it MASSEEV in chiptune, fo sho. | 2008 | 2019-12-07T00:28:52Z |
| DTIC ADA429736: TGF-Beta Resistance in Breast Cancer | Transforming growth factor-Beta (TGF-Beta) potently inhibits cell proliferation by causing cell cycle arrest at the Gl phase. Smad proteins mediate the TGF-Beta antiproliferative responses by regulating the expression of several cell cycle components. We have recently discovered that Smad3, a key Smad protein for the TGF-Beta antiproliferative responses, is a major physiological substrate for cyclin-dependent kinases CDK4 and cDK2. Except for the Rb family members, Smad3 is the only cDK4 substrate demonstrated so far. CDK phosphorylation of Smad3 inhibits its transcriptional activity and antiproliferative function. Since cyclin Dl that activates CDK4 and the related cDK6 is amplified or overexpressed in a high percentage of human breast cancers, we examined whether Smad3 is highly phosphorylated by CDK in breast cancers. Using primary human breast cancer tissue microarrays and a phosphopeptide antibody against a CDK phosphorylation site in Smad3, we have found that overexpression of cy; | 2004 | 2018-05-22T14:32:34Z |
| DR. IDA - THE INSPIRING STORY OF DR. IDA SCUDDER, FIFTY YEARS A MEDICAL MISSIONARY IN INDIA. | | 1959 | 2023-12-29T19:48:32Z |
| Capillary Gas Chromatography in Essential Oil Analysis | | 1987 | 2023-12-22T14:00:41Z |
| West Hollywood Movers.pdf (PDFy mirror) | This public document was automatically mirrored from PDFy . Original filename: West Hollywood Movers.pdf URL: https://pdf.yt/d/M2VcwciF_cdk_IN4 Upload date: November 18, 2014 09:52:26 | 2014 | 2014-11-18T10:00:35Z |
| [CDK 056] Steady C - He Started It | [CDK 056] Steady C - He Started It | 2011 | 2020-01-05T21:08:08Z |
| [CDK 059] Cerebral Scars - Northern Dancing Town | [CDK 059] Cerebral Scars - Northern Dancing Town | 2012 | 2020-01-05T21:30:32Z |
| [CDK 009] Generate | Finnish chiptuner Nestroyer is going through somewhat of a music ‘purple patch’ at the moment, and CDK Records are honoured to host his latest set of tunes. A top collection of tunes, so good Timbaland might even nick ’em! Let’s hope not though. | 2008 | 2019-12-06T21:26:46Z |
| [CDK 016] Flappiest Bits | Awww hells yeah! Jellica, the UK’s answer to goto80 (and IMO, the most underrated chiptuner in the country) kindly gives CDKr his ‘Flappiest Bits’ – an album which is similar to a wedding. How come? As there’s something old, something new, something borrowed, and something blue! (Some old tracks, some new tracks, a few covers and Pull My Nipples Hard , fact fans) Anyway, away with the awful analogies, just kick back and enjoy some fantastic chiptunes ‘n’ VST tracks! And if you like it, purchase his forthcoming miniCD from RetinaScan! The artwork for this is from the supremely talented Raquel Meyers , who also did the fantastic video for Jellica’s “I wld di 4 u” cover . Jellica also runs the UK’s second best chiptune weblabel (after CDKr of course ^_^), Kittenrock ! It’s down at the moment, and more’s the pity. Kittenrock and CDKr are also releasing a split CD-R soon, hopefully before the year is out! | 2008 | 2019-12-06T23:30:08Z |
| Check-List of Birds of the World. Volume IV | | 1940 | 2023-07-29T08:55:41Z |
| The Early theory of equations : on their nature and constitution : translations of three treatises | 218 p. ; 23 cm // On the recognition of equations / by François Viète -- A new discovery in algebra / by Albert Girard -- On the nature and constitution of equations / by Florimond de Beaune | 1986 | 2023-12-22T11:17:45Z |
| github.com-sindresorhus-awesome_-_2022-01-21_04-06-07 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-21T12:39:20Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-07T09:45:28Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| github.com-angular-components_-_2021-09-01_20-08-54 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-09-01T21:39:39Z |
| Commissioner Sullivan message to Clatsop County April 22 | | 2020 | 2022-10-14T13:47:04Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_02-24-10 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-05T12:18:54Z |
| The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells. | This article is from Cell Division , volume 8 . Abstract Background: Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that β-adrenergic receptors (β-ARs) may play an important role in the pathogenesis of IH. Results: In the present study, we investigated the β-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both β1- and β2-ARs were expressed in HemECs. Stimulation of the β-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was a; | 2013 | 2014-10-29T13:12:50Z |
| Graphs with Diameter $n-e$ Minimizing the Spectral Radius | The spectral radius $\rho(G)$ of a graph $G$ is the largest eigenvalue of its adjacency matrix $A(G)$. For a fixed integer $e\ge 1$, let $G^{min}_{n,n-e}$ be a graph with minimal spectral radius among all connected graphs on $n$ vertices with diameter $n-e$. Let $P_{n_1,n_2,...,n_t,p}^{m_1,m_2,...,m_t}$ be a tree obtained from a path of $p$ vertices ($0 \sim 1 \sim 2 \sim ... \sim (p-1)$) by linking one pendant path $P_{n_i}$ at $m_i$ for each $i\in\{1,2,...,t\}$. For $e=1,2,3,4,5$, $G^{min}_{n,n-e}$ were determined in the literature. Cioab\v{a}-van Dam-Koolen-Lee \cite{CDK} conjectured for fixed $e\geq 6$, $G^{min}_{n,n-e}$ is in the family ${\cal P}_{n,e}=\{P_{2,1,...1,2,n-e+1}^{2,m_2,...,m_{e-4},n-e-2}\mid 2 | 2011 | 2013-09-23T15:53:26Z |
| DTIC ADA388443: Development and Use of Novel Tools to Directly Screen for Substrates of Cyclin Dependent Kinases | The aim of this research is to gain further insights into the means by which cell proliferation is controlled by cyclin dependent kinases. To this end, a screen has been carried out for proteins that interact with the budding yeast cdk, Cdc28. 10 novel interacting proteins have been identified in a two-hybrid screen using a Gal4/Cdc28 fusion as the bait. Several of the putative interacting proteins have been shown to interact with specific cyclin-Cdc28 kinase complexes. For each of the 10 two-hybrid positives the nature of the Cdc28 interaction is currently being determined by biochemical means. The functional difference between cyclins in their abilities to induce and repress transcription has been investigated using the genomic technology of microarrays. In addition, the complete set of cell cycle regulated genes in yeast has been defined. This work has now been published (MBC 9:3273-3297 1998), and a full description and complete data sets are available on a public website at http:/; | 2000 | 2018-05-01T07:37:13Z |