| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| Linea Dorada | Tracklist: 1. El numero uno 2. La camioneta gris 3. La bronco negra 4. Chico Fuentes 5. Setecientas libras 6. Doctor Fonseca 7. Juan Ramos 8. Rosita la morena 9. Crimen en Chihuahua 10. La entallada 11. Gumaro Vazquez 12. Candido Rodriguez 13. El culichi 14. Esperanza Valero 15. Pedro Paez 16. Los traficantes 17. La ley del contrabandista 18. Los dos contrabandistas 19. El aguila real 20. El corrido de Gabino | 2002 | 2024-11-21T12:12:01Z |
| Musica Para La Raza, Vol.9 | Tracklist: 1. Carinito de Mi Vida 2. Sabiendo Quien Era Yo 3. Dijiste y Juraste 4. Te Aplacas o Te Aplaco 5. Tuve Una Novia 6. Tu Delirio 7. Dos Mujeres 8. Vamonos 9. Alta y Delgadita 10. La Fe Perdida 11. No Me Vuelvo A Enamorar 12. Que Sabes Tu | 2001 | 2024-11-26T05:52:03Z |
| The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. | This article is from Nucleic Acids Research , volume 40 . Abstract The protein arginine methyltransferase 6 (PRMT6) is a coregulator of gene expression and executes its repressing as well as activating function by asymmetric dimethylation of histone H3 at R2 (H3 R2me2a). Given that elevated expression levels of PRMT6 have been reported in various cancer types, we explore here its role in cell proliferation and senescence. We find that knockdown of PRMT6 results in proliferation defects of transformed as well as non-transformed cells, causes G1-phase arrest and induces senescence. This phenotype is accompanied by transcriptional upregulation of important cell cycle regulators, most prominently the cyclin-dependent kinase (CDK) inhibitor gene p21 (p21CIP1/WAF1, CDKN1A) and p16 (p16INK4A, CDKN2A). Chromatin immuno-precipitation analysis reveals that the p21 gene is a direct target of PRMT6 and the corresponding histone mark H3 R2me2a. Using a cell model of oncogene-induced senescence (OIS; | 2012 | 2014-10-28T05:36:50Z |
| So It Seemed (Autobiography of a newspaper editor & publisher) | | 1952 | 2023-12-21T19:12:59Z |
| Docking studies for screening anticancer compounds of Azadirachta indica using Saccharomyces cerevisiae as model system. | This article is from Journal of Natural Science, Biology, and Medicine , volume 5 . Abstract Introduction:: Plants have a long history of use in the treatment of cancer. Plant-derived compounds have played an important role in the development of several clinically useful anticancer agents. In the recent years, more emphasis has been placed on identifying plant-derived compounds that can be used as an effective treatment for life-threatening diseases such as cancer. Cancer is a disease where there is abnormal cell proliferation. The proliferation of the cancer cells are restrained by cdk/cyclin complexes, which control the normal process of cell cycle. Materials and Method:: The current study involves the investigation of the anticancer property of the chemical compounds present in the leaves of Azadirachta indica by performing docking studies with the cell cycle control protein using Arguslab. Result:: The compounds were docked with the cdk1 protein to identify suitable inhibitors agai; | 2014 | 2014-10-24T01:23:37Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| CIA Reading Room cia-rdp84b00148r000100370001-5: OEXA RECORDS MANAGEMENT | Charles E. Wilson Chief, Public Affairs Division OEXA Records Management 1. Action Requested: Transfer primary PAD records management responsibility to OEXA Registry. 2. Background: Since PA ceased to exist as an Independent Office and became a Division in OEXA, PAD has nevertheless retained a Records Management Officer (RMO) and primary responsibility for this function. Since this is normally a Registry function, we are probably overdue in transferring it. I understand the OEXA Registry is already RMO for LLD. It seems to me that in a perfect world PAD would retain day-to-day maintenance of its decentralized files, but the Registry would assume responsi- bility for such things as reporting annual volume surveys, maintaining file retirement schedules, file renumbering projects, and the like. 3. Recommendation: Request OEXA Administrative Officer's assistance in establishing the Chief, OEXA Registry as RMO for all of OEXA and in transferring PAD's responsibility. We are prepared to assi; | 1982 | 2025-02-19T12:51:25Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells. | This article is from BMC Cancer , volume 14 . Abstract Background: Pancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence, the search for more effective anti-pancreatic cancer agents is urgent. Methods: PaTu8988 pancreatic cancer cells were treated with different concentrations of suberoylanilide hydroxamic acid (SAHA), cell survival, proliferation, migration and vasculogenic mimicry (VM) were analyzed. Associated signaling changes were also analyzed by RT-PCR and Western blots. Results: Here, we reported that SAHA, a histone deacetylase inhibitor (HDACi), exerted significant inhibitory efficiency against pancreatic cancer cell survival, proliferation, migration and VM. SAHA dose-dependently inhibited PaTu8988 pancreatic cancer cell growth with the IC-50 of 3.4 ± 0. 7 μM. Meanwhile, SAHA suppressed PaTu8988 cell cycle progression through inducing G2/M arrest, which was associated with cyclin-dependent kinase 1 (CDK-1)/; | 2014 | 2014-10-21T20:47:25Z |
| Death is a silent room | | 1965 | 2023-08-29T22:36:40Z |
| sinceretheory.podcast_v1.3 | 01 I've switched to Mac, goodbye Windows. The Bluescreen is going through reorganization. What is Google Pack? 02 Louis Braille's birthday Download File List iPod with WiFi 03 Flickr: "2.5.8." by powerbooktrance (license) Music: CDK - Midnight Bliss (Green Dub Mix) (license) I'm a little upset about del.icio.us being swooped by Yahoo! | | 2006-01-05T18:47:03Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| Het Utrechts Archief 807733 | Het Utrechts Archief catalog number: 807733 Description (Dutch): Afbeelding van de CDk-bak van het ontspoorde electrische treinstel nr. 302 (mat. 1940) van de N.S. bij de spoorbrug over de Haven te Maassluis. | 1956 | 2021-02-26T01:03:42Z |
| Clave Azul | Tracklist: 1. Lamberto Quintero 2. Pedro Aviles 3. Los Gallos de Sinaloa 4. El Corrido de Guasave 5. Ruben Cabada 6. Catarino y los Rurales 7. El Prieto "Crispin" 8. Cornelio Vage 9. El Contrabando de Nogales 10. Rosendo G. Castro | 2001 | 2024-12-13T11:33:31Z |
| Formula Sports Cars, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-07-01T09:06:32Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| Persuading science : the art of scientific rhetoric | xi, 212 p. : 24 cm // Includes bibliographical references and index | 1991 | 2023-12-23T17:00:10Z |
| github.com-localstack-localstack_-_2022-11-12_23-39-58 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-13T09:19:09Z |
| Pathfinders in Medicine. | | 1929 | 2023-12-22T15:43:03Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| github.com-debezium-debezium_-_2021-12-10_11-35-09 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-10T12:09:39Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| github.com-dabit3-awesome-aws-amplify_-_2021-02-13_23-48-59 | Curated list of AWS Amplify Resources Awesome AWS Amplify curates the best AWS Amplify, tools, tutorials, articles and more. PRs are welcome! Check out the Amplify Discord server Getting Started Github Documentation Workshops Serverless GraphQL API with AppSync and DynamoDB AWS Amplify Photo Sharing Workshop Next.js AWS Amplify Workshop Building real-time applications with React, GraphQL & AWS AppSync Building Mobile Applications with React Native & AWS Amplify AWS Amplify UnicornFlix Workshop (Video on Demand) AWS Amplify UnicornTrivia Workshop (Live streaming video) Tutorials - Blogs & tutorials General blogs & tutorials Full Stack Cloud Development with AWS Amplify TensorFlow.js + AWS Amplify 10 Minute Tutorial: Creating a Serverless Express Web Server & API ⚡️ 10 Ways to Use Serverless Functions Real quick GraphQL service with AWS Amplify & Appsync Visualizing Focus with Neurosity's Notion and AWS Amplify Build a Music Sharing App with Amazon S3 and AWS Amplify Introducing Conf; | 2021 | 2021-02-22T13:28:20Z |
| cuu-dinh-ky | | | 2024-04-09T14:17:26Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T21:59:48Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| DTIC ADA389310: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | The periodicity of CDK activity provides the molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins has been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with another multigene family of evolutionarily conserved proteins, the ROC/APC11 family, to form a complex that contains E3 ubiquitin ligase activity. We have show; | 2000 | 2018-05-01T22:46:59Z |
| [CDK 023] Urban Bits | The second of CDKr’s Hip Hop themed compilations – this one is a covers filled release, with tracks from Combat Dave, Josstin Timberlake, Oxygenstar and more! Covers include tracks by Jay Z, KanYe West, Hurricane Chris and loads of others too. The artwork is by the supremely talented Sir Count Ville Von Konttinen III esq (AKA KeFF) – thanks for that mate! The full tracklist is after the jump! | 2008 | 2019-12-07T00:23:58Z |
| Dante the Central Man of All the World | | 1922 | 2023-08-10T02:07:56Z |
| coderedfm27062020 | your weekly drum&bass radioshow outta stuttgart / germany | | 2020-06-28T15:02:26Z |
| FReeKS014: Make Rave Not Hate Stays Drum'n' Bass | Make Rave, not Hate stays Drum'n'Bass! In this show our Radio DJ Robb plays an one hour Drum'n'Bass-Set – strictly Open Music found on the Netaudio Platform ccMixter . In addition we also have some radio information for our German and Rhein-Neckar based listeners. Playlist Apoxode – Escape from Mars 180 Blake – Jack Frost Analog By Nature – Don't go (RumbleStep Mix) Analog By Nature – If God Was Sleeping (cdk Mix) Analog By Nature – Loveshadow - You Made It Up ^ (cdk Mix) Abstract Audio – Dorst Blake – I know your voice spinningmerkaba – Reusenoise (DNB Mix) Abstract Audio – CCMixter (We are not evil) Scott Altham – I got the rhymes (Electric Fish Mix) Alex – Dancing Like A Maniac bangcorrupt – Freedom Analog By Nature – Time (cdk Give Me Some Dubstep Extended Mix) Abstract Audio – Dinosaur Bones Apoxode – Crystal Clear 180 | 2020 | 2020-07-22T21:25:21Z |
| Jay Kay Collision Center, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-06-27T09:15:55Z |
| github.com-angular-components_-_2019-11-09_08-00-19 | Component infrastructure and Material Design components for Angular Components and Material Design for Angular This is the home for the Angular team's UI components built for and with Angular.These include Material Design components and the Angular Component Development Kit (CDK). Quick links Documentation, demos, and guides | Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if you're building your first project with Angular Material. Check out our directory of design documents for more insight into our process. If you'd like to contribute, you must follow our contributing guidelines .You can look through the GitHub issues (which should be up-to-date on who is working on which featuresand which pieces are blocked) and make a comment. Please see our help wanted label for a list of issues where we could use help from the community. High level stuff planned for Q4 2019 (Oct - Nov): Remove dependency on HammerJS Finish remaining test harnesses; | 2019 | 2019-11-09T10:02:31Z |
| Bedienungsanleitung/Garantie CDK 676 Sing Along CD | | | 2021-05-16T13:06:38Z |
| github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-15_19-09-44 | Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ; | 2021 | 2021-01-16T03:16:22Z |
| Het bericht ‘CdK haalt ongemeen fel uit naar de NAM’ | This document is issued on date 2015-05-27. | 2015 | 2018-03-14T20:02:09Z |
| Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. | This article is from Biomolecules & Therapeutics , volume 20 . Abstract Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents. In recent years, a number of structurally diverse HDAC inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. However, the underlying molecular mechanisms remain unclear. This study aimed at investigating the anti-tumor activity of various HDAC inhibitors, IN-2001, using T47D human breast cancer cells. Moreover, the possible mechanism by which HDAC inhibitors exhibit anti-tumor activity was also explored. In estrogen receptor positive T47D cells, IN-2001, HDAC inhibitor showed anti-proliferative effects in dose-and time-dependent manner. In T47D human breast cancer; | 2011 | 2014-10-24T20:14:53Z |
| Re-thinking cell cycle regulators: the cross-talk with metabolism. | This article is from Frontiers in Oncology , volume 3 . Abstract Analysis of genetically engineered mice deficient in cell cycle regulators, including E2F1, cdk4, and pRB, showed that the major phenotypes are metabolic perturbations. These key cell cycle regulators contribute to lipid synthesis, glucose production, insulin secretion, and glycolytic metabolism. It has been shown that deregulation of these pathways can lead to metabolic perturbations and related metabolic diseases, such as obesity and type II diabetes. The cyclin–cdk–Rb–E2F1 pathway regulates adipogenesis in addition to its well-described roles in cell cycle regulation and cancer. It was also shown that E2F1 directly participates in the regulation of pancreatic growth and function. Similarly, cyclin D3, cdk4, and cdk9 are also adipogenic factors with strong effects on whole organism metabolism. These examples support the emerging notion that cell cycle regulatory proteins also modulate metabolic processes. These ce; | 2013 | 2014-10-28T16:47:52Z |
| Programming Visual Basic for Palm OS | xvi, 406 p. : 23 cm // Includes index // Programming with AppForge -- Palm Software -- Main Features of AppForge -- Installing AppForge -- Using AppForge -- Application Development -- User Interface Design -- Basic Application Layout Example -- Language and Libraries Support -- Palm Database Programming -- The Palm Database -- AppForge PDB Library -- The AppForge Database Converter -- Data Connectivity -- Conduit Development -- Applications and Conduits -- Conduit Design -- Installing the CDK -- Nuts and Bolts -- Synchronization Logic -- Data Formats -- SQL Databases -- SQL Publishing -- Universal Conduit -- Web Clipping Applications -- Palm.Net Wireless Architecture -- Simple WCA Tour -- Building a Large Application -- Palm OS 4.0 -- Advanced Topics -- Operating System Access -- Fuser Mechanics -- A Data Encryption Program -- Shared Libraries -- Memory Concepts -- Memory Management Functions -- DBSLib Shared Library -- DBSLib Driver Application -- DBSLib Fuser -- AppForge Driver Appli; | 2002 | 2023-07-12T13:15:57Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_17-00-30 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-06T00:37:52Z |