| Title | Description | Published | Added |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| In re: Dealer Management Systems Antitrust Litig. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-03-22T17:58:37Z |
| Mahatma Gandhi | | 2012 | 2024-01-04T12:38:14Z |
| The King of Fighters 2002: (BR) K-RND CEARA vs(BR) [CDK]-Shaka - 2022-11-29 13:17:50 | (BR) K-RND CEARA vs (BR) [CDK]-Shaka - 2022-11-29 13:17:50 Fightcade replay id: 1669727870043-5314 #fightcade #kof2002 #[CDK]-Shaka #K-RNDCEARA For more videos check out: https://fightcadevids.com | | 2023-01-21T17:36:39Z |
| Lawyer Says Bin Laden Did Not Orchestrate 9/11 | Al-Qaeda leader never claimed responsibility for attack, Van de Wiel tells Australian Supreme Court Paul Joseph Watson Prison Planet Thursday, February 28th, 2008 Skepticism towards the 9/11 official story reached the Australian Supreme Court this week after a lawyer asserted that the attacks were not orchestrated by Osama bin Laden during the trial of an alleged terror group in Melbourne. "To say that this was all orchestrated by Osama bin Laden is a silly thing to do. He's never claimed responsibility for it," Remy van de Wiel QC told the Australian jury. Full Story Here: http://prisonplanet.com/articles/february2008/022808_bin_laden.htm | 2008 | 2024-05-09T20:01:58Z |
| The Hindu-Arabic numerals | | 1990 | 2024-01-10T08:39:12Z |
| Indian rubber man | | 1939 | 2025-09-09T22:39:54Z |
| Nov 04 2025 Town meeting | | 2025 | 2025-11-06T13:34:51Z |
| Not Every Workstation Is Built For Rendering. | Not Every Workstation Is Built For Rendering. Some Are Built To Create Experiences. This CDK Radiant Series System Was Developed For Real-time Unreal Engine Architectural Presentations, Enabling Real Estate Developers To Showcase Projects Through Smooth Interactive Walkthroughs. With The RTX 4090 At Its Core, The System Ensures Fluid Navigation Through Complex Environments, Delivering A Seamless And Immersive Experience For Clients And Stakeholders. Custom Built By CDK. 📞 +91 92707 66589 🌐 www.designsbykira.In #cdkworkstations #unrealengine #realtimevisualization #architecturevisualization | | 2026-04-09T09:41:51Z |
| Analytical Geometry | | 1980 | 2023-12-22T12:13:27Z |
| DTIC ADA384004: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal and Tumorigenic Human Breast Cells | Sequential activation and inactivation of cyclin dependent kinases (CDK) regulate eukaryotic cell cycle transitions. The periodicity of CDK activity provides a molecular basis for unidirectional cell cycle progression and is partly controlled by ubiquitin-mediated proteolysis of both cyclins and CDK inhibitors. Deregulated expression of G1 CDK inhibitors and G1 cyclins have been directly linked to breast cancer development. The mechanisms regulating the ubiquitination of these two protein families constitute essential components of G1 cell cycle control in mammalian cells, but they are poorly understood at present. Polyubiquitination of proteins is known to be catalyzed by a cascade of enzymes: El (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligating). Two issues critical to our understanding of the regulation of protein turnover are how E3 ligases target proteins for ubiquitination and how they themselves are regulated. We have found that cullins partner with ; | 1999 | 2018-04-30T00:33:35Z |
| Ebank Trademark Video 2 | Ebank ® company video music of song attributed to, Download the music in this video, this one song at, ccmixter.org/files/cdk/17432 To learn more about the creator and owner of this song go to the following link, this song used in Creative Commons License, "Silence Await" by cdk ccmixter.org/files/cdk/17432 | 2016 | 2016-09-30T21:51:44Z |
| 1998-04-30 PCWJUL98 | [541M 1998-04-30] . ├── [ 41 1996-07-01] AUTORUN.INF ├── [ 308 1996-07-04] CATMPC.TRS ├── [ 99 1996-07-04] CDID.TRS ├── [ 36K 1996-02-19] CYRIL1.TTF ├── [ 13M 1998-04-30] DXRS │ ├── [ 20K 1997-03-03] ASK32.EXE │ ├── [261K 1998-04-30] CDXPCW07.DXR │ ├── [ 63K 1997-06-20] COPY.EXE │ ├── [ 63K 1997-06-26] COPYSL.EXE │ ├── [ 18K 1994-12-21] DLLGLUE.DLL │ ├── [ 397 1997-04-04] DUMMY.HTM │ ├── [ 1 1997-04-03] DUMMY.PDF │ ├── [374K 1998-04-30] FGAPCW07.DXR │ ├── [ 13K 1996-03-15] FILEIO.DLL │ ├── [ 20K 1997-03-03] FNAME32.DLL │ ├── [352K 1998-04-30] HANPCW07.DXR │ ├── [628K 1998-04-30] INTPCW07.DXR │ ├── [ 46K 1997-03-03] MASTRAPP.DLL │ ├── [ 42K 1998-04-30] MENUBAR.DXR │ ├── [ 31K 1998-04-28] PCW0798.V12 │ ├── [1.1M 1998-04-30] PCW16.EXE │ ├── [1.4M 1998-04-30] ; | 1998 | 2025-08-22T15:26:41Z |
| Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. | This article is from eLife , volume 3 . Abstract During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here that PP2A-B55 is the enzyme responsible for dephosphorylating pEndos during M phase exit. The kinetic parameters for PP2A-B55’s action on pEndos are orders of magnitude lower than those for CDK-phosphorylated substrates, suggesting a simple model for PP2A-B55 regulation that we call inhibition by unfair competition. As the name suggests, during M phase PP2A-B55’s attention is diverted to pEndos, which binds much more avidly and is dephosphorylated more slowly than other substrates. When Gwl is inactivated during the M phase-to-interphase transition, the dynamic balance changes: pEndos dephosphorylated by PP2A-B55 cannot be replaced, so the phosphatase can refocus its attention on CDK-phospho; | 2014 | 2014-10-23T20:21:36Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| Loop LLC v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-10-07T16:05:38Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| The role of ?-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells. | This article is from Cell Division , volume 8 . Abstract Background: Infantile hemangioma (IH) is a benign vascular neoplasm that arises from the abnormal proliferation of endothelial cells and enhanced angiogenesis. Recently, propranolol has been found to be effective in the management of IH, suggesting that β-adrenergic receptors (β-ARs) may play an important role in the pathogenesis of IH. Results: In the present study, we investigated the β-adrenergic signaling that is associated with hemangioma-derived endothelial cell (HemEC) proliferation. The results showed that both β1- and β2-ARs were expressed in HemECs. Stimulation of the β-ARs by isoprenaline induced cell proliferation and elevation of second messenger cAMP levels. The proliferation-promoting action of isoprenaline was abolished by a β1-selective antagonist and was more effectively abolished by a β2-selective antagonist; the mechanism for the action of the antagonists was a G0/G1 phase cell cycle arrest which was a; | 2013 | 2014-10-29T13:12:50Z |
| Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents. | This article is from Biochemical Journal , volume 446 . Abstract In the present paper, we report that mitosis is a key step in the cellular response to genotoxic agents in human cells. Cells with damaged DNA recruit γH2AX (phosphorylated histone H2AX), phosphorylate Chk1 (checkpoint kinase 1) and arrest in the G2-phase of the cell cycle. Strikingly, nearly all cells escape the DNA damage checkpoint and become rounded, by a mechanism that correlates with Chk1 dephosphorylation. The rounded cells are alive and in mitosis as measured by low phospho-Tyr15 Cdk1 (cyclin-dependent kinase 1), high Cdk activity, active Plk1 (Polo-like kinase 1) and high phospho-histone H3 signals. This phenomenon is independent of the type of DNA damage, but is dependent on pharmacologically relevant doses of genotoxicity. Entry into mitosis is likely to be caused by checkpoint adaptation, and the HT-29 cell-based model provides a powerful experimental system in which to explore its molecular basis. We propose; | 2012 | 2014-10-24T08:13:53Z |
| Pride Flag Raised in Silver Spring | Montgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 995 | 2022 | 2022-06-02T01:32:19Z |
| DTIC ADA412764: Use P27KIP1 Degradation for Breast Cancer Diagnosis and Therapy | P27 IS A CDK inhibitor that controls the Gl/S transition. Low or absent expression of p27 has been observed in many malignant tumors including breast cancer. SCF(SKP2) is a ubiquitin E3 ligase that interacts and targets p27 for ubiquitin-dependent proteolysis. One aim of the proposal is to determine whether there is an inverse relationship between SCF(SKP2) and p27 in breast cancer and the experiments are in progress. Another aim is to determine the domain on SKP2 that binds to p27. We have determined the carboxy-terminal region of SKP2 is required for binds to phosphorylated p27. The critical aim is to determine whether inhibition of SCF(SKP2) in breast cancer cells causes cell cycle arrest. Our studies suggest that inhibition of SCF(SKP2) in breast cancer and other cancer cells causes accumulation of p27 and Gi cell cycle block. Thus SCF(SKP2) may be used as a target for breast cancer therapy. | 2002 | 2018-05-12T16:38:48Z |
| DTIC ADA323678: General Methods for Identifying G1-Phase Substrates of Cdk Protein Kinases. | We are using two-dimensional gels in combination with genetic and biochemical techniques to identify G1-phase substrates of cyclin-Cdk complexes. We have optimized protocols for labeling proteins with 32P prior to two-dimensional gel electrophoresis. So far, we have successfully identified one important in vivo substrate, Sic1. We have characterized Sic1, and have shown that phosphorylation of Sic1 by cyclin-Cdk complexes promotes DNA synthesis in yeast. We have made peptide antigens for the purpose of making antibodies against phosphorylated Cdk substrates. Mice have been immunized; their sera are positive; and fusions for monoclonal antibodies are about to be done. | 1996 | 2018-04-05T02:36:00Z |
| Herpes Simplex Virus 1 (HSV-1) ICP22 Protein Directly Interacts with Cyclin-Dependent Kinase (CDK)9 to Inhibit RNA Polymerase II Transcription Elongation. | This article is from PLoS ONE , volume 9 . Abstract The Herpes Simplex Virus 1 (HSV-1)-encoded ICP22 protein plays an important role in viral infection and affects expression of host cell genes. ICP22 is known to reduce the global level of serine (Ser)2 phosphorylation of the Tyr1Ser2Pro3Thr4Ser5Pro6Ser7 heptapeptide repeats comprising the carboxy-terminal domain (CTD) of the large subunit of RNA polymerase (pol) II. Accordingly, ICP22 is thought to associate with and inhibit the activity of the positive-transcription elongation factor b (P-TEFb) pol II CTD Ser2 kinase. We show here that ICP22 causes loss of CTD Ser2 phosphorylation from pol II engaged in transcription of protein-coding genes following ectopic expression in HeLa cells and that recombinant ICP22 interacts with the CDK9 subunit of recombinant P-TEFb. ICP22 also interacts with pol II in vitro. Residues 193 to 256 of ICP22 are sufficient for interaction with CDK9 and inhibition of pol II CTD Ser2 phosphorylation but do not; | 2014 | 2014-10-01T20:40:34Z |
| CDK-120 | | | 2021-04-17T01:59:16Z |
| Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. | This article is from Cell Cycle , volume 11 . Abstract The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with its enhanced potency previously observed in a variety of human cancer cell lines. More importantly, in vivo MRI and single voxel proton MR-Spectroscopy further established that VMY-1-103 ; | 2012 | 2014-10-26T21:07:18Z |
| Protein kinase C signaling and cell cycle regulation. | This article is from Frontiers in Immunology , volume 3 . Abstract A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about 30 years. However, despite the wealth of information on PKC-mediated control of, T cell activation, understanding of the effects of PKCs on the cell cycle machinery in this cell type remains limited. Studies in other systems have revealed important cell cycle-specific effects of PKC signaling that can either positively or negatively impact proliferation. The outcome of PKC activation is highly context-dependent, with the precise cell cycle target(s) and overall effects determined by the specific isozyme involved, the timing of PKC activation, the cell type, and the signaling environment. Although PKCs can regulate all stages of the cell cycle, they appear to predominantly affect G0/G1 and G2. PKCs can modulate multiple cell cycle regulatory molecules, including cyclins, cyclin-dependent kin; | 2013 | 2014-10-28T20:08:08Z |
| yahoo-groups-2018-03-04T05-55-15Z-98b2c9 | Yahoo! Groups API grab. Contains messages of the following groups: a2vd9699 aamfaculty abcajuniors aeradosextremos algona57reunion alumnis_ecuador amc_akkb arch_group_hau artedoinconsciente ascofbcstockdog atownaza156_board-mail auditorias_pb bagma2007 bailoutrobinhoodhackerhoffacker baiturrahman-pq bambizamfir bayarea_women_hikers bdwettersanon bilisim-msce bjug boymillionlinkproject bsf_modelhorses buufgs cachildhoodinteraction carnivallibertyclub casculptorssymposium cbadcoalition cdk_beed chefsinptists choas666 collage_mnc com107_sectionc coordinadoraongsespanolasmarruecos coppiaverabdsm cppmecha cwhspurplemartins d05k46hut dbasworld democracia_radical descriptivogrupoii dibbydog diretoriadotuba dotnet_dev eaa486 eaemba eastregcong06_08 ech_iam enetilah_3ro_3ra_cse_1981 enrique_hot esayan_1895 esdecedi espanol101-spanishonline ess_06 ex_honda_malaysia fbf_leadership filmandoesamujer fmsfinest foam_pfo folkschoolstlouis forcedshearing friday_nights_lights_onnbc-rpg gaurang1235 ggil2; | | 2018-03-04T05:55:23Z |
| Handbook of Paleontology for Beginners and Amateurs: The Fossils, Part 1 | | 1965 | 2023-08-09T06:02:18Z |
| CDK-8 Platform Board | | | 2021-03-01T05:29:25Z |
| github.com-localstack-localstack_-_2021-11-18_13-41-48 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Run • Configure • Play – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment.With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider!Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services,LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more!The Pro version of LocalStack supports additional APIs and advanced features.You c; | 2021 | 2021-11-18T13:56:44Z |
| github.com-duo-labs-cloudmapper_-_2019-12-18_01-58-27 | CloudMapper helps you analyze your Amazon Web Services (AWS) environments. CloudMapper CloudMapper helps you analyze your Amazon Web Services (AWS) environments. The original purpose was to generate network diagrams and display them in your browser. It now contains much more functionality, including auditing for security issues. Network mapping demo Report demo Intro post Post to show spotting misconfigurations in networks Post on performing continuous auditing Commands audit : Check for potential misconfigurations. collect : Collect metadata about an account. More details here . find_admins : Look at IAM policies to identify admin users and roles, or principals with specific privileges. More details here . find_unused : Look for unused resources in the account. Finds unused Security Groups, Elastic IPs, network interfaces, volumes and elastic load balancers. prepare / webserver : See Network Visualizations public : Find public hosts and port ranges. More details here . sg_ips : Get ge; | 2019 | 2019-12-29T21:52:58Z |
| github.com-sindresorhus-awesome_-_2021-10-02_04-49-15 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2021 | 2021-10-02T15:21:09Z |
| github.com-sindresorhus-awesome_-_2022-01-23_12-29-31 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-23T13:31:49Z |
| github.com-sindresorhus-awesome_-_2023-10-26_15-42-21 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-27T01:55:02Z |
| github.com-sindresorhus-awesome_-_2026-03-09_07-59-57 | 😎 Awesome lists about all kinds of interesting topics Check out my macOS app Supercharge Elevate your Mac experience My open source work is supported by the community Special thanks to: Effortless backends with infrastructure from code An open-source framework that supports any programming language, cloud provider, or deployment automation tool. Wispr Flow Talk to code, stay in the Flow. Flow is built for devs who live in their tools. Speak and give more context, get better results. Fast remote container builds and GitHub Actions runners. What is an awesome list? Contribution guide Creating a list Twitter Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentrali; | 2026 | 2026-03-11T17:33:52Z |
| Gaudenzio Ferrari, (The great masters in painting and sculpture) | | 1904 | 2024-01-12T07:49:39Z |
| github.com-awslabs-aws-cdk_-_2019-07-04_08-54-12 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation.The CDK integrates fully with AWS services and offers a higher level object-orientedabstraction to define AWS resources imperatively. Using the CDK’s library ofinfrastructure [constructs], you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. TheCDK improves the end-to-end development experience because you get to use the powerof modern programming languages to define your AWS infrastructure in a predictableand efficient manner. The following languages are currently supported: JavaScript, TypeScript Python Java .NET The CDK is currently in developer preview and we look forward to community feedback and collaboration!; | 2019 | 2019-07-04T09:05:48Z |
| github.com-DovAmir-awesome-design-patterns_-_2021-07-10_17-58-07 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Books Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns ca; | 2021 | 2021-09-22T22:10:51Z |
| github.com-sindresorhus-awesome_-_2021-12-26_03-21-28 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-26T22:03:58Z |
| github.com-sindresorhus-awesome_-_2023-05-14_15-35-37 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Today Quickly view your schedule in the macOS menu bar My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Paperwork that makes the data work. Easy APIs for paperwork. PDF generation, e-signature and embeddable no-code webforms. The easiest way to build paperwork automation into your product. Paperwork that makes the data work. E; | 2023 | 2023-05-14T17:50:28Z |
| github.com-sindresorhus-awesome_-_2023-10-24_23-57-20 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-25T11:07:00Z |
| Soil and freshwater niematodes | | 1951 | 2025-09-08T04:35:20Z |
| miR-449a and CDK6 in gastric carcinoma. | This article is from Oncology Letters , volume 8 . Abstract The present study aimed to identify the association between microRNA (miR/miRNA)-449a, the cyclin-dependent kinase (CDK)6 protein and gastric carcinoma, and discuss the effect of miR-449a on the expression of the CDK6 protein. Quantitative (q)PCR and western blot analysis were used to analyze the expression of the miR-449a and the CDK6 protein in gastric carcinoma and tumor-adjacent normal tissues. The real-time cell analyzer and the DAPI staining test were used to monitor the different miR-449a levels regulating the proliferation and apoptosis of the MGC-803 cell line. Immunofluorescence and western blot analyses were used to detect the expression level of the CDK6 protein in the cells of the miR-449a upregulation and downregulation groups, and a control group. A scratch test was used to study the effects of miR-449a expression on migration and invasion. It was found that the expression of miR-449a was downregulated and the e; | 2014 | 2014-10-04T11:07:24Z |
| Soapbox 1396: Canines for Disabled Kids | WCCA TV Executive Director Mauro DePasquale interviews Kristin Hartness, Executive Director of Canines for Disabled Kids. The organization supports the creation of child–canine service dog teams to promote independence and social awareness. Offering free services to families and communities across the United States, Canines for Disabled Kids helps connect children with the service dog that can best assist them in overcoming disabilities, while helping communities become welcoming and supportive of these special partnerships. Scholarships are offered to help cover training costs. Kristin explains what a service animal is, how CDK supports service dog partners and their communities, when kids should be considered for service dogs, and details the 5th Annual Rappel to raise awareness and funds on November 15 at 120 Front Street in Worcester. https://caninesforkids.org. Please support your local public access TV channel, WCCA TV, and keep shows like Soapbox on the air and in your homes. ; | 2025 | 2025-11-04T00:12:14Z |
| Overbrenging archieven Rijkstaken CdK naar het Historisch Centrum Overijssel | | 2015 | 2018-03-12T22:24:05Z |
| github.com-sindresorhus-awesome_-_2022-01-21_21-53-36 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-22T00:52:52Z |
| Ep 35: The Case of the Alleged Real-Life Gone Girl | A 29-year-old woman goes missing in Vallejo, California in 2015, and the details surrounding her disappearance are bizarre, to say the least. There are many things in this case that may surprise you and have you thinking that you know what's going on....until you don't. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music in this episode: Three kites circling by Axletree - http://freemusicarchive.org/music/Axletree/Cormorant_EP/Three_kites_circling a letter from doxent by Stefan Kartenberg - http://dig.ccmixter.org/files/JeffSpeed68/51322 Celestial Navigation by Blue Dot Sessions - http://freemusicarchive.org/music/Blue_Dot_Sessions/Aeronaut/Celestial_Navigation Someday I'll like you but before let me rest in my solitude (Lonely character's theme) by Komiku - http://freemusicarchive.o; | 2017 | 2023-05-31T20:57:33Z |
| Religion In Life - Season 6 Episode 4 | For more content and information about AppTV, visit www.watchapptv.com Religion in Life is a show that explores how faith and spirituality play an integral part in the world today. Ozzie Ostwalt, Ph.D., from the Department of Philosophy and Religion hosts the show and engages in discussion with panelists that range from professors, local religious leaders and spiritually engaged community members. | 2017 | 2023-03-30T17:28:36Z |
| The Old Architecture of Quebec | | 1947 | 2025-05-22T17:20:02Z |
| Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina; | 2013 | 2014-10-28T15:40:11Z |