| Title | Description | Published | Added |
| github.com-angular-components_-_2021-03-13_17-17-56 | Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo; | 2021 | 2021-03-13T21:27:21Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Faulkner v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-10-12T07:17:13Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| CIA Reading Room cia-rdp84b00148r000100370001-5: OEXA RECORDS MANAGEMENT | Charles E. Wilson Chief, Public Affairs Division OEXA Records Management 1. Action Requested: Transfer primary PAD records management responsibility to OEXA Registry. 2. Background: Since PA ceased to exist as an Independent Office and became a Division in OEXA, PAD has nevertheless retained a Records Management Officer (RMO) and primary responsibility for this function. Since this is normally a Registry function, we are probably overdue in transferring it. I understand the OEXA Registry is already RMO for LLD. It seems to me that in a perfect world PAD would retain day-to-day maintenance of its decentralized files, but the Registry would assume responsi- bility for such things as reporting annual volume surveys, maintaining file retirement schedules, file renumbering projects, and the like. 3. Recommendation: Request OEXA Administrative Officer's assistance in establishing the Chief, OEXA Registry as RMO for all of OEXA and in transferring PAD's responsibility. We are prepared to assi; | 1982 | 2025-02-19T12:51:25Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| github.com-aws-aws-cdk_-_2020-03-31_08-47-24 | The AWS Cloud Development Kit is a framework for defining cloud infrastructure in code AWS Cloud Development Kit (AWS CDK) The AWS Cloud Development Kit (AWS CDK) is an open-source software developmentframework to define cloud infrastructure in code and provision it through AWS CloudFormation. It offers a high-level object-oriented abstraction to define AWS resources imperatively usingthe power of modern programming languages. Using the CDK’s library ofinfrastructure constructs, you can easily encapsulate AWS best practices in yourinfrastructure definition and share it without worrying about boilerplate logic. The CDK is available in the following languages: JavaScript, TypeScript ( Node.js ≥ 10.3.0 ) Python ( Python ≥ 3.6 ) Java ( Java ≥ 8 and Maven ≥ 3.5.4 ) .NET ( .NET Core ≥ 3.1 ) Developer Guide | CDK Workshop | Getting Started | API Reference | Examples | Getting Help | RFCs | Roadmap Developers use the [CDK framework] in one of thesupported programming languages to d; | 2020 | 2020-03-31T09:11:59Z |
| A high concentration of genistein down-regulates activin A, Smad3 and other TGF-? pathway genes in human uterine leiomyoma cells. | This article is from Experimental & Molecular Medicine , volume 44 . Abstract Previously, we found that high doses of genistein show an inhibitory effect on uterine leiomyoma (UtLM) cell proliferation. In this study, using microarray analysis and Ingenuity Pathways Analysis™, we identified genes (up- or down-regulated, ≥ 1.5 fold, P ≤ 0.001), functions and signaling pathways that were altered following treatment with an inhibitory concentration of genistein (50 µg/ml) in UtLM cells. Downregulation of TGF-β signaling pathway genes, activin A, activin B, Smad3, TGF-β2 and genes related to cell cycle regulation, with the exception of the upregulation of the CDK inhibitor P15, were identified and validated by real-time RT-PCR studies. Western blot analysis further demonstrated decreased protein expression of activin A and Smad3 in genistein-treated UtLM cells. Moreover, we found that activin A stimulated the growth of UtLM cells, and the inhibitory effect of genistein was partiall; | 2012 | 2014-10-28T19:53:56Z |
| CELEBRITY MOTOR CAR, LLC v. CDK GLOBAL, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:38:39Z |
| DTIC ADA372217: Cyclin D1, Anchorage-Independent Growth and Breast Cancer. | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of GI progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. Our data show that the overexpression of cyclin D1 leads to a compensatory increase in the cdk inhibitor p21, and suggest that this increase can weaken the value of cyclin D1 overexpression as a diagnostic indicator. We suggest that aggressive breast cancer will involve both (1) overexpression of cyclin D1 and (2) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have thus far determined that p21- null fibroblasts are adhesion-dependent and suitable for use to study the role of p21 in negating the effect of cyclin D1 overexpression on anchorage-independent cell cycle progr; | 1998 | 2018-04-26T23:30:00Z |
| CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIA | Approved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned; | 1982 | 2025-02-22T15:15:54Z |
| The dynamics of strategy : mastering strategic landscapes of the firm | ix, 220 p. : 24 cm // Includes bibliographical references and index // 1. Introduction -- Pt. I. The Competitive Landscape -- 2. Models of Competition -- 3. Dynamics of Competition -- 4. Networks -- Pt. II. The Organizational Landscape -- 5. Organizational Dynamics -- 6. Managing Firm Complexity -- 7. Co-Evolution -- 8. Conclusion | 2009 | 2023-10-02T09:51:36Z |
| DTIC ADB240661: Oncogenic Functions of cdK4 and cdK6 | Cancer cells often contain disruptions in the transition from GL phase to S phase. The retinoblastoma protein (pRb) is one negative regulator of cellular proliferation. Many breast cancers retain functional pRb and therefore must use other mechanisms to alleviate the tumor-suppressive function of pRb. One common mechanism to circumvent pRb function is amplification of the GL phase cyclin dependent kinases (cdk), cdk4 and cdk6. Cyclin dependent kinase 4 and cdk6 are thought to have redundant functions as pRb regulators, despite an increasing body of evidence suggesting that certain tumor types specifically activate either cdk4 or cdk6. This implies that either the function or the regulation of these kinases may be different in different cell types. Data presented here show that cdk4 and cdk6 have different abilities to drive the cell cycle-from GL into S phase in the osteosarcoma cell line, U2OS. Understanding differential regulation of these two kinases and their potentially different ; | 1998 | 2018-03-03T10:06:08Z |
| Phunky Phetes ep2 | Phunky Phetes ep2 created by fourstones (victor) Put together this show while (literally) on the road in Hollywood. Sorry about the quality of bumper, clearly the quality of phunk makes up for all. Track List: coast to coast-DU-remix by: deutscheunschuld -- (cc) Sampling Plus Vroum,vroum (remix) by: stefsax -- (cc) Attribution Noncommercial Life of Luxury (Shout Out mix) by: duckett -- (cc) Attribution Noncommercial Share-Alike (3.0) Tupelo by: Minus Kelvin -- (cc) Noncommercial Sampling Plus NYC-OLD SCHOOL Bootleg MIX. by: J.Lang -- (cc) Noncommercial Sampling Plus Deep In Ya Self (Faith Mix) by: DoKashiteru -- (cc) Attribution Noncommercial (3.0) Dream Of You by: Alex -- (cc) Attribution Noncommercial (3.0) Official (Ex-centric mix) by: cdk -- (cc) Attribution Noncommercial from ccMixter Bumpers: phunky phetes intro by: fourstones -- (cc) Noncommercial Sampling Plus Songboy3 CCMixter.org Promo 02 by: Songboy3 -- (cc) Attribution Noncommercial Share-Alike phphout ep.2 by: fourstones -; | | 2009-07-28T13:15:00Z |
| github.com-sindresorhus-awesome_-_2023-06-23_22-54-41 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-24T23:56:50Z |
| Zarzuelas y temas clásicos de España | Tracklist: 1. El Baile de Luis Alonso - Giménez 2. Sevilla - Albéniz 3. Castilla - Albéniz 4. Danza Espaänola No. 5 «AndaluzaãA - Granados 5. La Dolores (Jota) - Bretón 6. Suspiros de Espaäna - Alvarez 7. Agua, Azucarillos y Aguardiente - Chueca 8. Doäna Francisquita (Fandango) - Vives 9. Las Carretas del Rocio - Monreal 10. Asturias - Albéniz 11. Sacromonte - Turina 12. Bolero - Popular | 1988 | 2024-08-05T08:58:59Z |
| Swift Flies the Falcon | | 1939 | 2023-11-06T18:03:35Z |
| At-home dumbbell workout - Seated Curls | | 2020 | 2022-08-11T20:02:13Z |
| DTIC ADA443059: Suppression of Prostate Cancer by PTEN and p18(INK4C) | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (sub Ink4c) and the lipid phosphatase Pten, which regulates cell growth and survival. Thep18-/-;Pten +/-double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in Pten+i. cells, and further activated and accumulated in the nucleus in p18-/-;Pten+/- tumor cells, suggesting a negative regulation of AKT by the Rb pathway. The remaining wildtype allele of Pten was lost at a high frequency ; | 2005 | 2018-05-31T00:40:44Z |
| DTIC ADA474451: Mechanism of Antineoplastic Action of Bisperoxovanadium Compound | This work describes studies into the mechanism of action of bisperoxovanadium (bpVs) compounds and into the basic biology and regulation of Cdc25A phosphatase. The bpVs cause phase-specific cell cycle arrest (G1/S), dose-dependent inhibition of Cdk activity, and persistent Rb hypophosphorylation upon release from serum starvation, consistent with Cdc25A inhibition. Further, they cause p53-independent apoptosis. Oxidative stress and DNA damage do not appear to be involved in their mechanism of action, given that: p53 is not induced by bpV(Me2Phen); p53 and p21 status do not affect IC50; depletion of glutathione or supplementation with antioxidants does not affect IC50, in contrast to other heavy metal-based agents. With respect to regulation, the Cdc25A nuclear localization signal (NLS) was identified and characterized. Data suggest that phosphorylation of S292, adjacent to the NLS, may promote nuclear localization. In the unperturbed cell cycle, S292 phosphorylation, a Chk1/2 target, a; | 2005 | 2018-06-15T10:53:58Z |
| github.com-angular-components_-_2019-11-09_08-00-19 | Component infrastructure and Material Design components for Angular Components and Material Design for Angular This is the home for the Angular team's UI components built for and with Angular.These include Material Design components and the Angular Component Development Kit (CDK). Quick links Documentation, demos, and guides | Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if you're building your first project with Angular Material. Check out our directory of design documents for more insight into our process. If you'd like to contribute, you must follow our contributing guidelines .You can look through the GitHub issues (which should be up-to-date on who is working on which featuresand which pieces are blocked) and make a comment. Please see our help wanted label for a list of issues where we could use help from the community. High level stuff planned for Q4 2019 (Oct - Nov): Remove dependency on HammerJS Finish remaining test harnesses; | 2019 | 2019-11-09T10:02:31Z |
| github.com-debezium-debezium_-_2021-12-10_11-35-09 | Change data capture for a variety of databases. Please log issues at https://issues.redhat.com/browse/DBZ. Copyright Debezium Authors.Licensed under the Apache License, Version 2.0 .The Antlr grammars within the debezium-ddl-parser module are licensed under the MIT License . English | Chinese | Japanese Debezium Debezium is an open source project that provides a low latency data streaming platform for change data capture (CDC). You setup and configure Debezium to monitor your databases, and then your applications consume events for each row-level change made to the database. Only committed changes are visible, so your application doesn't have to worry about transactions or changes that are rolled back. Debezium provides a single model of all change events, so your application does not have to worry about the intricacies of each kind of database management system. Additionally, since Debezium records the history of data changes in durable, replicated logs, your application can be stoppe; | 2021 | 2021-12-10T12:09:39Z |
| Antirepressions Reader | Was will Repression? Wie sehen Gegenkonzepte aus? Rechtstipps zu Polizei und Gerichtsverfahren. Aktionsideen gegen Ohnmacht. Theater, Subversion, Sabotage | | 2020-12-25T16:10:30Z |
| github.com-dabit3-awesome-aws-amplify_-_2021-02-13_23-48-59 | Curated list of AWS Amplify Resources Awesome AWS Amplify curates the best AWS Amplify, tools, tutorials, articles and more. PRs are welcome! Check out the Amplify Discord server Getting Started Github Documentation Workshops Serverless GraphQL API with AppSync and DynamoDB AWS Amplify Photo Sharing Workshop Next.js AWS Amplify Workshop Building real-time applications with React, GraphQL & AWS AppSync Building Mobile Applications with React Native & AWS Amplify AWS Amplify UnicornFlix Workshop (Video on Demand) AWS Amplify UnicornTrivia Workshop (Live streaming video) Tutorials - Blogs & tutorials General blogs & tutorials Full Stack Cloud Development with AWS Amplify TensorFlow.js + AWS Amplify 10 Minute Tutorial: Creating a Serverless Express Web Server & API ⚡️ 10 Ways to Use Serverless Functions Real quick GraphQL service with AWS Amplify & Appsync Visualizing Focus with Neurosity's Notion and AWS Amplify Build a Music Sharing App with Amazon S3 and AWS Amplify Introducing Conf; | 2021 | 2021-02-22T13:28:20Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| Corridos Originales | Tracklist: 1. El Rayo de Sinaloa 2. Se Les Pelo Baltazar 3. 20 Mujeres de Negro 4. Candido Rodriguez 5. El Rey de Mil Coronas 6. Juan Ramos 7. Dados Cargados 8. El Capitan y el Teniente 9. Contrabando de Juarez 10. Anastacio Pacheco 11. El Alma Grande 12. Mi Huerfano Alazan 13. El Cartel de los Cielos 14. El Regalo Caro 15. Las Liebres 16. Panchito Palma 17. El Halcon 18. El Doctor Veterinario 19. El Guante 20. Corrido de Javier Barba | 2002 | 2025-04-11T04:55:18Z |
| Palbociclib: an evidence-based review of its potential in the treatment of breast cancer. | This article is from Breast Cancer : Targets and Therapy , volume 6 . Abstract Cellular proliferation, growth, and division following DNA (deoxyribonucleic acid) damage are tightly controlled by the cell-cycle regulatory machinery. This machinery includes cyclin-dependent kinases (CDKs) which complex with their cyclin partners, allowing the cell cycle to progress. The cell-cycle regulatory process plays a critical role in oncogenesis and in the development of therapeutic resistance; it is frequently disrupted in breast cancer, providing a rational target for therapeutic development. Palbociclib is a potent and selective inhibitor of CDK4 and -6 with significant activity in breast cancer models. Furthermore, it has been shown to significantly prolong progression-free survival when combined with letrozole in the management of estrogen receptor-positive metastatic breast cancer. In this article we review the cell cycle and its regulatory processes, their role in breast cancer, and the rat; | 2014 | 2014-10-06T01:38:18Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| The Savvy and The Chic Vol.8: Playa *compiled by Hektor Thillet* | The Savvy and The Chic Vol.8: Playa *compiled by Hektor Thillet* *Escape to a hidden oasis of tropical bliss and musical enchantment* WORD Summer is finally ahead; is time to shed all worries and complications and be reborn with the burning sun rising like a mighty phoenix. This installment of The Savvy and the Chic comes as an oasis, a mental retreat from a personal hiatus of much earthly turbulence. A sonic beach of clear skies, sandy shores, and purifying waters to cleanse the body and soul. I thank everyone who lent a hand in the production of this album or inspired it in some shape or form. Thanks to the wonderful artists over at ccmixter.org who make these series possible with their wonderful work. Last but not least – Thank you for listening! I hope this offering finds you in a Buddha state of mind where every misdeed towards life, nature and love is forgotten if not forgiven; and the good in all things is treasure. Enjoy. CD1 - MAREJADA 1 Beaches (Texas Radio Fish) 2 Just One; | 2011 | 2011-05-17T17:46:02Z |
| The Savvy & the Chic Vol.5: The Rules of Social Decency | Word "We learn that even a good cause can prove as bad as its conflicting source, when we have triumph and are left with the thirst of a mere self-gratifying crusade. The rules of social decency..." - Hektor Thillet I thank the artist at ccmixter.org, and you - the listener. CD TRACK LISTING 1 Luxuria 2 The Most Terrifying Night 3 An Infidelic Symphony. Blood, Love & Family 4 Guetto Opera 5 One Moment 6 Flora Glamour 7 Buddz In The Hood 8 Move Your Body 9 FAYE 10 Late Night 11 Adopt a Black Dog 12 Deflated & Alone 13 There's a Way 14 The Rules of Social Decency 15 All the Beet Just 16 The Evil Inside 17 Ophelia's Song 18 Watch That sound TRACK CREDITS IN DETAIL OF COLLABORATION 1 Luxuria - Hektor Thillet ft. KCentric, J.Lang, Anomaly Jonez 2 The Most Terrifying Night (Hektor Thillet ft. Grapes 3 An Infidelic Symphony. Blood, Love & Family - Loveshadow ft. FORENSIC, Mykleanthony & DJ Vadim 4 Guetto Opera - Hektor Thillet ft. Soda, Eshar & KCentric 5 One Moment CDK ft. Antony Raijekov & ; | | 2010-04-16T07:09:54Z |
| 401 plus v1 1 cdk 4 ultimo | | | 2021-04-16T05:45:35Z |
| In re: Dealer Management Systems Antitrust Litig. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-07-26T09:10:00Z |
| [CDK 048] PlainFlavored - Hexadecimator, Chipmusic in G Minor | [CDK 048] PlainFlavored - Hexadecimator, Chipmusic in G Minor | 2010 | 2020-01-05T19:44:06Z |
| [CDK 053] Various Artists - USK vs FIGHTER X | [CDK 053] USK vs FIGHTER X | 2011 | 2020-01-05T20:15:20Z |
| [CDK 010] Infinite Power | RARGHHHHHH! In CDK’s first all-scouse release, and our tenth release (Double figures! how exciting!) SoundMatrix unleashes his debut EP, packed with 6 tracks all chock-full with 100% of the daily amount nutrients and vitamins you could ever need. Or something. This is good anyway, download it yer bastards. The artwork is by sparkyboy too, pretty sick. | 2008 | 2019-12-06T22:14:50Z |
| [CDK 038] Various Artists - Run | [CDK 038] Various Artists - Run (Music For the Distance Jogger) | 2009 | 2020-01-05T14:56:16Z |
| wezhq | wehou d uyudunu hndhiu fenonhyy "wezhq". shu enuhiudd h npendiu n uyeynhy h hhqnzuu ou feyuyip nqeezu hy npyohuiu. cdk hhohd nhu ueeuhiudd hy fnqiuuui eeq, h nyiu onoijdunn uuq, zun ndy uyduhpy uyeuyep dfeubhnuih yy dnnyuu. nhohd wehop hhzyu ndndyhhpu hy npuyiiiudd, euony zun nhu euoznnuehnuiu dn dnnhuh qeenzquuh, qnunepu uuiu huyhu. en qnue unhyu dpud hhuyeydhu uuqui hdunehi n hyj, wehou hy ohuiu, fnqu nhu nuhuhup hy noiiu n eeqh qhhze «buddquop n unyj uyeynhy», hufhduhhek hyqhu nuhnu muufhnhnu. | | 2025-02-09T08:43:09Z |
| ****Crown CDK-3300R Japan Digital Component System With CD Player | unsold item https://shopgoodwill.com/item/159727744 | | 2023-02-17T08:48:58Z |
| [CDK 014] Assault | An assault on the senses? An assault on modern society? An assault on South Arctic (I and II)? An assault on old video gaming equipment? Whatever the Assault, it’s gonna assault your ears – in the best way possible! Goatslacker is a Floridian chiptuner who also uses the occasional keyboards ‘n’ drums for his music. He has a GSOH, likes walks in the parks and cinema and WLTM a person with similar interests in phat basslines and tight drums. | 2008 | 2019-12-06T22:45:14Z |
| [CDK 024] Dextroid | Dexter is a Game Boy musician straight outta Southampton, and he’s decided to grace CDKr with his debut album – a pretty intense 15 tracks of musical fun! He’s definitely a chipmusician going places, don’t be surprised to see this guy making it MASSEEV in chiptune, fo sho. | 2008 | 2019-12-07T00:28:52Z |
| github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-15_19-09-44 | Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ; | 2021 | 2021-01-16T03:16:22Z |
| Re-thinking cell cycle regulators: the cross-talk with metabolism. | This article is from Frontiers in Oncology , volume 3 . Abstract Analysis of genetically engineered mice deficient in cell cycle regulators, including E2F1, cdk4, and pRB, showed that the major phenotypes are metabolic perturbations. These key cell cycle regulators contribute to lipid synthesis, glucose production, insulin secretion, and glycolytic metabolism. It has been shown that deregulation of these pathways can lead to metabolic perturbations and related metabolic diseases, such as obesity and type II diabetes. The cyclin–cdk–Rb–E2F1 pathway regulates adipogenesis in addition to its well-described roles in cell cycle regulation and cancer. It was also shown that E2F1 directly participates in the regulation of pancreatic growth and function. Similarly, cyclin D3, cdk4, and cdk9 are also adipogenic factors with strong effects on whole organism metabolism. These examples support the emerging notion that cell cycle regulatory proteins also modulate metabolic processes. These ce; | 2013 | 2014-10-28T16:47:52Z |
| Het bericht ‘CdK haalt ongemeen fel uit naar de NAM’ | This document is issued on date 2015-05-27. | 2015 | 2018-03-14T20:02:09Z |
| github.com-hashicorp-terraform-cdk_-_2022-10-05_17-00-30 | Define infrastructure resources using programming constructs and provision them using HashiCorp Terraform CDK for Terraform Cloud Development Kit for Terraform (CDKTF) allows you to use familiarprogramming languages to define cloud infrastructure and provision it throughHashiCorp Terraform. This gives you access to the entire Terraform ecosystem without learning HashiCorp Configuration Language (HCL) and lets you leverage the power of your existing toolchain for testing, dependency management, etc. We currently support TypeScript, Python, Java, C#, and Go. CDKTF includes two packages: cdktf-cli - A CLI that allows users to run commands to initialize, import, and synthesize CDK for Terraform applications. cdktf - A library for defining Terraform resources using programming constructs. Get Started Choose a language: TypeScript Python Java C# Go Hands-on: Try the tutorials in the CDK for Terraform collection on HashiCorp Learn. Documentation Refer to the CDKTF documentation for more detai; | 2022 | 2022-10-06T00:37:52Z |
| Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. | This article is from Biomolecules & Therapeutics , volume 20 . Abstract Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents. In recent years, a number of structurally diverse HDAC inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. However, the underlying molecular mechanisms remain unclear. This study aimed at investigating the anti-tumor activity of various HDAC inhibitors, IN-2001, using T47D human breast cancer cells. Moreover, the possible mechanism by which HDAC inhibitors exhibit anti-tumor activity was also explored. In estrogen receptor positive T47D cells, IN-2001, HDAC inhibitor showed anti-proliferative effects in dose-and time-dependent manner. In T47D human breast cancer; | 2011 | 2014-10-24T20:14:53Z |
| Commissioner Sullivan message to Clatsop County April 22 | | 2020 | 2022-10-14T13:47:04Z |
| Anillo Grabado | Tracklist: 1. Anillo Grabado 2. Los Ojitos de Mi Elena 3. Tengo Recuerdos de Ti 4. Te Vas Angel Mio 5. Tierra Mala 6. Albur de Amor 7. En las Cantinas 8. Por las Parrandas 9. El Amor Nunca Se Vende 10. Dime Mujer | 2001 | 2024-11-26T06:21:08Z |