| Title | Description | Published | Added |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Indian rubber man | | 1939 | 2025-09-09T22:39:54Z |
| treatment of the patient past fifty | | 1941 | 2025-09-04T01:47:40Z |
| Everyday Things In American Life | | 1941 | 2025-09-09T13:08:10Z |
| Indian Oasis | | 1939 | 2025-08-24T05:44:54Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. | This article is from Molecular Cell , volume 54 . Abstract The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1. During S phase, Cdk-mediated phosphorylation of Yen1 promotes its nuclear exclusion and inhibits catalytic activity by reducing the efficiency of DNA binding. Later in the cell cycle, at anaphase, Cdc14 drives Yen1 dephosphorylation, leading to its nuclear relocalization and enzymatic activation. Using a constitutively activated form of Yen1, we show that uncontrolled Yen1 activity is detrimental to the cell: spatial and temporal restriction of Yen1 protects against g; | 2014 | 2014-10-23T07:40:09Z |
| yahoo-groups-2018-07-22T15-57-51Z-09afd9 | Yahoo! Groups API grab. Contains messages of the following groups: 1cemerlang_cikguyatie 1st0910rc301_mpe_rdpou 212d03_ics_1stsem2009 225x01_ess_1stsem2009 26auxiliary 4s4_ihc_diplomacy a1amsterdam acupuntura01_incisa-sp aiesecateneoapplicants0910 alanatura alumni787 alumni_kursus_pplh_ipb amocabelo angkan_ni_nita_at_totoy atmku basicon_hr101p bassettrd beauty-of-nature bioclass_sjcbalanga bolitas_5 bshrm3b_csu bsn_tri-b12 btrsport cdd_comp_comm_109 cdk_database_system cdplayers cg_services citsrtece cmsfac cnpbr collinsresearcher constanciaesperanca constructiontoysuperstation copro1_bs102a cs30dbloggroup cso_09 cuetcse_10yearsanniv curvydiamonddivaschicago cwts1_complab cwts1i_gkhousebuild09 cwts-sw1 denvershuls desisofgreaterdayton dlspbeccounselors dlsplearningleaderstec2 dragonsoffirevalley ds2013 dungeonsofeberron eeplangkawi09 elite3rcbc emsa_rostock euusmilliondollarlicensing ff_09-10 fhunpad04 fineartsmhc1 firstsemsy0910mth2ndclass forte_mens_chorus forum_editores gameigamel g; | | 2018-07-22T15:58:00Z |
| yahoo-groups-2018-09-04T07-32-48Z-3ec9b9 | Yahoo! Groups API grab. Contains messages of the following groups: 9csmpdobozmanado abu3loush adm_etec_malu adrian-umina ailiv_tennis alumnisma7bdg80 americanfieldhockey anne_ssa anotherm3group arduinohome arianaprfghanipoursummer2010 arrkoola_uq asma_feab asolidstepforward asorii_2010 asra_group bedogjakarta bellocienciacriminal bge07_ku bianchigil bp_pta_board_10-11 bte2006-2010 caribbeanpirates390 ccc-philippines cdk_dsp ceni_meeting centralboard_usteduc clubfetichistademexico colmbankfact coup_depouce cpaf-gsaofficers2010-2011 d1015westernchampion dailyhotactress ddfep10kce dil_se_delhi ea2010_pubpromo eccwomenclergy education_batch25a edu_infantil_sme empregos_vagas_rj enfermagem_unoesc02 escuelatv02 espeflorania ethnopharma_uoda falconcoachken fciprog fil11-bbb forum_agenda21_cidadeademar fossbbsr gaqhxm gctalumni-bangalorechapter genocidio_e_politica gmcs_july2010 graycouncilofarnor gudgurlzzz iba_bicolanos_in_la ibanezblack igrab-2012mbc-bid iiucete imt_tacvps indonesia_sde_com; | | 2018-09-04T07:32:59Z |
| Anti-Cancer Effect of IN-2001 in T47D Human Breast Cancer. | This article is from Biomolecules & Therapeutics , volume 20 . Abstract Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and have a key role in the epigenetic regulation of gene expression. Histone deacetylase (HDAC) inhibitors are emerging as an exciting new class of potential anti-cancer agents. In recent years, a number of structurally diverse HDAC inhibitors have been identified and these HDAC inhibitors induce growth arrest, differentiation and/or apoptosis of cancer cells in vitro and in vivo. However, the underlying molecular mechanisms remain unclear. This study aimed at investigating the anti-tumor activity of various HDAC inhibitors, IN-2001, using T47D human breast cancer cells. Moreover, the possible mechanism by which HDAC inhibitors exhibit anti-tumor activity was also explored. In estrogen receptor positive T47D cells, IN-2001, HDAC inhibitor showed anti-proliferative effects in dose-and time-dependent manner. In T47D human breast cancer; | 2011 | 2014-10-24T20:14:53Z |
| Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication. | This article is from The Journal of Cell Biology , volume 193 . Abstract Phosphorylation of human Treslin by Cdk is essential for its association with TopBP1 and for the initiation of DNA replication in S phase. | 2011 | 2014-10-25T19:09:59Z |
| CIA Reading Room cia-rdp83m00914r002800040039-0: LETTER TO WILLIAM F. JASPER FROM CHARLES E. WILSON | Approved~For Release 2007/03123: CIA-RDP83M00914~Q 800040039-0 PUBLIC AFFAIRS Phone: (703) 351-7676 Mr. 4lilliam F. Jasper Dear Mr. Jasper: In response to your letter of January 20 to Admiral Inman, we are enclosing the available news clippings which have appeared in the American press on the subject of U.S. technological aid to the Soviet arms buildup. lJe hope the enclosed material will provide you with the kind of information you requested. Sincerely, STAT STAT Charles E. tJilson Chief, Public Affairs Division Enclosures Admiral Inman's 7 January Remarks to AAAS; News Clippings OEXA/CDK/4 Feb 82/x7676 Distribution: 0 - Addressee - OEXA Reg 82-0310 - ER 82-6077 w/enc 1 - LL 1 - PAD Subj. w/enc 1 - Chron ~w/enc 4 February 1982 STAT Approved For Release 2007/0:3123: CIA-RDP83M00914R002800040039-0 ~~~4ppr~~ed"~oryRelease 2007/03123;: CIA=RDP83M~10914R00280~C~4~1039-0 STAT January 20, 198 Robert Inman, Deputy Director Central Intelligence agency. ',lashington, D.C. 20505 Dear T"ir. Inman; | 1982 | 2025-02-22T14:17:55Z |
| Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1?MYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase. | This article is from Biochemical Journal , volume 461 . Abstract NUAK1 (NUAK family SnF1-like kinase-1) and NUAK2 protein kinases are activated by the LKB1 tumour suppressor and have been implicated in regulating multiple processes such as cell survival, senescence, adhesion and polarity. In the present paper we present evidence that expression of NUAK1 is controlled by CDK (cyclin-dependent kinase), PLK (Polo kinase) and the SCFβTrCP (Skp, Cullin and F-boxβTrCP) E3 ubiquitin ligase complex. Our data indicate that CDK phosphorylates NUAK1 at Ser445, triggering binding to PLK, which subsequently phosphorylates NUAK1 at two conserved non-catalytic serine residues (Ser476 and Ser480). This induces binding of NUAK1 to βTrCP, the substrate-recognition subunit of the SCFβTrCP E3 ligase, resulting in NUAK1 becoming ubiquitylated and degraded. We also show that NUAK1 and PLK1 are reciprocally controlled in the cell cycle. In G2–M-phase, when PLK1 is most active, NUAK1 levels are low and ; | 2014 | 2014-10-10T19:09:13Z |
| Nov 04 2025 Town meeting | | 2025 | 2025-11-06T13:34:51Z |
| FACTS ABOUT ORIENTAL RUGS: Volume I | | 1952 | 2023-08-10T14:43:59Z |
| Soil and freshwater niematodes | | 1951 | 2025-09-08T04:35:20Z |
| github.com-tiantianGPU-reg-factory_-_2026-06-04_06-12-01 | None # 🏭 reg-factory### Outlook · ChatGPT · Grok · Claude 全自动注册机**自动批量注册 Outlook 邮箱 → 用它在 ChatGPT / Grok / Claude 上注册账号 → 导出可直登 cookie** reg-factory 是一套全自动注册流水线：先自注册 Outlook 邮箱，再用同一邮箱在 ChatGPT / Grok / Claude 上批量注册账号，并导出可直登的 cookie。底层用 比特浏览器(BitBrowser) 做指纹隔离、 Clash Verge 做节点切换绕区域封锁与 Cloudflare 风控、接码/打码平台过手机号与验证码。 ⚠️ 仅供学习与授权测试使用。所有密钥通过环境变量提供，仓库内不含任何明文凭据。 1. 前置条件 ① 比特浏览器 BitBrowser 安装并 启动 比特浏览器客户端，确保本地 API 在线（默认 http://127.0.0.1:54345 ）。 客户端要保持运行——脚本通过该 API 创建/打开/关闭浏览器窗口。 ② Clash Verge（开启 API 权限） 安装 Clash Verge 并导入你的机场; | 2026 | 2026-06-04T22:05:03Z |
| The Harvard Classics : Vol. 2: Plato, Epictetus, Marcus, Aurelius | | 1909 | 2023-11-06T15:11:16Z |
| Het Utrechts Archief 163904 | Het Utrechts Archief catalog number: 163904 Description (Dutch): Afbeelding va een aantal monteurs tijdens werkzaamheden aan het draaistel van de CDk-bak van het electrische treinstel nr. 657 (mat. 1946) van de N.S. in de revisieloods van de werkplaats Zaanstraat te Amsterdam. | 1950 | 2021-02-24T23:03:58Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| Creatures of the deep sea | | 1956 | 2023-09-10T05:28:42Z |
| parerga and paralipomena | | 1974 | 2025-05-22T10:33:49Z |
| Cool Music - (October 15 - October 22) | Cool Music - (October 15 - October 22) created by MC Jack in the Box (mcjackinthebox) get those Cool Secret Mixter remixes ready so I can play them in a couple weeks! Track List: The Crime (Blues Rock Mix) by: unreal_dm -- (cc) Attribution Noncommercial (3.0) 1962 is gone gone by: colab -- (cc) Attribution Noncommercial (3.0) Please Don't Go by: Briareus -- (cc) Attribution (3.0) Persephone (robomix) by: robomusic -- (cc) Attribution TIQUE TYPIQUE ft. Sebco by: Black Sunday Productions -- (cc) Attribution WELCOME TO A NEW ERA by: BOCrew -- (cc) Attribution Noncommercial Share-Alike (3.0) Future Shock ft. KCentric by: cdk -- (cc) Attribution Noncommercial (3.0) Polaroid Lucid Dream by: Geert Veneklaas -- (cc) Attribution Noncommercial (3.0) Our words mean nothing (Duet) by: Scomber -- (cc) Attribution Noncommercial (3.0) Sgt Bitter's Lonely Heart by: duckett -- (cc) Noncommercial Sampling Plus from ccMixter Bumpers: site promo - cool music by: teru -- (cc) Attribution Noncommercial (3.0; | | 2009-10-22T16:11:00Z |
| The cry of Vietnam: poetry | | 1968 | 2024-06-24T16:35:37Z |
| Y 2mate.com Exotic Wyvern Speed Paint CDK 8t FNl BL 4 1080p | Mm m mm | | 2020-09-07T16:43:56Z |
| The Bolshoi Theatre Ballet. | | 1963 | 2024-02-07T18:33:58Z |
| CIA Reading Room cia-rdp91-00929r000200680025-9: FR:SHUBKIN V.N. TO:SHULISHOVA O.I. | - 14 , /.el iconelvto stuat at seem lw V. ov*WAD ,15 P9owns Pori, 1b 3# FM 65# IV WOW$I" 2Z3.1ummemApr 65 7no ?rlIbmis ft no& 206or a* zatw yorms lw To so /0Mdu%,%Tw~m vwo so= tumob ft so ow^ wo WIGNo st3ps~ kl,~oV, ~- -, k L)--um9mAn 6520630quanutatAve Nrtboft la ftWWUWt by Yo So17 vp o--- - vwp &g= UMMW 1b- 3~ X967ioIV? 0JIPMB "3~t. IV SHU6KIAl.2 cumbd4kc ftlime 67 329pM'4-4 7'r-QV'4rtl*S Of DWGIVUlt 4'AtlrAinS Of tl%w 45Vino of vie (.4cm tior~4s (,,orivo siqlax),UY %* F~, Ct 419'it ~*T, v--~Virux %lo it IL66v 17-p 74-76.i. ~~41 ~ ~''Cim"Alrvu f, I 3tiows0~. ( J /' (~. 6 ' ~ /' t"The so-called Homology of Crystals,, by A. V. ShubnikovRUSSIAN, per, Doklady Akadewit Nauk SSSR Vol 88,pp 453-456NAVY/NISC-3346Oct 72Growth ct C4ft*IkUt tV A. V. MuUdkNp V, X.abdull0 -U:WROM ppmo "a cc VWM&A& !=Wamom-Nms To, AW f,~ 4 -, . I r -- , (tic!AVv 4,i*l 1 ~ -swo4w Ge dbs ftugk as"d via llsbr5-1 eusumbohm-Aodk*V&t v IV 91 At 99 pw* It 901 "s 19496or 209-43"-ftota isterimKrArrA-324brek 1970-ft 33Oft L; | 1983 | 2026-04-05T21:18:00Z |
| The King of Fighters 2002: (BR) MAGAIV01 vs(BR) [CDK]-Shaka - 2023-01-22 00:48:40 | (BR) MAGAIV01 vs (BR) [CDK]-Shaka - 2023-01-22 00:48:40 Fightcade replay id: 1674348520865-7914 #fightcade #kof2002 #[CDK]-Shaka #MAGAIV01 For more videos check out: https://fightcadevids.com | | 2023-01-22T02:02:43Z |
| Lirici greci: antologia | | 1977 | 2024-02-17T18:00:09Z |
| DTIC ADA407447: Role of Cyclin D1 and cdk Inhibitors in Breast Cancer Pathogenesis | Cyclin Dl is frequently overexpressed in breast cancer tumors. Thus, an understanding of cyclin Dl regulation in normal and malignant cells may prove beneficial in the search for therapeutic targets. In fibroblastic cell lines, cyclin Dl expression is regulated by Rho/Rho kinase: i) when Rho/Rho kinase is active, ERK activity is sustained and consequently cyclin Dl is induced in mid-G1 phase, and ii) when Rho/Rho kinase is inactive, cyclin Dl is induce in early G1 phase through a rac-mediated pathway (implicating PI-3 kinase signaling) . In this report, I examined the consequences and regulation of rac-mediated cyclin Dl expression in terms of Rho kinase-dependent stress fiber formation. Selective inhibition of Rho kinase allowed for rac-mediated cyclin Dl expression, the downregulation of p21ci pl% %% and p27 kiPl and S phase entry, indicating that cell proliferation can occur under conditions where stress fiber formation is. compromised. The suppress ion of the rac pathway to cyclin ; | 2002 | 2018-05-09T21:16:49Z |
| DTIC ADA398172: Role of c-Myc in Estrogen Stimulated Cell Proliferation in Normal and Malignant Breast Epithelial Cells | Estrogenic steroids have diverse physiological functions and are critically involved in the pathogenesis of breast cancer. The transcriptional regulator c-Myc has been implicated in estrogen-induced mitogenesis and we are therefore investigating the contribution of c-Myc to various downstream molecular and cellular events after estrogen stimulation. We have now developed a series of cell lines expressing c-Myc and mutants lacking one or both of the conserved 'Myc boxes' required for transcriptional regulation activity, under the control of an inducible promoter. Ongoing experiments are examining whether these mutants can mimic the effects of estrogen in activating cyclin E-Cdk2 and inducing cell cycle progression. We have recently shown that decreased expression of the CDK inhibitor p21, a c-Myc target, is critical for estrogen activation of cyclin E-Cdk2 and consequently the effect of the c-Myc mutants on p21 expression is of particular interest. We have also shown that decreased c-My; | 2001 | 2018-05-05T20:39:40Z |
| DTIC ADA366953: General Methods for Identifying Gl-phase Substrates of Cdk Protein Kinases. | We are developing methods to identify Gi-phase substrates of cyclin-Cdk: complexes. In earlier years of this project, we optimized two-dimensional gels for visualization of phosphorylation of Cdc28 substrates, and we developed monoclonal antibodies with reactivity to phospho-Ser-Pro or phospho-Thr- Pro. We identified one important in vivo substrate, Sic 1. However, it appears that these methods by themselves are insufficiently powerful to identify many substrates, since most substrates seem to be very rare. We have therefore supplemented these methods with three other approaches: (1) purification of affinity tagged cyclins, to look for co-purifying proteins; (2) complete genome two-hybrid screens with Cdc28 and with Gi cyclins, to look for interacting proteins; and (3) genome-wide analysis of cell cycle regulated transcription, on the basis that some important substrates might be regulated at the transcriptional level as well as at the activity level. All three approaches are going ver; | 1998 | 2018-04-24T23:15:05Z |
| CIA Reading Room cia-rdp90-00552r000100550040-8: PANEL FINDS CASEY NOT UNFIT FOR JOB | Sanitized Copy Approved for Release 2010/07/29: CIA-RDP90-00552R000100550040-8 NEW YORK TIES E, i' i CLE AIPPEA D 2 DECEMBER 1981 C )IN, PAGE' PANEL ~ , "mg a~ ~t~t tbar~rt the public at saon WadDeKI&Y. r. Noyaiban MW the delay wos.d ernmit ? flies UNFIT I$ the m ;" r of tld c xx* atte,e?a 13 members .rno crula not attend today's s tasks aboutbair v3ee-s on the pane 's eaneiusiom, erxd we+ald Per=ft; Mr. Caaay tozs+3ew them, But 'Whole. Situation is Not rroE,a Moynihan mW uttering,' Senator Sa M. a tthhet: ?o"'di of intelligence Director$ ~- ,to on o`r 1he added ;w 1e ji vse,.a, a sms~ ' used to ref 4Z931JAl3331R33i~ grtoi Josepb R BiBea Jr., Demoemt of Deiawere, said in an WASB1NGTa f,13ee. I -The Se stet iota view aZter the m eetin, that be disa.. Select C ommit ee en bMH*mm will geed with the etanmittee's ~? that and has no ham roe William J. Cawy is "mat to aeey-e as m 0'1 bare a very dirfermt V3tw iron rectorof Caatr*i;atailia,estca,seco~rdins that of nay cdk~e es m the ~iZer,'? t; | 1981 | 2025-06-03T23:01:26Z |
| [CDK 049] jmr - Skywave Effect | [CDK 049] jmr - Skywave Effect | 2010 | 2020-01-05T19:50:06Z |
| [CDK 061] Various Artists - Micro Music For Micro People | It’s here, it’s finally here! In 2008, a younger James CalmDownKidder went to a little-known festival called Blip Festival, and this laid the seeds for CDKr’s most ambitious project yet – a chipmusic tribute to Fat Wreck Chord’s Small Music For Small People. 101 tracks, 101 different artists, all approximately 30 seconds or less. All-new original songs from some of Chipmusic’s biggest names, including Bit Shifter, gwEm, 4mat, Nordloef, and many (97, to be precise) more! On the Anniversary of CalmDownKidder’s first ChipFest event, Micro Music for Micro People is as much a Time Capsule of 2008-2009 chipmusic as it is an exciting and new release! Thanks to Thomas ’0010100′ Mahon for Mastering Thanks to Ville Kontinnen for Artwork Thanks to all the artists who have contributed, and thanks to all the artists who have contributed to CalmDownKidder Records over the years – and most importantly, thank you, the listener, for keeping CalmDownKidder Records alive throughout th; | 2013 | 2020-01-05T21:45:22Z |
| [CDK 007] Bottle | Aww yeah boy, it’s the release Big Chip fans everywhere have been waiting for! And if you’re not a Big Chip fan, then what’s wrong wit’choo boy? 6 tracks, 5 BUTT-SPANKIN’ NEW AND FRESH Big Chip style NES punches to the face! Also contains hot Ukelele action, and the man himself Big Chip signing! So, a little less time reading this, and a little more time downloading this EP! | 2008 | 2017-09-30T18:00:21Z |
| [CDK 028] Super Eurobit Vol.1 | [CDK 028] Super Eurobit Vol.1 | 2008 | 2019-12-30T21:22:36Z |
| [CDK 041] Various Artists - Eightbreeders | [CDK 041] Various Artists - Eightbreeders | 2009 | 2020-01-05T18:26:43Z |
| die mikromorphologie der menschlichen zahnpulpa | | 1970 | 2025-09-04T05:39:32Z |
| Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4. | This article is from PLoS Genetics , volume 10 . Abstract DNA double-strand breaks (DSBs) can be repaired by one of two major pathways—non-homologous end-joining (NHEJ) and homologous recombination (HR)—depending on whether cells are in G1 or S/G2 phase, respectively. However, the mechanisms of DSB repair during M phase remain largely unclear. In this study, we demonstrate that transient treatment of M-phase cells with the chemotherapeutic topoisomerase inhibitor etoposide induced DSBs that were often associated with anaphase bridge formation and genome instability such as dicentric chromosomes. Although most of the DSBs were carried over into the next G1 phase, some were repaired during M phase. Both NHEJ and HR, in particular NHEJ, promoted anaphase-bridge formation, suggesting that these repair pathways can induce genome instability during M phase. On the other hand, C-terminal-binding protein interacting protein (CtIP) suppressed anaphase bridge formation, implying that CtIP fu; | 2014 | 2014-10-06T07:32:29Z |
| Ep 35: The Case of the Alleged Real-Life Gone Girl | A 29-year-old woman goes missing in Vallejo, California in 2015, and the details surrounding her disappearance are bizarre, to say the least. There are many things in this case that may surprise you and have you thinking that you know what's going on....until you don't. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music in this episode: Three kites circling by Axletree - http://freemusicarchive.org/music/Axletree/Cormorant_EP/Three_kites_circling a letter from doxent by Stefan Kartenberg - http://dig.ccmixter.org/files/JeffSpeed68/51322 Celestial Navigation by Blue Dot Sessions - http://freemusicarchive.org/music/Blue_Dot_Sessions/Aeronaut/Celestial_Navigation Someday I'll like you but before let me rest in my solitude (Lonely character's theme) by Komiku - http://freemusicarchive.o; | 2017 | 2023-05-31T20:57:33Z |
| The Old Architecture of Quebec | | 1947 | 2025-05-22T17:20:02Z |
| The story of W.T. Grant and the early days of the business he founded | | 1954 | 2024-06-24T16:28:55Z |
| la struttura letteraria della preghiera eucaristica | | 1981 | 2025-06-16T05:49:58Z |
| Founders of american economic thought and policy | | 1958 | 2025-09-08T05:32:17Z |
| The Basic College Of Michigan State | | 1955 | 2025-09-12T17:56:25Z |
| treatment of the child in emotional conflict | | 1962 | 2025-09-04T03:35:05Z |
| The microwave convection cookbook | | 1989 | 2025-09-10T00:55:05Z |
| CIA Reading Room cia-rdp85m00364r002204280082-7: (SANITIZED)USA TODAY, REQUEST FOR INTERVIEW | Approved For Release 2007/12/19: CIA-RDP85M00364R002204280082-7 MEMORANDUM FOR: Director of Central Intelligence SUBJECT Director, ice o External Affairs USA TODAY, Request for Interview Action Re uested: Decline or accept request for interview by reporter for USA TODAY. 2. Background: requested an interview on the international climate and said he would be wci ing to avoid discussing the Reagan campaign and issues relating to it that have been in the press recently. 3. Recommendation: None. Indicate whether you wish to decline or accept this interview and authorize Public Affairs to respond in your behalf. STAT STAT STAT STAT STAT ACCEPT THE INTERVIEW: Director of Central Intelligence DECLINE THE INTERVIEW: is! oaiaf Aa cas11 Director of Central Intelligence Date '15 Jth 1 Date) OEXA/PAD/KR/cdk/12 Jul 83/7676 Distribution: Orig - Addressee 1 - DDCI 1 - EXDIR c2 ERegistry 1 - OEXA 83-1705 1 - D/OEXA 1 - DD/OEXA 1 - PAD Return 1 - PAD Subj. 1 - Chron 1 - Reading Board Approved For Relea; | 1983 | 2025-02-24T15:35:21Z |
| Jet Set Planet November 4, 2011: Bongos-are-us | A radio show playing Higher-Than-Fi instrumentals from Thrift Store U.S.A. since 2005, hosted by Glen Leslie and heard every Friday night from 9 to 10:30 on KFAI-FM, 90.3 FM Minneapolis, 106.7 FM St. Paul, and KFAI.org. | 2011 | 2011-11-09T17:06:22Z |