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DostupnostNázevAutorDatumTypID
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Výroční zpráva2025periodical/periodicalvolume/periodicalitem/pageuuid:4adb403f-b839-4d2d-91e2-cd3d9ac4e3bd
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Meziměstská telefonní ústředna v Praze1929monograph/pageuuid:e20a6970-253d-11ee-8650-005056827e51
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Francouzská revoluce : populární dějiny bojů francouzské společnosti na sklonku 18. století. Díl 1. Zápas s královstvím1929monograph/pageuuid:840ef410-0803-11ed-be35-5ef3fc9bb22f
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X. mezinárodní sjezd slavistů : Sofija 14. - 22. 9. 1988 : bibliografie1994monograph/monographunit/pageuuid:45d9d8e0-a20e-11ed-9ac7-5ef3fc9bb22f
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Veterinární medicína10.2010periodical/periodicalvolume/periodicalitem/pageuuid:6354c070-9632-11e8-b07a-5ef3fc9bb22f
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Galerie du Palais Royal gravée d'aprés les tableaux des différentes écoles qui la composent: avec un abrégé de la vie des peintres et une description historique de chaque tableau1786monograph/pageuuid:17fda895-f78f-4d9c-90ad-dca3cb9e3a75
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Eklogy a písně1916monograph/pageuuid:441044f0-f6f8-11e9-a329-005056827e51
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Starší literatura česká1910, 1911monograph/pageuuid:b4692cb0-bd01-11ea-b68c-005056827e52
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Mythy : básně Jaroslava Vrchlického : 1. cyklus (1874-1878)1915monograph/pageuuid:0998a060-f496-11e9-a329-005056827e51
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Stavební stroje: Seznam a výrobci1947monograph/pageuuid:0442b1d0-84ab-11e2-aa2b-005056827e51
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Základové měřictví pro nižší třídy gymnasií1886monograph/pageuuid:3c6e4dc0-d47b-11dc-b5f4-000d606f5dc6
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Katoličtí mučedníci doby husitské1927monograph/pageuuid:6de55980-a2be-11e3-b833-005056827e52
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Jan Slavík (1885-1978): a Czech historian of revolutions2009monograph/pageuuid:bdbc8db0-38cf-11ed-a118-5ef3fc9bb22f
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Základové měřictví pro nižší třídy gymnasií1893monograph/pageuuid:eca38890-36a8-11ee-9691-005056827e52
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Porovnávací tabulky měr a vah i příslušných cen ku snadnému užívání metrické soustavy v říši rakouské vůbec a v zemi české zvlášť1875monograph/pageuuid:34f65bc0-6d52-11de-9cc7-000d606f5dc6
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Beylage zur Brünner Zeitung29.10.1808periodical/periodicalvolume/supplement/pageuuid:40d23930-7bf1-11e2-b930-005056827e51
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Učebné listy jazyka anglického pro samouky1886monograph/monographunit/pageuuid:55367630-80c8-11dd-b860-000d606f5dc6
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Hospodář: týdenník věnovaný rolnictví, hospodářskému průmyslu a národnímu hospodářství : týdenník věnovaný rolnictví, hospodářskému průmyslu, národnímu hospodářství a veřejné správě vůbec9.4.1887periodical/periodicalvolume/periodicalitem/pageuuid:0c579719-c6f8-4a16-8a4f-c6b12e6d449b
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Fysika pro vyšší školy1870monograph/pageuuid:7141d2c0-e6f8-11dd-a324-000d606f5dc6
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Posledních dvě stě let v historii rajhradského kláštera2013monograph/pageuuid:fd326900-7245-11e9-b253-005056827e52

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TitleDescriptionPublishedAdded
Ep 10 Part 1: Kristine Bunch's NightmareIn part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.   Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike  (3.0) license. htt;20162023-07-08T12:43:39Z
The man who made the peace: Neville Chamberlain19382024-01-13T01:51:01Z
Long Valley, The19672023-02-23T18:38:22Z
Mahatma Gandhi20122024-01-04T12:38:14Z
Lawyer Says Bin Laden Did Not Orchestrate 9/11Al-Qaeda leader never claimed responsibility for attack, Van de Wiel tells Australian Supreme Court Paul Joseph Watson Prison Planet Thursday, February 28th, 2008 Skepticism towards the 9/11 official story reached the Australian Supreme Court this week after a lawyer asserted that the attacks were not orchestrated by Osama bin Laden during the trial of an alleged terror group in Melbourne. "To say that this was all orchestrated by Osama bin Laden is a silly thing to do. He's never claimed responsibility for it," Remy van de Wiel QC told the Australian jury. Full Story Here: http://prisonplanet.com/articles/february2008/022808_bin_laden.htm20082024-05-09T20:01:58Z
Indian rubber man19392025-09-09T22:39:54Z
The King of Fighters 2002: (BR) K-RND CEARA vs(BR) [CDK]-Shaka - 2022-11-29 13:17:50(BR) K-RND CEARA vs (BR) [CDK]-Shaka - 2022-11-29 13:17:50 Fightcade replay id: 1669727870043-5314 #fightcade #kof2002 #[CDK]-Shaka #K-RNDCEARA For more videos check out: https://fightcadevids.com2023-01-21T17:36:39Z
Living embers: the life and writings of George William Griffith19372023-12-28T00:31:16Z
942 epjl btctk ek pjtipydeikbdes keilyks. jetk cdk. ldlnljzcdes k ylewltdes eiljkae ijkeieipjtdle eyctek – yediejsw, ncp li bpwt zypisbepi cbly wkieeewlnl kxzpyeilye, llkcepi zyekcdlbedks wtdtakp, lixpkepxlnl zl jtddlxt wejpdceyz jlblnl nlce. apjkwe kpeit tcleilkites zyknjetpdks de kxzpyeilyewke zykpx de zjljeck zpypc eblyalx apjkwlnl blnjeeks.2026-03-30T23:35:09Z
Amarna in religion und kunst19312025-05-22T20:55:21Z
Ebank Trademark Video 2Ebank  ® company video music of song attributed to, Download the music in this video, this one song at, ccmixter.org/files/cdk/17432 To learn more about the creator and owner of this song go  to the following link, this song used in Creative Commons License, "Silence Await" by cdk ccmixter.org/files/cdk/1743220162016-09-30T21:51:44Z
CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITYApproved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known;19812024-05-13T17:20:36Z
Stella Dysart of Ambrosia Lake19592024-01-08T12:14:29Z
Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families.This article is from Journal of Carcinogenesis , volume 10 . Abstract Background:: Cisplatin (CDDP) is a drug used for treatment of many types of malignancy but pancreatic cancer is relatively resistant to it. This study aims to determine whether and how cyclin D1 (D1) and c-Myc influence the response of pancreatic cancer cells to CDDP. Materials and Methods:: Ela-mycPT mouse pancreatic cancer cells were transfected with D1 or c-myc cDNA and treated with CDDP alone or together with NPCD, an inhibitor of cyclin dependent ckinase (CDK) 4 and 6. Reverse transcription followed by polymerase chain reaction (RT-PCR) and western blot assays were used to determine the mRNA and protein levels of interested genes. Cell viability was determined using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results:: Treatment of Ela-mycPT1 cells with CDDP caused an increase in c-myc expression but a slightly latent decrease in D1 expression, whereas D1 and c-Myc proteins repres;20112014-10-28T18:52:34Z
the student's chronological new testament19042025-06-16T06:50:48Z
the new testament19232025-06-16T23:39:05Z
ccMixter - Songs of DreamsccMixter - Songs of Dreams Jamendo Album #180014 Tracklisting: 01 - Breathe (Copperhead Mix) [feat Jeris] 02 - Deeper Nights Deeper Dreams (feat CDK, Haskel) 03 - Eye of the Owl (feat Calling Sister Midnight, Haskel) 04 - Breathe the Sun (feat AT, Porch Cat, NASA, Stanford, Sandyrb, Erratic, Bulbastre) 05 - Choices (Abstract Audio Mix) 06 - Goddess Dance (feat BWD Chorus, AT, Rocavaco, Porch Cat, Afrit, William Berry, Bmccosar, Mghicks) 07 - Changes (Urmymuse Mix) 08 - Urgency (feat Ass Over Tea Kettle, Haskel) 09 - Growth in the Garden (feat Darkroom, Rocavaco, Haskel) 10 - Turning into Normal (feat Analog by Nature, Haskel) 11 - Waiting (feat Haskel) 12 - Dreamt (feat Jeris, Haskel) Please read the Readme.txt and License.txt files for important origin and licensing information.20182026-03-28T08:49:44Z
Matos v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2018-10-05T16:04:41Z
github.com-angular-components_-_2021-03-13_08-50-59Component infrastructure and Material Design components for Angular Official components for Angular The Angular team builds and maintains both common UI components and tools to help you build yourown custom components. The team maintains several npm packages. | Package | Description | Docs || ------------------------- | ----------------------------------------------------------------------------------- | ---------------- || @angular/cdk | Library that helps you author custom UI components with common interaction patterns | Docs || @angular/material | Material Design UI components for Angular applications | Docs || @angular/google-maps | Angular components built on top of the Google Maps JavaScript API | Docs || @angular/youtube-player | Angular component built on top of the YouTube Player API | Docs | Quick links Documentation, demos, and guides | Frequently Asked Questions | Community Google group | Contributing | StackBlitz Template Getting started See our Getting Started Guide if yo;20212021-03-13T09:29:32Z
THE DOLOMITES19252025-05-22T18:39:58Z
github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ;20222022-02-07T09:45:28Z
European Regalia19672023-07-25T15:19:42Z
sinceretheory.podcast_v1.301 I've switched to Mac, goodbye Windows. The Bluescreen is going through reorganization. What is Google Pack? 02 Louis Braille's birthday Download File List iPod with WiFi 03 Flickr: "2.5.8." by powerbooktrance (license) Music: CDK - Midnight Bliss (Green Dub Mix) (license) I'm a little upset about del.icio.us being swooped by Yahoo!2006-01-05T18:47:03Z
Pride Flag Raised in Silver SpringMontgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 99520222022-06-02T01:32:19Z
ccMixter unwind (a chillout compilation) - vol. 2A studio DJ set featuring ambient, chill and downtempo remixes from ccMixter.org exclusively. All tracks are CC-licensed. DJ-mixed by s.c.mixer. ------------- http://ccmixter.org/ http://ccmixter.org/people/scmixer/2009-07-19T19:31:22Z
1998-04-30 PCWJUL98[541M 1998-04-30] . ├── [ 41 1996-07-01] AUTORUN.INF ├── [ 308 1996-07-04] CATMPC.TRS ├── [ 99 1996-07-04] CDID.TRS ├── [ 36K 1996-02-19] CYRIL1.TTF ├── [ 13M 1998-04-30] DXRS │   ├── [ 20K 1997-03-03] ASK32.EXE │   ├── [261K 1998-04-30] CDXPCW07.DXR │   ├── [ 63K 1997-06-20] COPY.EXE │   ├── [ 63K 1997-06-26] COPYSL.EXE │   ├── [ 18K 1994-12-21] DLLGLUE.DLL │   ├── [ 397 1997-04-04] DUMMY.HTM │   ├── [ 1 1997-04-03] DUMMY.PDF │   ├── [374K 1998-04-30] FGAPCW07.DXR │   ├── [ 13K 1996-03-15] FILEIO.DLL │   ├── [ 20K 1997-03-03] FNAME32.DLL │   ├── [352K 1998-04-30] HANPCW07.DXR │   ├── [628K 1998-04-30] INTPCW07.DXR │   ├── [ 46K 1997-03-03] MASTRAPP.DLL │   ├── [ 42K 1998-04-30] MENUBAR.DXR │   ├── [ 31K 1998-04-28] PCW0798.V12 │   ├── [1.1M 1998-04-30] PCW16.EXE │   ├── [1.4M 1998-04-30] ;19982025-08-22T15:26:41Z
The ABC Of Flight19282025-09-11T16:02:03Z
CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIAApproved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned;19822025-02-22T15:15:54Z
the new testament a new translation19132025-06-17T02:27:47Z
la renaissance des lettres en france19252025-09-24T06:10:17Z
[CDK 053] Various Artists - USK vs FIGHTER X[CDK 053] USK vs FIGHTER X20112020-01-05T20:15:20Z
CIA Reading Room cia-rdp91-00929r000200760015-1: FR:ADAMS E. TO:JOIDO T.Y.m ffill umlr% IW a& EMMKIM pwo T"k Sm MM AW Owma M&va lot Jl* No JPT# a zx9-=." s=6-36-08614Mowt 69 2%3%The Behavior of ProtectIve Host Shields atIWporscnic Flight V610c4ties, by E. Maws 108 ppGEMAN. bk. Das Verh<en vcn Warmschutnchildmbol Itursenischen Plummsdmindigoiten, lm,VIDO309068-VFrD-UT-67-465FOR OFFICIAL USE ONLY FOR IWITINAL USE W111UNTM DEPAMMT OF DEFEM ONLYSci/AarmauticsSep 68 366,480bg t v m 6urtjLm 4wd lobu at Callte&.0 to a~0 ~ all 14 1~ at Lm Us" #~ - 6 jp*ma i-m=p~ - voku - Imff 49 v1WHIP M-m ampt1"s md RRJ-MoARM*4hvgmftl@opt 65"AITA Tsetiftsto 21-bapstsum at 00 Maewaft cru"o tv ftw wau"s 20 W,rim=0 Pw hLaolb lb got N4~Im" w i4.am 4y%mwm a Zara"ftlDO 67WARRr"Wh ?"&dolt* cAualim cob" ftlidskFWq, kW UIM IAWate U M,MOO pwo I& v v Aft--OWV J*# pp 196.0.arm 4302LA-*A&ha"V 673"IP9camcitution of Intermattomallat commmistOrganization, 9 pp,rkjakma Pat# Is VOSAIMI, No. 541, lute,Apgtl-"ay 651, pp. 41-471Ails 43,315InwastionalrolitlealMay 68 338."6savowwwo vasommm tvOugh CR&A;19832026-04-02T14:15:30Z
Carvelli v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2024-07-19T09:07:31Z
The King of Fighters 2002: (BR) [CDK]-Shaka vs(BR) [KOFB]LUIZ - 2022-06-16 05:06:48(BR) [CDK]-Shaka vs (BR) [KOFB]LUIZ - 2022-06-16 05:06:48 Fightcade replay id: 1655356008548-4901 #fightcade #kof2002 #[KOFB]LUIZ #[CDK]-Shaka For more videos check out: https://fightcadevids.com2023-01-21T17:42:48Z
Soil and freshwater niematodes19512025-09-08T04:35:20Z
CDK Global, LLC v. Tekion CorpThis item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly.2023-06-13T09:55:11Z
CIA Reading Room cia-rdp91-00929r000200680025-9: FR:SHUBKIN V.N. TO:SHULISHOVA O.I.- 14 , /.el iconelvto stuat at seem lw V. ov*WAD ,15 P9owns Pori, 1b 3# FM 65# IV WOW$I" 2Z3.1ummemApr 65 7no ?rlIbmis ft no& 206or a* zatw yorms lw To so /0Mdu%,%Tw~m vwo so= tumob ft so ow^ wo WIGNo st3ps~ kl,~oV, ~- -, k L)--um9mAn 6520630quanutatAve Nrtboft la ftWWUWt by Yo So17 vp o--- - vwp &g= UMMW 1b- 3~ X967ioIV? 0JIPMB "3~t. IV SHU6KIAl.2 cumbd4kc ftlime 67 329pM'4-4 7'r-QV'4rtl*S Of DWGIVUlt 4'AtlrAinS Of tl%w 45Vino of vie (.4cm tior~4s (,,orivo siqlax),UY %* F~, Ct 419'it ~*T, v--~Virux %lo it IL66v 17-p 74-76.i. ~~41 ~ ~''Cim"Alrvu f, I 3tiows0~. ( J /' (~. 6 ' ~ /' t"The so-called Homology of Crystals,, by A. V. ShubnikovRUSSIAN, per, Doklady Akadewit Nauk SSSR Vol 88,pp 453-456NAVY/NISC-3346Oct 72Growth ct C4ft*IkUt tV A. V. MuUdkNp V, X.abdull0 -U:WROM ppmo "a cc VWM&A& !=Wamom-Nms To, AW f,~ 4 -, . I r -- , (tic!AVv 4,i*l 1 ~ -swo4w Ge dbs ftugk as"d via llsbr5-1 eusumbohm-Aodk*V&t v IV 91 At 99 pw* It 901 "s 19496or 209-43"-ftota isterimKrArrA-324brek 1970-ft 33Oft L;19832026-04-05T21:18:00Z
github.com-sottlmarek-DevSecOps_-_2022-01-15_03-45-55Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def;20222022-01-15T10:00:54Z
I was a probationer19372025-09-08T07:44:38Z
Predict shipment ETA with no-code machine learning using Amazon SageMaker CanvasOver the last few years, online education platforms have seen an increase in adoption of and an uptick in demand for video-based learnings because it offers an effective medium to engage learners. To expand to international markets and address a culturally and linguistically diverse population, businesses are also looking at diversifying their learning offerings by localizing content into multiple languages. These businesses are looking for reliable and cost-effective ways to solve their localization use cases. Localizing content mainly includes translating original voices into new languages and adding visual aids such as subtitles. Traditionally, this process is cost-prohibitive, manual, and takes a lot of time, including working with localization specialists. With the power of AWS machine learning (ML) services such as Amazon Transcribe , Amazon Translate , and Amazon Polly , you can create a viable and a cost-effective localization solution. You can use Amazon Transcribe to create a;20222022-08-10T05:07:03Z
The Osborne/McGraw-Hill CP/M-86 user's guideviii, 568 p. : 24 cm // On t.p. the registered trademark symbol "R" is superscript following "86" in the title // Includes index19852023-12-22T13:18:25Z
Religion In Life - Season 6 Episode 4For more content and information about AppTV, visit www.watchapptv.com Religion in Life is a show that explores how faith and spirituality play an integral part in the world today. Ozzie Ostwalt, Ph.D., from the Department of Philosophy and Religion hosts the show and engages in discussion with panelists that range from professors, local religious leaders and spiritually engaged community members.20172023-03-30T17:28:36Z
The Old Architecture of Quebec19472025-05-22T17:20:02Z
John O'Neil Johnson Toyota, LLC v. CDK Global, LLCThis item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly.2020-03-22T03:34:24Z
Fu Manchu's Bride19332023-07-25T02:29:21Z
Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases.This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina;20132014-10-28T15:40:11Z
la struttura letteraria della preghiera eucaristica19812025-06-16T05:49:58Z
Founders of american economic thought and policy19582025-09-08T05:32:17Z
The Basic College Of Michigan State19552025-09-12T17:56:25Z
die mikromorphologie der menschlichen zahnpulpa19702025-09-04T05:39:32Z