| Title | Description | Published | Added |
| Authenticom, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-03-25T23:18:28Z |
| Flight Without Power | | 1940 | 2025-09-12T12:32:24Z |
| The pageant of Japanese history, | | 1938 | 2023-07-28T12:19:13Z |
| CDK Global, LLC v. API International, Inc. | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-04-17T10:02:11Z |
| AD #3841 - Rivian Hits Paydirt With Massive VW Investment; Revealed The Last Pontiac Concept Car; CATL Flies 4-Ton Electric Plane | - Rivian Hits Paydirt With Massive VW Investment- Rivian Hints At 5 Future Models- Tesla Drops Under 50% U.S. EV Market Share- CDK Cyberattack Lasts Longer Than Expected- U.S. June Sales At 16.2 Million SAAR- Revealed The Last Pontiac Concept Car- GM-SAIC Use Robots for Car Testing- Bentley Unleashes Most Powerful Model Ever- CATL Flies 4-Ton Electric Plane | 2024 | 2024-11-16T18:41:55Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| Mannen Med Salgpiporna | | 1960 | 2025-09-26T02:02:52Z |
| Two Kinds of Time: Life in Provincial China During the Crucial Years 1940-1941, Revised and Abridged | | 1967 | 2023-12-23T07:35:21Z |
| Aviles v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-06-28T09:07:16Z |
| Predictive value of progesterone receptor in advanced-stage breast cancer patients treated with CDK 4/6 inhibitors | ABSTRACT Aims: Phase III studies investigating CDK 4/6 inhibitors have failed to identify significant predictive or prognostic markers that aid clinicians in therapeutic decision-making. Given the complex treatment landscape in breast cancer, identifying patient and tumor characteristics that optimize the utilization of CDK 4/6 inhibitors across diverse therapeutic approaches is crucial. In our study, we aimed to evaluate the predictive role of progesterone receptor (PR) expression levels in patients with estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative advanced-stage breast cancer treated with CDK 4/6 inhibitors. Methods: This study retrospectively evaluated 244 patients who received a combination of CDK 4/6 inhibitors and endocrine therapy as their first-line treatment. Those with PR levels below 20% were designated as low PR expression patients, and those with levels of 20% or above were classified as high PR expression patients. These two; | 2025 | 2025-08-14T08:44:59Z |
| [CDK 008] AmigaNoizeRaveEP2 | Hot dayum! C64 and Amiga using mentalist Josstin Timberlake has blessed CDK Records with a 6-track of tracking goodness! If you likes yer chiptunes off the wall and off the hook, slap this on yer hard drive now! | 2008 | 2017-09-30T18:10:04Z |
| yahoo-groups-2018-07-21T22-47-06Z-4bbc23 | Yahoo! Groups API grab. Contains messages of the following groups: 1ahoahong 2009cmsc128 abajarcolesterol abqphilosophers aceng1-ib agentorangeveterans alumnisaba93 ap12thv1 apn_maamvanne aquascape-indonesia arabic_inside arkiyoliji1 artsbabes asteric_of_smpn4_bogor ba186_sad bch_tongdoan_2008_2010 beginnerbluegrassjam biblebeegurnee binjakon bits_dlpd_msss2009 blogbirudotcom bsa_bag bspe1-1_economist ca411-1m canoepolohunks0809 ccfcommittee_09_10 che_141_142_tqruv chem2a_woodland cict_itfnds-icb citihi85 contratoscinemauff cool_hood_babii cpi_2009_2010 csci12_tz curriculoseprogramas2009essb dbti_tarlac_faculty discretemath_it2nd dmt_people dnyandeepnews dpms_2010 ec102h eco101_09 eco11_0910 ecoprofessionals_nea edp111_addu elladerma emc_ss_dames encoreestate esjsem1admu0910 galeradoingles2008 genevaacademicfoundation glawenko h-383lpu hau_6comgrad hiltech_group homplantes hum1_thu1 iit-kgp-met75 imtak-05 infoamie ingenieria_gay inspirationaldesignsvoices irc-sbg ironbros-team_one it10; | | 2018-07-21T22:47:14Z |
| Ultimate Mortal Kombat 3: (BR) [CDK]-heldinho vs(BR) [CDK]-Chakality - 2022-04-03 01:22:00 | (BR) [CDK]-heldinho vs (BR) [CDK]-Chakality - 2022-04-03 01:22:00 Fightcade replay id: 1648948920772-7644 #fightcade #umk3 #[CDK]-heldinho #[CDK]-Chakality For more videos check out: https://fightcadevids.com | | 2022-07-24T22:02:35Z |
| Street Fighter Alpha 2 (960430 USA): (BR) [CDK]-Shaka vs(BR) SweetG - 2022-08-22 04:08:29 | (BR) [CDK]-Shaka (Rank D) vs (BR) SweetG C - 2022-08-22 04:08:29 Fightcade replay id: 1661141309737-2933 0:00 Ryu vs Sagat 02:38 Ryu vs Dan 04:15 Dan vs Sagat 06:25 Evil Ryu vs Dan 08:19 Dan vs Zangief #fightcade #sfa2u #0:06:25 #[CDK]-Shaka #SweetG #0:08:19 #Sagat #Zangief #0:02:38 #0:00:10 #Dan #0:04:15 For more videos check out: https://fightcadevids.com | | 2023-01-23T15:42:54Z |
| Cdk-mediated phosphorylation of the Kv?2 auxiliary subunit regulates Kv1 channel axonal targeting. | This article is from The Journal of Cell Biology , volume 192 . Abstract Phosphorylation of Kvβ2 releases Kv1 channels from microtubules to control their specific distribution at the axonal membrane. | 2011 | 2014-10-24T23:30:53Z |
| CDK Global Holdings, LLC v. Tekion Corp. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-02-11T10:29:53Z |
| Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks. | This article is from BMC Systems Biology , volume 6 . Abstract Background: High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately characterize biological processes that have been perturbed at the mechanistic level. Here, a new approach is built on previous methodologies in which high-throughput data was interpreted using prior biological knowledge of cause and effect relationships. These relationships are structured into network models that describe specific biological processes, such as inflammatory signaling or cell cycle progression. This enables quantitative assessment of network perturbation in response to a given stimulus. Results: Four complementary methods were devised to quantify treatment-induced activity changes in processes described by ; | 2012 | 2014-10-25T01:34:45Z |
| Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina; | 2013 | 2014-10-28T15:40:11Z |
| CDK-8 Platform Board - AV-iQ | | | 2021-03-26T15:08:14Z |
| the seal of the spirit | | 1967 | 2025-05-22T15:08:01Z |
| Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy. | This article is from PLoS ONE , volume 9 . Abstract Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects. Olomoucine II and roscovitine, purine-based inhibitors of CDKs, were described as effective antiviral agents that inhibit replication of a broad range of wild type human viruses. Olomoucine II and roscovitine show high selectivity for CDK7 and CDK9, with important functions in the regulation of RNA polymerase II transcription. RNA polymerase II is necessary for viral transcription and following replication in cells. We analyzed the effect of inhibition of CDKs by olomoucine II on gene expression from viral promoters and compared its effect to widely-used roscovitine. We found that both roscovitine and olomoucine II blocked the phosphorylation of RNA polymerase II C-termi; | 2014 | 2014-10-23T20:50:01Z |
| Proteomics of a fuzzy organelle: interphase chromatin. | This article is from The EMBO Journal , volume 33 . Abstract Chromatin proteins mediate replication, regulate expression, and ensure integrity of the genome. So far, a comprehensive inventory of interphase chromatin has not been determined. This is largely due to its heterogeneous and dynamic composition, which makes conclusive biochemical purification difficult, if not impossible. As a fuzzy organelle, it defies classical organellar proteomics and cannot be described by a single and ultimate list of protein components. Instead, we propose a new approach that provides a quantitative assessment of a protein's probability to function in chromatin. We integrate chromatin composition over a range of different biochemical and biological conditions. This resulted in interphase chromatin probabilities for 7635 human proteins, including 1840 previously uncharacterized proteins. We demonstrate the power of our large-scale data-driven annotation during the analysis of cyclin-dependent kinase (CD; | 2014 | 2014-10-23T08:11:58Z |
| Historic Preservation Awards 2013 | | 2013 | 2016-10-07T01:03:50Z |
| U3WM-LPAL: www.autonews.com | Perma.cc archive of https://www.autonews.com/dealers/cdk-reynolds-challenge-ariz-dealer-data-law created on 2021-11-14 00:51:55+00:00. | 2021 | 2021-11-15T02:08:09Z |
| 401 plus v1 1 cdk 4 ultimo | | | 2021-04-16T05:45:35Z |
| On The Development of Biophysical Models for Space Radiation Risk Assessment | Experimental techniques in molecular biology are being applied to study biological risks from space radiation. The use of molecular assays presents a challenge to biophysical models which in the past have relied on descriptions of energy deposition and phenomenological treatments of repair. We describe a biochemical kinetics model of cell cycle control and DNA damage response proteins in order to model cellular responses to radiation exposures. Using models of cyclin-cdk, pRB, E2F's, p53, and GI inhibitors we show that simulations of cell cycle populations and GI arrest can be described by our biochemical approach. We consider radiation damaged DNA as a substrate for signal transduction processes and consider a dose and dose-rate reduction effectiveness factor (DDREF) for protein expression. | 1999 | 2011-05-29T02:54:15Z |
| Laraqua's Masks Of Nyarlathotep Prologue | The prologue for my Masks of Nyarlathotep solo game designed to get the protagonist to New York ready for the Half-Moon Cult adventure followed by Masks itself. More information on the campaign can be found, including Easter Eggs during the various sessions and a little context, can be found under the Masks of Nyarlathotep tag on http://stwildonroleplaying.blogspot.com.au/ The opening music is CDK's Sunday Sunrise which is Creative Commons (Attribution 3.0) and can be found at http://ccmixter.org/files/cdk/13613 Episode 3's subway soundtrack is Public Domain material which can be found at the Soundbible at http://soundbible.com/386-Riding-NYC-Subway-Car.html | 2013 | 2013-11-24T21:58:36Z |
| Behind The Scenes and Updates On Each Case | In this episode, I take you behind-the-scenes of each case I covered in the Court Junkie podcast, as well as go over the latest updates. You'll also hear from Pravin Varughese's mom and family friend, as well as other Court Junkies. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter; | 2017 | 2023-07-08T12:41:02Z |
| Bob Baker Volkswagen v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-16T22:44:00Z |
| Psychology of Personal Adjustment Student's Introduction to Mental Hygience | | 1949 | 2025-09-10T00:53:02Z |
| The Osborne/McGraw-Hill CP/M-86 user's guide | viii, 568 p. : 24 cm // On t.p. the registered trademark symbol "R" is superscript following "86" in the title // Includes index | 1985 | 2023-12-22T13:18:25Z |
| custompc | A Great Design Workflow Starts Before You Open The Software. It Starts With The Right Machine. This CDK Core Performance Series Workstation Is Built For Architects And Designers Who Need Fast Drafting, Smooth BIM Performance, Responsive 3D Navigation, And Reliable Rendering—Without Interrupting Momentum. Because Real Workflows Move Fast. Concepts Become Drawings. Drawings Become Models. Models Become Visuals. And Deadlines Keep Moving. That’s Why This System Is Engineered To Stay Responsive Under Pressure With Optimized Processing Power, Balanced Memory, GPU Acceleration, And Stable Cooling For Long Sessions. What You Get? Cleaner Workflow Transitions. Less Waiting Between Tasks. Smooth Handling Of Large Files. Consistent Performance Across Daily Workloads. AutoCAD, Revit, SketchUp, Lumion, Enscape, Twinmotion & More. This Is The Difference Between A PC And A CDK Workstation. Powering Tomorrow’s Workstations. 📞 +91 92707 66589 🌐 www.designbykira.in #cdkworkstations #archite; | | 2026-06-09T11:25:41Z |
| Sir Kenelm Digby, the ornament of England, 1603-1665 | | 1956 | 2023-12-27T07:06:29Z |
| the zambesi doctors | | 1964 | 2025-06-16T09:45:55Z |
| Federated Learning on AWS with FedML: Health analytics without sharing sensitive data - Part 1 | This post was co-authored with Mark Lott, Distinguished Technical Architect, Salesforce, Inc. Enterprises that operate globally are experiencing challenges sourcing customer support professionals with multi-lingual experience. This process can be cost-prohibitive and difficult to scale, leading many enterprises to only support English for chats. Using human interpreters for translation support is expensive, and infeasible since chats need real-time translation. Adding multi-lingual machine translation to these customer support chat workflows provides cost-effective, scalable options that improve the customer experience by providing automated translations for users and agents, create an inclusive customer experience, and improve brand loyalty. Amazon Translate is a neural machine translation service that delivers fast, high-quality, affordable, and customizable language translation. Service Cloud by Salesforce is one of the world's most popular and highly rated customer service software; | 2023 | 2023-01-29T23:45:49Z |
| DTIC ADA316821: Cellular Proteins Interacting with the Tumor Suppressor Protein p53. | Tumor suppressor protein p53 interacts directly with the DNA replication factor RPA and inhibits its ability to bind single-strand-DNA. We defined the domain of p53 that bound to RPA and constructed p53 mutants that failed to bind RPA, but still functioned as transcriptional activators. We found that while these mutants of p53 lost their ability to bind RPA; they still maintained the growth suppression function of p53. Growth suppression function of p53 is dependent on its transactivation activity, probably by inducing p21 and other cell cycle inhibitors. We have extended our study to the p2l protein, which is induced by p53 and interacts with both the cdk2 Icinase and a DNA replication factor PcNA. Here we have demonstrated the importance of PCNA-inhibitory domain of p21 in vivo. We have also shown that p21 has to interact directly with both cyclin subunit and cdk2 subunit of the cyclin-cdk complex in order to inhibit the kinase activity and suppress cell growth in vivo. | 1996 | 2018-04-03T17:57:56Z |
| Geology And Ireland | | 1963 | 2025-09-11T15:36:50Z |
| The reason you can't buy a car is the same reason that your health insurer let hackers dox you | This week on my podcast, I read The reason you can't buy a car is the same reason that your health insurer let hackers dox you , a column from one of last week's editions of my Pluralistic newsletter; it describes a monopoly pattern whereby companies execute a series of mergers to dominate a sector, leaving their IT systems brittle and tangled - and vital to the nation. Just like with Equifax, the 737 Max disasters tipped Boeing into a string of increasingly grim catastrophes. Each fresh disaster landed with the grim inevitability of your general contractor texting you that he's just opened up your ceiling and discovered that all your joists had rotted out – and that he won't be able to deal with that until he deals with the termites he found last week, and that they'll have to wait until he gets to the cracks in the foundation slab from the week before, and that those will have to wait until he gets to the asbestos he just discovered in the walls. Drip, drip, drip, as you realize th; | 2024 | 2024-06-30T21:51:55Z |
| DTIC ADA435854: The Role of Ubiquitin E3 Ligase SCFSKP2 in Prostate Cancer Development | The CDK inhibitor p27Kipl acts as a negative regulator in the cell cycle and in prostate tumorigenesis. Either the loss of p27 or over-expression of its key regulator ubiquitin E3 ligase SKP2 is associated with prostate cancer. Prostate-sepcific expression of SKP2 is sufficient to induce hyperplasia, displasia, and low grade carcinoma in the mouse prostate gland. We propose to examine whether SKP2 cooperates with or is regulated by tumor suppressors such as Pten or Nkx3.1 implicated in prostatic tumorigenesis. In the past year, we have initiated the experiments by breeding and expansion of the colonies, crossing the SKP2 transgenic mice into Pten +/- strains, and ordering Nkx3.1 mice. Compound mice of SKP2 transgene and Pten +/- were made. Our initial studies suggest that there i&. no substantial difference in tumor frequency and grade in the SKP2 and Pten +/- compound mice versus single genetic alterations. These results suggest that PTEN may act through SKP2 for tumorigenesis. Since ; | 2005 | 2018-05-27T08:46:56Z |
| DTIC ADA378108: Role of the Cdk Inhibitor Sic 1 in Start | Nearly 180,000 women will develop breast cancer in 1999 and 44,000 will die. Cancer is essentially a disease of inappropriate proliferation due to a loss of normal cell cycle controls. We study cell cycle controls in the budding yeast S. cerevisiae. We have shown that the formation of active G1-cyclin dependent kinase complexes (Cdks) is rate limiting for cell cycle progression. The activity of these complexes is regulated through their association with highly unstable G1 cyclins. G1 cyclins are constitutively unstable, and their only essential function is to phosphorylate the B-type Cdk inhibitor, Sic1, and target it for degradation. Sic1 is one of few known in vivo substrates of yeast G1-Cdks. The amount and phosphorylation state of Sic1 appears to determine the timing and size of cell division. Sic1 mutants lacking several phosphorylation sites are stabilized and completely block cell cycle progression. Thus, the phosphorylation and subsequent degradation of Sic1 appears to be the c; | 1999 | 2018-04-28T13:18:00Z |
| DTIC ADA482640: Suppression of Prostate Tumors by INK4C and PTEN | Work during this entire funding period thoroughly characterized mutant mice in the cyclin-dependent kinase (CDK) inhibitor p18Ink4c, which causes hyperplastic cell growth in various tissues including the prostate and the lipid phosphatase Pten, which regulates cell growth and is highly associated with the development of human prostate cancer. The first two years of funding were highly productive and resulted in one manuscript publication supporting a functional collaboration between p18Ink4c and Pten in tumor suppression. Both the rate and spectrum of tumor development in the compound mutant mice were substantially accelerated and expanded. Combined genetic, histological, cellular, and biochemical analyses led to four major findings: (i) that p18 and PTEN each have previously unrecognized functions in tumor suppression, such as p18's function in the prostate and anterior lobe of the pituitary and PTEN's function in the pituitary, (ii) that the p18-Pten double mutant mice developed vari; | 2007 | 2018-06-22T04:53:07Z |
| Congenital Dislocation of the Knee in a Newborn | Congenital dislocation of the knee (CDK) is a relatively rare condition with an estimated prevalence of 1 per 100 000 live births, which is approximately 1% of the incidence of developmental dysplasia of the hip1. It may occur in isolation, but often occurs in the presence of muscle imbalance such as that seen with arthrogryposis, Larsen syndrome, and myelomeningocele. CDK has also been reported to occur with other musculoskeletal abnormalities including developmental hip dysplasia, clubfoot, congenital vertical talus, and congenital dislocation of the elbow2. | 2020 | 2024-05-09T10:25:38Z |
| DTIC ADA453395: Suppression of Prostate Cancer by PTEN and p18INK4c | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (exp Ink4c) and the lipid phosphatase PTEN, which regulates cell growth and survival. The p18(exp -/-) ; PTEN (exp +/-) double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C-cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in PTEN (exp +/-) cells, and further activated and accumulated in the nucleus in p18 (exp -/-) ; PTEN (exp +/-) tumor cells, suggesting a tissue- and genetic background-dependent haploinsufficiency of Pten in tum; | 2006 | 2018-06-05T18:22:11Z |
| DTIC ADA300399: Functions of Wild-Type and Mutant Forms of p53 in Breast Cancer. | Cells induced to accumulate the p53 tumor suppressor protein have been shown to arrest in G1. This arrest is characterized by accumulation of the cyclin dependent kinase (CDK) inhibitor p2l (WAF1/CIP1) and of underphosphorylated forms of retinoblastoma protein (pRB). We show here that accumulation of the wild-type pS3 protein in either human or murine cells markedly increases expression of cyclin Dl. The induction of cyclin Dl can also be mediated by a target of p53, the p21 (WAF1/CIP1) inhibitor of cyclin-dependent kinases. The relationship between the induction of cyclin Dl and G1 arrest defines a new cellular response to p53. | 1995 | 2018-03-24T09:25:56Z |
| DTIC ADA398199: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal Tumorigenic Human Breast Cells | Ubiquitin-mediated proteolysis of cyclins, cyclin-dependent kinase inhibitors and certain other substrates, including proteins whose degradation is necessary for progression through mitosis, provide a molecular basis for unidirectional progression through the eukaryotic cell cycle. Aberrations in the ubiquitin-mediated destruction pathways, and particularly in the destruction of the Dl cyclin, have been implicated in human breast cancer. A cascade of enzymes leads to ubiquitination of substrate: El enzyme (ubiquitin activating); E2 enzyme (ubiquitin conjugating), and E3 enzyme (ubiquitin ligase). This last class of enzyme is large, and it performs the functions of targeting substrate and catalyzing formation of the polvubiquitin chains that mark substrate for destruction. We have found that all three members of the yeast cullin family are capable of performing the ubiquitination activity of E3 enzyme. All three yeast cullins undergo covalent modification with Rub1 protein, presumably t; | 2001 | 2018-05-05T21:00:08Z |
| DTIC ADA412793: Chemotherapy of Late Stage Breast Cancer Targeted Towards Cell Cycle Regulatory Components | Our original goal was to target cell cycle regulatory components as a potential therapy for breast cancer. The target p16 is a tumor suppressor and a CDK inhibitor and is inactivated by gene methylation. The drug 5-aza-2'deoxycytidine (5-Aza-CdR), an inhibitor of DNA methylation, is targeted for reexpression of a repressed p16 in late stage breast cancer patients. Re-activation of the p16 gene in cells in which the gene is methylated will restore normal growth control and be efficacious in treatment of breast cancer. A mouse model for the action of the drug was developed and used to test the efficacy of the drug. | 2002 | 2018-05-12T16:53:07Z |
| DTRASH10 - Bastards United - Bastards United | This is a killer collection of breakneck headbanger digital thrash music. Bastards United have are a complete digicore band with guitarists, MCs and program thrashers. Straight from the Netherlands, BU collaborates on some slammin' tracks with Rabies/CDK and b57 from CPUWAR in the mix! | 1999 | 2008-04-19T16:24:14Z |
| CDK Core Performance Series | CDK Architectural Performance Workstation — Built for Architecture at Scale. When Speed Is Non-Negotiable. Powered by the Intel Core i7-14700F, ZOTAC GeForce RTX 5060 16GB, and 32GB ADATA DDR5-4800 on the ASUS Prime B760M-A platform, this configuration is engineered for fast modeling, smooth viewport performance, and accelerated rendering workflows. Seamlessly run Autodesk Revit, AutoCAD, SketchUp, 3ds Max, Lumion, Enscape, V-Ray, Twinmotion, and BIM coordination tools with stable real-time performance and efficient resource allocation. From concept modeling to high-resolution renders and large-scale BIM projects, this workstation delivers responsive navigation, faster render iterations, optimized memory handling, and reliable thermal stability for long production hours. Expect smoother real-time visualization, reduced render wait times, efficient multitasking, and zero workflow bottlenecks — even on complex architectural assemblies. If your studio demands consistency, scalability,; | | 2026-04-09T10:47:02Z |
| Het Utrechts Archief 168792 | Het Utrechts Archief catalog number: 168792 Description (Dutch): Afbeelding van een gezelschap op het 4e perron van het N.S.-station Rotterdam C.S. te Rotterdam, bij het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het betreft hier een gezelschap uit een extra trein voor de Handelsmaatschappij R.S. Stokvis en Zonen. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). | 1961 | 2021-02-05T03:16:03Z |
| DTIC ADA382749: Resistance to Tamoxifen: A Consequence of Altered p27Kipl Regulation During Breast Cancer Progression | This grant addresses the molecular mechanisms of resistance to the anti-estrogen, Tamoxifen, in breast cancers. Both estrogens and antiestrogens influence the cell cycle during the GI phase. In breast tumors, loss of the cdk inhibitor, p27, is associated with a poor prognosis and with steroid resistance. We postulate that altered p27 degradation in breast cancer may contribute to resistance to antiestrogen therapy. In the last year, we have assayed cell cycle effects of estradiol in the ER+ breast cancer cell line, MCF-7. MCF-7 arrests in G1 upon removal of estradiol or on addition of Tamoxifen. Upon re-addition of estradiol, cells re-enter the cell cycle with onset of S phase by 12 hours and loss of both p21 and p27 proteins. Cyclin D1 associated kinase activity rose transiently in early G1. Activation of cyclin E/cdk2 kinase in mid-late G1 was accompanied by loss of cyclin E-associated p21 and p27. The requirement for p27 in the quiescence induced by estradiol depletion was investiga; | 1999 | 2018-04-29T17:57:19Z |