| Title | Description | Published | Added |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| CDK 01 20 | 01*200 | | 2023-03-23T13:43:39Z |
| I was a probationer | | 1937 | 2025-09-08T07:44:38Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Irradiation And The Nervous System | | 1963 | 2025-09-11T15:24:38Z |
| Authenticom, Inc. v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2020-03-25T23:18:28Z |
| A surgeon remembers | | 1953 | 2023-12-22T18:53:56Z |
| Flight Without Power | | 1940 | 2025-09-12T12:32:24Z |
| le mouvement baptiste en palestine et syrie | | 1935 | 2025-06-16T22:29:54Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| Mannen Med Salgpiporna | | 1960 | 2025-09-26T02:02:52Z |
| Education and society in modern Germany | | 1949 | 2023-07-25T04:04:04Z |
| CIA Reading Room cia-rdp79-01209a000400060001-9: Weekly Situation Report on International Terrorism | Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 No em Abroad Co oiled Dissem Weekly Situation Report on into tional Terrorism Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9----~ Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-925X1 C3b2 Next 6 Page(s) In Document Exempt Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 SE NOTES Khartoum BSO Terrorists Imprisoned in Egypt The eight Black September Organization terrorists con- victed of murdering two U.S. diplomats and the Belgian Charge d'Affaires in Khartoum in. March 1973 are currently in an Egyp- tian prison, according to the State Department. The eight, sentenced to life imprisonment on 24 June by a Khartoum court, had their terms reduced by Sudanese President Numayri and were reportedly to be turned over to the Palestine Liberation Organi- zation (PLO) to serve seven-year sentences. According to pre; | 1974 | 2023-06-26T22:33:05Z |
| Separation - Invuduation | | 1971 | 2025-09-08T02:57:52Z |
| CDK Global, LLC v. Southeast Atlantic Peterbilt of North Carolina, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-30T20:14:22Z |
| le bapteme et la confirmation | | 1969 | 2025-06-16T09:29:09Z |
| the valaue theory of karl marx | | 1976 | 2025-05-22T13:48:47Z |
| The Future of Public Access TV and The Internet | Mark Cooper of the Consumer Federation of America speaks with local independent radio host John Grebe about current bills in Congress affecting the future of Public Access Television and the Internet. We also hear from Jason Crow, Access Coordinator of Cambridge Community Television and Michael Eisenmenger of Manhattan Neighborhood Network about how pending legislation in Congress takes away local control of media and places more power in the hands of Big Cable and Telephone companies. Click here to listen to the ACMEBoston Podcast February 11, 2006. Also discussed is the issue of Network Neutrality which Free Press , the national media reform organization, describes as "the guiding principle of the Internet that fosters open competition and innovation, while preserving the independence and accessibility of the World Wide Web" - Free Press, Net Freedom Now . To take a closer look at these issues, we'll hear John Grebe's interview from his program, "Sounds of Dissent" broadcast live on ; | 2006 | 2006-07-27T08:21:29Z |
| DTIC ADB231798: Biochemical Characterization of Complexes with p21, a CDK Inhibitor | The cyclin-dependent kinases (CDKs) are of pivotal importance for driving cell proliferation. The p2l/WAFl protein, by contrast, belongs to a family of growth regulators that are thought to restrain cell growth primarily as a consequence of their ability to inhibit CDKs. In vivo, p2l is known to form stable, higher order complexes with cyclin-dependent kinases and the DNA polymerase processivity factor, PCNA. As an important downstream target of the p53 checkpoint gene, p21 is thought to execute a critical growth arrest function in response to DNA damage and other cellular stress and differentiation signals. In addition, loss of p21 function may be associated with cellular transformation in some settings. Despite this information, it is not yet clear how p21 functions in vivo to regulate the multiple complexes with which it associates. Nor is it clear how p21 specifically regulates CDKs in vivo or whether all components of p21 complexes have been identified. Given the role of p21 and r; | 1997 | 2018-02-28T13:39:40Z |
| github.com-TinkoffCreditSystems-taiga-ui_-_2021-01-15_11-30-12 | Angular UI Kit and components library for awesome people Taiga UI Website • Documentation • CDK Wiki • Core team Taiga UI is fully-treeshakable Angular UI Kit consisting of multiple base libraries and several add-ons. It is based on ng-polymorpheus dynamic content approach and uses Web APIs for Angular for required browser APIs. Why Taiga UI 🧩 Modular and fully-treeshakable. We harnessed the power of Secondary Entry Points mechanism. You can import even just one entity from our library and be sure that there is no redundant code in your bundle 🧙 Agnostic . Our components are very flexible and are ready for any use case. But we take care of basic UX aspects to let you focus on your project features 🦋 Customizable . We use CSS custom properties for all our styling and provide easy methods to customize all UI components 🛠 Well engineered . We are not afraid of DI, all our components use OnPush and the whole project is developed with strict TypeScript mode 📦 It's big! ; | 2021 | 2021-01-15T15:07:20Z |
| Aktu 20.05.1 | Toute l'aKtualité de Kubernetes en français. https://github.com/p7t/actus https://github.com/goharbor/harbor/releases/tag/v2.0.0 https://github.com/kubernetes-sigs/kind/releases/tag/v0.8.0 https://cdk8s.io/ https://github.com/ahmetb/kubectx/releases/tag/v0.9.0 | 2020 | 2020-05-20T10:34:03Z |
| DTIC ADA443026: Radiation Sensitization in Breast Cancer via Targeting Survivin Expression | We proposed to determine whether overexpression- of surviving results in radio resistance and the possible mechanisms; whether irradiation down regulates p34(CDC2) and its mechanism in vascular endothelium and whether CDK (cyclin dependent kinase) inhibitors sensitize it to radiation injury; the mechanism of surviving- deregulation in breast cancer and whether inhibition of surviving or its regulator, p34(CDC2) abolishes radio resistance. We found that overexpression of surviving leads to radiation resistance and CDK inhibitors result in radiosensitization. We also found that deregulation of surviving in breast cancer is mediated by Stat3 (Signal transducer and activator of transcription). Co-inhibition of surviving and Stat3 results in significantly increased sensitization of breast cancer. In the next two years, we will determine the biological significance of combining surviving inhibitors or CDK inhibitors with radiotherapy in xenograft models of breast cancer. The proposed study w; | 2005 | 2018-05-30T23:48:34Z |
| DTIC ADA388035: Cyclin D1, Anchorage-Independent Growth and Breast Cancer | Derangements in the cell cycle machinery contribute to uncontrolled cell growth and tumorigenesis. Regulators of G1 progression including cyclin D1 and the cyclin-dependent kinase inhibitors p21 and p27 appear to be of particular importance in the pathogenesis of breast cancer. We suggest that aggressive breast cancer will involve both (i) overexpression of cyclin D1 and (ii) the failure to undergo a compensatory upregulation of cdk inhibitors. The specific aims are designed to test these hypotheses in cell culture models, nude mice, and breast cancer biopsies. We have generated mouse embryo fibroblasts (MEFs) that stably express a tetracycline-regulated cyclin D1 construct. In contrast to the data in NIH-3T3 cells, there was no compensatory upregulation of p2l in MEFs despite significant overexpression of cyclin D1. This may be due to the acquisition of p53 mutations. In addition, human breast cancer tissues have been analyzed for cyclin D1, p27 and Ki67 expression. Following optimiza; | 1999 | 2018-05-01T07:57:13Z |
| On The Development of Biophysical Models for Space Radiation Risk Assessment | Experimental techniques in molecular biology are being applied to study biological risks from space radiation. The use of molecular assays presents a challenge to biophysical models which in the past have relied on descriptions of energy deposition and phenomenological treatments of repair. We describe a biochemical kinetics model of cell cycle control and DNA damage response proteins in order to model cellular responses to radiation exposures. Using models of cyclin-cdk, pRB, E2F's, p53, and GI inhibitors we show that simulations of cell cycle populations and GI arrest can be described by our biochemical approach. We consider radiation damaged DNA as a substrate for signal transduction processes and consider a dose and dose-rate reduction effectiveness factor (DDREF) for protein expression. | 1999 | 2011-05-29T02:54:15Z |
| Nutrient limitations alter cell division control and chromosome segregation through growth-related kinases and phosphatases. | This article is from Philosophical Transactions of the Royal Society B: Biological Sciences , volume 366 . Abstract In dividing fission yeast Schizosaccharomyces pombe cells, the balance between Wee1 kinase and Cdc25 phosphatase which control the cyclin-dependent kinase (CDK) at the G2–M transition determines the rod-shaped cell length. Under nitrogen source starvation or glucose limitation, however, cell size determination is considerably modulated, and cell size shortening occurs for wild-type cells. For several mutants of kinases or phosphatases, including CDK, target of rapamycin complex (TORC) 1 and 2, stress-responsive mitogen-activated protein kinase (MAPK) Sty1/Spc1, MAPK kinase Wis1, calcium- and calmodulin-dependent protein kinase kinase-like Ssp1, and type 2A and 2A-related phosphatases inhibitor Sds23, this cell shortening does not normally occur. In tor1 and ssp1 mutants, cell elongation is observed. Sds23 that binds to and inhibits 2A and 2A-related phosphatases is syne; | 2011 | 2014-10-27T03:15:22Z |
| Re-thinking cell cycle regulators: the cross-talk with metabolism. | This article is from Frontiers in Oncology , volume 3 . Abstract Analysis of genetically engineered mice deficient in cell cycle regulators, including E2F1, cdk4, and pRB, showed that the major phenotypes are metabolic perturbations. These key cell cycle regulators contribute to lipid synthesis, glucose production, insulin secretion, and glycolytic metabolism. It has been shown that deregulation of these pathways can lead to metabolic perturbations and related metabolic diseases, such as obesity and type II diabetes. The cyclin–cdk–Rb–E2F1 pathway regulates adipogenesis in addition to its well-described roles in cell cycle regulation and cancer. It was also shown that E2F1 directly participates in the regulation of pancreatic growth and function. Similarly, cyclin D3, cdk4, and cdk9 are also adipogenic factors with strong effects on whole organism metabolism. These examples support the emerging notion that cell cycle regulatory proteins also modulate metabolic processes. These ce; | 2013 | 2014-10-28T16:47:52Z |
| Molecular mechanisms of anti-tumor properties of P276-00 in head and neck squamous cell carcinoma. | This article is from Journal of Translational Medicine , volume 11 . Abstract Background: Tumors of the head and neck present aggressive pathological behavior in patients due to high expression of CDK/CCND1 proteins. P276-00, a novel CDK inhibitor currently being tested in clinic, inhibits growth of several cancers in vitro and in vivo. The pre clinical activity of P276-00 in head and neck cancer and its potential mechanisms of action at molecular level are the focus of the current studies. Method: We have investigated the anti-cancer activity of P276-00 in head and neck tumors in vitro and in vivo. Candidate gene expression profiling and cell based proteomic approaches were taken to understand the pathways affected by P276-00 treatment. Results: It was observed that P276-00 is cytotoxic across various HNSCC cell lines with an IC50 ranging from 1.0-1.5 μmoles/L and culminated in significant cell-cycle arrest in G1/S phase followed by apoptosis. P276-00 treatment suppressed cell prolif; | 2013 | 2014-10-24T19:52:55Z |
| Particled Mica, STB-HO has chemopreventive potential via G1 arrest, and inhibition of proliferation and vascular endothelial growth factor receptor 2 in HCT colorectal cancer cells. | This article is from BMC Complementary and Alternative Medicine , volume 13 . Abstract Background: Though Mica, a thin and sheet like mineral, has been used as a mineral medicine for treatment of bleeding, dysentery and inflammation in traditional medicine including Ayurveda, the biological evidences of Mica were not clearly elucidated so far. Thus, in the present study, the antitumor mechanism of particled Mica (STB-HO) was examined in colorectal cancers. Methods: Athymic nude mice were inoculated with HCT116 colon cancer cells and orally administered STB-HO daily for 41 days, and HCT116 and human umbilical vein endothelial cells (HUVECs) were treated with STB-HO for 0 ~ 24 hours to perform immunoblotting, cytotoxicity assay, FACs analysis and measurement of matrix metalloproteinase 9 (MMP-9) secretion and other experiments. Significant differences of all date were evaluated using Student’s t-test and a Turkey-Kramer multiple-comparison post test. Results: STB-HO significantly; | 2013 | 2014-10-25T04:28:02Z |
| ccMixter unwind (a chillout compilation) - vol. 2 | A studio DJ set featuring ambient, chill and downtempo remixes from ccMixter.org exclusively. All tracks are CC-licensed. DJ-mixed by s.c.mixer. ------------- http://ccmixter.org/ http://ccmixter.org/people/scmixer/ | | 2009-07-19T19:31:22Z |
| [CDK 010] Infinite Power | RARGHHHHHH! In CDK’s first all-scouse release, and our tenth release (Double figures! how exciting!) SoundMatrix unleashes his debut EP, packed with 6 tracks all chock-full with 100% of the daily amount nutrients and vitamins you could ever need. Or something. This is good anyway, download it yer bastards. The artwork is by sparkyboy too, pretty sick. | 2008 | 2019-12-06T22:14:50Z |
| [CDK 038] Various Artists - Run | [CDK 038] Various Artists - Run (Music For the Distance Jogger) | 2009 | 2020-01-05T14:56:16Z |
| [CDK 048] PlainFlavored - Hexadecimator, Chipmusic in G Minor | [CDK 048] PlainFlavored - Hexadecimator, Chipmusic in G Minor | 2010 | 2020-01-05T19:44:06Z |
| [CDK 053] Various Artists - USK vs FIGHTER X | [CDK 053] USK vs FIGHTER X | 2011 | 2020-01-05T20:15:20Z |
| The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. | This article is from Nucleic Acids Research , volume 40 . Abstract The protein arginine methyltransferase 6 (PRMT6) is a coregulator of gene expression and executes its repressing as well as activating function by asymmetric dimethylation of histone H3 at R2 (H3 R2me2a). Given that elevated expression levels of PRMT6 have been reported in various cancer types, we explore here its role in cell proliferation and senescence. We find that knockdown of PRMT6 results in proliferation defects of transformed as well as non-transformed cells, causes G1-phase arrest and induces senescence. This phenotype is accompanied by transcriptional upregulation of important cell cycle regulators, most prominently the cyclin-dependent kinase (CDK) inhibitor gene p21 (p21CIP1/WAF1, CDKN1A) and p16 (p16INK4A, CDKN2A). Chromatin immuno-precipitation analysis reveals that the p21 gene is a direct target of PRMT6 and the corresponding histone mark H3 R2me2a. Using a cell model of oncogene-induced senescence (OIS; | 2012 | 2014-10-28T05:36:50Z |
| [CDK 012] Spurs Of A Dead Ranger | YEEE-HAW! Sparkyboy , possibly South Africa’s only chipartist, has unleashed this heaven for us – It’s one of the more unique releases out there, utilising everything from Game Boys to his toy guitar collection! I’m loving it all at the moment, especially ‘Gloom’ – what an opener! | 2008 | 2019-12-06T22:32:39Z |
| One system. Zero compromises. | One system. Zero compromises. Built for professionals who demand speed, stability, and long-term reliability — whether it’s heavy multitasking, high-resolution content creation, or GPU-accelerated compute. Custom-engineered by CDK to handle modern workflows effortlessly and perform consistently under real-world loads. This isn’t just power on paper — it’s performance you can rely on, every single day. 🔧 Engineered for serious work ⚡ Optimized for sustained performance 🛡️ Built to last, not just benchmark Powering Tomorrow’s Workstations. 📞 Call us: +91 92707 66589 🌐 Visit us: www.designsbykira.in #CDKWorkstations #BuiltForProfessionals #HighPerformancePC | | 2026-04-09T10:28:48Z |
| The mystery of baptism | | 1901 | 2025-05-22T17:56:48Z |
| Living embers: the life and writings of George William Griffith | | 1937 | 2023-12-28T00:31:16Z |
| Spagnoli v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2024-04-26T09:11:10Z |
| Laraqua's Masks Of Nyarlathotep Prologue | The prologue for my Masks of Nyarlathotep solo game designed to get the protagonist to New York ready for the Half-Moon Cult adventure followed by Masks itself. More information on the campaign can be found, including Easter Eggs during the various sessions and a little context, can be found under the Masks of Nyarlathotep tag on http://stwildonroleplaying.blogspot.com.au/ The opening music is CDK's Sunday Sunrise which is Creative Commons (Attribution 3.0) and can be found at http://ccmixter.org/files/cdk/13613 Episode 3's subway soundtrack is Public Domain material which can be found at the Soundbible at http://soundbible.com/386-Riding-NYC-Subway-Car.html | 2013 | 2013-11-24T21:58:36Z |
| IUMA: ballantine skuadra | Todo Partio por el año 98', cuando se conocieron Knowman y Black Market. Paso el tiempo y fueron formando distintos grupos (BLG, AGS, CDK), hasta que el 2002 dieron en el clavo creando la BALLANTINE'SKUADRA (un poco en broma, un poco en realidad), con el tiempo fue tomando fuerza e integrando a mas personajes. Un "gancho" en esa creación fue God Killah quien tenia una larga amistad con Get Killah, y este con Dj Killah. Al mismo tiempo otra amistad de antaño es la de God Killah y Glace one, lo que facilito la union entre todos (God Killah conocio hace muchos años a Black Market jejeje.). Get Killah con God Killah, hicieron el primer tema con el respaldo de Dj Killah. Se fueron creando distintas formulas, muchas practicas, todo para obtener el sonido que tenemos. La BTS como cada uno tubo un "comenzar" diferente, tienen muchos estilos y muchas influencias, esta mescla es la que le da el "toque". Los estudios son Black Label Studios a cargo de Dj Killah y la colaboración de los demas; | | 2012-05-16T19:45:45Z |
| Are phylogenetic trees suitable for chemogenomics analyses of bioactivity data sets: the importance of shared active compounds and choosing a suitable data embedding method, as exemplified on Kinases. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: ‘Phylogenetic trees’ are commonly used for the analysis of chemogenomics datasets and to relate protein targets to each other, based on the (shared) bioactivities of their ligands. However, no real assessment as to the suitability of this representation has been performed yet in this area. We aimed to address this shortcoming in the current work, as exemplified by a kinase data set, given the importance of kinases in many diseases as well as the availability of large-scale datasets for analysis. In this work, we analyzed a dataset comprising 157 compounds, which have been tested at concentrations of 1 μM and 10 μM against a panel of 225 human protein kinases in full-matrix experiments, aiming to explain kinase promiscuity and selectivity against inhibitors. Compounds were described by chemical features, which were used to represent kinases (i.e. each kinase had an active set of features and an ina; | 2013 | 2014-10-28T15:40:11Z |
| acculturation in the americas | | 1952 | 2025-06-17T03:22:59Z |
| Bob Baker Volkswagen v. CDK Global, LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. This information is uploaded quarterly. To see our most recent version please use the source url parameter, linked below. To see the canonical source for this data, please consult PACER directly. | | 2018-09-16T22:44:00Z |
| the civilizations of ancient america | | 1951 | 2025-06-17T02:55:30Z |
| linuxbrew cdk | linuxbrew cdk | | 2021-04-07T20:55:45Z |
| The cry of Vietnam: poetry | | 1968 | 2024-06-24T16:35:37Z |
| Jones v. CDK Global LLC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2019-11-07T10:41:43Z |
| the zambesi doctors | | 1964 | 2025-06-16T09:45:55Z |
| MESSIAH: His Redemptive Career | | 1935 | 2024-08-13T06:44:04Z |