| Title | Description | Published | Added |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Irradiation And The Nervous System | | 1963 | 2025-09-11T15:24:38Z |
| Research in physiology | | 1971 | 2025-09-08T00:26:07Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| De Racine Au Parthenon: Essais Sur La Litterature Et L'Art A L'age Classique | | 1977 | 2025-09-04T14:43:38Z |
| John Gay, his place in the eighteenth century | | 1938 | 2023-12-27T15:46:10Z |
| Marine molluscan genera of western north america | | 1963 | 2025-09-08T08:50:24Z |
| AD #3850 - Lyriq Now #2 in Cadillac Sales; GM Backs Off 1 Million EV Goal by 2025; Chinese Suppliers Race Into Mexico | - GM Backs Off 1 Million EV Goal by 2025- Lyriq Now #2 in Cadillac Sales- Forecasts BEVs to Hit 50% U.S. Sales by 2030- Cyberattack Cost Dealers $1 Billion- Lucid Claims Most Efficient EV- Stellantis Sues Another Supplier- Stellantis To Sell Recycled Oil- TotalEnergies to Install 3,000 Chargers in UK- With New A5 Audi Has No Coupe or Convertible- Chinese Suppliers Race Into Mexico- Suddenly EREVs Make A Lot of Sense | 2024 | 2024-11-16T17:25:08Z |
| Education and society in modern Germany | | 1949 | 2023-07-25T04:04:04Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-07T09:45:28Z |
| github.com-sottlmarek-DevSecOps_-_2022-01-14_09-42-59 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def; | 2022 | 2022-01-14T21:43:52Z |
| 534: How Toma is Transforming Car Dealerships with Voice AI Technology | Host Chad Pytel interviews Monik Pamecha, the Co-Founder and CEO of Toma, a company specializing in AI for the automotive industry. Monik discusses how Toma automates phone calls for car dealerships, enhancing customer service and streamlining interactions. Despite advancements in digital communication, phone calls remain crucial in the automotive sector, and Toma leverages AI to improve these experiences significantly.Monik shares his journey in the tech industry, detailing Toma's evolution from experimenting with different AI applications to focusing on voice AI. He explains the challenges and successes faced along the way, highlighting how AI technology has matured since his early work with chatbots in 2016. The conversation reveals how Toma's voice AI quickly gained user traction, validating their focus on this innovative technology.The episode also delves into the practical implementation of Toma's AI solutions in the automotive industry. Monik emphasizes the importance of integra; | 2024 | 2025-03-09T20:57:37Z |
| The King of Fighters 2002: (BR) PPSh-41 vs(BR) [CDK]-Shaka - 2023-01-27 13:30:18 | (BR) PPSh-41 vs (BR) [CDK]-Shaka - 2023-01-27 13:30:18 Fightcade replay id: 1674826218824-5406 #fightcade #kof2002 #[CDK]-Shaka #PPSh-41 For more videos check out: https://fightcadevids.com | | 2023-01-27T18:11:11Z |
| An Antioxidant Extract of Tropical Lichen,Parmotrema reticulatum, Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cell Line MCF-7. | This article is from PLoS ONE , volume 8 . Abstract This report highlights the phytochemical analysis, antioxidant potential and anticancer activity against breast carcinoma of 70% methanolic extract of lichen, Parmotrema reticulatum (PRME). Phytochemical analysis of PRME confirms the presence of various phytoconstituents like alkaloids, carbohydrates, flavonoids, glycosides, phenols, saponins, tannins, anthraquinones, and ascorbic acid; among which alkaloids, phenols and flavonoids are found in abundant amount. High performance liquid chromatography (HPLC) analysis of PRME revealed the presence of catechin, purpurin, tannic acid and reserpine. Antioxidant activity was evaluated by nine separate methods. PRME showed excellent hydroxyl and hypochlorous radical scavenging as well as moderate DPPH, superoxide, singlet oxygen, nitric oxide and peroxynitrite scavenging activity. Cytotoxicity of PRME was tested against breast carcinoma (MCF-7), lung carcinoma (A549) and normal lung fibroblas; | 2013 | 2014-10-28T23:51:24Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |
| Fangchinoline induces G0/G1 arrest by modulating the expression of CDKN1A and CCND2 in K562 human chronic myelogenous leukemia cells. | This article is from Experimental and Therapeutic Medicine , volume 5 . Abstract Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by the oncoprotein BCR-ABL, which exhibits a constitutive tyrosine kinase activity. Imatinib mesylate (IM), an inhibitor of the tyrosine kinase activity of BCR-ABL, has been used as a first-line therapy for CML. However, IM is less effective in the accelerated phase and blastic phases of CML and certain patients develop IM resistance due to the mutation and amplification of the BCR-ABL gene. Fangchinoline, an important chemical constituent from the dried roots of Stephaniae tetrandrae S. Moore, exhibits significant antitumor activity in various types of cancers, including breast, prostate and hepatocellular carcinoma. However, the effects and the underlying mechanisms of fangchinoline in CML remain unclear. In the present study, we identified that fangchinoline inhibits cell proliferation in a dose- and time-dependent manner in K562; | 2013 | 2014-10-29T06:42:29Z |
| Nathan The Caveman | | 2008 | 2025-09-09T14:18:04Z |
| [CDK 017] NSF File | Californian badass TristEndo is a Famitrackin’ motherfucker – and this album is CDK’s first all NSF release! A very rock influenced release, it’s a surefire way to get your fists pumping, and TristEndo doesn’t even need to resort to excessive unce! I’m especially loving the song ‘Destination’ – TristEndo is an artist to look out for in 2008/2009! There are two downloads, one with the MP3s and NSFs of the album, and a NSF only version! For those not in the know, a NSF (or NES Sound File) file is a chiptune only file, which (even though it has a tiny size) is less compressed than the mp3! So download a NSF player (I recommend VirtuaNSF (go to “Other program / data”) , whack this in and enjoy!) Or you could, y’know, just put the mp3s in your media player and enjoy them that way. | 2008 | 2019-12-06T23:51:18Z |
| [CDK 035] Josstin Timberlake - eatfuck | [CDK 035] Josstin Timberlake - eatfuck | 2009 | 2020-01-03T02:21:31Z |
| [CDK 012] Spurs Of A Dead Ranger | YEEE-HAW! Sparkyboy , possibly South Africa’s only chipartist, has unleashed this heaven for us – It’s one of the more unique releases out there, utilising everything from Game Boys to his toy guitar collection! I’m loving it all at the moment, especially ‘Gloom’ – what an opener! | 2008 | 2019-12-06T22:32:39Z |
| East McComb Body Shop, Individually and on behalf of all similarly situated persons v. CDK GLOBAL INC | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:31:20Z |
| Super Mario moonshine bloopers 2.1: Mario checks (not) in. | Originally uploaded by LordPenguin777 on April 30th, 2007. Original description: The entire part whas too big and I had too split it up in 2 parts. Enjoy it | | 2023-11-26T14:29:33Z |
| Social Behavior | | 1978 | 2025-09-11T18:35:52Z |
| Lars Hartman Auf den namen desherrn jesus | | 1992 | 2025-06-20T04:18:02Z |
| DTIC ADA303157: Role of Changes in the Expression of Cyclins and Retinoblastoma Protein in the Development of Breast Cancer. | In the initial year of the grant, we have carried out the bulk of the studies to characterize breast cancer cell lines with respect to overexpression of cyclin Dl protein and the presence of Rb (retinoblastoma) protein (Specific Aim No. 1). In addition, we have begun examination of surgically obtained breast cancer tissue samples for cyclin Dl protein overexpression and Rb protein content (Specific Aim No. 6). Since the original grant proposal was submitted, advances in our understanding of cell cycle regulation, and in particular advances in our understanding of the importance of defects in cell cycle regulation to the development of cancer, have proceeded at a rapid pace( )( ). In order to incorporate these advances into our investigation of cell cycle regulatory defects in breast cancer, we have expanded and reoriented some aspects of our approach. This has included a detailed assessment of the levels of cyclin dependent kinase (cdk) 4 and cdk 6, and of the cdk4/cdk6-specific cdk in; | 1995 | 2018-03-26T00:06:56Z |
| yahoo-groups-2018-07-21T22-47-06Z-4bbc23 | Yahoo! Groups API grab. Contains messages of the following groups: 1ahoahong 2009cmsc128 abajarcolesterol abqphilosophers aceng1-ib agentorangeveterans alumnisaba93 ap12thv1 apn_maamvanne aquascape-indonesia arabic_inside arkiyoliji1 artsbabes asteric_of_smpn4_bogor ba186_sad bch_tongdoan_2008_2010 beginnerbluegrassjam biblebeegurnee binjakon bits_dlpd_msss2009 blogbirudotcom bsa_bag bspe1-1_economist ca411-1m canoepolohunks0809 ccfcommittee_09_10 che_141_142_tqruv chem2a_woodland cict_itfnds-icb citihi85 contratoscinemauff cool_hood_babii cpi_2009_2010 csci12_tz curriculoseprogramas2009essb dbti_tarlac_faculty discretemath_it2nd dmt_people dnyandeepnews dpms_2010 ec102h eco101_09 eco11_0910 ecoprofessionals_nea edp111_addu elladerma emc_ss_dames encoreestate esjsem1admu0910 galeradoingles2008 genevaacademicfoundation glawenko h-383lpu hau_6comgrad hiltech_group homplantes hum1_thu1 iit-kgp-met75 imtak-05 infoamie ingenieria_gay inspirationaldesignsvoices irc-sbg ironbros-team_one it10; | | 2018-07-21T22:47:14Z |
| Zentrum Paul Klee Bern | | 2006 | 2023-07-25T19:49:11Z |
| Built By CDK For Server-Grade Reliability | Most Servers Can Run. This One Doesn’t Stop. Built By CDK For Server-Grade Reliability, This Server Is Configured For Continuous Operation—Where Uptime, Data Stability, And Consistent Throughput Are Non-Negotiable. From Optimized Storage Architecture To Balanced Memory Configuration, Clean Power Delivery, And Carefully Matched Components, Every Element Is Tuned To Work In Sync—Reducing Fail Points And Delivering Stable Performance For Years To Come. The Result? Uninterrupted 24x7 Operation. Reliable Data Handling At Scale. Consistent Performance Under Sustained Load. Long-Term Reliability You Can Depend On. Because In Server Environments, Stopping Isn’t An Option. Engineered By CDK. 📞 +91 92707 66589 🌐 www.designsbykira.in #cdkserver #serversolutions #datacenter #enterprisesystems #highavailability | | 2026-04-22T12:28:58Z |
| linuxbrew cdk | linuxbrew cdk | | 2021-04-07T20:55:45Z |
| Psychology of Personal Adjustment Student's Introduction to Mental Hygience | | 1949 | 2025-09-10T00:53:02Z |
| Pride Flag Raised in Silver Spring | Montgomery County celebrates Pride Month Music provided by Manhattan Production Music. Montgomery Community Media (MCM) is the only independent, nonprofit organization providing access to public media (public access television and broadband media) directly to Montgomery County’s over one million residents as well as the resident non-profit organizations, associations and businesses. We engage, educate and empower individuals and the community to express diverse viewpoints. Stay up to date on news in Montgomery County! » Subscribe to MCM here: https://goo.gl/fi9sqQ » Check out MCM for more: https://www.mymcmedia.org Follow MCM on these platforms! » Facebook: https://goo.gl/89YTJN » Twitter: https://twitter.com/mymcmedia » Instagram: https://goo.gl/BkuFnD For more Montgomery County, Maryland residents can tune to Comcast channels 21 and 995 | 2022 | 2022-06-02T01:32:19Z |
| IUMA: cdk Dashiell | Started like 6 months ago, now dominating the arts of sampling and sythetizing, I've decided to become a house dj, even got myself a couple of Gemini XL-400 II Turntables and a Gemini PMX 40 Mixer to start practicing for what I've greatly planned is my first presentation in a couple of years. That doesn't means that i've stopped producing! Actually I'm working with the Mirage corporation, a producing crew from Orlando, and another producer from Wisconsin, Da Corster. With both these influences I've learned a lot more and have applied it on this two new songs I got...Enjoy! :) | | 2012-05-18T17:23:07Z |
| Cell cycle control : mechanisms and protocols | Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle / Anna Philpott and P. Renee Yew -- The mammalian cell cycle / Jane Vera Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane Vera Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and virus infection / Steven Emmett ... [et al.] --^ // Methods fo; | 2005 | 2012-05-22T14:15:36Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T23:53:12Z |
| Finite element methods for Navier-Stokes equations : theory and algorithms | x, 374 p. : 24 cm // Extended version of: Finite element approximation of the Navier-Stokes equations. 1979 // Bibliography: p. [368]-371 // Includes indexes | 1986 | 2023-12-22T11:10:09Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| die mikromorphologie der menschlichen zahnpulpa | | 1970 | 2025-09-04T05:39:32Z |
| The Life of Jonathan M. Bennett- A Study of the Virginias In Transition | | 1943 | 2023-12-22T16:18:38Z |
| The United States and civilization | | 1943 | 2023-12-27T14:40:37Z |
| the new testament | | 1937 | 2025-06-17T00:05:16Z |
| Shoreline City Council Regular Meeting - December 2, 2024 | # Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern; | 2024 | 2026-09-03T10:16:24Z |
| The life of Edward, Earl of Clarendon, Lord High Chancellor of England | | 1911 | 2024-01-12T08:38:15Z |
| High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. | This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co; | 2012 | 2014-10-28T23:41:32Z |
| The CDK regulators Cdh1 and Sic1 promote efficient usage of DNA replication origins to prevent chromosomal instability at a chromosome arm. | This article is from Nucleic Acids Research , volume 42 . Abstract Robustness and completion of DNA replication rely on redundant DNA replication origins. Reduced efficiency of origin licensing is proposed to contribute to chromosome instability in CDK-deregulated cell cycles, a frequent alteration in oncogenesis. However, the mechanism by which this instability occurs is largely unknown. Current models suggest that limited origin numbers would reduce fork density favouring chromosome rearrangements, but experimental support in CDK-deregulated cells is lacking. We have investigated the pattern of origin firing efficiency in budding yeast cells lacking the CDK regulators Cdh1 and Sic1. We show that each regulator is required for efficient origin activity, and that both cooperate non-redundantly. Notably, origins are differentially sensitive to CDK deregulation. Origin sensitivity is independent on normal origin efficiency, firing timing or chromosomal location. Interestingly, at a chrom; | 2014 | 2014-10-21T00:10:14Z |
| AD #3841 - Rivian Hits Paydirt With Massive VW Investment; Revealed The Last Pontiac Concept Car; CATL Flies 4-Ton Electric Plane | - Rivian Hits Paydirt With Massive VW Investment- Rivian Hints At 5 Future Models- Tesla Drops Under 50% U.S. EV Market Share- CDK Cyberattack Lasts Longer Than Expected- U.S. June Sales At 16.2 Million SAAR- Revealed The Last Pontiac Concept Car- GM-SAIC Use Robots for Car Testing- Bentley Unleashes Most Powerful Model Ever- CATL Flies 4-Ton Electric Plane | 2024 | 2024-11-16T18:41:55Z |
| Indole-3-Carbinol Inhibits Nasopharyngeal Carcinoma Growth through Cell Cycle Arrest In Vivo and In Vitro. | This article is from PLoS ONE , volume 8 . Abstract Nasopharyngeal carcinoma is a common malignant tumor in the head and neck. Because of frequent recurrence and distant metastasis which are the main causes of death, better treatment is needed. Indole-3-carbinol (I3C), a natural phytochemical found in the vegetables of the cruciferous family, shows anticancer effect through various signal pathways. I3C induces G1 arrest in NPC cell line with downregulation of cell cycle-related proteins, such as CDK4, CDK6, cyclin D1 and pRb. In vivo, nude mice receiving I3C protectively or therapeutically exhibited smaller tumors than control group after they were inoculated with nasopharyngeal carcinoma cells. The expression of CDK4, CDK6, cyclin D1 and pRb in preventive treatment group and drug treatment group both decreased compared with the control group. We conclude that I3C can inhibit the growth of NPC in vitro and in vivo by suppressing the expression of CDK and cyclin families. The drug was s; | 2013 | 2014-10-27T03:53:00Z |
| Applications of the InChI in cheminformatics with the CDK and Bioclipse. | This article is from Journal of Cheminformatics , volume 5 . Abstract Background: The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. Results: We here describe how the InChI library is used in the Bioclipse workbench and the Chemistry Development Kit (CDK) cheminformatics library. To make this possible, a JNI bridge to the InChI library was developed, JNI-InChI, allowing Java software to access the InChI algorithms. By using this bridge, the CDK project packages the InChI binaries in a module and offers easy access from Java using the CDK API. The Bioclipse project packages and offers InChI as a dynamic OSGi bundle that can easily be used by any OSGi-compliant software, in addition to the regular Java Archive and Maven bundles. Bioclipse itself uses the InChI as a key component and calculates it on the fly whe; | 2013 | 2014-10-27T02:14:25Z |
| Regulation of T Cell Differentiation and Alloimmunity by the Cyclin-Dependent Kinase Inhibitor p18ink4c. | This article is from PLoS ONE , volume 9 . Abstract Cellular proliferation in response to mitogenic stimuli is negatively regulated by the Cip/Kip and the Ink4 families of cyclin-dependent kinase (CDK) inhibitors. Several of these proteins are elevated in anergic T cells, suggesting a potential role in the induction or maintenance of tolerance. Our previous studies showed that p27kip1 is required for the induction of T cell anergy and transplantation tolerance by costimulatory blockade, but a role for Ink4 proteins in these processes has not been established. Here we show that CD4+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals. However, this gain of proliferative function was accompanied by a moderate increase in the rate of cell death, and was accompanied by an overall defect in the generation of alloreactive IFNγ-producing effector cells. Consistent with this, p18ink4c-d; | 2014 | 2014-10-24T00:58:58Z |
| Butler v. CDK DISTRIBUTION, INC. | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-06-17T09:45:11Z |