| Title | Description | Published | Added |
| github.com-DovAmir-awesome-design-patterns_-_2022-12-08_10-37-12 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage DevOps & containers Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalo; | 2022 | 2022-12-15T12:47:03Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| BRITANNICA WORLD LANGUAGE DICTIONARY | | 1959 | 2025-08-24T15:43:03Z |
| CDK Construction Co., Inc. v. Parkway C&A, LP | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-05-09T09:18:03Z |
| the valaue theory of karl marx | | 1976 | 2025-05-22T13:48:47Z |
| Timely Activation of Budding Yeast APCCdh1 Involves Degradation of Its Inhibitor, Acm1, by an Unconventional Proteolytic Mechanism. | This article is from PLoS ONE , volume 9 . Abstract Regulated proteolysis mediated by the ubiquitin proteasome system is a fundamental and essential feature of the eukaryotic cell division cycle. Most proteins with cell cycle-regulated stability are targeted for degradation by one of two related ubiquitin ligases, the Skp1-cullin-F box protein (SCF) complex or the anaphase-promoting complex (APC). Here we describe an unconventional cell cycle-regulated proteolytic mechanism that acts on the Acm1 protein, an inhibitor of the APC activator Cdh1 in budding yeast. Although Acm1 can be recognized as a substrate by the Cdc20-activated APC (APCCdc20) in anaphase, APCCdc20 is neither necessary nor sufficient for complete Acm1 degradation at the end of mitosis. An APC-independent, but 26S proteasome-dependent, mechanism is sufficient for complete Acm1 clearance from late mitotic and G1 cells. Surprisingly, this mechanism appears distinct from the canonical ubiquitin targeting pathway, exhibitin; | 2014 | 2014-10-11T23:56:58Z |
| CIA Reading Room cia-rdp91-00403r000200380008-6: FR:IZSO L TO:BAGER G | Traffic Organization and Preparation of Tim Tableofor Pusenger Shippliig on the Balaton.MMGARIANI perk Kozlekedese KozIony) 24 may 1970.,PP 384-387.DTA LN 1328-70Ju1Y 71The Plans and Tasks of Mobart for the Year 1970.RMARIM., per. KozIekedesi Kbzlony, No 16,19 April 1970, p 285.DTA rX 114g-7oJ'AlY 71Trends In Transportmbion and Postal Output Devicing1969.MMGMIM~ perk Kozelekedsi lCozIony, No 153April 12, 1970, p~ M7-2',11.DIA LN 1148-70May 71The Twerity-Five Years of Hungarian Shipping.UMMIM, per, I-a-ziekedesi KoziMp .4 April 1970sPp 248-250-DiA Lw 1147-70State PAIUVWU# IM Task* MftbWobyWay &*Wlo 9 pp.HUWARW Paogo 90 IYAOr 0ins 50417RF,NungaryF400&F ?0 407j,346V^aq;mBow&r 70 4020445NW& 7111 lans for I~ailroad Containerization wotexi.by Laszlo Izao, k~yorgy ionyrd, 9 pp,10WARIAW, por, Xozlq)cedAk 1~q pnv, lWapust,30 I'~ov 1969. pp W~Z~d- L4 _-i ei~s 49688U~ImngaryBconi-eb 70 40o,6o,6-laticnal aid i iiaij)our L,; 40I )ILL.14lUji"'It"L.'j, ~ILEi2!L~ 17 ~.;,),vo, 1'J69Ilil.,\ 1~~ U48-69(D; | 1983 | 2026-03-31T13:43:14Z |
| Christian Initiation the Reformation Period | | 1970 | 2025-06-16T04:36:46Z |
| CIA Reading Room cia-rdp91-00772r000100750011-3: A FR: LITVINUV, I. TO: LIVANOV, H. A. | 44 Atmat of byI A A Ogg * I* Ao L4tVi*iOV* 41Ira, .A&SOltwolaku yena 00.14tsa Valk VI 1,0 kto 41,0TITO i&-$17anITVI I~y d others. Some data on the structureI i ~ 0l fFE,,le fi~,el,, , xprecipitation.rudy gllaly.g,~, ~is.'Obs. 230:60-4 (1968)9LL/5~82!~J~r-, (hl 7799))-77S~ aphy, by L. D. ]Atvinov,MAe~ko,~ *prcx 208 pp.~j6k a. 1970.I I I' -ge-m-w-aNS, TS Bum-w/piamIm Pm;ssci Proptilsim and fus3m398,593I'll ;tat crthirv 71~4nv::zzl 1,ardact!vivo,it 4c~ E-31, W1TIP7r T 57.7-tttl-4.t Sttvctv" mad Propsniospy, i4res4cs of the sio 0 Al 0 -40rp.o4IT M4046366th W~ UW Ar!,!LStgi3p.Part 1"!"a astSupJIM j ppNMHAlm a t .'Ot.4mv ~by 14tvinm 1, 14 pp*t Ali Oi 0 0 June011&PL,~:Trticiesl/Pan.. 0-16-311s v ii;. F. j;;Ol I szl~dk.ov,IV4L~iy #,PL/Jr;U T-21244S c i - 41, i.6,piIPUO 1547 6; c 4 3I&VOAOck Atm:9? ppe4toescow, ilo9vp9110rmc~ 11 luitetrically Active Uq-urities onu4~rxtat'iwi ui~ c-ermiduu, by -".* S. c.creii~,Yu, I Li~v'inov11ok Al. HaUL. ~."ISSRS1 Vol liql, '-'v, 21,At; frkV-01Jarl, 1!,W:~L--7; | 1983 | 2026-03-31T12:29:08Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 | DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 DDT Iron Man Heavy Metal Title Match Toru Owashi (c) vs. Akito Pre-Show Ten Man Tag Team Match DISASTER BOX (Kazuki Hirata, Naomi Yoshimura & Toru Owashi), Saki Akai & Yuki Ishida vs. CDK (Chris Brookes & Masahiro Takanashi), Akito, Antonio Honda & Yusuke Okada Pre-Show Tag Team Hardcore Match Hideki Okatani & Yuya Koroku vs. The 37KAMIINA (Shunma Katsumata & Toi Kojima) Tag Team Match Daisuke Sasaki & MJ Paul vs. Mizuki Watase & Soma Takao Six Man Tag Team Match MAO, Yuji Hino & Yukio Naya vs. Pheromones (Danshoku Dino, Yuki Ino & Yumehito Imanari) D-Ou Grand Prix 2021 2 Block A Match Jun Akiyama vs. The Bodyguard D-Ou Grand Prix 2021 2 Block B Match HARASHIMA vs. Yuji Okabayashi D-Ou Grand Prix 2021 2 Block B Match Konosuke Takeshita vs. Kazusada Higuchi D-Ou Grand Prix 2021 2 Block A Match Tetsuya Endo vs. Yuki Ueno | 2021 | 2021-11-22T00:19:53Z |
| Recall Ft Kara Square (Stems) | Recall - Vocals by Kara Square (c) 2013 Licensed under a Creative Commons Attribution Noncommercial (3.0) license. http://dig.ccmixter.org/files/mindmapthat/43023 Ft: CDK The vocals to this Secret Mixter remix of CDK. Thank you to CDK for the inspiration. Here is a link to CDK's sample pack. WORDS I could bare my soul Tell you things I’ve held on for so long I could let it go Be the way I wish I were But you won’t recall Anything, anything, anything You won’t remember Anything, anything, anything When will you forget Everything? There are things that hurt I used to think you chose to forget them Things you don’t remember I learned to block things out by the best man But you won’t recall Anything, anything, anything You won’t remember Anything, anything, anything When will you forget Everything? Guilt and denial Have been your prison for so, so long Maybe you’ll break free As you continue to lose your memory But you won’t recall Anything, anything, anything You w; | | 2016-05-06T23:35:17Z |
| CIA Reading Room cia-rdp96-00788r000700130014-7: SPOT REPORT | F t'R. C EFIC,\L USE ONL y 4########### PEt IT AGU i IELFCG?tilLNICAT IONS CEN TEI PTTEZYL , RUavfMFDA01315 0252257 IJR i TY/KDUT INE r' 1 252BUOZ JAN 82 h-,vj C(JRI:SAINiSC(7~ MI ()ET FT LEWIS WA //LAGPA-C-LE// TL CDK SPECIAL 'PINS CET '.-1 NEADE MD //IASC// +U/_L;;~IC,E FT M CACE D SL1// CC;z JSAIT A C AHS Vi\ X-T,\-t?,// l-t0 DA WASF-GC //DAM, -CIC/FIO// 11,LLL'i FT I"NSCIJ' :\HS VA // i. L PS ('SF) SFFAN CA //IAGPA-C-OP// C'_ E~ S c r- I iU F JUC NU N Iuh,T AC T I (iNN REL;U IR EC T I ~, ,:) L i7 = Z r ; ,. l ( OT kE PnF r i . ( F'-jLi)) K1J?JAP0I iNB CF 13L JAMES DEL LEN, ASS FEPGPTED F3Y GERALDINE ILS ("\? A':(,RY TARASFWICH9 :1N() R5 ARA KiJPIK P1,TTEN, KENT, WASHINGTON, ['-;LaE (/. b) 631_.68G6 (CFFICEI- 631-?81)18 (H0MEI, F.4 RA S" C3 ( rS r.:vcF =". (I i?`iITI,AL SP ur r,Ei-~:ir,T9 SAD, 2U24CUZ JAN 82. L~m 2, (U) G I.LNH tFPC1RI 3 (a l (FLUUI i N! 7.1 JA,' 82 , FLMID ,AS 0:KrHF. VISIilNS CONCERNING 10TH` PLACE J~=5C1 | 1982 | 2023-06-26T04:57:16Z |
| CIA Reading Room cia-rdp91-00929r000100090020-0: FR:KURTA G. TO:KUGAKOV M.M. | Retaxmion Phenomew for Attenwalm of Sxvdin Ductop by G. K=txp.GERMM, per, A~M Vol )as 1961, pp 112-117.NASA TT P-9277Sci-Mectrmay 65U.S. GOVERNMENT ONLY28(4190mTransplantation of Himan Carcitwom.9 by Raw Kurtzabn,10 pp?)=WAN, perp Ki. usch.., Vol Uls, 1926o pp 1166-1168.inScientific - Medicine CTS/DIX // .2 P401Proceocs lor Yonufactur-ling a Cb--ese ?rwuct of GrGratGd Hl&~i-Fat Chaese, by 2. 24 Tlxalsmaa,W, J. Kurt--lial3,, 6 pp.amm, potperrit 949,6i6i 30 Aug -1956.sLA 6o-149aI f- -1 -7,SciROSTE.Tmals B. 1.KURUKLISP G. A.Stanki I instrument# Vol. 17, xo. 6, 11figures wo 3 tableav 2600 words- 1946.Deep Dry Cyaniding of Cutting- Toole.Brutcher Trans, Order No* 1914s, $4-55amom Lai to latruall"Is 3*MQWbt,-Nw 73cateshoWalow contsm As foblize 40""*1. rA* 4UNft Of & IPYT*V"* &*SUQW(""I) ft sbo AOL".' coutaft of the sx*itStan a" on ow ant" Tore"sumaby T. gulmas *t RuJAPAUMS, Fifirs MUM TakwLELS it Val LisU64v pp 463oMaw MIN X0scl - S/wMay 66The !~!chanlce c-f Beending of the SbRP.-, of incUne; | 1983 | 2026-03-25T15:12:02Z |
| github.com-sindresorhus-awesome_-_2022-01-22_21-24-15 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-23T01:20:47Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| github.com-apache-incubator-apisix_-_2019-11-01_09-03-27 | Cloud-Native Microservices API Gateway 中文 APISIX QQ group : 552030619 APISIX is a cloud-native microservices API gateway, delivering the ultimate performance, security, open source and scalable platform for all your APIs and microservices. APISIX is based on OpenResty and etcd. Compared with traditional API gateways, APISIX has dynamic routing and plug-in hot loading, which is especially suitable for API management under micro-service system. Installation | Documentation | Development ENV | FAQ Why APISIX? If you are building a website, mobile device or IoT (Internet of Things) application, you may need to use an API gateway to handle interface traffic. APISIX is a cloud-based microservices API gateway that handles traditional north-south traffic and handles east-west traffic between services. APISIX provides dynamic load balancing, authentication, rate limiting, and other plugins through plugin mechanisms, and supports plugins you develop yourself. For more detailed information, s; | 2019 | 2019-11-01T09:09:58Z |
| CIA Reading Room cia-rdp91-00772r000200830062-7: A FR: KOZLOWSKI, T.B. TO: KOZYREVA, L.S. | LABOR SU. :ITION AS A MEASURE OF EFFECTIVENESSOF` S, ISING THE CHEMICAL INDUSTRY AS ANITW IE !BY Tii B. KOZLOWSKI 14 pp.POL IS ERIP PLANOWA, NO 12, 1962,PP G.EEURECOWMARJPRS 17865224,oo4osulD.,Z:yby 11OTIS 52~1lccvi'u.DESCRwrU,eters', ousli~(Chemistry"!K-HIn.ROANALYSIS OF MC07INE BYIR AND ITS APPUCATION.2S K-H S176 bI mono. (thesis) Bachelor ofI July 31.tine, ONUcrosulysis, Photom-Tr, v. 8, no. 8)62-225201. Title: Nephelometer1. Kozu, T.U. K-H-5176 b111. Kresge-Hooker ScienceUbrary Associates.Detroit, Mich.22-23 2 S IOffice of Uchalcal S~IcesStu CC tbAdsoltiibnTe=e aand T,~Del: ofV1. T. i'MsovRUSSLW,~ pe1961, !7 24SciElectronic State of Catalysts Durinr,id Cate3.ysis. Communleationi. The)ependence of Electrical Conductivity;6~nductivity of Cata3ysts for theIsobutyl Alcohol., by G. M. :Lb~zet al. 5 PP.iUnetika i Katal*, Vol II, Uo 2,-244.CB2003101*No* "LILbrim SjmdLes atLty Po"Oft "sum unift a Gasc Haft" of Mml7siLs# byN. KPirskt Cbes" VDII 17, 1962,P 7~=PZ2'8 9 r'292o*BI[St 1i 0, 977Bj; | 1983 | 2026-03-26T05:32:28Z |
| Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families. | This article is from Journal of Carcinogenesis , volume 10 . Abstract Background:: Cisplatin (CDDP) is a drug used for treatment of many types of malignancy but pancreatic cancer is relatively resistant to it. This study aims to determine whether and how cyclin D1 (D1) and c-Myc influence the response of pancreatic cancer cells to CDDP. Materials and Methods:: Ela-mycPT mouse pancreatic cancer cells were transfected with D1 or c-myc cDNA and treated with CDDP alone or together with NPCD, an inhibitor of cyclin dependent ckinase (CDK) 4 and 6. Reverse transcription followed by polymerase chain reaction (RT-PCR) and western blot assays were used to determine the mRNA and protein levels of interested genes. Cell viability was determined using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results:: Treatment of Ela-mycPT1 cells with CDDP caused an increase in c-myc expression but a slightly latent decrease in D1 expression, whereas D1 and c-Myc proteins repres; | 2011 | 2014-10-28T18:52:34Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| Flourescent Protein Tracing | | 1962 | 2025-09-12T10:44:29Z |
| DTIC ADA453395: Suppression of Prostate Cancer by PTEN and p18INK4c | The Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (exp Ink4c) and the lipid phosphatase PTEN, which regulates cell growth and survival. The p18(exp -/-) ; PTEN (exp +/-) double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C-cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in PTEN (exp +/-) cells, and further activated and accumulated in the nucleus in p18 (exp -/-) ; PTEN (exp +/-) tumor cells, suggesting a tissue- and genetic background-dependent haploinsufficiency of Pten in tum; | 2006 | 2018-06-05T18:22:11Z |
| github.com-sottlmarek-DevSecOps_-_2022-06-02_09-30-05 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Report typos as issue not via PR. Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevS; | 2022 | 2022-06-02T11:24:44Z |
| github.com-localstack-localstack_-_2022-11-12_20-26-32 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-12T20:48:32Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-06_04-11-10 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-06T21:32:41Z |
| github.com-sindresorhus-awesome_-_2021-11-26_04-57-42 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-11-28T17:59:53Z |
| github.com-sindresorhus-awesome_-_2021-04-02_19-51-59 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-03T12:50:55Z |
| github.com-sindresorhus-awesome_-_2021-04-05_16-07-23 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-06T01:27:34Z |
| CIA Reading Room cia-rdp91-00403r000200500046-0: FR:BARBIERI R TO:BARDENHEUER P | Research on Vackarmoderle Reaction.Note 11. On the Maolianism of theYormatiou of lutovuul S-,alfur inPolythionic Acid9l, by Ro Barbieri*ITALIANp perlVvI 920, 1%2* 0-6?5NTO 72-12316-07BJuly 72Studleo on the Weakenrodar Reaotion.Note 1. Thiaoulphurie Acids as ProbableIntermediate Produatep by Re Barbieri.ITALIAIT, parp Ricerea Scientifica.Far&a 11, Hendleonti.Vol 2j No 1,, 19620 pp 62-67073July 72investigations of the Reaction H2StSO2Analytical Procedures for Separatingand Breaking Down Maercquantities ofNfur Componanto in Research WithS , by Ro Barbieri*ITALIAN# porp ifigalVol 30, 1960l pp 1509-1517UTO 72-11838-07BJune 72.191 ( [erawl. M2911AVIM, Gliuscme). ami" 63-129098eHiuf['MbaMj. 1. Barbieri, R*AtULYSIS OF ORGANOMETALUC CONIOUNDS. 17. Taghavint, G.DITIMONATES OF RjPbCI AND R2PbC]- f19621.10p.K-H50 K-H121 MOdf M. BaJilgo, U.K -H - 1117IV1aromer,r1 1 - a-V. Kresge-Hooker7YRm Of [U] U, y) 1960, Science Mraryv. 30, no. 12, p. 1963-1968. Associatca, Detroit, Mich.DESCMMRS: 0=1cal andysi; | 1983 | 2026-03-26T07:30:01Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| CIA Reading Room cia-rdp83m00914r002800040028-2: REQUEST FOR INTERVIEW - JOSEPH FROMM, U.S. NEWS & WORLD REPORT | Approved For Relgrase 2007/03123: CIA-RDP83M00914R(~~C~4f~'f OEXA 82-272 MEMORANDUM FOR: Director of Central Intelligence FROM: erector, Office of External Affairs STAT SUBJECT: Request for Interview - Joseph Fromm, U.S. News & World Report 1. Action Requested: Decline an on-the-record interview with Joseph Fromm, U.S. News & World Report. 2. Background: Fromm's telephoned request is based on his impression that you would like to get your views accurately on the public record. He offers a recorded interview with a pre-publication screening opportunity. The subject would be the role of .intelligence and your role in improving it. Joseph Fromm and other reporters met with you at a breakfast meeting at Headquarters in Rpril 1981. 3. Staff Position: Too frequent on-the-record interviews are not consistent with the current low-profile policy. One leads to another. Your recent interview with David Kahn should suffice for awhile, unless you have some special reason for doing another. The DDCI; | 1982 | 2025-02-22T17:14:43Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |
| Remarkable women of france ( from 1431 to 1749 ) | | 1914 | 2025-09-08T04:07:29Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation. | This article is from PLoS ONE , volume 9 . Abstract Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic; | 2014 | 2014-10-22T18:28:08Z |
| cyyo oyousym – doxzmzytr yoizc jyioyzu | cynmso ntyniyyzd kyjsq sgqkd iqsukz lncnjz yo ioxzmzyt. dopny-tn gmykd kr zsdk, yz n cdk yy sqkod, aingyn lirgdk ln tycyyzq. c gsmqm — moxgzipo, z yzpopzc qpoxqqdzc pokyyu. vzptn yy lnsapojyt tyxy, pqso aiysqyt agymyqtu, ctnxr snatzcu acoatud. vzptn yy lnsapojyt tyxy gymyru lqtu, gysu jzxyu yy apoxpo. fniupn g apoxpy npmqjoqdzy syidtad yo snxmrc z xirc, g syuatgztyiuynatz jy gad mnmoxsn ainjyyy. | | 2024-07-06T12:14:46Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| Overtures Of Biology | | 1964 | 2025-09-11T12:55:51Z |
| CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITY | Approved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known; | 1981 | 2024-05-13T17:20:36Z |
| yahoo-groups-2018-06-30T23-49-20Z-213b6b | Yahoo! Groups API grab. Contains messages of the following groups: abass_t92 adaevi adeala agec424group almostfamous-bvds apurv_heavymetal arch_ugm_05 asd-trainees-0809 avrilavigneavlav aw_groups backlanebizneskl baeeunice bazket_sport besmart_group biotechresearchers bscs_1b_prog_cdk bsn_4a_frieslovers c3_noticeboard cagarencuclillas camobutts ccsflitjournal cfne_22008 chatters cheap-pet-supplies cicstcollege cisco_ghana clubfiatecuador cmpe274_business_intelligence_fall2008 coa08_iiu conexaoamsterda coolfriends_ngp cool_raj1989_hot copi_nijmegen cosbuc2008_12r1 cpa-world csc_8 cscst-argaocampusmis-ict darla_fux52a_livecams darvazeh dc_metro_angels dhrumil88 digitaldial_diversidial_online ds112grouppapergk dyala eca_maniez efbalicobacoba entreprisemichite fierydemon2008 filmstadensickla fina6335_uh2008 flat4677 fuad_online ga-fesc garciamendozafamilytree gay60plus gcet_cs2012 gdc-organic gherti-entertainment ghp_group gkm_2k8 grandmas-recipe-box grupoutp113 gw78 het_tien_roi_89 hottes; | | 2018-06-30T23:49:27Z |
| github.com-localstack-localstack_-_2022-11-12_23-39-58 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-13T09:19:09Z |
| 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. | This article is from Cell Death & Disease , volume 5 . Abstract The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase (Pfk-1). PFKFB3 is overexpressed in human cancers, regulated by HIF-1α, Akt and PTEN, and required for the survival and growth of multiple cancer types. Although most functional studies of the role of PFKFB3 in cancer progression have invoked its well-recognized function in the regulation of glycolysis, recent observations have established that PFKFB3 also traffics to the nucleus and that its product, F2,6BP, activates cyclin-dependent kinases (Cdks). In particular, F2,6BP stimulates the Cdk-mediated phospho; | 2014 | 2014-10-08T05:47:42Z |
| CIA Reading Room cia-rdp79-01209a000300030001-3: Weekly Situation Report on International Terrorism | Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 No For Dissem No sem Abroad ontrolled Dissem Weekly Situation Report on International Terrorism 7 November 1973 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300g30D.0.1.:_3.-.-.- -, .a 25X1 C3b2 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 Next 11 Page(s) In Document Exempt Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 25X1 C3b2 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 Approved For Release 1999/09/21 : CIA-RDP79-01209A000300030001-3 Approved For Release 1999/09/21 : CIA-RP? @fn9AO00300030001-3 No Fore'ici.n Dissem/N sem ~Abrocrd/Controlled :Dissem he presumably smuggled aboard,the aircraft in Maracaibo. The hijacker, who is in critical' Condition and not expected to live, apparently wanted to fly to Cuba to live with his par; | 1973 | 2023-06-26T23:01:38Z |
| github.com-localstack-localstack_-_2023-09-29_02-11-07 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-29T05:13:28Z |
| CIA Reading Room cia-rdp83m00914r002900060005-4: I AM PLEASED TO INVITE YOU TO A ONE-DAY SPECIAL SECURITY PRESENTATION | Approved For Release 2006/0 Y2rY A`TR _ 83M00914R002900060005-4 Washington. D. C 20505 31 MAR 1982 ER 82-4708/1 I am pleased to invite you to a one-day-special security pres- entation sponsored by the White House and hosted by the Central Intelligence Agency at n Thursday, 25X1 13 May 1982. This session w i l l give those o you who were unable to attend last year the chance to do so. The schedule is enclosed. This highly-selective session has been designed to meet your special needs as an official Government spokes- person. I promise you it will be interesting and informative. The day is intended to broaden your knowledge and enhance your effective- ness throughout your period of Government service. If my schedule holds, I plan to be with you for at least a portion of the day. Kindly direct your response to CIA's Public Affairs office, telephone 351-7676. I hope to see you there. Sincerely, I g ail William J. Casey Director of Central Intelligence Enclosure UNCLASSIFIED WHEN SEPARATED ; | 1982 | 2024-07-15T20:22:12Z |
| CIA Reading Room cia-rdp85m00364r002204280136-7: LETTER TO (SANITIZED) | Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 CENTRAL INTELLIGENCE AGENCY PUBLIC AFFAIRS Phone: (703) 351-7676 18 April 1983 STAT Thank you for writing Mr. Casey for whom I am responding. I am sorry but the Central Intelligence Agency is in no position to help you. Thank you for writing our Agency. I am sorry we cannot be of assistance to you. Sincerely, STAT OEXA/PAD/KJH/cdk/18 Apr 83/7676 Di strib..a.. __ C/e Pd Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 _ STAT | 1983 | 2025-02-20T13:56:07Z |
| [CDK 033] Cheer Up Emo Kid -The Happy Compilation! | Various Artists - Cheer Up Emo Kid -The Happy Compilation! | 2009 | 2019-12-30T22:18:05Z |