| Title | Description | Published | Added |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation. | This article is from PLoS ONE , volume 9 . Abstract Few of >150 published cell cycle modeling efforts use significant levels of data for tuning and validation. This reflects the difficultly to generate correlated quantitative data, and it points out a critical uncertainty in modeling efforts. To develop a data-driven model of cell cycle regulation, we used contiguous, dynamic measurements over two time scales (minutes and hours) calculated from static multiparametric cytometry data. The approach provided expression profiles of cyclin A2, cyclin B1, and phospho-S10-histone H3. The model was built by integrating and modifying two previously published models such that the model outputs for cyclins A and B fit cyclin expression measurements and the activation of B cyclin/Cdk1 coincided with phosphorylation of histone H3. The model depends on Cdh1-regulated cyclin degradation during G1, regulation of B cyclin/Cdk1 activity by cyclin A/Cdk via Wee1, and transcriptional control of the mitotic; | 2014 | 2014-10-22T18:28:08Z |
| Sodium Tanshinone IIA Silate Inhibits High Glucose-Induced Vascular Smooth Muscle Cell Proliferation and Migration through Activation of AMP-Activated Protein Kinase. | This article is from PLoS ONE , volume 9 . Abstract The proliferation of vascular smooth muscle cells may perform a crucial role in the pathogenesis of diabetic vascular disease. AMPK additionally exerts several salutary effects on vascular function and improves vascular abnormalities. The current study sought to determine whether sodium tanshinone IIA silate (STS) has an inhibitory effect on vascular smooth muscle cell (VSMC) proliferation and migration under high glucose conditions mimicking diabetes without dyslipidemia, and establish the underlying mechanism. In this study, STS promoted the phosphorylation of AMP-activated protein kinase (AMPK) at T172 in VSMCs. VSMC proliferation was enhanced under high glucose (25 mM glucose, HG) versus normal glucose conditions (5.5 mM glucose, NG), and this increase was inhibited significantly by STS treatment. We utilized western blotting analysis to evaluate the effects of STS on cell-cycle regulatory proteins and found that STS increased the; | 2014 | 2014-10-23T07:02:40Z |
| Christian Initiation the Reformation Period | | 1970 | 2025-06-16T04:36:46Z |
| Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. | This article is from Cell Cycle , volume 11 . Abstract The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with its enhanced potency previously observed in a variety of human cancer cell lines. More importantly, in vivo MRI and single voxel proton MR-Spectroscopy further established that VMY-1-103 ; | 2012 | 2014-10-26T21:07:18Z |
| Protein kinase C signaling and cell cycle regulation. | This article is from Frontiers in Immunology , volume 3 . Abstract A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about 30 years. However, despite the wealth of information on PKC-mediated control of, T cell activation, understanding of the effects of PKCs on the cell cycle machinery in this cell type remains limited. Studies in other systems have revealed important cell cycle-specific effects of PKC signaling that can either positively or negatively impact proliferation. The outcome of PKC activation is highly context-dependent, with the precise cell cycle target(s) and overall effects determined by the specific isozyme involved, the timing of PKC activation, the cell type, and the signaling environment. Although PKCs can regulate all stages of the cell cycle, they appear to predominantly affect G0/G1 and G2. PKCs can modulate multiple cell cycle regulatory molecules, including cyclins, cyclin-dependent kin; | 2013 | 2014-10-28T20:08:08Z |
| Pathway of Programmed Cell Death and Oxidative Stress Induced by ?-Hydroxybutyrate in Dairy Cow Abomasum Smooth Muscle Cells and in Mouse Gastric Smooth Muscle. | This article is from PLoS ONE , volume 9 . Abstract The administration of exogenous β-hydroxybutyrate (β-HB), as well as fasting and caloric restriction, is a condition associated with β-HB abundance and decreased appetite in animals. Increased β-HB and decreased appetite exist simultaneously in some diseases, such as bovine left displaced abomasums (LDA) and human chronic gastritis. However, the effects of β-HB on stomach injuries have not been explored. To elucidate the possible effects of exogenous β-HB on the stomach, mice were injected intraperitoneally with β-HB, and bovine abomasum smooth muscle cells (BSMCs) were treated with different concentrations of β-HB. We found that β-HB induced BSMCs endoplasmic reticulum- and mitochondria-mediated apoptotic cell death. β-HB promoted Bax expression and caspase-12, -9, and -3 activation while blocking Bcl-2 expression. β-HB also promoted AIF, EndoG release and p53 expression. β-HB acted on key molecules in the apoptotic cell ; | 2014 | 2014-10-22T19:40:13Z |
| Street Fighter Alpha 2 (960430 USA): (BO) Charli1 vs(BR) [CDK]-Shaka - 2022-08-22 01:50:02 | (BO) Charli1 (Rank B) vs (BR) [CDK]-Shaka C - 2022-08-22 01:50:02 Fightcade replay id: 1661133002235-2363 0:00 Charlie vs Ryu 02:06 Charlie vs Guy #fightcade #sfa2u #Charli1 #Ryu #[CDK]-Shaka #0:00:12 #Guy #0:02:06 For more videos check out: https://fightcadevids.com | | 2023-01-23T15:42:07Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| Canonical Non-Homologous End Joining in Mitosis Induces Genome Instability and Is Suppressed by M-phase-Specific Phosphorylation of XRCC4. | This article is from PLoS Genetics , volume 10 . Abstract DNA double-strand breaks (DSBs) can be repaired by one of two major pathways—non-homologous end-joining (NHEJ) and homologous recombination (HR)—depending on whether cells are in G1 or S/G2 phase, respectively. However, the mechanisms of DSB repair during M phase remain largely unclear. In this study, we demonstrate that transient treatment of M-phase cells with the chemotherapeutic topoisomerase inhibitor etoposide induced DSBs that were often associated with anaphase bridge formation and genome instability such as dicentric chromosomes. Although most of the DSBs were carried over into the next G1 phase, some were repaired during M phase. Both NHEJ and HR, in particular NHEJ, promoted anaphase-bridge formation, suggesting that these repair pathways can induce genome instability during M phase. On the other hand, C-terminal-binding protein interacting protein (CtIP) suppressed anaphase bridge formation, implying that CtIP fu; | 2014 | 2014-10-06T07:32:29Z |
| PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis. | This article is from Oncology Letters , volume 7 . Abstract Preclinical and clinical studies have demonstrated the anticancer activity of PD-0332991, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, in the treatment of various types of cancer in a retinoblastoma protein (RB)-dependent manner. However, it remains unclear whether CDK4, CDK6 or both are required for RB phosphorylation in colorectal carcinoma and thus PD-0332991 can be used to target this CDK-RB axis for the cancer therapy. The aim of this study was to determine whether CDK4, CDK6 and phosphorylated RB proteins were overexpressed in colorectal carcinoma tissues as compared to matched normal colorectal tissues. The results showed that knockdown of CDK6 but not CDK4 reduced RB phosphorylation and inhibited carcinoma cell growth. Thus, CDK6 plays a critical role in RB phosphorylation and cancer growth. PD-0332991 treatment blocked RB phosphorylation and inhibited cell growth through the induction of G1 arrest of co; | 2014 | 2014-10-23T06:07:14Z |
| Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation. | This article is from Cell Death and Differentiation , volume 19 . Abstract Terminally differentiated neutrophils are short-lived but the key effector cells of the innate immune response, and have a prominent role in the pathogenesis and propagation of many inflammatory diseases. Delayed apoptosis, which is responsible for their extended longevity, is critically dependent on a balance of intracellular survival versus pro-apoptotic proteins. Here, we elucidate the mechanism by which the cyclin-dependent kinase (CDK) inhibitor drugs such as R-roscovitine and DRB (5,6-dichloro-1-beta-𝒟-ribofuranosylbenzimidazole) mediate neutrophil apoptosis. We demonstrate (by a combination of microarray, confocal microscopy, apoptosis assays and western blotting) that the phosphorylation of RNA polymerase II by CDKs 7 and 9 is inhibited by R-roscovitine and that specific effects on neutrophil transcriptional capacity are responsible for neutrophil apoptosis. Finally, we show that specific CDK7 and 9 i; | 2012 | 2014-10-26T21:30:14Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| Ep 10 Part 2: Kristine Bunch's Struggle For Freedom | In Part 2 of this episode, Kristine and her newly-formed defense team fight to win back her freedom. Armed with advances in fire science, a potential Brady violation, and some shocking revelations about the State's evidence at trial, Kristine and her team fight till the very end. A special thank you to Kristine Bunch for helping me tell her story. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. http://dig.ccmixter.org/files/cdk/48915 Ft: Phasenwandler Homesick (Keymix) by keytronic (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/Keytronic/47457 Ft: Kizzylotus Paper Planes - Durd; | 2016 | 2023-07-08T12:43:12Z |
| CIA Reading Room cia-rdp79-01209a000400060001-9: Weekly Situation Report on International Terrorism | Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 No em Abroad Co oiled Dissem Weekly Situation Report on into tional Terrorism Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9----~ Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-925X1 C3b2 Next 6 Page(s) In Document Exempt Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 Sanitized - Approved For Release : CIA-RDP79-01209A000400060001-9 SE NOTES Khartoum BSO Terrorists Imprisoned in Egypt The eight Black September Organization terrorists con- victed of murdering two U.S. diplomats and the Belgian Charge d'Affaires in Khartoum in. March 1973 are currently in an Egyp- tian prison, according to the State Department. The eight, sentenced to life imprisonment on 24 June by a Khartoum court, had their terms reduced by Sudanese President Numayri and were reportedly to be turned over to the Palestine Liberation Organi- zation (PLO) to serve seven-year sentences. According to pre; | 1974 | 2023-06-26T22:33:05Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. | This article is from Oncotarget , volume 5 . Abstract Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Here we present direct evidence that cdk9 is important for cancer cell survival and describe the characterization of the potent cdk9 inhibitor CDKI-73 in primary human leukemia cells. CDKI-73 induced caspase-dependent apoptosis that was preceded by dephosphorylation of cdk9 and serine 2 of RNA polymerase II. CDKI-73 was more potent than the pan-cdk inhibitor flavopiridol and showed >200-fold selectivity against primary leukemia cells when compared with normal CD34+ cells. Furthermore, CDKI-73 was equipotent in poor prognostic sub-groups of leukemia patients and showed cytotoxic synergy with the nucleoside analog fludarabine. The Mechanism of synergy was associated with CDKI-73-mediated transcriptional inhibition of MCL1 and XIAP that was maintained when used in combination with fludarabine. Our data pres; | 2013 | 2014-10-23T22:14:55Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Retrospectiva 2016 | Foi um ano difícil, mas nós sobrevivemos. Eleve o cosmo e siga o Armadura Nerd: www.armaduranerd.com.br facebook.com/ArmaduraNerd youtube.com/ArmaduraNerd twitter.com/ArmaduraNerd instagram.com/armaduranerd Contato comercial: armaduranerd@gmail.com Trilha sonora do podcast: New York City (Instrumental) by spinningmerkaba (c) copyright 2011 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/jlbrock44/30389 Bad_Attraction by Stefan Kartenberg (c) copyright 2015 Licensed under a Creative Commons Attribution license. http://dig.ccmixter.org/files/JeffSpeed68/48947 Ft: brad sucks The Game Has Changed (cdk RumbleStep Mix) by cdk (c) copyright 2013 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/41830 Ft: My Free Mickey You Believed It Yourself by Siobhan Dakay (c) copyright 2015 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/SiobhanD/50482 Ft: Fluffy Story; | | 2017-02-05T01:22:06Z |
| My Top Cases of 2016 | We all have cases that we follow and that stick with us, whether it's on a personal level or because we're oddly fascinated with them. In this episode, I count down the top cases that affected me the most this year. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13; | 2016 | 2023-07-08T12:41:41Z |
| AutoDesk Cyberspace Developer Kit v1.0.1 | From the README: Notes on the Autodesk Cyberspace Developer Kit 1.0.1 ==================================================== INCOMPATIBILITIES ----------------- IMPORTANT: This release, CDK 1.0.1, is incompatible with release 1.0 in several areas, including displays, solids, and DSCVR. To use this new release, it is necessary to recompile any of your code that refers to CDK header files. HIGHLIGHTS OF THIS RELEASE -------------------------- This is an update of CDK Release 1.0. Some bugs have been fixed (most notably in the SPEAdisp and VESAdisp display classes), and some features added (particularly in the CDF reader). Also, this release supports the MetaWare C++ compiler release 3.1, the Phar Lap DOS Extender release 5.1, and the FTP Software release 2.2, in addition to previously supported releases of these products. The Zortech C++ compiler release 3.0 is supported as well. This README.TXT document also contains a complete summary of environment variable settings needed for c; | 1993 | 2022-05-13T07:50:27Z |
| Shoreline City Council Regular Meeting - December 2, 2024 | # Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern; | 2024 | 2026-09-03T10:16:24Z |
| DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 | DDT D-Ou Grand Prix 2021 2 In Korakuen Hall 21-11-21 DDT Iron Man Heavy Metal Title Match Toru Owashi (c) vs. Akito Pre-Show Ten Man Tag Team Match DISASTER BOX (Kazuki Hirata, Naomi Yoshimura & Toru Owashi), Saki Akai & Yuki Ishida vs. CDK (Chris Brookes & Masahiro Takanashi), Akito, Antonio Honda & Yusuke Okada Pre-Show Tag Team Hardcore Match Hideki Okatani & Yuya Koroku vs. The 37KAMIINA (Shunma Katsumata & Toi Kojima) Tag Team Match Daisuke Sasaki & MJ Paul vs. Mizuki Watase & Soma Takao Six Man Tag Team Match MAO, Yuji Hino & Yukio Naya vs. Pheromones (Danshoku Dino, Yuki Ino & Yumehito Imanari) D-Ou Grand Prix 2021 2 Block A Match Jun Akiyama vs. The Bodyguard D-Ou Grand Prix 2021 2 Block B Match HARASHIMA vs. Yuji Okabayashi D-Ou Grand Prix 2021 2 Block B Match Konosuke Takeshita vs. Kazusada Higuchi D-Ou Grand Prix 2021 2 Block A Match Tetsuya Endo vs. Yuki Ueno | 2021 | 2021-11-22T00:19:53Z |
| Topology of C. W. Complexes | | 1969 | 2023-12-22T18:35:46Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| CIA Reading Room cia-rdp91-00403r000200470001-3: FR:CAHEN G TO:CALDIROLA P | wwlNftm or tw lmuwtAwl um" Eoe=UQA Dea-Alm L*.),v GLUot Calm.im. Mul" lb 12,6 1963.Varioug hj;plj,catjOrjq of tW Gomm! EPoraiulac fortha TranwiaBiOu Of Simmoidalby L. 42 pp.pir, Immicro 81cop 7 1 V~ 2~3 llq 1914.S TA 5 7 -PI'lay 56libten ~m Their OporatIm ana Tbfto 3hoo.-tvzcefor LaDZ-Distanoe-Cable ftglneertmg., by L.Cabenp I~pGMIMN., Nr, Tech lattp Vol =1: ~--l Oat:Lql,2!iv pp 145-3.47.SIA Tr 57.2028Se - P-loc RauJW. 58The Frogress and Present State of the Technic u1,J,cmded Linei;, by L D. Cahen2 10 pp,.per, Rev Gen Rlec, Vol XVII, NO 7t 14r,ab 3,9215, pp 243-245.SIA Tr 232751,'1 .. Blectri...,ity ~ ~) " ~ //- I~zf~gu !j7]UsmdWm for 2ms-lwla Ow"nicup by 0. C&euo,a. itiolaomd4t" 12 pp. IM OMM Un mlyMIX310 rpt.. fta4*=4wu4w T"bacal BMIOV*Ilb A, IV i963# PP "-&V &,r 3mion W5Un - 'EloaLmOLA; 63 zi wj 7 -,o " IfePharir4ctlogy of p-C,111o,-,a o(L,-Uj.,.*t~WIaLinoetho.V)-Danz-, jrlpyridine. 1. -IL-itildstax-4nic Action and ~'Xfactcm the 1--triphraral and Central Ifervoua Systa,wl, by R." -; | 1983 | 2026-04-02T05:44:22Z |
| CIA Reading Room cia-rdp91-00929r000100440035-5: FR:ZAVROV M.I. TO:LAVROVSKIY M.P. | ProNems 0 Thawy 4 P U A 4 0 - W4narum=adon 45yalem of Guidame of AW-AbTrAft ArdbM Fire),by N, F. LAIMRU.~,aMv bk, Kv.~ TouU P U A Z Qm MOSWW*1960. pq 1-Ul -OVTI)--Mi:~~75us"MilApr 65C j 2.=duced in Underarcund OPtniflentiv,x; byLavrovp ct al,Dept of iftUS Bur of VArms~Centrsl ftyer Staft. Ro 342D-6?7 73'by 59XXXZMNLM ACeliMatizaticM of MM3lSrUtl3 IU thtUSSR., by H - P - JAvro _A 150 pp e___yWMIAN, bkl AM] 4 tizatsUa Qmdatry v MR$Isdatellotvo Teentrosoyatao 1957-Dept of UteriorM C3 V 7Sai - Biol 14 k, z a ~?sop 61RusBinn Game Reports. Vol II. Muskrat, 1951-1955.Fluctuations and Forecasts of Muskrat Numbers, byN. F. Levrov.RUSSIAN, per, Voprosy Biologii Pushnykh ?verey iTekhniki Ckhotnichlyego Promysta (USSR), V07 xi-XIV, 1051-1955.Order from Queen's PrinterCanadaSci - BiclJul 59CTS 1, 12Russian Game OReports. Vol II. Muskrat, 1951-10,55.Interiml nnd External Parasites of Muskrats, byN. F. Lavrov.RUSSIPJ;, per, Voprosy Biologii Pushnykh Zverey iTekhniki Oldiotnichlyego Promysta (USSR), V; | 1983 | 2026-04-02T12:22:45Z |
| CIA Reading Room cia-rdp80-00810a000600660006-7: RAILROAD COAL STOCKS AND STATUS OF RAILROAD CARS | 25X1 ApFrP 1 1t aXe amn~/j : CIA-RDP80-0081 OA0006006600 6-7 25I I CENTRAL I 25XIEPORT NO, L INFORMATION REPORT CD NO. COUNTRY Iket Cary SUBJECT Rail.rocd Cool Stockal and Statu?s of Railrord Coro 25X1 PLACE .CQU1'? ECG )ATE CF INFO. T a, OOCU!,-V 3T COOTASNS Ili POP.D1IT4OF1 A"ACTINOTHE NATIONAL lib FEN1R P.'' O8 T141 UHi 1ZD STATES, tIT:lmf1 THE HBANIUIG OF TITLE 28. SFr TIGHS 703 I! i -D 794. 0: THE U. S. CODE, A.3 ASSEH050. IT5 TAAHSIiISSION ~)4I Rd1:EL? I' OI> OF 415 C0RT01470 TD O:7 RECEIPT ay AH UNAUTHOTIIZED PE100.0 f TS ":' mUl GIT D DY AV THE REPRODU70-t OP ':'H1S FORA IS PR-IuIIIITED. 25X1 25X1 Coal stocks and ;onsurr Lion of coal :I: ca o pe ua ~,.- l' ti Date in Hard Coal Raw E oT>r Jam-ary Coal `iota::. 21 49,131 17,280 Stocks 22 48,028 17,191 46,668 18,043 }3 } 25 25X1 DA FE 16)),c-TW 9 April 3.953 NO. OF Fii=GES NJO.. OF G--'1 CLS, {LUSTED E..iL(1'r!} #3:+L1: `ENT y~ y.f REPORT NO. THIS IS UNEJ''ELUAliTD !1[,,i'OP Q 61\14Oii ;+ c$Z? ? ttc 3~ 76,6ci 78,0313 76,724, 2%::,; | 1953 | 2024-02-24T10:38:21Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T21:59:48Z |
| Macintosh Mania 1 | | | 2019-07-06T06:46:50Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| [CDK 056] Steady C - He Started It | [CDK 056] Steady C - He Started It | 2011 | 2020-01-05T21:08:08Z |
| Innovative leukemia and lymphoma therapy | xiv, 598 pages : 24 cm // "Innovative Leukemia and Lymphoma Therapy gives a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as: tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors; radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination; monoclonal antibodies and anti-angiogenesis approaches."--BOOK JACKET // Includes bibliographical references and index // 1. Gene expression profiling to detect new treatment targets in leukemia and lymphoma : a future perspective / Torsten Haferlach, Wolfgang Kern, and Alexander Kohlmann -- 2. Individualized tumor response testing in leukemia and lymphoma / Andrew G. Bosanquet, Peter Nygren, and Larry M. Weisenthal -- 3. Minimal residual disease / Jacques J.M. van Dongen, Tomasz Szczepánski, a; | 2008 | 2020-05-13T05:13:52Z |
| DTIC ADA398172: Role of c-Myc in Estrogen Stimulated Cell Proliferation in Normal and Malignant Breast Epithelial Cells | Estrogenic steroids have diverse physiological functions and are critically involved in the pathogenesis of breast cancer. The transcriptional regulator c-Myc has been implicated in estrogen-induced mitogenesis and we are therefore investigating the contribution of c-Myc to various downstream molecular and cellular events after estrogen stimulation. We have now developed a series of cell lines expressing c-Myc and mutants lacking one or both of the conserved 'Myc boxes' required for transcriptional regulation activity, under the control of an inducible promoter. Ongoing experiments are examining whether these mutants can mimic the effects of estrogen in activating cyclin E-Cdk2 and inducing cell cycle progression. We have recently shown that decreased expression of the CDK inhibitor p21, a c-Myc target, is critical for estrogen activation of cyclin E-Cdk2 and consequently the effect of the c-Myc mutants on p21 expression is of particular interest. We have also shown that decreased c-My; | 2001 | 2018-05-05T20:39:40Z |
| Teaching and Learning Adolescent Psychiatry | | 1971 | 2025-09-26T19:28:34Z |
| github.com-apache-incubator-apisix_-_2019-11-01_09-03-27 | Cloud-Native Microservices API Gateway 中文 APISIX QQ group : 552030619 APISIX is a cloud-native microservices API gateway, delivering the ultimate performance, security, open source and scalable platform for all your APIs and microservices. APISIX is based on OpenResty and etcd. Compared with traditional API gateways, APISIX has dynamic routing and plug-in hot loading, which is especially suitable for API management under micro-service system. Installation | Documentation | Development ENV | FAQ Why APISIX? If you are building a website, mobile device or IoT (Internet of Things) application, you may need to use an API gateway to handle interface traffic. APISIX is a cloud-based microservices API gateway that handles traditional north-south traffic and handles east-west traffic between services. APISIX provides dynamic load balancing, authentication, rate limiting, and other plugins through plugin mechanisms, and supports plugins you develop yourself. For more detailed information, s; | 2019 | 2019-11-01T09:09:58Z |
| DTIC ADA407257: The Role of the Suppressor, Rsu-1, in Regulation of Ras Signal Transduction in Breast Cancer Cells | Rsu-1 is a cDNA previously identified as an inhibitor of Ras-induced transformation. An HA-epitope tagged Rsu-1 cDNA was introduced into the MCF7 breast carcinoma cell line. Stable transfectants were selected for analysis of effects of Rsu-1 expression on growth control and Ras-dependent kinase pathways. Assessment of biological activity of HA-Rsu-1 transfectants revealed slower anchorage dependent growth rates , a significant reduction in anchorage independent growth and increased apoptosis compared to control MCF7 cell lines. Analysis of cell cycle regulatory proteins required for transit through 61 revealed that HA-Rsu-1 transfectant cell lines expressed elevated levels of p21 (CIP) CDK inhibitor but not cyclin D or p27 KIP, This appears to be due to stabilization of P53 by Rsu-1 expression as revealed by pulse-chase experiments. Moreover, Rsu-1 transfectants exhibited reduced levels of cyclin D- associated kinase and cdk2 kinase activity. Perturbations in signal transduction pathwa; | 2001 | 2018-05-09T18:17:52Z |
| github.com-sindresorhus-awesome_-_2021-12-29_16-51-20 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-29T23:33:05Z |
| github.com-sindresorhus-awesome_-_2022-01-23_19-01-28 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-24T01:48:28Z |
| github.com-sindresorhus-awesome_-_2022-11-12_16-07-31 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-13T21:28:57Z |
| github.com-sindresorhus-awesome_-_2023-06-26_15-20-26 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-27T00:52:07Z |
| github.com-sottlmarek-DevSecOps_-_2021-11-26_17-57-22 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this Library of knowledge please create proper PR (Pull request) with description what you are adding following these set of rules: Clear description of PR Keep it simple Fact over feelings or personal opinions Add source and follow the Library style Note: Currently this is early version of the library. I recommend PR after first official release. DevSecOps Library info: This library contains list of tools and methodologies accompanied with resources. The main goal is provide to the engineers guide trough opensource DevSecOps tooling. This repository covers only cyber security in cloud and DevSecOps scope. Table of Contents Defintition Tooling Precommit and threat modeling SAST DAST Supply chain and dependencies Infrastructure as code Containers security Kubernetes Cloud Chaos engineering Policy as code Methodologies Other License What is DevSecOps DevSecOps fosuses on security automat; | 2021 | 2021-11-27T17:37:25Z |
| github.com-italiaremote-awesome-italia-remote_-_2023-09-07_16-15-21 | A list of remote-friendly or full-remote companies that targets Italian talents. Awesome Italia Remote A list of 324 remote-friendly or full-remote companies that targets Italian talents. Companies can be both based in Italy or around the world but with operations in Italy. Please read the contribution guidelines before opening a pull request or contributing to this repository. Web View https://italiaremote.com/companies Built and maintained by Alessandro Marino Edoardo Costantini Legenda Remote Policies Label | Meaning--- | ---Full | Company doesn't have physical offices, so you'll always work remotely.Hybrid | Company allows remote but only for some days.Optional | Company allows you to choose when work remotely or in office, but can ask you to go sometimes. Hiring Policies Label | Meaning--- | ---Direct | Company is hiring directly with a legal entity in Italy.Contract | Company is hiring contractors in Italy, VAT Number is required.Intermediary | Company is hiring using a payroll i; | 2023 | 2023-09-07T20:17:29Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-04_23-17-10 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-05T09:01:59Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| github.com-sindresorhus-awesome_-_2022-01-22_21-24-15 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-23T01:20:47Z |
| [CDK 045] Dauragon C. Mikado - The Inner Workings | [CDK 045] Dauragon C. Mikado - The Inner Workings | 2010 | 2020-01-05T19:29:06Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |