| Title | Description | Published | Added |
| github.com-DovAmir-awesome-design-patterns_-_2022-12-08_10-37-12 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage DevOps & containers Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalo; | 2022 | 2022-12-15T12:47:03Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| the valaue theory of karl marx | | 1976 | 2025-05-22T13:48:47Z |
| CIA Reading Room cia-rdp80-00810a000600660006-7: RAILROAD COAL STOCKS AND STATUS OF RAILROAD CARS | 25X1 ApFrP 1 1t aXe amn~/j : CIA-RDP80-0081 OA0006006600 6-7 25I I CENTRAL I 25XIEPORT NO, L INFORMATION REPORT CD NO. COUNTRY Iket Cary SUBJECT Rail.rocd Cool Stockal and Statu?s of Railrord Coro 25X1 PLACE .CQU1'? ECG )ATE CF INFO. T a, OOCU!,-V 3T COOTASNS Ili POP.D1IT4OF1 A"ACTINOTHE NATIONAL lib FEN1R P.'' O8 T141 UHi 1ZD STATES, tIT:lmf1 THE HBANIUIG OF TITLE 28. SFr TIGHS 703 I! i -D 794. 0: THE U. S. CODE, A.3 ASSEH050. IT5 TAAHSIiISSION ~)4I Rd1:EL? I' OI> OF 415 C0RT01470 TD O:7 RECEIPT ay AH UNAUTHOTIIZED PE100.0 f TS ":' mUl GIT D DY AV THE REPRODU70-t OP ':'H1S FORA IS PR-IuIIIITED. 25X1 25X1 Coal stocks and ;onsurr Lion of coal :I: ca o pe ua ~,.- l' ti Date in Hard Coal Raw E oT>r Jam-ary Coal `iota::. 21 49,131 17,280 Stocks 22 48,028 17,191 46,668 18,043 }3 } 25 25X1 DA FE 16)),c-TW 9 April 3.953 NO. OF Fii=GES NJO.. OF G--'1 CLS, {LUSTED E..iL(1'r!} #3:+L1: `ENT y~ y.f REPORT NO. THIS IS UNEJ''ELUAliTD !1[,,i'OP Q 61\14Oii ;+ c$Z? ? ttc 3~ 76,6ci 78,0313 76,724, 2%::,; | 1953 | 2024-02-24T10:38:21Z |
| AutoDesk Cyberspace Developer Kit v1.0.1 | From the README: Notes on the Autodesk Cyberspace Developer Kit 1.0.1 ==================================================== INCOMPATIBILITIES ----------------- IMPORTANT: This release, CDK 1.0.1, is incompatible with release 1.0 in several areas, including displays, solids, and DSCVR. To use this new release, it is necessary to recompile any of your code that refers to CDK header files. HIGHLIGHTS OF THIS RELEASE -------------------------- This is an update of CDK Release 1.0. Some bugs have been fixed (most notably in the SPEAdisp and VESAdisp display classes), and some features added (particularly in the CDF reader). Also, this release supports the MetaWare C++ compiler release 3.1, the Phar Lap DOS Extender release 5.1, and the FTP Software release 2.2, in addition to previously supported releases of these products. The Zortech C++ compiler release 3.0 is supported as well. This README.TXT document also contains a complete summary of environment variable settings needed for c; | 1993 | 2022-05-13T07:50:27Z |
| DTIC ADA357346: Biology of Somatostatin and Somatostatin Receptors in Breast Cancer. | Fifty additional primary human breast tumor samples were analysed for SSTR1-5 mRNA and shown to be all receptor positive. Mean SSTR mRNA level was the highest for SSTR3 followed by SSTR1, SSTR2, SSTR5, and SSTR4. Statistical analysis showed a negative correlation between SSTR2 and tumor size, a positive correlation between SSTR2 and estrogen receptors (ER), and a trend towards a positive correlation between SSTR2 and progesterone receptor, SSTR1 and ER, SSTR1 and lymph node status, and SSTR3 and tumor grade. Breast cancer cell lines also expressed multiple SSTR subtypes but the level of receptor expression was less than that in solid tumors. A panel of antibodies against hSSTR1-5 was produced which detected all five SSTR antigens by Western blots and immunocytochemistry. Both analyses showed a correlation between receptor subtype expression at the protein level with SSTR mRNA levels. All five SSTRs inhibited tumor cell growth, SSTR3 by triggering apoptosis, and the remaining four subty; | 1998 | 2018-04-21T02:02:12Z |
| github.com-localstack-localstack_-_2023-09-30_01-52-12 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-09-30T05:53:41Z |
| github.com-T-head-Semi-wujian100_open_-_2019-10-24_06-20-55 | IC design and development should be faster，simpler and more reliable wujian100_open wujian100_open is a MCU base SoC. We can simulate by EDA tools and emulate by FPGA. Also we can develop the IPs and software in this platform. We wish more and more developers building the open MCU ecosystem with T-Head. IC design and development should be faster simpler and more reliableDirectory Structure|--Project //open source project work directory |--riscv_toolchain //tool chain install directory download from t-head.cn |--wujian100_open //wujian100_open project get from github |--case //test case example for simulation |--doc //wujian100_open user guide |--fpga //FPGA script |--lib //compile script for simulation |--regress //regression result |--sdk //software design kit |--soc //Soc RTL source code |--tb //test bench |--tools //simulation script and setup file |--workdir //simulation directory |--LICENSE |--README.md Get Start 1. prepare a project work directory just like 'Project'2. cd Proje; | 2019 | 2019-10-24T09:00:18Z |
| Christian Initiation the Reformation Period | | 1970 | 2025-06-16T04:36:46Z |
| CIA Reading Room cia-rdp91-00929r000100090020-0: FR:KURTA G. TO:KUGAKOV M.M. | Retaxmion Phenomew for Attenwalm of Sxvdin Ductop by G. K=txp.GERMM, per, A~M Vol )as 1961, pp 112-117.NASA TT P-9277Sci-Mectrmay 65U.S. GOVERNMENT ONLY28(4190mTransplantation of Himan Carcitwom.9 by Raw Kurtzabn,10 pp?)=WAN, perp Ki. usch.., Vol Uls, 1926o pp 1166-1168.inScientific - Medicine CTS/DIX // .2 P401Proceocs lor Yonufactur-ling a Cb--ese ?rwuct of GrGratGd Hl&~i-Fat Chaese, by 2. 24 Tlxalsmaa,W, J. Kurt--lial3,, 6 pp.amm, potperrit 949,6i6i 30 Aug -1956.sLA 6o-149aI f- -1 -7,SciROSTE.Tmals B. 1.KURUKLISP G. A.Stanki I instrument# Vol. 17, xo. 6, 11figures wo 3 tableav 2600 words- 1946.Deep Dry Cyaniding of Cutting- Toole.Brutcher Trans, Order No* 1914s, $4-55amom Lai to latruall"Is 3*MQWbt,-Nw 73cateshoWalow contsm As foblize 40""*1. rA* 4UNft Of & IPYT*V"* &*SUQW(""I) ft sbo AOL".' coutaft of the sx*itStan a" on ow ant" Tore"sumaby T. gulmas *t RuJAPAUMS, Fifirs MUM TakwLELS it Val LisU64v pp 463oMaw MIN X0scl - S/wMay 66The !~!chanlce c-f Beending of the SbRP.-, of incUne; | 1983 | 2026-03-25T15:12:02Z |
| CIA Reading Room cia-rdp96-00788r000700130014-7: SPOT REPORT | F t'R. C EFIC,\L USE ONL y 4########### PEt IT AGU i IELFCG?tilLNICAT IONS CEN TEI PTTEZYL , RUavfMFDA01315 0252257 IJR i TY/KDUT INE r' 1 252BUOZ JAN 82 h-,vj C(JRI:SAINiSC(7~ MI ()ET FT LEWIS WA //LAGPA-C-LE// TL CDK SPECIAL 'PINS CET '.-1 NEADE MD //IASC// +U/_L;;~IC,E FT M CACE D SL1// CC;z JSAIT A C AHS Vi\ X-T,\-t?,// l-t0 DA WASF-GC //DAM, -CIC/FIO// 11,LLL'i FT I"NSCIJ' :\HS VA // i. L PS ('SF) SFFAN CA //IAGPA-C-OP// C'_ E~ S c r- I iU F JUC NU N Iuh,T AC T I (iNN REL;U IR EC T I ~, ,:) L i7 = Z r ; ,. l ( OT kE PnF r i . ( F'-jLi)) K1J?JAP0I iNB CF 13L JAMES DEL LEN, ASS FEPGPTED F3Y GERALDINE ILS ("\? A':(,RY TARASFWICH9 :1N() R5 ARA KiJPIK P1,TTEN, KENT, WASHINGTON, ['-;LaE (/. b) 631_.68G6 (CFFICEI- 631-?81)18 (H0MEI, F.4 RA S" C3 ( rS r.:vcF =". (I i?`iITI,AL SP ur r,Ei-~:ir,T9 SAD, 2U24CUZ JAN 82. L~m 2, (U) G I.LNH tFPC1RI 3 (a l (FLUUI i N! 7.1 JA,' 82 , FLMID ,AS 0:KrHF. VISIilNS CONCERNING 10TH` PLACE J~=5C1 | 1982 | 2023-06-26T04:57:16Z |
| Crazy Bytes 4 [REPACKED] | First, I'd like to thank the original uploader for this archive which contains some rare gems. Like some others, I had difficulty accessing the files easily. This isn't intended to stop on anyone's toes, but rather make it more readily accessible. If you are seeking the original, untouched archive go here: https://archive.org/details/CrazyBytes044CD If you simply want the software, continue on. The original text encoding on the password was difficult to work with. Now, everything has been zipped without passwords and all original file timestamps have been preserved. It is not necessary to run the menu or other included software to access the files. There are 6 .RAR files which will not fully extract because of CRC errors. While they can partially extract, they're likely corrupted or missing files. These corrupted RARs are included for consistency. The rars are in the zip of their respective folders. Unzip to see find the rar and it's password. If you'd like to try extracting the ; | | 2022-01-21T22:02:32Z |
| Differential roles of Smad2 and Smad3 in the regulation of TGF-?1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1. | This article is from Molecular Cancer , volume 10 . Abstract Background: Progression of pancreatic ductal adenocarcinoma (PDAC) is largely the result of genetic and/or epigenetic alterations in the transforming growth factor-beta (TGF-β)/Smad signalling pathway, eventually resulting in loss of TGF-β-mediated growth arrest and an increase in cellular migration, invasion, and metastasis. These cellular responses to TGF-β are mediated solely or partially through the canonical Smad signalling pathway which commences with activation of receptor-regulated Smads (R-Smads) Smad2 and Smad3 by the TGF-β type I receptor. However, little is known on the relative contribution of each R-Smad, the possible existence of functional antagonism, or the crosstalk with other signalling pathways in the control of TGF-β1-induced growth inhibition and cell migration. Using genetic and pharmacologic approaches we have inhibited in PDAC cells endogenous Smad2 and Smad3, as well as a potential regulator, th; | 2011 | 2014-10-29T05:01:17Z |
| Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families. | This article is from Journal of Carcinogenesis , volume 10 . Abstract Background:: Cisplatin (CDDP) is a drug used for treatment of many types of malignancy but pancreatic cancer is relatively resistant to it. This study aims to determine whether and how cyclin D1 (D1) and c-Myc influence the response of pancreatic cancer cells to CDDP. Materials and Methods:: Ela-mycPT mouse pancreatic cancer cells were transfected with D1 or c-myc cDNA and treated with CDDP alone or together with NPCD, an inhibitor of cyclin dependent ckinase (CDK) 4 and 6. Reverse transcription followed by polymerase chain reaction (RT-PCR) and western blot assays were used to determine the mRNA and protein levels of interested genes. Cell viability was determined using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results:: Treatment of Ela-mycPT1 cells with CDDP caused an increase in c-myc expression but a slightly latent decrease in D1 expression, whereas D1 and c-Myc proteins repres; | 2011 | 2014-10-28T18:52:34Z |
| Flourescent Protein Tracing | | 1962 | 2025-09-12T10:44:29Z |
| github.com-sottlmarek-DevSecOps_-_2022-06-02_09-30-05 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Report typos as issue not via PR. Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevS; | 2022 | 2022-06-02T11:24:44Z |
| [CDK 038] Various Artists - Run | [CDK 038] Various Artists - Run (Music For the Distance Jogger) | 2009 | 2020-01-05T14:56:16Z |
| github.com-sindresorhus-awesome_-_2021-04-23_16-56-34 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-25T20:56:24Z |
| github.com-sindresorhus-awesome_-_2022-01-21_04-06-07 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-21T12:39:20Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-03_19-01-38 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-04T20:51:28Z |
| Het Utrechts Archief 807112 | Het Utrechts Archief catalog number: 807112 Description (Dutch): Afbeelding van het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). Het treinstel werd voornamelijk gebruikt voor het vervoer van het Concertgebouworkest. | 1960 | 2021-02-03T04:46:45Z |
| cyyo oyousym – doxzmzytr yoizc jyioyzu | cynmso ntyniyyzd kyjsq sgqkd iqsukz lncnjz yo ioxzmzyt. dopny-tn gmykd kr zsdk, yz n cdk yy sqkod, aingyn lirgdk ln tycyyzq. c gsmqm — moxgzipo, z yzpopzc qpoxqqdzc pokyyu. vzptn yy lnsapojyt tyxy, pqso aiysqyt agymyqtu, ctnxr snatzcu acoatud. vzptn yy lnsapojyt tyxy gymyru lqtu, gysu jzxyu yy apoxpo. fniupn g apoxpy npmqjoqdzy syidtad yo snxmrc z xirc, g syuatgztyiuynatz jy gad mnmoxsn ainjyyy. | | 2024-07-06T12:14:46Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| CIA Reading Room cia-rdp91-00403r000200380008-6: FR:IZSO L TO:BAGER G | Traffic Organization and Preparation of Tim Tableofor Pusenger Shippliig on the Balaton.MMGARIANI perk Kozlekedese KozIony) 24 may 1970.,PP 384-387.DTA LN 1328-70Ju1Y 71The Plans and Tasks of Mobart for the Year 1970.RMARIM., per. KozIekedesi Kbzlony, No 16,19 April 1970, p 285.DTA rX 114g-7oJ'AlY 71Trends In Transportmbion and Postal Output Devicing1969.MMGMIM~ perk Kozelekedsi lCozIony, No 153April 12, 1970, p~ M7-2',11.DIA LN 1148-70May 71The Twerity-Five Years of Hungarian Shipping.UMMIM, per, I-a-ziekedesi KoziMp .4 April 1970sPp 248-250-DiA Lw 1147-70State PAIUVWU# IM Task* MftbWobyWay &*Wlo 9 pp.HUWARW Paogo 90 IYAOr 0ins 50417RF,NungaryF400&F ?0 407j,346V^aq;mBow&r 70 4020445NW& 7111 lans for I~ailroad Containerization wotexi.by Laszlo Izao, k~yorgy ionyrd, 9 pp,10WARIAW, por, Xozlq)cedAk 1~q pnv, lWapust,30 I'~ov 1969. pp W~Z~d- L4 _-i ei~s 49688U~ImngaryBconi-eb 70 40o,6o,6-laticnal aid i iiaij)our L,; 40I )ILL.14lUji"'It"L.'j, ~ILEi2!L~ 17 ~.;,),vo, 1'J69Ilil.,\ 1~~ U48-69(D; | 1983 | 2026-03-31T13:43:14Z |
| CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITY | Approved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known; | 1981 | 2024-05-13T17:20:36Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers. | This article is from eLife , volume 3 . Abstract During M phase, Endosulfine (Endos) family proteins are phosphorylated by Greatwall kinase (Gwl), and the resultant pEndos inhibits the phosphatase PP2A-B55, which would otherwise prematurely reverse many CDK-driven phosphorylations. We show here that PP2A-B55 is the enzyme responsible for dephosphorylating pEndos during M phase exit. The kinetic parameters for PP2A-B55’s action on pEndos are orders of magnitude lower than those for CDK-phosphorylated substrates, suggesting a simple model for PP2A-B55 regulation that we call inhibition by unfair competition. As the name suggests, during M phase PP2A-B55’s attention is diverted to pEndos, which binds much more avidly and is dephosphorylated more slowly than other substrates. When Gwl is inactivated during the M phase-to-interphase transition, the dynamic balance changes: pEndos dephosphorylated by PP2A-B55 cannot be replaced, so the phosphatase can refocus its attention on CDK-phospho; | 2014 | 2014-10-23T20:21:36Z |
| CIA Reading Room cia-rdp84-00581r000300800016-0: RUSSIA AND BACK FR: ARKHIV ANATOMII, GISTOLOGII I TO: ARKHIV ANATOMII, GISTOLOGII I | vaectrm Mieroscopy ce Intemourowl !'~navocsjby S. P, Sar-jaw-t., 19 PP.W.19MAI., por,, Anntld=U.,_GistolRj;~,~&-brioluail no 29 1962s vp 112-121.JPRS 15283Set - t4ttdlclwOct. 62(3F -22-J06)0PROBLEVsS OF EVOLUTIONARY MORPHOLOGY OF THECELL IN THE LIGHT OF DATA FROM ELECTRONMICROSCOPY, BY A. N. STUDITSKIY, 45 PP.RUSSIAN, PER, ARKHIV ANATOMII,_GISTOLOGII IE2461 OLOG I I . VOL XL I I , W IT 1 )G2, PP 3-27.--JPRS 14719SCI - BIOLOGYAUG ~2 205,985MORPHOLOGY OF CARDIAC GANGLIA IN 'ME CAT.11963] flip) (figs amirted) 26refsFASEB Nianuscript m S 122-3.Order from OTS or M-A $1. 60 Tr-63-23908figs available on loan fromTrans. of.ArMly Anatomil, Gistolop i EnibxlologU(USSR)avallable)DESCRIFTOM- *Ganglia, Cells (Molqgy)~ *Nerve cells,Nermw symem, 1-leart, *Autwornic nervous system.morpbologyIn this study of die neurone of the cardiac ganglis of theprecoriffum, three di utinct types of cells were tsolateci.Type I are Idezriflod as multipolar motor neuruns. Mwpericellular apparatus of these cells consis; | 1972 | 2026-03-31T21:12:45Z |
| BRITANNICA WORLD LANGUAGE DICTIONARY | | 1959 | 2025-08-24T15:43:03Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Overtures Of Biology | | 1964 | 2025-09-11T12:55:51Z |
| Pterostilbene Simultaneously Induced G0/G1-Phase Arrest and MAPK-Mediated Mitochondrial-Derived Apoptosis in Human Acute Myeloid Leukemia Cell Lines. | This article is from PLoS ONE , volume 9 . Abstract Background: Pterostilbene (PTER) is a dimethylated analog of the phenolic phytoalexin, resveratrol, with higher anticancer activity in various tumors. Herein, the molecular mechanisms by which PTER exerts its anticancer effects against acute myeloid leukemia (AML) cells were investigated. Methodology and Principal Findings: Results showed that PTER suppressed cell proliferation in various AML cell lines. PTER-induced G0/G1-phase arrest occurred when expressions of cyclin D3 and cyclin-dependent kinase (CDK)2/6 were inhibited. PTER-induced cell apoptosis occurred through activation of caspases-8-9/-3, and a mitochondrial membrane permeabilization (MMP)-dependent pathway. Moreover, treatment of HL-60 cells with PTER induced sustained activation of extracellular signal-regulated kinase (ERK)1/2 and c-Jun N-terminal kinase (JNK)1/2, and inhibition of both MAPKs by their specific inhibitors significantly abolished the PTER-induced activati; | 2014 | 2014-10-06T23:46:41Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| github.com-localstack-localstack_-_2022-11-12_23-39-58 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-11-13T09:19:09Z |
| CIA Reading Room cia-rdp90g00993r000200150021-6: CAREER LADDERS FOR SENIOR SECRETARIES | Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 P-A =1 SON C reer adders for ior Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Office of Communications Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 j _ j a L' _ ~, L_ -, L _ t l - L. Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 F a ova GM& ofd S Rwb a Calm o. 0 S. T o 0 0 5, hokZ9o 1 000 l~? oc~Q o~o[~i CDk [ o a G?Q o]~~ ? of ll [rte. B~ G?3~o ? o Telecommunications Specialist (Technical) GS -09 Operates communications equipment, pro- cesses messages; assignment worldwide. Electronics GS -09 Installs, repairs, maintains communications Technician (Technical) equipment; assign; | 1981 | 2026-04-09T03:36:55Z |
| github.com-sindresorhus-awesome_-_2021-12-26_03-21-28 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-26T22:03:58Z |
| github.com-sindresorhus-awesome_-_2022-01-24_22-26-30 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-25T02:20:23Z |
| github.com-sindresorhus-awesome_-_2023-05-14_15-35-37 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Today Quickly view your schedule in the macOS menu bar My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Paperwork that makes the data work. Easy APIs for paperwork. PDF generation, e-signature and embeddable no-code webforms. The easiest way to build paperwork automation into your product. Paperwork that makes the data work. E; | 2023 | 2023-05-14T17:50:28Z |
| github.com-sindresorhus-awesome_-_2023-10-24_23-57-20 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-25T11:07:00Z |
| CIA Reading Room cia-rdp82-00457r002300710003-9: ATTEMPT OF TRUJILLO TO OBTAIN U.S. CURRENCY | 25X1A2g CENTRAL INTE ENCE AGENCY REPORT N INFORMATI N REPORT CD NO. Sanitized - Approved Fo si (~IA-RDP82-00457R002300 CLASa1FICATIO 4 SE -T COUNTRY Dominican Republic/Haiti, same plane with Fred Imbert.) SUBJECT Attempt of Trujillo to obtain U. S. Currency - NO: OF PAGES 1 PLACE ACQUIRED DATE OF IN 25X1X6 25X1 A6 < WARNING NGTI : TH S DIS"IZsZ i'= LISTING MUST BE EXCIS#D ~3I:r .E PUBLIC RLLI"A51" OF THIS DOCUMENT. DATE DISTR. 9 February 1949 NO. OF ENCLS. (LISTED 9#LOW) 25X1A6a SUPPLEMENT TO REPORT NO. to It is reported that on the morning of 31 January 1949, Anselmo Paulin, Dominican Secretary of State, without portfolio, personally called at the home of Manuel Imbert, prominent Dominican banker, and requested him to obtain 120,000 in United States currency as soon as possible. Paulin advised that Vo money was urgently needed by President Trujillo. 2, During the afternoon of 31 January, Fred Imbert, brother of Manuel and a resident of San Juan, Puerto Rico, arrived in Ciudad Trujillo; | 1949 | 2023-06-28T00:44:17Z |
| CIA Reading Room cia-rdp83m00914r002900060005-4: I AM PLEASED TO INVITE YOU TO A ONE-DAY SPECIAL SECURITY PRESENTATION | Approved For Release 2006/0 Y2rY A`TR _ 83M00914R002900060005-4 Washington. D. C 20505 31 MAR 1982 ER 82-4708/1 I am pleased to invite you to a one-day-special security pres- entation sponsored by the White House and hosted by the Central Intelligence Agency at n Thursday, 25X1 13 May 1982. This session w i l l give those o you who were unable to attend last year the chance to do so. The schedule is enclosed. This highly-selective session has been designed to meet your special needs as an official Government spokes- person. I promise you it will be interesting and informative. The day is intended to broaden your knowledge and enhance your effective- ness throughout your period of Government service. If my schedule holds, I plan to be with you for at least a portion of the day. Kindly direct your response to CIA's Public Affairs office, telephone 351-7676. I hope to see you there. Sincerely, I g ail William J. Casey Director of Central Intelligence Enclosure UNCLASSIFIED WHEN SEPARATED ; | 1982 | 2024-07-15T20:22:12Z |
| CIA Reading Room cia-rdp85m00364r002204280136-7: LETTER TO (SANITIZED) | Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 CENTRAL INTELLIGENCE AGENCY PUBLIC AFFAIRS Phone: (703) 351-7676 18 April 1983 STAT Thank you for writing Mr. Casey for whom I am responding. I am sorry but the Central Intelligence Agency is in no position to help you. Thank you for writing our Agency. I am sorry we cannot be of assistance to you. Sincerely, STAT OEXA/PAD/KJH/cdk/18 Apr 83/7676 Di strib..a.. __ C/e Pd Approved For Release 2007/12/19: CIA-RDP85M00364R002204280136-7 _ STAT | 1983 | 2025-02-20T13:56:07Z |
| CIA Reading Room cia-rdp91-00772r000200890017-1: A FR: JOURNAL OF PHYSIQUE ET LE RADI TO: JOURNAL FUR PRAKTISCHE CHEMIE | Friu=.;-, by J. 7-van. U11CLASSIM-Dyer,'~ Journal of Phyal-quo et Le Radium. No-----------195'i7-Havy Tr 1.631/091-,127A E- C~Sci V410=10S.-iNb rDie Y90. TM trunaltion 0+---*~ 0:w r, lmdt of flwzt by U. T. Yuwmj14. Lab Igue-Frolow.. 15 pp.J. php. at :nLdlum4Hge 18, 48-P It98 15 dVth;b;r, 3,9'57.AND-tr-33MMA 58-505Sal 5P4 4~eAug 59pI irpriROF YICIHoilin~th hdo ~)y R-, Duverney,de'Physique et le Radium,16.!- 92261509270s611R-383-IqPreliininary;Ebcperiments on Radioactivities Consequentto J~xp.~osioa of Wires Containing D uterim, ByM. Bon~asFRENCH, per, Le Journal de Physique et le Radiixr,, Vol.2XVIII, No 1.0, 1957, PP 5E5-592*JP.RS for Army Rocket wid Guded Missile AAgency$7 SeP~ GOboalwaima Selector far slow Ifeutronsp by 0. GobertpD4 Tap---otp 21 pp.jrvaival dm- !I~T 10 Ruium.Val M 19501, -PP51-A-,wjuts 6.36aLqiulatlona of the Us *am Ymber of NeutronsEmitted by IndWed Flosion of u23tJ by Ifeutrowiof 11F.2 I%Vp by S. Alalse, M. Gaudin, at &I.FRMII., Oarj, Joamal 62 Rtyslque et le Radiu; | 1983 | 2026-03-25T23:48:15Z |
| B-Myb switches from Cyclin/Cdk-dependent to Jnk- and p38 kinase-dependent phosphorylation and associates with SC35 bodies after UV stress. | This article is from Cell Death & Disease , volume 4 . Abstract B-Myb is a highly conserved member of the Myb transcription factor family that has essential roles in cell-cycle progression. Recent work has suggested that B-Myb is also involved in the cellular DNA-damage response. Here, we have investigated the fate of B-Myb in UV-irradiated cells. UV stress leads to the appearance of phosphorylated B-Myb in nuclear SC35 speckles during transcriptional shutdown. Furthermore, we show that UV irradiation leads to a change of the phosphorylation pattern of B-Myb, which is caused by a switch from Cyclin/Cdk-dependent to Jnk and p38 kinase-dependent phosphorylation. Taken together, we have identified Jnk and p38 kinase as novel regulators of B-Myb and established the localization of phosphorylated B-Myb in SC35 speckles as a potential novel regulatory mechanism for B-Myb in UV irradiated cells. | 2013 | 2014-10-24T22:51:18Z |
| Teaching and Learning Adolescent Psychiatry | | 1971 | 2025-09-26T19:28:34Z |
| PD-0332991 induces G1 arrest of colorectal carcinoma cells through inhibition of the cyclin-dependent kinase-6 and retinoblastoma protein axis. | This article is from Oncology Letters , volume 7 . Abstract Preclinical and clinical studies have demonstrated the anticancer activity of PD-0332991, a selective cyclin-dependent kinase 4/6 (CDK4/6) inhibitor, in the treatment of various types of cancer in a retinoblastoma protein (RB)-dependent manner. However, it remains unclear whether CDK4, CDK6 or both are required for RB phosphorylation in colorectal carcinoma and thus PD-0332991 can be used to target this CDK-RB axis for the cancer therapy. The aim of this study was to determine whether CDK4, CDK6 and phosphorylated RB proteins were overexpressed in colorectal carcinoma tissues as compared to matched normal colorectal tissues. The results showed that knockdown of CDK6 but not CDK4 reduced RB phosphorylation and inhibited carcinoma cell growth. Thus, CDK6 plays a critical role in RB phosphorylation and cancer growth. PD-0332991 treatment blocked RB phosphorylation and inhibited cell growth through the induction of G1 arrest of co; | 2014 | 2014-10-23T06:07:14Z |
| Innovative leukemia and lymphoma therapy | xiv, 598 pages : 24 cm // "Innovative Leukemia and Lymphoma Therapy gives a complete and up-to-date overview of the exciting new treatment modalities in leukemia and lymphoma that are being introduced in the clinic today. Written by international experts in the field, this volume examines clinical studies on topics such as: tyrosine kinase inhibitors, histon deacetylase inhibitors, and farnesyl transferase inhibitors; radioimmunotherapy, gene-directed therapy, and immunotherapy by vaccination; monoclonal antibodies and anti-angiogenesis approaches."--BOOK JACKET // Includes bibliographical references and index // 1. Gene expression profiling to detect new treatment targets in leukemia and lymphoma : a future perspective / Torsten Haferlach, Wolfgang Kern, and Alexander Kohlmann -- 2. Individualized tumor response testing in leukemia and lymphoma / Andrew G. Bosanquet, Peter Nygren, and Larry M. Weisenthal -- 3. Minimal residual disease / Jacques J.M. van Dongen, Tomasz Szczepánski, a; | 2008 | 2020-05-13T05:13:52Z |