| Title | Description | Published | Added |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T21:59:48Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-07_09-07-40 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-07T09:45:28Z |
| github.com-sottlmarek-DevSecOps_-_2022-01-14_09-42-59 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def; | 2022 | 2022-01-14T21:43:52Z |
| Retrospectiva 2016 | Foi um ano difícil, mas nós sobrevivemos. Eleve o cosmo e siga o Armadura Nerd: www.armaduranerd.com.br facebook.com/ArmaduraNerd youtube.com/ArmaduraNerd twitter.com/ArmaduraNerd instagram.com/armaduranerd Contato comercial: armaduranerd@gmail.com Trilha sonora do podcast: New York City (Instrumental) by spinningmerkaba (c) copyright 2011 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/jlbrock44/30389 Bad_Attraction by Stefan Kartenberg (c) copyright 2015 Licensed under a Creative Commons Attribution license. http://dig.ccmixter.org/files/JeffSpeed68/48947 Ft: brad sucks The Game Has Changed (cdk RumbleStep Mix) by cdk (c) copyright 2013 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/41830 Ft: My Free Mickey You Believed It Yourself by Siobhan Dakay (c) copyright 2015 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/SiobhanD/50482 Ft: Fluffy Story; | | 2017-02-05T01:22:06Z |
| GNU GCC mipsel (CDK-patched) 2.7.2-cdk (PS1 MIPS R3000, linux) | Overview GNU GCC mipsel (CDK-patched) 2.7.2-cdk — historical compiler archived for software preservation and exact-version identification (catalog id <b>gcc2.7.2-cdk</b>). Key binaries File Size Version info SHA-256 cc1 3220572 GCC: (Ubuntu 9.4.0-1ubuntu1~20.04.2) 9.4.0 90db2db7bcfe372244ca4d9785a7bfbf7613d711f69ee3bfe6c91d82a85e611d Hashes cc1 md5 1aee0a1960288da8ef15b6f5eca185e9 sha1 3a4fbfa4f5cea14fef08f04ef2351bd2ce1db3ca Full per-file hashes: manifest.json / manifest.txt in this item. How to identify this compiler Object/ident string: # GNU C version cygnus-2.7.2-970404 SN32.3.7.0004 (SonyPSX) compiled by CC. Source Package source: https://github.com/decompals/old-gcc/releases/download/0.15/gcc-2.7.2-cdk.tar.gz Notes Linux i386-hosted GCC mipsel cross compiler, CDK variant, rebuilt with patches by decompals/old-gcc. Test compile is to assembly (cc1 only). Version string derived from the decomp.me id. | | 2026-10-29T04:58:45Z |
| Flourescent Protein Tracing | | 1962 | 2025-09-12T10:44:29Z |
| CIA Reading Room cia-rdp90-00077r000100040018-7: PROCUREMENT DIVISION STATISTICS AND WORKING RELATIONSHIPS WITH OFFICE OF COMMUNICATIONS | Declassified in Part -Sanitized Copy Approved for Release 2012/03/23 :CIA-RDP90-000778000100040018-7 STAT STAT "__""...."., '..,."~??"?` ~wr 27 January 1984 '?(O: Nam ,office symbol, rrrm number, .~, . 1. C/PD/OL L -. p royal s Requested (Coordination REMARKS Preparo Reply See Me The D/L is scheduled to speak to the Office of Communications staff meeting group on 5 March and he would like you to supply him with information and statistics relative to your rev 1 of Su~~ nrt to nr and your view of the workin s~?tion between your office and' Would appreciate your input by 24 Fe ruary. STAT STAT DO NOT uss this foam as a RECORD of approvals, concurrences, disposals. clearances, and similar actions FROM: (Name, org, symbol, Agency/Post) Frankie 0-D/L so4i-ioz _< ~p~ Eby cs~ ev. 76) _.:. f+ GPO , tON~ n _ an~_c~o .,~,. - F~YR [at Cdk~ ~m_~~ ene ~s Declassified in Part -Sanitized Copy Approved for Release 2012/03/23 :CIA-RDP90-00077R0~00100040018-7 Declassified in Part - Sanitized Copy Appr; | 1984 | 2026-04-28T20:15:47Z |
| Behind The Scenes and Updates On Each Case | In this episode, I take you behind-the-scenes of each case I covered in the Court Junkie podcast, as well as go over the latest updates. You'll also hear from Pravin Varughese's mom and family friend, as well as other Court Junkies. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter; | 2017 | 2023-07-08T12:41:02Z |
| github.com-sindresorhus-awesome_-_2022-01-21_04-06-07 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-21T12:39:20Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-03_19-01-38 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-04T20:51:28Z |
| github.com-sindresorhus-awesome_-_2021-04-23_16-56-34 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-25T20:56:24Z |
| Recall Ft Kara Square (Stems) | Recall - Vocals by Kara Square (c) 2013 Licensed under a Creative Commons Attribution Noncommercial (3.0) license. http://dig.ccmixter.org/files/mindmapthat/43023 Ft: CDK The vocals to this Secret Mixter remix of CDK. Thank you to CDK for the inspiration. Here is a link to CDK's sample pack. WORDS I could bare my soul Tell you things I’ve held on for so long I could let it go Be the way I wish I were But you won’t recall Anything, anything, anything You won’t remember Anything, anything, anything When will you forget Everything? There are things that hurt I used to think you chose to forget them Things you don’t remember I learned to block things out by the best man But you won’t recall Anything, anything, anything You won’t remember Anything, anything, anything When will you forget Everything? Guilt and denial Have been your prison for so, so long Maybe you’ll break free As you continue to lose your memory But you won’t recall Anything, anything, anything You w; | | 2016-05-06T23:35:17Z |
| CIA Reading Room cia-rdp70-00058r000200100098-1: PUZZLING FOREIGN POLICY OF THE U.S. | FE.B. 1 51962 Approved For Release 1999/09/'-pQ1 .RDP7 United 8tates'T e ro ruby die has rdad in. hiai iodal ,which goes MO A,maxrlcan w psper. head-- haq~_ Cominunlat lined' :"Vtl~ e d ti 4!- .,stay' cra* e iA- OOMDgiW11'k .. Cdk ? bif thin M4 Ctrants: : thy; ''zi ,e4 tent to foreigh.*ld' anti the Congo Leader:' it erptains ywQ s trong atfr pe Vol" of,A oa Yet the "iJnlt d gat- ' t d f th o re e e o .policies which go along with former . Batista government this vast pone, do. Tf a c$dl 1'9 goal di et .4 Yr t 1 1e pt Victory' )endue B +dk a ltfiil Q d ve tIs at gC'tbe ' muiifng ta11i fir .. < ;thd words et etc. have speeches ' men. _~ e "l ode ?tSat~ snatchesf h p_oeeibie' 14%, Dim kTuubaff~ ~*ent-in the T?os rte 's, the l" rnm #? ant i~ic tltt~aoty.. Vital, i o s e a slat t[1gli,~ ? f i'q~M,' Cato ndgixe ex+~ e s 1$ o bf t 1+ . 'e dl 'iral o 1, + # < Uride*rstar-dstr,~ Ikrta eager ~e~ e td l t ' :thew le' n logs ,tn ezontinq otii rj~Y .# tiYea rioltcy a it izas ttt-t era:.+1e tie; era; | 1962 | 2023-08-06T09:52:48Z |
| Crazy Bytes #04 (4 CD Set) | Looking for old abandonware warez CD ISO's - If you have any not in my collection please contact me (pascal_of_irate @ hotmail . com). I can remove any copy protections from them (if required) and repost cracked versions for the community to enjoy. I am especially interested in CD's from the likes of Blobby International, Playdoh, Voodoo, Ghost, Tango, Delta, USA, Gold, Redhot, Jurassic, Pepsi, Alkey, Capaccino, Coke, Total, Razor, Xenon etc. but also any others from this era. Please see our special requests as the bottom of this page. Coming soon File: CrazyBytes_04_CD1.iso SHA1: 02a0e3c66323a6cfb2ef7c171d9fb061a260ba14 File: CrazyBytes_04_CD2.iso SHA1: 65c9a1f58b87c4dd304decd6e1a8d3c0c8f2a5a1 File: CrazyBytes_04_CD3.iso SHA1: 8071596c237b3c2135cc7910fd2c3aec79e26122 File: CrazyBytes_04_CD4.iso SHA1: 08b63b01c9ae25e23b9476dcc788251d6ea81764 Special request if you have any of these CD's please contact us: Blobby #04 , #05 , #44 Onyx DVD #01 - November 2001 (Password: oynxdvd4youreyeson; | | 2023-03-13T02:11:51Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-10-22_18-36-37 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-10-24T11:37:01Z |
| Barts Installer #14 - Super Language Collection | Looking for old abandonware warez CD ISO's - If you have any not in my collection please contact me (pascal_of_irate @ hotmail . com). I can remove any copy protections from them (if required) and repost cracked versions for the community to enjoy. I am especially interested in CD's from the likes of Blobby International, Playdoh, Voodoo, Ghost, Tango, Delta, USA, Gold, Redhot, Jurassic, Pepsi, Alkey, Capaccino, Coke, Total, Razor, Xenon etc. but also any others from this era. Please see our special requests as the bottom of this page. BART`s INSTALLER 14 SUPER LANGUAGE COLLECTION BC50 [DIR] BORLAND C++ V5.0 DEVELOPERS SUITE COBOL [DIR] MS COBOL V4.5 CPU_CTL [DIR] SPECIAL COLLECTION FOR ELECTRONIC HOBBISTS DELPHI20 95 [DIR] BORLAND DELPHI 2.0 DEVELOPERS SUITE FORTH [DIR] FORTH V2.0 FORTRAN [DIR] MS FORTRAN V5.1 FOXLIB26 [DIR] MS FOXPRO 2.6 LIBRARY CDK FOXPODBC [DIR] MS FOXPRO 2.6 ODBC FOXPRO26 DOS [DIR] MS FOXPRO 2.6 FOR DOS MASM6 [DIR] MS MACRO ASSEMBLER 6.0 MSC70 [DIR] MS C/C++ V7.0 ; | | 2019-11-09T21:22:32Z |
| BRITANNICA WORLD LANGUAGE DICTIONARY | | 1959 | 2025-08-24T15:43:03Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| Ep 10 Part 2: Kristine Bunch's Struggle For Freedom | In Part 2 of this episode, Kristine and her newly-formed defense team fight to win back her freedom. Armed with advances in fire science, a potential Brady violation, and some shocking revelations about the State's evidence at trial, Kristine and her team fight till the very end. A special thank you to Kristine Bunch for helping me tell her story. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. http://dig.ccmixter.org/files/cdk/48915 Ft: Phasenwandler Homesick (Keymix) by keytronic (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/Keytronic/47457 Ft: Kizzylotus Paper Planes - Durd; | 2016 | 2023-07-08T12:43:12Z |
| Teaching and Learning Adolescent Psychiatry | | 1971 | 2025-09-26T19:28:34Z |
| Remarkable women of france ( from 1431 to 1749 ) | | 1914 | 2025-09-08T04:07:29Z |
| Het Utrechts Archief 168793 | Het Utrechts Archief catalog number: 168793 Description (Dutch): Afbeelding van een gezelschap op het 4e perron van het N.S.-station Rotterdam C.S. te Rotterdam, bij het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het betreft hier een gezelschap uit een extra trein voor de Handelsmaatschappij R.S. Stokvis en Zonen. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). | 1961 | 2021-02-03T11:11:51Z |
| CIA Reading Room cia-rdp80-00809a000600200257-6: CHEMISTRY | Sanitized Copy Approved for Release 2011/0(6/29: CIA-RDP80-00809A000600200257-6 PLACE ACQUIRED USSR DATE of TRIMMMON. 194; AENTRAL u' rELUGENCE AGENCY STAT' STAT Or 700 111700 11707" 7117'511 WE 10.10500 or 111E 177101001 007 10 0. t. C_ a1 Me at. 01010.10[0. 77 1100011111am 00 T111 10001707100 OF 111 00/110110 la 011 0.1000 TO .. 01.011007go r11100 11 0110. 010700 11101. 480e100cva1 00 1051 roam I1 roo119700. 001. 0010. 110700107011 co MUD 70 5001 or T01 0010 1001 am 0760t0 01 no to 01C01"" A at a1Ct105Et *0*1*?. AW&s aye' ; '"Wig une LY4/. rugs rer pm .t5Ta3 Translation e requested.) p.rifica]1p THIS IS UNEVALUATED INFORMATION FOR THE RESEARCH USE OF TRAINED INTELLIGENCE ANALYSTS ARMY now of the echenatic Grignard equation, R R > C a o f 111 1' - R- C ..- oLgx, (S) In the irks devoted to the investigation of the mechanism )f ,he Grignard reaction (we have in mind the works of Rees (1), L+eisenheimer (2) 1'feifer and Blank (3), Neen 'anov, A. W. sasonova (4) mid others), the reacti; | 1948 | 2026-05-13T04:59:10Z |
| CIA Reading Room cia-rdp86b00985r000100080009-5: LETTER TO MS. MINNIE REED DIRECTOR OF CAREER SERVICES PRINCETON UNIVERSITY | Approved For lease 2005/07/14: CIA-RDP86B00985~00100080009-5 CENTRAL [iVTl;!_LIGENCE AGENCY' WASHINGTON, A. C. 20505 PUBLIC AFFAIRS 3'hone: (703) 351-767!5 6 November 1981 Ms. Minnie Reed Director of Ca.re~er Services Clio Hall Princeton University Princeton, New Jersey 08544 -Dear Pis . Reed In connectiion with the forthcoming visit of CIA Personnel STAT Officer to Princeton, you have inquired as to the Agency's po icy w~ regard to hiring homosexuals. The CIA selects its employees on the basis ofi professional qualifications and aptitudes alone. Agency employees are entrusted with access to highly sensitive classified information relating to the national security. Consequently, before employment procedures are completed and an employee enters on duty the employee must receive a security clearance. f-or this purpose the employee must be deter-- - mined to be of unquestioned loyalty and.gaod character. Moreover, the employee must be found not likely to?be susceptible to techniques known; | 1981 | 2024-05-13T17:20:36Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| Cyclin K goes with Cdk12 and Cdk13. | This article is from Cell Division , volume 7 . Abstract The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. | 2012 | 2014-10-27T22:08:10Z |
| Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans. | This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract Although many critical roles of the RUNX family proteins have already been identified, little attention has been given to how these proteins interact with other factors. Elucidating RUNX protein interactions will help extend our understanding of their roles in normal development and tumorigenesis. In this study, we performed large-scale RNAi screening to identify genes that genetically interact with rnt-1, the sole homolog of RUNX protein in the nematode Caenorhabditis elegans. To this end, we took advantage of the fact that C. elegans can survive a severe loss of RNT-1 function with only mild phenotypes, and we looked for genes that caused a synthetic phenotype in the rnt-1 mutant background. We identified seven genes, three of which (cdk-8, cic-1, and sur-2) are involved in transcription, two of which (pgp-2 and cct-5) are involved in stress response, and two of which (D2045.7 and W09D10.4) are involved in signalin; | 2013 | 2014-10-28T00:42:20Z |
| Shoreline City Council Regular Meeting - December 2, 2024 | # Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern; | 2024 | 2026-09-03T10:16:24Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| A functional role for Smad7 in sustaining colon cancer cell growth and survival. | This article is from Cell Death & Disease , volume 5 . Abstract Initially identified as an inhibitor of transforming growth factor (TGF)-β mainly owing to its ability to bind TGF-β receptor type I and abrogate TGF-β-driven signaling, Smad7 can interact with additional intracellular proteins and regulate TGF-β-independent pathways, thus having a key role in the control of neoplastic processes in various organs. Genome-wide association studies have shown that common alleles of Smad7 influence the risk of colorectal cancer (CRC), even though the contribution of Smad7 in colon carcinogenesis is not fully understood. In this study, we assessed the expression and role of Smad7 in human and mouse models of sporadic CRC. We document a significant increase of Smad7 in human CRC relative to the surrounding nontumor tissues and show that silencing of Smad7 inhibits the growth of CRC cell lines both in vitro and in vivo after transplantation into immunodeficient mice. Knockdown of Smad7 result; | 2014 | 2014-10-24T02:06:36Z |
| vmmo | vjmom m zzmomkqjm rkmodcnkrn rmjcoqq, od m czmvm oq gzqcjmk. tom madgzqkmmk crq odcoq rtdrdgo dgomzrcmkc mrkzr. m cdk rcq c rkqomz mkmgqcmm tjqkqkrn odcmn rqkc, gkdgo tdqcmkc gqcrzkr. g vgq-kd gmjqkd, om gzrvdc kdotq rcqkm, kqcooq gdv vmmo m oq grcmqk rgmcmkcrn. mqgc mrkdzkm, dgomcgo tdgocmc c qvd dgpnkmnz, rkmjm qcr qiq orcoqq. to qil oq aomqk, gkd rqzgtq gqcrzkm gmcod dkgmod gzrvdcr, tdjkdcr oq gdtrrkmqk corjm, gkd cdcqk tdjrgmkc dkkma. | | 2024-08-05T20:01:20Z |
| Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. | This article is from Molecular Cell , volume 54 . Abstract The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1. During S phase, Cdk-mediated phosphorylation of Yen1 promotes its nuclear exclusion and inhibits catalytic activity by reducing the efficiency of DNA binding. Later in the cell cycle, at anaphase, Cdc14 drives Yen1 dephosphorylation, leading to its nuclear relocalization and enzymatic activation. Using a constitutively activated form of Yen1, we show that uncontrolled Yen1 activity is detrimental to the cell: spatial and temporal restriction of Yen1 protects against g; | 2014 | 2014-10-23T07:40:09Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| github.com-localstack-localstack_-_2022-08-19_18-22-53 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-08-20T01:25:04Z |
| yahoo-groups-2018-06-30T23-49-20Z-213b6b | Yahoo! Groups API grab. Contains messages of the following groups: abass_t92 adaevi adeala agec424group almostfamous-bvds apurv_heavymetal arch_ugm_05 asd-trainees-0809 avrilavigneavlav aw_groups backlanebizneskl baeeunice bazket_sport besmart_group biotechresearchers bscs_1b_prog_cdk bsn_4a_frieslovers c3_noticeboard cagarencuclillas camobutts ccsflitjournal cfne_22008 chatters cheap-pet-supplies cicstcollege cisco_ghana clubfiatecuador cmpe274_business_intelligence_fall2008 coa08_iiu conexaoamsterda coolfriends_ngp cool_raj1989_hot copi_nijmegen cosbuc2008_12r1 cpa-world csc_8 cscst-argaocampusmis-ict darla_fux52a_livecams darvazeh dc_metro_angels dhrumil88 digitaldial_diversidial_online ds112grouppapergk dyala eca_maniez efbalicobacoba entreprisemichite fierydemon2008 filmstadensickla fina6335_uh2008 flat4677 fuad_online ga-fesc garciamendozafamilytree gay60plus gcet_cs2012 gdc-organic gherti-entertainment ghp_group gkm_2k8 grandmas-recipe-box grupoutp113 gw78 het_tien_roi_89 hottes; | | 2018-06-30T23:49:27Z |
| Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation. | This article is from Cell Death and Differentiation , volume 19 . Abstract Terminally differentiated neutrophils are short-lived but the key effector cells of the innate immune response, and have a prominent role in the pathogenesis and propagation of many inflammatory diseases. Delayed apoptosis, which is responsible for their extended longevity, is critically dependent on a balance of intracellular survival versus pro-apoptotic proteins. Here, we elucidate the mechanism by which the cyclin-dependent kinase (CDK) inhibitor drugs such as R-roscovitine and DRB (5,6-dichloro-1-beta-𝒟-ribofuranosylbenzimidazole) mediate neutrophil apoptosis. We demonstrate (by a combination of microarray, confocal microscopy, apoptosis assays and western blotting) that the phosphorylation of RNA polymerase II by CDKs 7 and 9 is inhibited by R-roscovitine and that specific effects on neutrophil transcriptional capacity are responsible for neutrophil apoptosis. Finally, we show that specific CDK7 and 9 i; | 2012 | 2014-10-26T21:30:14Z |
| Roscovitine confers tumor suppressive effect on therapy-resistant breast tumor cells. | This article is from Breast Cancer Research : BCR , volume 13 . Abstract Introduction: Current clinical strategies for treating hormonal breast cancer involve the use of anti-estrogens that block estrogen receptor (ER)α functions and aromatase inhibitors that decrease local and systemic estrogen production. Both of these strategies improve outcomes for ERα-positive breast cancer patients, however, development of therapy resistance remains a major clinical problem. Divergent molecular pathways have been described for this resistant phenotype and interestingly, the majority of downstream events in these resistance pathways converge upon the modulation of cell cycle regulatory proteins including aberrant activation of cyclin dependent kinase 2 (CDK2). In this study, we examined whether the CDK inhibitor roscovitine confers a tumor suppressive effect on therapy-resistant breast epithelial cells. Methods: Using various in vitro and in vivo assays, we tested the effect of roscovitine on th; | 2011 | 2014-10-28T11:55:39Z |
| CIA Reading Room cia-rdp91-00772r000301760021-8: A FR: KOKUBO-KEIZAI, TSUSHIN TO: KOMMERCHESKIY, VESTNIK | Deff)')V) Agencyls Fiscal Year 197L4 Budget,(TOVT'1 7 I)p.SIRNMENT rjsl!,., ONLY,F -H, 'L,r0 1% .3 0 IZAI TSUSHIN, Tokyo, 23 Jan 7,u -.ZipJPIRS/L 41832Mar 71.1.11 ,.r], -;-~ 1~ -]HKO 'AV I.M.W. ifo =mm//LOW 1"PA(lelOp kitenna for, the Tokyo-lbarrid14f.crOw e fjolay Route,Mald "'olik-'buro Nember Ass,31sses PoliticalSitur.,,tlo-a, I-py E-liyahu Drulman, 10 T)p.HEBRITJ, nov, ",*ol Haam, Aviv, 7 Feb 73,P'o 10-11, ll~.-.1J,?R's, 5&.-LIr 7 3I-ICIo 1 -za anCoin-nrixaise)rol)lllr,a, LrY--IAclvocated to '3ett.l-- I'alesLinianWit La`a,-tv, 9 pr'.-.cl -alpin, Avi%r,IIL - -ar 73,ic~ yt remi s c rrl c j- !"ireas-ellLlus - u -11j.4,y OfbY Y(Aluda Lah.ev.-3: 1 EDI0 1 T,a LviV73,Aor 731" p T~ eo, a,.! ee a r a sI-jl:) ,oTY!"ofby'')taff 7)jSC- SSC.Solua Lahav,I r10junLahav., YehudaBedouin 3i.ipj,)o:*qteis Predict New CivilianEx-oulsions in Sinai, 10 pp.KOL HAIM, Aviv, 25 Jul 73, -.-jp 10. 1.!.JPRS 7-77,7Oc t 7.1,4m,q 11,ational convention for Tokodl List,5r-op .M IIA IAM,, Tel Aviv, 1 Aug 73, p 2.ip I; | 1983 | 2026-03-24T11:09:31Z |
| CIA Reading Room cia-rdp96-00788r000700130014-7: SPOT REPORT | F t'R. C EFIC,\L USE ONL y 4########### PEt IT AGU i IELFCG?tilLNICAT IONS CEN TEI PTTEZYL , RUavfMFDA01315 0252257 IJR i TY/KDUT INE r' 1 252BUOZ JAN 82 h-,vj C(JRI:SAINiSC(7~ MI ()ET FT LEWIS WA //LAGPA-C-LE// TL CDK SPECIAL 'PINS CET '.-1 NEADE MD //IASC// +U/_L;;~IC,E FT M CACE D SL1// CC;z JSAIT A C AHS Vi\ X-T,\-t?,// l-t0 DA WASF-GC //DAM, -CIC/FIO// 11,LLL'i FT I"NSCIJ' :\HS VA // i. L PS ('SF) SFFAN CA //IAGPA-C-OP// C'_ E~ S c r- I iU F JUC NU N Iuh,T AC T I (iNN REL;U IR EC T I ~, ,:) L i7 = Z r ; ,. l ( OT kE PnF r i . ( F'-jLi)) K1J?JAP0I iNB CF 13L JAMES DEL LEN, ASS FEPGPTED F3Y GERALDINE ILS ("\? A':(,RY TARASFWICH9 :1N() R5 ARA KiJPIK P1,TTEN, KENT, WASHINGTON, ['-;LaE (/. b) 631_.68G6 (CFFICEI- 631-?81)18 (H0MEI, F.4 RA S" C3 ( rS r.:vcF =". (I i?`iITI,AL SP ur r,Ei-~:ir,T9 SAD, 2U24CUZ JAN 82. L~m 2, (U) G I.LNH tFPC1RI 3 (a l (FLUUI i N! 7.1 JA,' 82 , FLMID ,AS 0:KrHF. VISIilNS CONCERNING 10TH` PLACE J~=5C1 | 1982 | 2023-06-26T04:57:16Z |
| Crazy Bytes 4 [REPACKED] | First, I'd like to thank the original uploader for this archive which contains some rare gems. Like some others, I had difficulty accessing the files easily. This isn't intended to stop on anyone's toes, but rather make it more readily accessible. If you are seeking the original, untouched archive go here: https://archive.org/details/CrazyBytes044CD If you simply want the software, continue on. The original text encoding on the password was difficult to work with. Now, everything has been zipped without passwords and all original file timestamps have been preserved. It is not necessary to run the menu or other included software to access the files. There are 6 .RAR files which will not fully extract because of CRC errors. While they can partially extract, they're likely corrupted or missing files. These corrupted RARs are included for consistency. The rars are in the zip of their respective folders. Unzip to see find the rar and it's password. If you'd like to try extracting the ; | | 2022-01-21T22:02:32Z |
| Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks. | This article is from BMC Systems Biology , volume 6 . Abstract Background: High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately characterize biological processes that have been perturbed at the mechanistic level. Here, a new approach is built on previous methodologies in which high-throughput data was interpreted using prior biological knowledge of cause and effect relationships. These relationships are structured into network models that describe specific biological processes, such as inflammatory signaling or cell cycle progression. This enables quantitative assessment of network perturbation in response to a given stimulus. Results: Four complementary methods were devised to quantify treatment-induced activity changes in processes described by ; | 2012 | 2014-10-25T01:34:45Z |
| Protein kinase C signaling and cell cycle regulation. | This article is from Frontiers in Immunology , volume 3 . Abstract A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about 30 years. However, despite the wealth of information on PKC-mediated control of, T cell activation, understanding of the effects of PKCs on the cell cycle machinery in this cell type remains limited. Studies in other systems have revealed important cell cycle-specific effects of PKC signaling that can either positively or negatively impact proliferation. The outcome of PKC activation is highly context-dependent, with the precise cell cycle target(s) and overall effects determined by the specific isozyme involved, the timing of PKC activation, the cell type, and the signaling environment. Although PKCs can regulate all stages of the cell cycle, they appear to predominantly affect G0/G1 and G2. PKCs can modulate multiple cell cycle regulatory molecules, including cyclins, cyclin-dependent kin; | 2013 | 2014-10-28T20:08:08Z |
| CIA Reading Room cia-rdp91-00929r000100090020-0: FR:KURTA G. TO:KUGAKOV M.M. | Retaxmion Phenomew for Attenwalm of Sxvdin Ductop by G. K=txp.GERMM, per, A~M Vol )as 1961, pp 112-117.NASA TT P-9277Sci-Mectrmay 65U.S. GOVERNMENT ONLY28(4190mTransplantation of Himan Carcitwom.9 by Raw Kurtzabn,10 pp?)=WAN, perp Ki. usch.., Vol Uls, 1926o pp 1166-1168.inScientific - Medicine CTS/DIX // .2 P401Proceocs lor Yonufactur-ling a Cb--ese ?rwuct of GrGratGd Hl&~i-Fat Chaese, by 2. 24 Tlxalsmaa,W, J. Kurt--lial3,, 6 pp.amm, potperrit 949,6i6i 30 Aug -1956.sLA 6o-149aI f- -1 -7,SciROSTE.Tmals B. 1.KURUKLISP G. A.Stanki I instrument# Vol. 17, xo. 6, 11figures wo 3 tableav 2600 words- 1946.Deep Dry Cyaniding of Cutting- Toole.Brutcher Trans, Order No* 1914s, $4-55amom Lai to latruall"Is 3*MQWbt,-Nw 73cateshoWalow contsm As foblize 40""*1. rA* 4UNft Of & IPYT*V"* &*SUQW(""I) ft sbo AOL".' coutaft of the sx*itStan a" on ow ant" Tore"sumaby T. gulmas *t RuJAPAUMS, Fifirs MUM TakwLELS it Val LisU64v pp 463oMaw MIN X0scl - S/wMay 66The !~!chanlce c-f Beending of the SbRP.-, of incUne; | 1983 | 2026-03-25T15:12:02Z |
| CIA Reading Room cia-rdp91-00772r000100750011-3: A FR: LITVINUV, I. TO: LIVANOV, H. A. | 44 Atmat of byI A A Ogg * I* Ao L4tVi*iOV* 41Ira, .A&SOltwolaku yena 00.14tsa Valk VI 1,0 kto 41,0TITO i&-$17anITVI I~y d others. Some data on the structureI i ~ 0l fFE,,le fi~,el,, , xprecipitation.rudy gllaly.g,~, ~is.'Obs. 230:60-4 (1968)9LL/5~82!~J~r-, (hl 7799))-77S~ aphy, by L. D. ]Atvinov,MAe~ko,~ *prcx 208 pp.~j6k a. 1970.I I I' -ge-m-w-aNS, TS Bum-w/piamIm Pm;ssci Proptilsim and fus3m398,593I'll ;tat crthirv 71~4nv::zzl 1,ardact!vivo,it 4c~ E-31, W1TIP7r T 57.7-tttl-4.t Sttvctv" mad Propsniospy, i4res4cs of the sio 0 Al 0 -40rp.o4IT M4046366th W~ UW Ar!,!LStgi3p.Part 1"!"a astSupJIM j ppNMHAlm a t .'Ot.4mv ~by 14tvinm 1, 14 pp*t Ali Oi 0 0 June011&PL,~:Trticiesl/Pan.. 0-16-311s v ii;. F. j;;Ol I szl~dk.ov,IV4L~iy #,PL/Jr;U T-21244S c i - 41, i.6,piIPUO 1547 6; c 4 3I&VOAOck Atm:9? ppe4toescow, ilo9vp9110rmc~ 11 luitetrically Active Uq-urities onu4~rxtat'iwi ui~ c-ermiduu, by -".* S. c.creii~,Yu, I Li~v'inov11ok Al. HaUL. ~."ISSRS1 Vol liql, '-'v, 21,At; frkV-01Jarl, 1!,W:~L--7; | 1983 | 2026-03-31T12:29:08Z |
| Ep 10 Part 1: Kristine Bunch's Nightmare | In part 1 of this episode, you'll hear about one woman's nightmare come true. In 1995, 21-year-old Kristine Bunch was abruptly awoken in the early morning hours to discover that her house was on fire. After escaping the flames, she watched in horror as firefighters were unable to save her 3-year-old son who was still trapped inside. Within hours of being released from the hospital, she discovered that detectives had a theory about the fire - someone had started the fire on purpose, and their main suspect was Kristine. A special thank you to Kristine Bunch for helping me tell her story.Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. htt; | 2016 | 2023-07-08T12:43:39Z |
| Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy. | This article is from PLoS ONE , volume 9 . Abstract Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects. Olomoucine II and roscovitine, purine-based inhibitors of CDKs, were described as effective antiviral agents that inhibit replication of a broad range of wild type human viruses. Olomoucine II and roscovitine show high selectivity for CDK7 and CDK9, with important functions in the regulation of RNA polymerase II transcription. RNA polymerase II is necessary for viral transcription and following replication in cells. We analyzed the effect of inhibition of CDKs by olomoucine II on gene expression from viral promoters and compared its effect to widely-used roscovitine. We found that both roscovitine and olomoucine II blocked the phosphorylation of RNA polymerase II C-termi; | 2014 | 2014-10-23T20:50:01Z |
| Predict shipment ETA with no-code machine learning using Amazon SageMaker Canvas | Over the last few years, online education platforms have seen an increase in adoption of and an uptick in demand for video-based learnings because it offers an effective medium to engage learners. To expand to international markets and address a culturally and linguistically diverse population, businesses are also looking at diversifying their learning offerings by localizing content into multiple languages. These businesses are looking for reliable and cost-effective ways to solve their localization use cases. Localizing content mainly includes translating original voices into new languages and adding visual aids such as subtitles. Traditionally, this process is cost-prohibitive, manual, and takes a lot of time, including working with localization specialists. With the power of AWS machine learning (ML) services such as Amazon Transcribe , Amazon Translate , and Amazon Polly , you can create a viable and a cost-effective localization solution. You can use Amazon Transcribe to create a; | 2022 | 2022-08-10T05:07:03Z |