| Title | Description | Published | Added |
| Topology of C. W. Complexes | | 1969 | 2023-12-22T18:35:46Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T23:53:12Z |
| Cell cycle control : mechanisms and protocols | Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle / Anna Philpott and P. Renee Yew -- The mammalian cell cycle / Jane Vera Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane Vera Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and virus infection / Steven Emmett ... [et al.] --^ // Methods fo; | 2005 | 2012-05-22T14:15:36Z |
| Dual Control of Yen1 Nuclease Activity and Cellular Localization by Cdk and Cdc14 Prevents Genome Instability. | This article is from Molecular Cell , volume 54 . Abstract The careful orchestration of cellular events such as DNA replication, repair, and segregation is essential for equal distribution of the duplicated genome into two daughter cells. To ensure that persistent recombination intermediates are resolved prior to cell division, the Yen1 Holliday junction resolvase is activated at anaphase. Here, we show that the master cell-cycle regulators, cyclin-dependent kinase (Cdk) and Cdc14 phosphatase, control the actions of Yen1. During S phase, Cdk-mediated phosphorylation of Yen1 promotes its nuclear exclusion and inhibits catalytic activity by reducing the efficiency of DNA binding. Later in the cell cycle, at anaphase, Cdc14 drives Yen1 dephosphorylation, leading to its nuclear relocalization and enzymatic activation. Using a constitutively activated form of Yen1, we show that uncontrolled Yen1 activity is detrimental to the cell: spatial and temporal restriction of Yen1 protects against g; | 2014 | 2014-10-23T07:40:09Z |
| Cyclin D1 inhibits whereas c-Myc enhances the cytotoxicity of cisplatin in mouse pancreatic cancer cells via regulation of several members of the NF-?B and Bcl-2 families. | This article is from Journal of Carcinogenesis , volume 10 . Abstract Background:: Cisplatin (CDDP) is a drug used for treatment of many types of malignancy but pancreatic cancer is relatively resistant to it. This study aims to determine whether and how cyclin D1 (D1) and c-Myc influence the response of pancreatic cancer cells to CDDP. Materials and Methods:: Ela-mycPT mouse pancreatic cancer cells were transfected with D1 or c-myc cDNA and treated with CDDP alone or together with NPCD, an inhibitor of cyclin dependent ckinase (CDK) 4 and 6. Reverse transcription followed by polymerase chain reaction (RT-PCR) and western blot assays were used to determine the mRNA and protein levels of interested genes. Cell viability was determined using 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results:: Treatment of Ela-mycPT1 cells with CDDP caused an increase in c-myc expression but a slightly latent decrease in D1 expression, whereas D1 and c-Myc proteins repres; | 2011 | 2014-10-28T18:52:34Z |
| High p27 protein levels in chronic lymphocytic leukemia are associated to low Myc and Skp2 expression, confer resistance to apoptosis and antagonize Myc effects on cell cycle. | This article is from Oncotarget , volume 5 . Abstract Myc (c-Myc) counteracts p27 effects, and low p27 usually correlates with high Myc expression in human cancer. However there is no information on the co-expression of both genes in chronic lymphocytic leukemia (CLL). We found a lack of correlation between RNA and protein levels of p27 and Myc in CLL cells, so we determined the protein levels by immunoblot in 107 cases of CLL. We observed a high p27 protein expression in CLL compared to normal B cells. Ectopic p27 expression in a CLL-derived cell line resulted in cell death resistance. Surprisingly, Myc expression was very low or undetectable in most CLL cases analyzed, with a clear correlation between high p27 and low Myc protein levels. This was associated with low Skp2 expression, which is consistent with the Skp2 role in p27 degradation and with SKP2 being a Myc target gene. High Myc expression did not correlate with leukemia progression, despite that cell cycle-related Myc target; | 2014 | 2014-10-06T05:32:23Z |
| CIA Reading Room cia-rdp90-00552r000100550040-8: PANEL FINDS CASEY NOT UNFIT FOR JOB | Sanitized Copy Approved for Release 2010/07/29: CIA-RDP90-00552R000100550040-8 NEW YORK TIES E, i' i CLE AIPPEA D 2 DECEMBER 1981 C )IN, PAGE' PANEL ~ , "mg a~ ~t~t tbar~rt the public at saon WadDeKI&Y. r. Noyaiban MW the delay wos.d ernmit ? flies UNFIT I$ the m ;" r of tld c xx* atte,e?a 13 members .rno crula not attend today's s tasks aboutbair v3ee-s on the pane 's eaneiusiom, erxd we+ald Per=ft; Mr. Caaay tozs+3ew them, But 'Whole. Situation is Not rroE,a Moynihan mW uttering,' Senator Sa M. a tthhet: ?o"'di of intelligence Director$ ~- ,to on o`r 1he added ;w 1e ji vse,.a, a sms~ ' used to ref 4Z931JAl3331R33i~ grtoi Josepb R BiBea Jr., Demoemt of Deiawere, said in an WASB1NGTa f,13ee. I -The Se stet iota view aZter the m eetin, that be disa.. Select C ommit ee en bMH*mm will geed with the etanmittee's ~? that and has no ham roe William J. Cawy is "mat to aeey-e as m 0'1 bare a very dirfermt V3tw iron rectorof Caatr*i;atailia,estca,seco~rdins that of nay cdk~e es m the ~iZer,'? t; | 1981 | 2025-06-03T23:01:26Z |
| Ep 10 Part 2: Kristine Bunch's Struggle For Freedom | In Part 2 of this episode, Kristine and her newly-formed defense team fight to win back her freedom. Armed with advances in fire science, a potential Brady violation, and some shocking revelations about the State's evidence at trial, Kristine and her team fight till the very end. A special thank you to Kristine Bunch for helping me tell her story. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. http://dig.ccmixter.org/files/cdk/48915 Ft: Phasenwandler Homesick (Keymix) by keytronic (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/Keytronic/47457 Ft: Kizzylotus Paper Planes - Durd; | 2016 | 2023-07-08T12:43:12Z |
| CIA Reading Room cia-rdp91-00929r000200680025-9: FR:SHUBKIN V.N. TO:SHULISHOVA O.I. | - 14 , /.el iconelvto stuat at seem lw V. ov*WAD ,15 P9owns Pori, 1b 3# FM 65# IV WOW$I" 2Z3.1ummemApr 65 7no ?rlIbmis ft no& 206or a* zatw yorms lw To so /0Mdu%,%Tw~m vwo so= tumob ft so ow^ wo WIGNo st3ps~ kl,~oV, ~- -, k L)--um9mAn 6520630quanutatAve Nrtboft la ftWWUWt by Yo So17 vp o--- - vwp &g= UMMW 1b- 3~ X967ioIV? 0JIPMB "3~t. IV SHU6KIAl.2 cumbd4kc ftlime 67 329pM'4-4 7'r-QV'4rtl*S Of DWGIVUlt 4'AtlrAinS Of tl%w 45Vino of vie (.4cm tior~4s (,,orivo siqlax),UY %* F~, Ct 419'it ~*T, v--~Virux %lo it IL66v 17-p 74-76.i. ~~41 ~ ~''Cim"Alrvu f, I 3tiows0~. ( J /' (~. 6 ' ~ /' t"The so-called Homology of Crystals,, by A. V. ShubnikovRUSSIAN, per, Doklady Akadewit Nauk SSSR Vol 88,pp 453-456NAVY/NISC-3346Oct 72Growth ct C4ft*IkUt tV A. V. MuUdkNp V, X.abdull0 -U:WROM ppmo "a cc VWM&A& !=Wamom-Nms To, AW f,~ 4 -, . I r -- , (tic!AVv 4,i*l 1 ~ -swo4w Ge dbs ftugk as"d via llsbr5-1 eusumbohm-Aodk*V&t v IV 91 At 99 pw* It 901 "s 19496or 209-43"-ftota isterimKrArrA-324brek 1970-ft 33Oft L; | 1983 | 2026-04-05T21:18:00Z |
| CIA Reading Room cia-rdp83m00914r002800040039-0: LETTER TO WILLIAM F. JASPER FROM CHARLES E. WILSON | Approved~For Release 2007/03123: CIA-RDP83M00914~Q 800040039-0 PUBLIC AFFAIRS Phone: (703) 351-7676 Mr. 4lilliam F. Jasper Dear Mr. Jasper: In response to your letter of January 20 to Admiral Inman, we are enclosing the available news clippings which have appeared in the American press on the subject of U.S. technological aid to the Soviet arms buildup. lJe hope the enclosed material will provide you with the kind of information you requested. Sincerely, STAT STAT Charles E. tJilson Chief, Public Affairs Division Enclosures Admiral Inman's 7 January Remarks to AAAS; News Clippings OEXA/CDK/4 Feb 82/x7676 Distribution: 0 - Addressee - OEXA Reg 82-0310 - ER 82-6077 w/enc 1 - LL 1 - PAD Subj. w/enc 1 - Chron ~w/enc 4 February 1982 STAT Approved For Release 2007/0:3123: CIA-RDP83M00914R002800040039-0 ~~~4ppr~~ed"~oryRelease 2007/03123;: CIA=RDP83M~10914R00280~C~4~1039-0 STAT January 20, 198 Robert Inman, Deputy Director Central Intelligence agency. ',lashington, D.C. 20505 Dear T"ir. Inman; | 1982 | 2025-02-22T14:17:55Z |
| github.com-sindresorhus-awesome_-_2021-10-02_04-49-15 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2021 | 2021-10-02T15:21:09Z |
| github.com-sindresorhus-awesome_-_2022-01-23_12-29-31 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-23T13:31:49Z |
| github.com-sindresorhus-awesome_-_2023-10-26_15-42-21 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app One Task Stop procrastination and get stuff done by focusing on one task at a time My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Develop; | 2023 | 2023-10-27T01:55:02Z |
| github.com-sindresorhus-awesome_-_2026-03-09_07-59-57 | 😎 Awesome lists about all kinds of interesting topics Check out my macOS app Supercharge Elevate your Mac experience My open source work is supported by the community Special thanks to: Effortless backends with infrastructure from code An open-source framework that supports any programming language, cloud provider, or deployment automation tool. Wispr Flow Talk to code, stay in the Flow. Flow is built for devs who live in their tools. Speak and give more context, get better results. Fast remote container builds and GitHub Actions runners. What is an awesome list? Contribution guide Creating a list Twitter Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentrali; | 2026 | 2026-03-11T17:33:52Z |
| github.com-sindresorhus-awesome_-_2022-02-27_08-48-06 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-02-28T11:15:45Z |
| github.com-sindresorhus-awesome_-_2022-07-25_14-23-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-07-26T01:20:50Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery. | This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t; | 2013 | 2014-10-23T22:24:00Z |
| A novel Cdk9 inhibitor preferentially targets tumor cells and synergizes with fludarabine. | This article is from Oncotarget , volume 5 . Abstract Cdk9 is a key elongation factor for RNA transcription and functions by phosphorylating the C-terminal domain of RNA polymerase II. Here we present direct evidence that cdk9 is important for cancer cell survival and describe the characterization of the potent cdk9 inhibitor CDKI-73 in primary human leukemia cells. CDKI-73 induced caspase-dependent apoptosis that was preceded by dephosphorylation of cdk9 and serine 2 of RNA polymerase II. CDKI-73 was more potent than the pan-cdk inhibitor flavopiridol and showed >200-fold selectivity against primary leukemia cells when compared with normal CD34+ cells. Furthermore, CDKI-73 was equipotent in poor prognostic sub-groups of leukemia patients and showed cytotoxic synergy with the nucleoside analog fludarabine. The Mechanism of synergy was associated with CDKI-73-mediated transcriptional inhibition of MCL1 and XIAP that was maintained when used in combination with fludarabine. Our data pres; | 2013 | 2014-10-23T22:14:55Z |
| Retrospectiva 2016 | Foi um ano difícil, mas nós sobrevivemos. Eleve o cosmo e siga o Armadura Nerd: www.armaduranerd.com.br facebook.com/ArmaduraNerd youtube.com/ArmaduraNerd twitter.com/ArmaduraNerd instagram.com/armaduranerd Contato comercial: armaduranerd@gmail.com Trilha sonora do podcast: New York City (Instrumental) by spinningmerkaba (c) copyright 2011 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/jlbrock44/30389 Bad_Attraction by Stefan Kartenberg (c) copyright 2015 Licensed under a Creative Commons Attribution license. http://dig.ccmixter.org/files/JeffSpeed68/48947 Ft: brad sucks The Game Has Changed (cdk RumbleStep Mix) by cdk (c) copyright 2013 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/41830 Ft: My Free Mickey You Believed It Yourself by Siobhan Dakay (c) copyright 2015 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/SiobhanD/50482 Ft: Fluffy Story; | | 2017-02-05T01:22:06Z |
| My Top Cases of 2016 | We all have cases that we follow and that stick with us, whether it's on a personal level or because we're oddly fascinated with them. In this episode, I count down the top cases that affected me the most this year. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13; | 2016 | 2023-07-08T12:41:41Z |
| vmmo | vjmom m zzmomkqjm rkmodcnkrn rmjcoqq, od m czmvm oq gzqcjmk. tom madgzqkmmk crq odcoq rtdrdgo dgomzrcmkc mrkzr. m cdk rcq c rkqomz mkmgqcmm tjqkqkrn odcmn rqkc, gkdgo tdqcmkc gqcrzkr. g vgq-kd gmjqkd, om gzrvdc kdotq rcqkm, kqcooq gdv vmmo m oq grcmqk rgmcmkcrn. mqgc mrkdzkm, dgomcgo tdgocmc c qvd dgpnkmnz, rkmjm qcr qiq orcoqq. to qil oq aomqk, gkd rqzgtq gqcrzkm gmcod dkgmod gzrvdcr, tdjkdcr oq gdtrrkmqk corjm, gkd cdcqk tdjrgmkc dkkma. | | 2024-08-05T20:01:20Z |
| Shoreline City Council Regular Meeting - December 2, 2024 | # Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern; | 2024 | 2026-09-03T10:16:24Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| ginerbreadman | ginerbreadman | | 2022-11-15T19:45:05Z |
| [CDK 056] Steady C - He Started It | [CDK 056] Steady C - He Started It | 2011 | 2020-01-05T21:08:08Z |
| github.com-sindresorhus-awesome_-_2021-04-05_11-52-56 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-05T13:17:05Z |
| github.com-sindresorhus-awesome_-_2022-01-22_21-24-15 | 😎 Awesome lists about all kinds of interesting topics My Actions app is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab; | 2022 | 2022-01-23T01:20:47Z |
| github.com-apache-incubator-apisix_-_2019-11-01_09-03-27 | Cloud-Native Microservices API Gateway 中文 APISIX QQ group : 552030619 APISIX is a cloud-native microservices API gateway, delivering the ultimate performance, security, open source and scalable platform for all your APIs and microservices. APISIX is based on OpenResty and etcd. Compared with traditional API gateways, APISIX has dynamic routing and plug-in hot loading, which is especially suitable for API management under micro-service system. Installation | Documentation | Development ENV | FAQ Why APISIX? If you are building a website, mobile device or IoT (Internet of Things) application, you may need to use an API gateway to handle interface traffic. APISIX is a cloud-based microservices API gateway that handles traditional north-south traffic and handles east-west traffic between services. APISIX provides dynamic load balancing, authentication, rate limiting, and other plugins through plugin mechanisms, and supports plugins you develop yourself. For more detailed information, s; | 2019 | 2019-11-01T09:09:58Z |
| CIA Reading Room cia-rdp91-00403r000200470001-3: FR:CAHEN G TO:CALDIROLA P | wwlNftm or tw lmuwtAwl um" Eoe=UQA Dea-Alm L*.),v GLUot Calm.im. Mul" lb 12,6 1963.Varioug hj;plj,catjOrjq of tW Gomm! EPoraiulac fortha TranwiaBiOu Of Simmoidalby L. 42 pp.pir, Immicro 81cop 7 1 V~ 2~3 llq 1914.S TA 5 7 -PI'lay 56libten ~m Their OporatIm ana Tbfto 3hoo.-tvzcefor LaDZ-Distanoe-Cable ftglneertmg., by L.Cabenp I~pGMIMN., Nr, Tech lattp Vol =1: ~--l Oat:Lql,2!iv pp 145-3.47.SIA Tr 57.2028Se - P-loc RauJW. 58The Frogress and Present State of the Technic u1,J,cmded Linei;, by L D. Cahen2 10 pp,.per, Rev Gen Rlec, Vol XVII, NO 7t 14r,ab 3,9215, pp 243-245.SIA Tr 232751,'1 .. Blectri...,ity ~ ~) " ~ //- I~zf~gu !j7]UsmdWm for 2ms-lwla Ow"nicup by 0. C&euo,a. itiolaomd4t" 12 pp. IM OMM Un mlyMIX310 rpt.. fta4*=4wu4w T"bacal BMIOV*Ilb A, IV i963# PP "-&V &,r 3mion W5Un - 'EloaLmOLA; 63 zi wj 7 -,o " IfePharir4ctlogy of p-C,111o,-,a o(L,-Uj.,.*t~WIaLinoetho.V)-Danz-, jrlpyridine. 1. -IL-itildstax-4nic Action and ~'Xfactcm the 1--triphraral and Central Ifervoua Systa,wl, by R." -; | 1983 | 2026-04-02T05:44:22Z |
| CIA Reading Room cia-rdp91-00929r000100440035-5: FR:ZAVROV M.I. TO:LAVROVSKIY M.P. | ProNems 0 Thawy 4 P U A 4 0 - W4narum=adon 45yalem of Guidame of AW-AbTrAft ArdbM Fire),by N, F. LAIMRU.~,aMv bk, Kv.~ TouU P U A Z Qm MOSWW*1960. pq 1-Ul -OVTI)--Mi:~~75us"MilApr 65C j 2.=duced in Underarcund OPtniflentiv,x; byLavrovp ct al,Dept of iftUS Bur of VArms~Centrsl ftyer Staft. Ro 342D-6?7 73'by 59XXXZMNLM ACeliMatizaticM of MM3lSrUtl3 IU thtUSSR., by H - P - JAvro _A 150 pp e___yWMIAN, bkl AM] 4 tizatsUa Qmdatry v MR$Isdatellotvo Teentrosoyatao 1957-Dept of UteriorM C3 V 7Sai - Biol 14 k, z a ~?sop 61RusBinn Game Reports. Vol II. Muskrat, 1951-1955.Fluctuations and Forecasts of Muskrat Numbers, byN. F. Levrov.RUSSIAN, per, Voprosy Biologii Pushnykh ?verey iTekhniki Ckhotnichlyego Promysta (USSR), V07 xi-XIV, 1051-1955.Order from Queen's PrinterCanadaSci - BiclJul 59CTS 1, 12Russian Game OReports. Vol II. Muskrat, 1951-10,55.Interiml nnd External Parasites of Muskrats, byN. F. Lavrov.RUSSIPJ;, per, Voprosy Biologii Pushnykh Zverey iTekhniki Oldiotnichlyego Promysta (USSR), V; | 1983 | 2026-04-02T12:22:45Z |
| CIA Reading Room cia-rdp80-00810a000600660006-7: RAILROAD COAL STOCKS AND STATUS OF RAILROAD CARS | 25X1 ApFrP 1 1t aXe amn~/j : CIA-RDP80-0081 OA0006006600 6-7 25I I CENTRAL I 25XIEPORT NO, L INFORMATION REPORT CD NO. COUNTRY Iket Cary SUBJECT Rail.rocd Cool Stockal and Statu?s of Railrord Coro 25X1 PLACE .CQU1'? ECG )ATE CF INFO. T a, OOCU!,-V 3T COOTASNS Ili POP.D1IT4OF1 A"ACTINOTHE NATIONAL lib FEN1R P.'' O8 T141 UHi 1ZD STATES, tIT:lmf1 THE HBANIUIG OF TITLE 28. SFr TIGHS 703 I! i -D 794. 0: THE U. S. CODE, A.3 ASSEH050. IT5 TAAHSIiISSION ~)4I Rd1:EL? I' OI> OF 415 C0RT01470 TD O:7 RECEIPT ay AH UNAUTHOTIIZED PE100.0 f TS ":' mUl GIT D DY AV THE REPRODU70-t OP ':'H1S FORA IS PR-IuIIIITED. 25X1 25X1 Coal stocks and ;onsurr Lion of coal :I: ca o pe ua ~,.- l' ti Date in Hard Coal Raw E oT>r Jam-ary Coal `iota::. 21 49,131 17,280 Stocks 22 48,028 17,191 46,668 18,043 }3 } 25 25X1 DA FE 16)),c-TW 9 April 3.953 NO. OF Fii=GES NJO.. OF G--'1 CLS, {LUSTED E..iL(1'r!} #3:+L1: `ENT y~ y.f REPORT NO. THIS IS UNEJ''ELUAliTD !1[,,i'OP Q 61\14Oii ;+ c$Z? ? ttc 3~ 76,6ci 78,0313 76,724, 2%::,; | 1953 | 2024-02-24T10:38:21Z |
| Cyclin K goes with Cdk12 and Cdk13. | This article is from Cell Division , volume 7 . Abstract The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development. | 2012 | 2014-10-27T22:08:10Z |
| Capsaicin-Induced Apoptosis of FaDu Human Pharyngeal Squamous Carcinoma Cells. | This article is from Yonsei Medical Journal , volume 53 . Abstract Purpose: To investigate the anti-tumor effect of capsaicin on human pharyngeal squamous carcinoma cells (FaDu). Materials and Methods: The expression of apoptosis/cell cycle-related proteins (or genes) was examined by reverse transcriptase-polymerase chain reaction, western blotting and ELISA methods, while the apoptotic cell population, cell morphology and DNA fragmentation levels were assessed using flow cytometry, fluorescence microscopy and agarose gel electrophoresis. Results: Capsaicin was found to inhibit the growth and proliferation of FaDu cells in a dose- and time-dependent manner. Apoptotic cell death was confirmed by observing increases in nuclear condensation, nuclear DNA fragmentation and sub-G1 DNA content. The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent. G; | 2012 | 2014-10-24T15:33:22Z |
| DTIC ADA398172: Role of c-Myc in Estrogen Stimulated Cell Proliferation in Normal and Malignant Breast Epithelial Cells | Estrogenic steroids have diverse physiological functions and are critically involved in the pathogenesis of breast cancer. The transcriptional regulator c-Myc has been implicated in estrogen-induced mitogenesis and we are therefore investigating the contribution of c-Myc to various downstream molecular and cellular events after estrogen stimulation. We have now developed a series of cell lines expressing c-Myc and mutants lacking one or both of the conserved 'Myc boxes' required for transcriptional regulation activity, under the control of an inducible promoter. Ongoing experiments are examining whether these mutants can mimic the effects of estrogen in activating cyclin E-Cdk2 and inducing cell cycle progression. We have recently shown that decreased expression of the CDK inhibitor p21, a c-Myc target, is critical for estrogen activation of cyclin E-Cdk2 and consequently the effect of the c-Myc mutants on p21 expression is of particular interest. We have also shown that decreased c-My; | 2001 | 2018-05-05T20:39:40Z |
| Teaching and Learning Adolescent Psychiatry | | 1971 | 2025-09-26T19:28:34Z |
| github.com-sindresorhus-awesome_-_2021-12-29_16-51-20 | 😎 Awesome lists about all kinds of interesting topics My macOS app Pandan is on Product Hunt My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with G; | 2021 | 2021-12-29T23:33:05Z |
| github.com-sindresorhus-awesome_-_2022-01-23_19-01-28 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-01-24T01:48:28Z |
| github.com-sindresorhus-awesome_-_2022-11-12_16-07-31 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-13T21:28:57Z |
| github.com-sindresorhus-awesome_-_2023-06-26_15-20-26 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-27T00:52:07Z |
| github.com-sottlmarek-DevSecOps_-_2021-11-26_17-57-22 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this Library of knowledge please create proper PR (Pull request) with description what you are adding following these set of rules: Clear description of PR Keep it simple Fact over feelings or personal opinions Add source and follow the Library style Note: Currently this is early version of the library. I recommend PR after first official release. DevSecOps Library info: This library contains list of tools and methodologies accompanied with resources. The main goal is provide to the engineers guide trough opensource DevSecOps tooling. This repository covers only cyber security in cloud and DevSecOps scope. Table of Contents Defintition Tooling Precommit and threat modeling SAST DAST Supply chain and dependencies Infrastructure as code Containers security Kubernetes Cloud Chaos engineering Policy as code Methodologies Other License What is DevSecOps DevSecOps fosuses on security automat; | 2021 | 2021-11-27T17:37:25Z |
| github.com-italiaremote-awesome-italia-remote_-_2023-09-07_16-15-21 | A list of remote-friendly or full-remote companies that targets Italian talents. Awesome Italia Remote A list of 324 remote-friendly or full-remote companies that targets Italian talents. Companies can be both based in Italy or around the world but with operations in Italy. Please read the contribution guidelines before opening a pull request or contributing to this repository. Web View https://italiaremote.com/companies Built and maintained by Alessandro Marino Edoardo Costantini Legenda Remote Policies Label | Meaning--- | ---Full | Company doesn't have physical offices, so you'll always work remotely.Hybrid | Company allows remote but only for some days.Optional | Company allows you to choose when work remotely or in office, but can ask you to go sometimes. Hiring Policies Label | Meaning--- | ---Direct | Company is hiring directly with a legal entity in Italy.Contract | Company is hiring contractors in Italy, VAT Number is required.Intermediary | Company is hiring using a payroll i; | 2023 | 2023-09-07T20:17:29Z |
| github.com-serverless-stack-serverless-stack_-_2022-02-04_23-17-10 | 💥 SST makes it easy to build serverless apps. Set breakpoints and test your functions locally. https://serverless-stack.com Serverless Stack (SST) is a framework that makes it easy to build serverless apps. It's an extension of AWS CDK and it features: A Live Lambda Development environment Support for setting breakpoints and debugging in VS Code Support for deploying to multiple environments and regions Higher-level constructs designed specifically for serverless apps Zero-config support for JS and TS (using esbuild ), Go, Python, C#, and F# Quick Start Create your first SST app. ```bash Create your app $ npx create-serverless-stack@latest my-sst-app$ cd my-sst-app Start Live Lambda Development $ npx sst start Deploy to prod $ npx sst deploy --stage prod``` Documentation SST docs SST examples Public roadmap Feature requests Contributing to SST Follow us on Twitter and subscribe to our newsletter for updates. About SST We think SST can make it dramatically easier to build serverless ; | 2022 | 2022-02-05T09:01:59Z |
| DTIC ADA407257: The Role of the Suppressor, Rsu-1, in Regulation of Ras Signal Transduction in Breast Cancer Cells | Rsu-1 is a cDNA previously identified as an inhibitor of Ras-induced transformation. An HA-epitope tagged Rsu-1 cDNA was introduced into the MCF7 breast carcinoma cell line. Stable transfectants were selected for analysis of effects of Rsu-1 expression on growth control and Ras-dependent kinase pathways. Assessment of biological activity of HA-Rsu-1 transfectants revealed slower anchorage dependent growth rates , a significant reduction in anchorage independent growth and increased apoptosis compared to control MCF7 cell lines. Analysis of cell cycle regulatory proteins required for transit through 61 revealed that HA-Rsu-1 transfectant cell lines expressed elevated levels of p21 (CIP) CDK inhibitor but not cyclin D or p27 KIP, This appears to be due to stabilization of P53 by Rsu-1 expression as revealed by pulse-chase experiments. Moreover, Rsu-1 transfectants exhibited reduced levels of cyclin D- associated kinase and cdk2 kinase activity. Perturbations in signal transduction pathwa; | 2001 | 2018-05-09T18:17:52Z |
| High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a. | This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co; | 2012 | 2014-10-28T23:41:32Z |
| 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. | This article is from Cell Death & Disease , volume 5 . Abstract The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the cell cycle. The family of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFKFB1-4) are well established regulators of glucose metabolism via their synthesis of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of 6-phosphofructo-1-kinase (Pfk-1). PFKFB3 is overexpressed in human cancers, regulated by HIF-1α, Akt and PTEN, and required for the survival and growth of multiple cancer types. Although most functional studies of the role of PFKFB3 in cancer progression have invoked its well-recognized function in the regulation of glycolysis, recent observations have established that PFKFB3 also traffics to the nucleus and that its product, F2,6BP, activates cyclin-dependent kinases (Cdks). In particular, F2,6BP stimulates the Cdk-mediated phospho; | 2014 | 2014-10-08T05:47:42Z |
| Chebulagic acid from Terminalia chebula causes G1 arrest, inhibits NF?B and induces apoptosis in retinoblastoma cells. | This article is from BMC Complementary and Alternative Medicine , volume 14 . Abstract Background: Plants are the valuable source of natural products with important medicinal properties. Most of the approved anti cancer drugs have a natural product origin or are natural products. Retinoblastoma is the most common ocular cancer of children. Although chemotherapy is the preferred mode of therapy, a successful treatment for retinoblastoma requires enucleation. Chebulagic acid (CA) from Terminalia chebula was shown to have anti-proliferative properties in the studies on cancerous cell lines. Due to anti cancer properties of CA and due to limitation in treatment options for retinoblastoma, the present study is undertaken to understand the role of CA on the proliferation of retinoblastoma cells. Methods: Anti proliferative potential of CA was determined by MTT assay. The expression levels of various cell death mediators in retinoblastoma cells with CA treatment were assessed by Western blott; | 2014 | 2014-10-03T09:05:05Z |
| [CDK 045] Dauragon C. Mikado - The Inner Workings | [CDK 045] Dauragon C. Mikado - The Inner Workings | 2010 | 2020-01-05T19:29:06Z |