| Title | Description | Published | Added |
| The three Jameses | | 1962 | 2025-05-22T16:21:27Z |
| Second international meeting of the international society for neurochemistry | | 1969 | 2025-09-08T04:17:18Z |
| Scientists In Organizations | | 1966 | 2025-09-11T18:21:23Z |
| Cell cycle control : mechanisms and control | xii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v; | 2005 | 2020-05-25T21:59:48Z |
| CIA Reading Room cia-rdp62-00634a000200010059-3: CIA ELINT TRAINING PROGRAM INITIAL REPORT OF THE EAS SUB-COMMITTEE ON TRAINING 17 DECEMBER 1958 | Approved For Releas'2005/11/17 : CIA-RDF CONFIDENTIAL CIA ELINT TBAINING PROGRAM Initial Report of the EAC Sub-Committee on Training 17 December 1958 A. BACKGROUND: The EAC Sub-Committee on ELINT Training has held three meetings during which the following points were considered and, agreed upon: 1. Purpose of a CIA FLINT Training Program a. To prepare technical personnel for assignments to specific ELINT activities when and where required by the Agency ELINT Program. b. To acquaint non-technical personnel not partici- pating directly in the Agency ELINT Program with the capa- bilities and potential of DINT as a scientific intelligence tool. 2. Categories of personnel. needing training Intercept Operators; Data Reduction Personnel Maintenance Engineers R&D Engineers Intelligence Analysts Operations Personnel Administrators 3. Methods of training Document No. no CN, N(!E tat class. ^ DECI,AST,-,rrD Class. C"',1.r- aC: Aut: Date: a. Internal CIA courses b. On-the-job (training site and op; | 1958 | 2024-05-26T01:59:38Z |
| CIA Reading Room cia-rdp78-04722a000300030030-9: OPERATIONS DIRECTORATE SUPPORT OFFICERS MEETING 21 AUGUST 1974 | Approved For i T ease 2~6-T/ 14 131 &N Cdk 04722A&300030030-9 21 August 1974 1. Items of interest from the DDO Staff Meeting - 21 August 25X1A a. attended his first meeting as Chief, EUR. Mr. ill attend as 25X1A Special Assistant (probably to be known as SAR). b. Cost of Paper. Last week it was brought to Mr. Nelson's attention that a great deal of paper work is required to obtain DCI approval for visits of Ambassadors or other VIP's. This was discussed with the Director, and Mr. Colby said he would be willing to accept a hand-written memo on yellow paper. Consequently, it is now established policy that internal documentation need not be a perfect manuscript; corrections are acceptable. Anything going outside the Agency should continue to be a perfect manuscript. During the discussion it was pointed out that a number of actions can be approved with a modest amount of paper work, but that substantial numbers of copies are distributed. Mr. Nelson asked the SSA to conduct a study to deter; | 1974 | 2023-11-16T20:11:08Z |
| Novel structural features of CDK inhibition revealed by an ab initio computational method combined with dynamic simulations | The rational development of specific inhibitors for the ~500 protein kinases encoded in the human genome is impeded by a poor understanding of the structural basis for the activity and selectivity of small molecules that compete for ATP binding. Combining classical dynamic simulations with a novel ab initio computational approach linear-scalable to molecular interactions involving thousands of atoms, we have investigated the binding of five distinct inhibitors to the cyclin-dependent kinase CDK2. We report here that polarization and dynamic hydrogen bonding effects, so far undetected by crystallography, affect both their activity and selectivity. The effects arise from the specific solvation patterns of water molecules in the ATP binding pocket or the intermittent formation of hydrogen bonds during the dynamics of CDK/inhibitor interactions and explain the unexpectedly high potency of certain inhibitors such as 3-(3H-imidazol-4-ylmethylene)-5-methoxy-1,3-dihydro-indol-2-one (SU9516). T; | 2008 | 2013-09-17T19:30:51Z |
| Zds1 regulates PP2ACdc55 activity and Cdc14 activation during mitotic exit through its Zds_C motif. | This article is from Journal of Cell Science , volume 125 . Abstract At anaphase onset, highly active mitotic cyclin-dependent kinase (Cdk) is inactivated to promote exit from mitosis and completion of cytokinesis. The budding yeast Cdc14p phosphatase is a key mitotic regulator that counteracts cyclin-dependent kinase (Cdk) activity during mitotic exit. Separase, together with Zds1p, promotes the downregulation of the protein phosphatase 2A in conjunction with its Cdc55p regulatory subunit (PP2ACdc55) in early anaphase, enabling accumulation of phosphorylated forms of Net1p and release of Cdc14p from the nucleolus. Here we show that the C-terminal domain of Zds1p, called the Zds_C motif, is required for Zds1-induced release of Cdc14p, and the N-terminal domain of the protein might be involved in regulating this activity. More interestingly, Zds1p physically interacts with Cdc55p, and regulates its localization through the Zds_C motif. Nevertheless, expression of the Zds_C motif at endo; | 2012 | 2014-10-28T00:57:58Z |
| Flourescent Protein Tracing | | 1962 | 2025-09-12T10:44:29Z |
| vmmo | vjmom m zzmomkqjm rkmodcnkrn rmjcoqq, od m czmvm oq gzqcjmk. tom madgzqkmmk crq odcoq rtdrdgo dgomzrcmkc mrkzr. m cdk rcq c rkqomz mkmgqcmm tjqkqkrn odcmn rqkc, gkdgo tdqcmkc gqcrzkr. g vgq-kd gmjqkd, om gzrvdc kdotq rcqkm, kqcooq gdv vmmo m oq grcmqk rgmcmkcrn. mqgc mrkdzkm, dgomcgo tdgocmc c qvd dgpnkmnz, rkmjm qcr qiq orcoqq. to qil oq aomqk, gkd rqzgtq gqcrzkm gmcod dkgmod gzrvdcr, tdjkdcr oq gdtrrkmqk corjm, gkd cdcqk tdjrgmkc dkkma. | | 2024-08-05T20:01:20Z |
| github.com-sindresorhus-awesome_-_2021-10-02_04-49-15 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2021 | 2021-10-02T15:21:09Z |
| [CDK 045] Dauragon C. Mikado - The Inner Workings | [CDK 045] Dauragon C. Mikado - The Inner Workings | 2010 | 2020-01-05T19:29:06Z |
| Overtures Of Biology | | 1964 | 2025-09-11T12:55:51Z |
| the valaue theory of karl marx | | 1976 | 2025-05-22T13:48:47Z |
| CIA Reading Room cia-rdp83m00914r002900060005-4: I AM PLEASED TO INVITE YOU TO A ONE-DAY SPECIAL SECURITY PRESENTATION | Approved For Release 2006/0 Y2rY A`TR _ 83M00914R002900060005-4 Washington. D. C 20505 31 MAR 1982 ER 82-4708/1 I am pleased to invite you to a one-day-special security pres- entation sponsored by the White House and hosted by the Central Intelligence Agency at n Thursday, 25X1 13 May 1982. This session w i l l give those o you who were unable to attend last year the chance to do so. The schedule is enclosed. This highly-selective session has been designed to meet your special needs as an official Government spokes- person. I promise you it will be interesting and informative. The day is intended to broaden your knowledge and enhance your effective- ness throughout your period of Government service. If my schedule holds, I plan to be with you for at least a portion of the day. Kindly direct your response to CIA's Public Affairs office, telephone 351-7676. I hope to see you there. Sincerely, I g ail William J. Casey Director of Central Intelligence Enclosure UNCLASSIFIED WHEN SEPARATED ; | 1982 | 2024-07-15T20:22:12Z |
| ＰＨＯＮＫ ＦＲＩＤＡＹＳ | iNFMS - The Don Chronicles pt.1 | PHONK FRIDAY SEASON 3 | Episode 1 --------------------------------------------------------------- Produced by iNFMS | https://infms495.bandcamp.com/ Video Edit by iNFMS chapter 3: 𝖙𝖍𝖊 𝖉𝖔𝖓 𝖈𝖍𝖗𝖔𝖓𝖎𝖈𝖑𝖊𝖘 - [00:20] MAKE SOME ENDZ [03:14] SHE DONT EVEN SMOKE [06:23] ADRENOCHROME [09:48] ADRENOCHROME PT 2 [11:49] 200 THOUSAND ON MY WRIST [15:07] $CREWED UP [17:34] SMOKIN OUT - -special thanks: LORDKADO, STVSHBOI, PXSSXSSXD, BADRADIO and ANALOG BY NATURE - -audio drip: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 - https://www.analogbynature.tv https://www.badradio.nz Twitter - twitter.com/official_iNFMS Twitch - twitch.tv/analogbynature DLive - https://dlive.tv/cdk - Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: http://bitSubmit.net/21 ---100% Free Music Distribution on spotify , itunes , and more http://www.amuse.io?utm_source=RC ▶▶Co; | 2020 | 2024-02-12T06:19:34Z |
| CIA Reading Room cia-rdp91-00772r000200890017-1: A FR: JOURNAL OF PHYSIQUE ET LE RADI TO: JOURNAL FUR PRAKTISCHE CHEMIE | Friu=.;-, by J. 7-van. U11CLASSIM-Dyer,'~ Journal of Phyal-quo et Le Radium. No-----------195'i7-Havy Tr 1.631/091-,127A E- C~Sci V410=10S.-iNb rDie Y90. TM trunaltion 0+---*~ 0:w r, lmdt of flwzt by U. T. Yuwmj14. Lab Igue-Frolow.. 15 pp.J. php. at :nLdlum4Hge 18, 48-P It98 15 dVth;b;r, 3,9'57.AND-tr-33MMA 58-505Sal 5P4 4~eAug 59pI irpriROF YICIHoilin~th hdo ~)y R-, Duverney,de'Physique et le Radium,16.!- 92261509270s611R-383-IqPreliininary;Ebcperiments on Radioactivities Consequentto J~xp.~osioa of Wires Containing D uterim, ByM. Bon~asFRENCH, per, Le Journal de Physique et le Radiixr,, Vol.2XVIII, No 1.0, 1957, PP 5E5-592*JP.RS for Army Rocket wid Guded Missile AAgency$7 SeP~ GOboalwaima Selector far slow Ifeutronsp by 0. GobertpD4 Tap---otp 21 pp.jrvaival dm- !I~T 10 Ruium.Val M 19501, -PP51-A-,wjuts 6.36aLqiulatlona of the Us *am Ymber of NeutronsEmitted by IndWed Flosion of u23tJ by Ifeutrowiof 11F.2 I%Vp by S. Alalse, M. Gaudin, at &I.FRMII., Oarj, Joamal 62 Rtyslque et le Radiu; | 1983 | 2026-03-25T23:48:15Z |
| TurboSync | This software will help you with Java, C++ and even CDK. It supports Delphi 4 and 5. Using the full version of this software, source code is included, as are free, small upgrades. The trial version includes free e-mail suppport, and it works with Delphi running. The application can define a Palm database visually at design time. | 2001 | 2004-10-24T20:22:22Z |
| CIA Reading Room cia-rdp91-00403r000200500046-0: FR:BARBIERI R TO:BARDENHEUER P | Research on Vackarmoderle Reaction.Note 11. On the Maolianism of theYormatiou of lutovuul S-,alfur inPolythionic Acid9l, by Ro Barbieri*ITALIANp perlVvI 920, 1%2* 0-6?5NTO 72-12316-07BJuly 72Studleo on the Weakenrodar Reaotion.Note 1. Thiaoulphurie Acids as ProbableIntermediate Produatep by Re Barbieri.ITALIAIT, parp Ricerea Scientifica.Far&a 11, Hendleonti.Vol 2j No 1,, 19620 pp 62-67073July 72investigations of the Reaction H2StSO2Analytical Procedures for Separatingand Breaking Down Maercquantities ofNfur Componanto in Research WithS , by Ro Barbieri*ITALIAN# porp ifigalVol 30, 1960l pp 1509-1517UTO 72-11838-07BJune 72.191 ( [erawl. M2911AVIM, Gliuscme). ami" 63-129098eHiuf['MbaMj. 1. Barbieri, R*AtULYSIS OF ORGANOMETALUC CONIOUNDS. 17. Taghavint, G.DITIMONATES OF RjPbCI AND R2PbC]- f19621.10p.K-H50 K-H121 MOdf M. BaJilgo, U.K -H - 1117IV1aromer,r1 1 - a-V. Kresge-Hooker7YRm Of [U] U, y) 1960, Science Mraryv. 30, no. 12, p. 1963-1968. Associatca, Detroit, Mich.DESCMMRS: 0=1cal andysi; | 1983 | 2026-03-26T07:30:01Z |
| EP 12: Kelsey Smith - Abducted In Broad Daylight | Kelsey Smith was just 18 years old when she was abducted from a Target parking lot in Overland Park, Kansas in June 2007. Finding her would take a battle with a cellular phone company and heartbreaking surveillance video from Target, that shows that no one is ever really safe, even if you're running a simple errand in broad daylight. A special thank you to Kelsey's mom, Missey Smith, for speaking with me for this episode. To learn more about the Kelsey Smith Foundation and the Kelsey Smith Act, please visit kelseysarmy.org. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/cdk/13112 - Like Music (cdk Mix) by c; | 2017 | 2023-07-08T12:40:23Z |
| Behind The Scenes and Updates On Each Case | In this episode, I take you behind-the-scenes of each case I covered in the Court Junkie podcast, as well as go over the latest updates. You'll also hear from Pravin Varughese's mom and family friend, as well as other Court Junkies. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter; | 2017 | 2023-07-08T12:41:02Z |
| CIA Reading Room cia-rdp70-00058r000200100098-1: PUZZLING FOREIGN POLICY OF THE U.S. | FE.B. 1 51962 Approved For Release 1999/09/'-pQ1 .RDP7 United 8tates'T e ro ruby die has rdad in. hiai iodal ,which goes MO A,maxrlcan w psper. head-- haq~_ Cominunlat lined' :"Vtl~ e d ti 4!- .,stay' cra* e iA- OOMDgiW11'k .. Cdk ? bif thin M4 Ctrants: : thy; ''zi ,e4 tent to foreigh.*ld' anti the Congo Leader:' it erptains ywQ s trong atfr pe Vol" of,A oa Yet the "iJnlt d gat- ' t d f th o re e e o .policies which go along with former . Batista government this vast pone, do. Tf a c$dl 1'9 goal di et .4 Yr t 1 1e pt Victory' )endue B +dk a ltfiil Q d ve tIs at gC'tbe ' muiifng ta11i fir .. < ;thd words et etc. have speeches ' men. _~ e "l ode ?tSat~ snatchesf h p_oeeibie' 14%, Dim kTuubaff~ ~*ent-in the T?os rte 's, the l" rnm #? ant i~ic tltt~aoty.. Vital, i o s e a slat t[1gli,~ ? f i'q~M,' Cato ndgixe ex+~ e s 1$ o bf t 1+ . 'e dl 'iral o 1, + # < Uride*rstar-dstr,~ Ikrta eager ~e~ e td l t ' :thew le' n logs ,tn ezontinq otii rj~Y .# tiYea rioltcy a it izas ttt-t era:.+1e tie; era; | 1962 | 2023-08-06T09:52:48Z |
| CIA Reading Room cia-rdp91-00772r000100180064-8: A FR: MARINOV, A. I. TO: MARKELOV, I. M. | W(CAd , M. h~ and Properties of Sheets of NowgingSteeip 4ed by Aluminiumo by D. A., LitvinenkovA. 11,Mar ~ v Vo K. Barzy,, V. 1. Yakushin. MCLMM34% Or* stals Wo 10# 1958# PP 931-938.DSIR LLU (loan) )L492ac t MqNtsbl~ 59(SF-1038)Sv,erdlovsk, MR 500 KV Electric-PowerSubstaiion.. by L. D. Gustav., M. I. Levin,A.11M. M''arinov, L. M. Myzin) A. P. Petrokov,12 pp.iRu~SLOTI,, per,, Hlektrichestvo, No 7, 1960,pp 61-6 5.JpRs 4c~oBe16n jKlectric PowerSep 60iFWThe V-ml, Pollilp-o' Sygtmm as of tbm 40th Anniverrmyy ofthn lInvolution by A~ M, fTrangpor,olt an lt~n ~110 v~2-mal "-a Eactric Pover in th!.CF4cct-.Ichcvhlyn StnntEtii, No il,19571,U&9REcon25 Max, J-958BuIWU Vu-Ug the L"t 20 Tears,, by12 ypsWLW~Mo per, bidrolo&Va i Motemologiva#! vca:sorlso :UUP No 4* 1964s pip 19-27.JFIRS Z76A46Sci4kAh ~Wl wid Astron21r,4205vp of tM ItLvoo. in 940W114 byV..,.V Akio lintri-illet-M-300iolto Am M-4Wouls100 by M. lbriww,, 9 pp.m4 pop Glavaomp Vol Vs No 8# BonatAUS 8-U.CILAw u-8471poor 17./,g./C IculiFLLUX-IS; | 1983 | 2026-03-31T10:45:48Z |
| CIA Reading Room cia-rdp91-00929r000200790054-5: FR:YURKOV D.A. TO:YUR JEV V. | ner. FIz Tvvrdo&,o TnIAw.. Val I I Vo U~AIPScm ftj-, - doiid ft-atcVol I!, No arcrbardcart or *l,-i '.1r:-IVIV of ALM tku Djp~.ndwwca i5fcir, .4ut A14,*,act yomation an U.0 01,16.-t-4tim Ofw1U) tbe Dapwndanov cf tho !-"to of !)&foctor) the of a ~;~3L;Ll aMth-.1-cetran at~4m, 17 7. S. VaTiln, 7. pata~c--Mr, Ytri4r. lVorlor.0 Tala, 'lol -f- No 1,40AV,&j!'JuU." vi, t~wrrzyperv- Zbw T"b rizp '101 X(YM,, Wo 7t (If FbV-Orvv-~hVol I=,reaeustum or sa"tro" In*/44810"We &OdUU*m, by 2. T&. lubevo 5 pp.MULWO We zbw Sam nal %I XXTUI, so O~ 1VA,pp U"-LVA.Amr bwt et Ptasftv M" - T*eb ftlevia& wt, ft 6S" . PanIrob ~q gr/, 6 f,2.7hc=-,cl,!cL-ic Propertiss of Cd-6b AUoyog byV. A. Yhrkov, X. 1. Alskseywmp 2 pp.RMIAN, per, Zbur Takh I= nso Val Ml; No 4,,Apr 1956,, pp 9U-912.Awr Ust, of PhysSoviet no-"cbftl I so 4~742 9154-A - "IceAug 57The lborav*loozris PropwtUt a tM AllMmft-Cd &M ft.C4# by V. Am Yaxkmp T. V. Iskmam.,4 pp.mnums per# m NVUL I Noun"# VOL Tma, so 1j,IMP pp al-ehopp5"oat 6c / 3 0', /t~~To la; | 1983 | 2026-04-02T13:08:43Z |
| CIA Reading Room cia-rdp84-00581r000300800016-0: RUSSIA AND BACK FR: ARKHIV ANATOMII, GISTOLOGII I TO: ARKHIV ANATOMII, GISTOLOGII I | vaectrm Mieroscopy ce Intemourowl !'~navocsjby S. P, Sar-jaw-t., 19 PP.W.19MAI., por,, Anntld=U.,_GistolRj;~,~&-brioluail no 29 1962s vp 112-121.JPRS 15283Set - t4ttdlclwOct. 62(3F -22-J06)0PROBLEVsS OF EVOLUTIONARY MORPHOLOGY OF THECELL IN THE LIGHT OF DATA FROM ELECTRONMICROSCOPY, BY A. N. STUDITSKIY, 45 PP.RUSSIAN, PER, ARKHIV ANATOMII,_GISTOLOGII IE2461 OLOG I I . VOL XL I I , W IT 1 )G2, PP 3-27.--JPRS 14719SCI - BIOLOGYAUG ~2 205,985MORPHOLOGY OF CARDIAC GANGLIA IN 'ME CAT.11963] flip) (figs amirted) 26refsFASEB Nianuscript m S 122-3.Order from OTS or M-A $1. 60 Tr-63-23908figs available on loan fromTrans. of.ArMly Anatomil, Gistolop i EnibxlologU(USSR)avallable)DESCRIFTOM- *Ganglia, Cells (Molqgy)~ *Nerve cells,Nermw symem, 1-leart, *Autwornic nervous system.morpbologyIn this study of die neurone of the cardiac ganglis of theprecoriffum, three di utinct types of cells were tsolateci.Type I are Idezriflod as multipolar motor neuruns. Mwpericellular apparatus of these cells consis; | 1972 | 2026-03-31T21:12:45Z |
| CDK Construction Co., Inc. v. Parkway C&A, LP | This item represents a case in PACER, the U.S. Government's website for federal case data. If you wish to see the entire case, please consult PACER directly. | | 2025-05-09T09:18:03Z |
| Ep 10 Part 2: Kristine Bunch's Struggle For Freedom | In Part 2 of this episode, Kristine and her newly-formed defense team fight to win back her freedom. Armed with advances in fire science, a potential Brady violation, and some shocking revelations about the State's evidence at trial, Kristine and her team fight till the very end. A special thank you to Kristine Bunch for helping me tell her story. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike (3.0) license. http://dig.ccmixter.org/files/cdk/48915 Ft: Phasenwandler Homesick (Keymix) by keytronic (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/Keytronic/47457 Ft: Kizzylotus Paper Planes - Durd; | 2016 | 2023-07-08T12:43:12Z |
| github.com-italiaremote-awesome-italia-remote_-_2023-09-08_05-00-32 | A list of remote-friendly or full-remote companies that targets Italian talents. Awesome Italia Remote A list of 325 remote-friendly or full-remote companies that targets Italian talents. Companies can be both based in Italy or around the world but with operations in Italy. Please read the contribution guidelines before opening a pull request or contributing to this repository. Web View https://italiaremote.com/companies Built and maintained by Alessandro Marino Edoardo Costantini Legenda Remote Policies Label | Meaning--- | ---Full | Company doesn't have physical offices, so you'll always work remotely.Hybrid | Company allows remote but only for some days.Optional | Company allows you to choose when work remotely or in office, but can ask you to go sometimes. Hiring Policies Label | Meaning--- | ---Direct | Company is hiring directly with a legal entity in Italy.Contract | Company is hiring contractors in Italy, VAT Number is required.Intermediary | Company is hiring using a payroll i; | 2023 | 2023-09-08T06:53:31Z |
| github.com-localstack-localstack_-_2021-11-19_13-25-02 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Run • Configure • Play – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment.With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider!Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services,LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more!The Pro version of LocalStack supports additional APIs and advanced features.You c; | 2021 | 2021-11-19T14:17:34Z |
| github.com-localstack-localstack_-_2023-09-30_18-12-34 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline :zap: Join the LocalStack Insiders program to help us shape the future of LocalStack! Test drive new features & engage in conversations with us so we can learn from your use cases :zap: LocalStack provides an easy-to-use test/mocking framework for developing cloud applications. Overview • Install • Example • Run • Usage • Releases • Contributing 📖 Docs • 💻 Pro version • ☑️ LocalStack coverage Overview LocalStack is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack s; | 2023 | 2023-10-01T06:18:17Z |
| github.com-sottlmarek-DevSecOps_-_2021-11-27_19-24-52 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this Library of knowledge please create proper PR (Pull request) with description what you are adding following these set of rules: Clear description of PR Keep it simple Fact over feelings or personal opinions Add source and follow the Library style Note: Currently this is early version of the library. I recommend PR after first official release. DevSecOps Library info: This library contains list of tools and methodologies accompanied with resources. The main goal is provide to the engineers guide trough opensource DevSecOps tooling. This repository covers only cyber security in cloud and DevSecOps scope. Table of Contents Defintition Tooling Precommit and threat modeling SAST DAST Supply chain and dependencies Infrastructure as code Containers security Kubernetes Cloud Chaos engineering Policy as code Methodologies Other License What is DevSecOps DevSecOps fosuses on security automat; | 2021 | 2021-11-28T05:49:34Z |
| github.com-sottlmarek-DevSecOps_-_2021-11-29_22-24-32 | Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this Library of knowledge please create proper PR (Pull request) with description what you are adding following these set of rules: Clear description of PR (What tool, why, stars, maturity and topic) Keep it simple Fact over feelings or personal opinions Add source and follow the Library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently Open-source only Add only active projects Note: Currently this is early version of the library. I recommend PR after first official release. DevSecOps Library info: This library contains list of tools and methodologies accompanied with resources. The main goal is provide to the engineers guide trough opensource DevSecOps tooling. This repository covers only cyber security in cloud and DevSecOps scope. Table of Contents Defintition Tooling Precommit and threat modeling SAST DAST Supply chain and dependenci; | 2021 | 2021-11-30T06:31:12Z |
| CIA Reading Room cia-rdp80-00810a000600660006-7: RAILROAD COAL STOCKS AND STATUS OF RAILROAD CARS | 25X1 ApFrP 1 1t aXe amn~/j : CIA-RDP80-0081 OA0006006600 6-7 25I I CENTRAL I 25XIEPORT NO, L INFORMATION REPORT CD NO. COUNTRY Iket Cary SUBJECT Rail.rocd Cool Stockal and Statu?s of Railrord Coro 25X1 PLACE .CQU1'? ECG )ATE CF INFO. T a, OOCU!,-V 3T COOTASNS Ili POP.D1IT4OF1 A"ACTINOTHE NATIONAL lib FEN1R P.'' O8 T141 UHi 1ZD STATES, tIT:lmf1 THE HBANIUIG OF TITLE 28. SFr TIGHS 703 I! i -D 794. 0: THE U. S. CODE, A.3 ASSEH050. IT5 TAAHSIiISSION ~)4I Rd1:EL? I' OI> OF 415 C0RT01470 TD O:7 RECEIPT ay AH UNAUTHOTIIZED PE100.0 f TS ":' mUl GIT D DY AV THE REPRODU70-t OP ':'H1S FORA IS PR-IuIIIITED. 25X1 25X1 Coal stocks and ;onsurr Lion of coal :I: ca o pe ua ~,.- l' ti Date in Hard Coal Raw E oT>r Jam-ary Coal `iota::. 21 49,131 17,280 Stocks 22 48,028 17,191 46,668 18,043 }3 } 25 25X1 DA FE 16)),c-TW 9 April 3.953 NO. OF Fii=GES NJO.. OF G--'1 CLS, {LUSTED E..iL(1'r!} #3:+L1: `ENT y~ y.f REPORT NO. THIS IS UNEJ''ELUAliTD !1[,,i'OP Q 61\14Oii ;+ c$Z? ? ttc 3~ 76,6ci 78,0313 76,724, 2%::,; | 1953 | 2024-02-24T10:38:21Z |
| CIA Reading Room cia-rdp91-00929r000100440035-5: FR:ZAVROV M.I. TO:LAVROVSKIY M.P. | ProNems 0 Thawy 4 P U A 4 0 - W4narum=adon 45yalem of Guidame of AW-AbTrAft ArdbM Fire),by N, F. LAIMRU.~,aMv bk, Kv.~ TouU P U A Z Qm MOSWW*1960. pq 1-Ul -OVTI)--Mi:~~75us"MilApr 65C j 2.=duced in Underarcund OPtniflentiv,x; byLavrovp ct al,Dept of iftUS Bur of VArms~Centrsl ftyer Staft. Ro 342D-6?7 73'by 59XXXZMNLM ACeliMatizaticM of MM3lSrUtl3 IU thtUSSR., by H - P - JAvro _A 150 pp e___yWMIAN, bkl AM] 4 tizatsUa Qmdatry v MR$Isdatellotvo Teentrosoyatao 1957-Dept of UteriorM C3 V 7Sai - Biol 14 k, z a ~?sop 61RusBinn Game Reports. Vol II. Muskrat, 1951-1955.Fluctuations and Forecasts of Muskrat Numbers, byN. F. Levrov.RUSSIAN, per, Voprosy Biologii Pushnykh ?verey iTekhniki Ckhotnichlyego Promysta (USSR), V07 xi-XIV, 1051-1955.Order from Queen's PrinterCanadaSci - BiclJul 59CTS 1, 12Russian Game OReports. Vol II. Muskrat, 1951-10,55.Interiml nnd External Parasites of Muskrats, byN. F. Lavrov.RUSSIPJ;, per, Voprosy Biologii Pushnykh Zverey iTekhniki Oldiotnichlyego Promysta (USSR), V; | 1983 | 2026-04-02T12:22:45Z |
| CIA Reading Room cia-rdp91-00403r000200470001-3: FR:CAHEN G TO:CALDIROLA P | wwlNftm or tw lmuwtAwl um" Eoe=UQA Dea-Alm L*.),v GLUot Calm.im. Mul" lb 12,6 1963.Varioug hj;plj,catjOrjq of tW Gomm! EPoraiulac fortha TranwiaBiOu Of Simmoidalby L. 42 pp.pir, Immicro 81cop 7 1 V~ 2~3 llq 1914.S TA 5 7 -PI'lay 56libten ~m Their OporatIm ana Tbfto 3hoo.-tvzcefor LaDZ-Distanoe-Cable ftglneertmg., by L.Cabenp I~pGMIMN., Nr, Tech lattp Vol =1: ~--l Oat:Lql,2!iv pp 145-3.47.SIA Tr 57.2028Se - P-loc RauJW. 58The Frogress and Present State of the Technic u1,J,cmded Linei;, by L D. Cahen2 10 pp,.per, Rev Gen Rlec, Vol XVII, NO 7t 14r,ab 3,9215, pp 243-245.SIA Tr 232751,'1 .. Blectri...,ity ~ ~) " ~ //- I~zf~gu !j7]UsmdWm for 2ms-lwla Ow"nicup by 0. C&euo,a. itiolaomd4t" 12 pp. IM OMM Un mlyMIX310 rpt.. fta4*=4wu4w T"bacal BMIOV*Ilb A, IV i963# PP "-&V &,r 3mion W5Un - 'EloaLmOLA; 63 zi wj 7 -,o " IfePharir4ctlogy of p-C,111o,-,a o(L,-Uj.,.*t~WIaLinoetho.V)-Danz-, jrlpyridine. 1. -IL-itildstax-4nic Action and ~'Xfactcm the 1--triphraral and Central Ifervoua Systa,wl, by R." -; | 1983 | 2026-04-02T05:44:22Z |
| github.com-localstack-localstack_-_2022-04-21_12-24-24 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-04-21T12:25:55Z |
| github.com-lloesche-valheim-server-docker_-_2021-03-15_23-08-06 | Valheim dedicated gameserver with automatic update, World backup and ValheimPlus mod support lloesche/valheim-server Docker image Valheim Server in a Docker Container (with ValheimPlus support) Table of contents Basic Docker Usage Environment Variables Log filters Event hooks Event hook examples Install extra packages Copy backups to another location Delay restarts by 1 minute and notify on Discord ValheimPlus config from Environment Variables System requirements Deployment Deploying with Docker and systemd Deploying with docker-compose Deploying to Kubernetes Deploying to AWS ECS Updates Backups Finding Your Server In-game Steam Server Browser Steam Server Favorites & LAN Play Admin Commands Supervisor Supervisor API Status web server ValheimPlus Updates Configuration Server data rate Disable server password Changing startup CMD in Portainer Synology Help First install Updating the container image to the latest version Error after download of new container image Basic Docker Usage The; | 2021 | 2021-03-16T07:10:56Z |
| github.com-localstack-localstack_-_2022-04-21_22-18-03 | 💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Example • Run • Usage • Changelog • Contributing – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment. With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider! Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services, LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more! The Pro version of LocalStack supports additiona; | 2022 | 2022-04-22T00:42:51Z |
| CIA Reading Room cia-rdp90-00077r000100040018-7: PROCUREMENT DIVISION STATISTICS AND WORKING RELATIONSHIPS WITH OFFICE OF COMMUNICATIONS | Declassified in Part -Sanitized Copy Approved for Release 2012/03/23 :CIA-RDP90-000778000100040018-7 STAT STAT "__""...."., '..,."~??"?` ~wr 27 January 1984 '?(O: Nam ,office symbol, rrrm number, .~, . 1. C/PD/OL L -. p royal s Requested (Coordination REMARKS Preparo Reply See Me The D/L is scheduled to speak to the Office of Communications staff meeting group on 5 March and he would like you to supply him with information and statistics relative to your rev 1 of Su~~ nrt to nr and your view of the workin s~?tion between your office and' Would appreciate your input by 24 Fe ruary. STAT STAT DO NOT uss this foam as a RECORD of approvals, concurrences, disposals. clearances, and similar actions FROM: (Name, org, symbol, Agency/Post) Frankie 0-D/L so4i-ioz _< ~p~ Eby cs~ ev. 76) _.:. f+ GPO , tON~ n _ an~_c~o .,~,. - F~YR [at Cdk~ ~m_~~ ene ~s Declassified in Part -Sanitized Copy Approved for Release 2012/03/23 :CIA-RDP90-00077R0~00100040018-7 Declassified in Part - Sanitized Copy Appr; | 1984 | 2026-04-28T20:15:47Z |
| github.com-tiantianGPU-reg-factory_-_2026-06-08_15-52-51 | None 🏭 reg-factory Outlook · Gmail · ChatGPT · Grok · Claude · Gemini · GitHub · Google One 全自动注册/授权机 自动批量注册 Outlook / Gmail 邮箱 → 平台注册 / 订阅授权 → 导出 cookie 或导入 SUB2API / CPA ---**reg-factory** 是一套全自动注册流水线：先自注册 **Outlook** 邮箱，再用同一邮箱在**ChatGPT / Grok / Claude** 上批量注册账号，并导出可直登的 cookie。底层用**比特浏览器(BitBrowser)** 做指纹隔离、**Clash Verge** 做节点切换绕区域封锁与 Cloudflare 风控、接码/打码平台过手机号与验证码。> 🔜 即将上新：**Gmail 注册机 → Google One 授权 → SUB2API / CPA 导入**完整链路。> ⚠️ 仅供学习与授权测试使用。所有密钥通过环境变量提供，仓库内不含任何明文凭据。---## 1. 前置条件### ① 比特浏览器 BitBrowser- 安装并**启动**比特浏览器客户端，确保本地 API 在线（默认 `; | 2026 | 2026-06-08T16:42:34Z |
| github.com-sindresorhus-awesome_-_2021-04-26_11-53-30 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru; | 2021 | 2021-04-26T21:11:26Z |
| github.com-sindresorhus-awesome_-_2022-02-06_04-16-17 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-02-07T22:05:38Z |
| github.com-sindresorhus-awesome_-_2022-07-23_10-37-54 | 😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au; | 2022 | 2022-07-23T11:35:40Z |
| github.com-sindresorhus-awesome_-_2022-11-23_17-40-35 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing u; | 2022 | 2022-11-24T01:59:00Z |
| github.com-sindresorhus-awesome_-_2023-06-23_22-54-41 | 😎 Awesome lists about all kinds of interesting topics Check out my latest app Hyperduck Send links from your iOS devices to your Mac (better than AirDrop) My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. API to get search engine results with ease. API to get search engine results with ease. What is an awesome list? Contribution guide Creating a list Twitter Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my apps and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development E; | 2023 | 2023-06-24T23:56:50Z |
| github.com-DovAmir-awesome-design-patterns_-_2022-11-09_07-18-54 | A curated list of software and architecture related design patterns. Awesome Software and Architectural Design Patterns A curated list of software and architecture related design patterns. Software design pattern - A general, reusable solution to a commonly occurring problem within a given context in software design. It is a description or template for how to solve a problem that can be used in many different situations. Contents Programming language design patterns General Architecture Cloud Architecture Serverless Architecture Micro services & Distributed Systems Internet of things Big Data Databases and storage Docker and DevOps Mobile Front End Development Security Programming Language Design Patterns AngularJS design patterns C# design-patterns design-patterns-for-human - ultra simplified explanation to design patterns. Design Patterns Library C++ design-patterns Closure design-patterns Go design-patterns Java sourcemaking - patterns and anti patterns. oodesign - patterns catalog ; | 2022 | 2022-11-09T18:39:55Z |
| Het Utrechts Archief 168793 | Het Utrechts Archief catalog number: 168793 Description (Dutch): Afbeelding van een gezelschap op het 4e perron van het N.S.-station Rotterdam C.S. te Rotterdam, bij het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het betreft hier een gezelschap uit een extra trein voor de Handelsmaatschappij R.S. Stokvis en Zonen. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610). | 1961 | 2021-02-03T11:11:51Z |
| CIA Reading Room cia-rdp80b01676r002800250020-5: LETTER TO HONORABLE JOEL T. BROYHILL FROM LIEUTENANT GENERAL MARSHALL S. CARTER | Approved For Release 2003/11/04: CIA-RDP80B01676R002800250020-5 E.::c. a .. y . C. O"r w- *401u, E=7-7~ .r u yu It bw bum son t L IVV14md And w" I- I Distribution; 0&1-Adressee 1 -DCI 1-D RR w/basic rag. CO.... a;. 1 ` Sub ect?s tils f/e3.d is CkVQw R Approved For l4lease 2003/1/04: CIA-RDP80B01676R002800250020-5 STAT 'JOT 5 Approved For Release 2003/11/04: CIA-RDP80B01676R002800250020-5 APR 1962 STAT STAT DiathbuiAcn: 0 - AMdresaes l~ Rep. STAT 1-DCI 1?~ . -Sub t,' v car basic OD/.Peru/[:=Pr (16 Apr 62) Approved For Release 2003/11/04: CIA-RDP80BO1676R002800250020-5 STAT -. JOEL T. BROYHILLApproved For Release 2003/11/04: CIA-RDP80B01676R00280025002 ,MITTEES: i OTH DISTRICT, VIRGINIA POST OFFICE AND CIVIL SERVICE ? DISTRICT OF COLUMBIA CITIES: COUNTIES: ALEXANDRIA ARLINGTON FAIRFAX CITY FAIRFAX FALLS CHURCH (tongreo of the Nniteb 'tateo 3ouze of 3epresentatibeg 40bington, D. C. April 11, 1962 The Honorable John A. McCone Director, Central Intelligence Agency Washington 25, D.C. HOMER ; | 1962 | 2024-01-16T09:53:19Z |
| CIA Reading Room cia-rdp83m00914r002300100097-4: PUBLICATION OF UNCLASSIFIED ANALYSIS | Approved For Release 2007/03/09: CIA-RDP83MOO914R002300100097-4 .xcacutlve Rayic4ig FEB 17 4 05 P4 ?8L MEMORANDUM FOR: Director of Central Intelligence OEXA 82-0455/1 17 FEB 1982 Director, ice o External Affairs SUBJECT: Publication of Unclassified Analysis 1. Action. Requested: Sign the attached letter to Gustav F. Papanek, Boston University, President of the Association for .Comparative Economic Studies. 2. Background: Pananek wrote you on 5 February 1982 to ask that you resume release of unclassified. CIA analysis to the public. (Tab A) The attached proposed response is consistent with your 20 January 1982 letter to Messrs. Becker and Horelick at the.Rand Corporation, and a more recent letter Bob Gates sent to Dr. Grossman of the University.of California on the same subject. (Tab B) It has been adjusted to avoid the look of a form letter, however, since it is likely that these people exchange letters with each other. 3. Recommendation: Sign the attached letter. U -:, Ui1- Director o; | 1982 | 2025-02-22T15:23:14Z |
| Quantifying the CDK inhibitor VMY-1-103's activity and tissue levels in an in vivo tumor model by LC-MS/MS and by MRI. | This article is from Cell Cycle , volume 11 . Abstract The development of new small molecule-based therapeutic drugs requires accurate quantification of drug bioavailability, biological activity and treatment efficacy. Rapidly measuring these endpoints is often hampered by the lack of efficient assay platforms with high sensitivity and specificity. Using an in vivo model system, we report a simple and sensitive liquid chromatography-tandem mass spectrometry assay to quantify the bioavailability of a recently developed novel cyclin-dependent kinase inhibitor VMY-1-103, a purvalanol B-based analog whose biological activity is enhanced via dansylation. We developed a rapid organic phase extraction technique and validated wide and functional VMY-1-103 distribution in various mouse tissues, consistent with its enhanced potency previously observed in a variety of human cancer cell lines. More importantly, in vivo MRI and single voxel proton MR-Spectroscopy further established that VMY-1-103 ; | 2012 | 2014-10-26T21:07:18Z |