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Česká digitální knihovna

DostupnostNázevAutorDatumTypID
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Eklogy a písně1916monograph/pageuuid:441044f0-f6f8-11e9-a329-005056827e51
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Meziměstská telefonní ústředna v Praze1929monograph/pageuuid:e20a6970-253d-11ee-8650-005056827e51
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Mythy : básně Jaroslava Vrchlického : 1. cyklus (1874-1878)1915monograph/pageuuid:0998a060-f496-11e9-a329-005056827e51
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Základové měřictví pro nižší třídy gymnasií1886monograph/pageuuid:3c6e4dc0-d47b-11dc-b5f4-000d606f5dc6
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Základové měřictví pro nižší třídy gymnasií1893monograph/pageuuid:eca38890-36a8-11ee-9691-005056827e52
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Bibliografie české katolické literatury náboženské od roku 1828 až do konce roku 1913: vydáno v pamět osmdesátiletého jubilea "Časopisu katolického duchovenstva" a padesátiletého jubilea "Dědictví sv. Prokopa". Část druhá1913monograph/pageuuid:ca1622c0-9dfa-11e3-8e84-005056827e51
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Posledních dvě stě let v historii rajhradského kláštera2013monograph/pageuuid:fd326900-7245-11e9-b253-005056827e52
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Monografie města Smíchova1882monograph/pageuuid:db2985d0-2a1b-11e0-a7e1-000bdb925259
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Lidové noviny8.6.1911periodical/periodicalvolume/periodicalitem/supplement/pageuuid:bdc405b0-e5f9-11dc-bfb2-000d606f5dc6
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Bibliografický katalog ČSSR. Články v českých časopisech31.12.1965periodical/periodicalvolume/periodicalitem/pageuuid:a9a83430-741e-11e2-86a5-005056827e52
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Porovnávací tabulky měr a vah i příslušných cen ku snadnému užívání metrické soustavy v říši rakouské vůbec a v zemi české zvlášť1875monograph/pageuuid:34f65bc0-6d52-11de-9cc7-000d606f5dc6
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Hospodář: týdenník věnovaný rolnictví, hospodářskému průmyslu a národnímu hospodářství : týdenník věnovaný rolnictví, hospodářskému průmyslu, národnímu hospodářství a veřejné správě vůbec9.4.1887periodical/periodicalvolume/periodicalitem/pageuuid:0c579719-c6f8-4a16-8a4f-c6b12e6d449b
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Diferenciální geometrie. Část 3. Parametrické vyjádření ploch, útvary přímkové1914monograph/pageuuid:ceb551b0-6bf0-11e4-b202-005056827e52
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Malý čtenář: Kniha české mládeže1899-1900periodical/periodicalvolume/periodicalitem/pageuuid:ae7d75e5-435d-11dd-b505-00145e5790ea
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Spisy M. Jana Husi. 2. De corpore Christi1903monograph/pageuuid:5b4a7cc0-7b5e-11e7-aab4-005056827e52
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Verlustliste ausgegeben am22.5.1917periodical/periodicalvolume/periodicalitem/pageuuid:6b980390-1630-11df-b3c0-0013d398622b
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Názorný atlas k slovníku naučnému1882monograph/monographunit/pageuuid:e47f7300-ac93-11dc-9552-000d606f5dc6
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Výroční zpráva2025periodical/periodicalvolume/periodicalitem/pageuuid:4adb403f-b839-4d2d-91e2-cd3d9ac4e3bd
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Galerie du Palais Royal gravée d'aprés les tableaux des différentes écoles qui la composent: avec un abrégé de la vie des peintres et une description historique de chaque tableau1786monograph/pageuuid:17fda895-f78f-4d9c-90ad-dca3cb9e3a75
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Moravská orlice25.4.1897periodical/periodicalvolume/periodicalitem/pageuuid:02203ad6-32f0-11de-992b-00145e5790ea

Archive (50)

TitleDescriptionPublishedAdded
The three Jameses19622025-05-22T16:21:27Z
Second international meeting of the international society for neurochemistry19692025-09-08T04:17:18Z
Scientists In Organizations19662025-09-11T18:21:23Z
github.com-sindresorhus-awesome_-_2021-04-26_06-18-48😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. What is an awesome list?     Contribution guide     Creating a list     Twitter     Stickers & t-shirts Follow the Awesome Twitter account for updates on new list additions. Just type awesome.re to go here. Check out my blog and follow me on Twitter . Contents Platforms Programming Languages Front-End Development Back-End Development Computer Science Big Data Theory Books Editors Gaming Development Environment Entertainment Databases Media Learn Security Content Management Systems Hardware Business Work Networking Decentralized Systems Higher Education Events Testing Miscellaneous Related Platforms Node.js - Async non-blocking event-driven JavaScript ru;20212021-04-26T09:03:37Z
github.com-sindresorhus-awesome_-_2021-10-03_06-27-07😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au;20212021-10-03T15:40:16Z
github.com-localstack-localstack_-_2021-11-18_21-21-57💻 A fully functional local AWS cloud stack. Develop and test your cloud & Serverless apps offline! LocalStack provides an easy-to-use test/mocking framework for developing Cloud applications. Overview • Install • Run • Configure • Play – 📖 Docs • 💻 Pro version • ☑️ Feature coverage • 📢 Announcements Overview LocalStack 💻 is a cloud service emulator that runs in a single container on your laptop or in your CI environment.With LocalStack, you can run your AWS applications or Lambdas entirely on your local machine without connecting to a remote cloud provider!Whether you are testing complex CDK applications or Terraform configurations, or just beginning to learn about AWS services,LocalStack helps speed up and simplify your testing and development workflow. LocalStack supports a growing number of AWS services, like AWS Lambda, S3, Dynamodb, Kinesis, SQS, SNS, and many more!The Pro version of LocalStack supports additional APIs and advanced features.You c;20212021-11-19T02:08:38Z
github.com-sindresorhus-awesome_-_2022-12-19_19-23-01😎 Awesome lists about all kinds of interesting topics Check out my latest app Favorites Widget Call your favorite people directly from the iPhone Lock Screen My open source work is supported by the community Special thanks to: Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Build Scalable Feeds & Chat Applications with Powerful APIs and Front End Components Paperwork that makes the data;20222022-12-20T15:22:10Z
CIA Reading Room cia-rdp83m00914r002700200048-3: REQUEST FOR SPEAKING ENGAGEMENT - CHIEF EXECUTIVE S FORUM, PALM SPRINGS, CALIFORNIAApproved For Release 2007/03/15: CIA-RDP83M0091 2-fR009g~l~ 3 OEXA 82-0226 MEMORANDUM FOR: Director of Central Intelligence Director, fT-ice o External Affairs STAT SUBJECT: Request for Speaking Engagement - Chief Executive's Forum, Palm Springs, California 1. Action Requested: Regret an invitation to speak to the Chief Executive's Forum in Palm Springs on 21 February. 2. Background: Public Affairs received this invitation by telephone from Leo Greenland, Program Chairman of the Chief Executive's For m. A formal invitation is in the mail. Greenland says you met at home in New York. You are committed to Palm Beach 19-23 February. 3. Recommendation: To ease Greenland's problem in arranging for another speaker, authorize Public Affairs to telephone your regrets. Director of Central Intelligence (Date) /s/ _ - ___ T2- Director of Central Intelligence (Date) STAT STAT OEXA/CEW/cdk/27 Jan 82/x7676 Distribution: Orig - Addressee DDCI - ER 1 - D/OEXA 1 - OEXA Registry 1 - C/PAD (To Be Returned;19822025-02-22T15:15:54Z
FRIGHT NIGHT 2[Visual Mixtape]FRIGHT NIGHT 2 | Phonk Fridays ...𝔪𝔬𝔯𝔢 𝔱𝔥𝔞𝔫 𝔞 𝔰𝔢𝔮𝔲𝔢𝔩 𝔦𝔱'𝔰 𝔞 𝖘𝖈𝖗𝖊𝖆𝖒... FOR US, BY US VOL 666: Curated/mixed by iNFMS Full tape: https://soundcloud.com/iaminfms/fright-night-part-2 --------------------------------------------------------------------------------- T r a c k l i s t 00:20 : iNFMS - SPIT YO GAME [https://soundcloud.com/iaminfms] 02:13 : LORDKADO - MIDNIGHT SHOOTOUT w/ ABO [https://soundcloud.com/lordkado // https://soundcloud.com/mahatmaganja420] 04:37 : NIGHTINGALE - RED DROP [https://soundcloud.com/itsnightingale] 06:58 : otto22 - TAKE WHAT YOU WANT [https://soundcloud.com/otto22beats] 09:36 : WOBVSE - Hunter [https://soundcloud.com/wobase] 12:15 : DEISHIN - San [https://soundcloud.com/deishin] 14:40 : PXSSXSSXD - COLDEST [https://soundcloud.com/pxssxssxd] 18:05 : BEXFIELD - THOUGHT YOU KNEW [https://soundcloud.com/yaboibex] 20:15 : OG Marv - Water w/ RXIMV [https://soundcloud.com/ogmarv // https://;20192024-02-12T20:23:57Z
THE DON CHRONICLES: VOLUME THREE | The best of 2024 PHONK TAPESiNFMS presents THE DON CHRONICLES: VOLUME THREE produced by iNFMS // Visuals by AnalogByNature respect this thing of ours... Volume 1: https://soundcloud.com/iaminfms/the-don-chronicles-vol-1 Volume 2: https://soundcloud.com/iaminfms/don-chronicles-2 Purchase: https://infms495.bandcamp.com/album/the-don-chronicles-volume-3 - dedicated to all the Fallen Soldiers, Hustlers, Macks, Pimps and Dons. Rest in power, gone but never forgotten. Shout Outs: STVSHBOI, Justillionaire, CDK, BADRADIO, SWAY, Flat Sprite, POSS PLAYA, SKINNYKID, Camyo, SHELTR. and LORDKADO - [00:00] H8 ME [03:29] TAKE NOTE$ [06:04] DOLLAZ N SENSE [08:16] HALF A MILL [10:42] WHY NOW? [13:53] PIMPIN HARD [16:46] INHALEXHALE [18:52] EARNERZ - linktr.ee/official_infms www.analogbynature.tv www.badradio.nz merch and stuff ; http://STORE.RYANCELSIUS.COM Official Spotify Playlist: https://spoti.fi/2V5Jzqr Join : https://bit.ly/2UIIw08 ▶▶ATTENTION ARTISTS AND PRODUCERS▶▶ ----Submissions: Ryan.Celsius@gmail.com ---100% F;20242024-08-11T21:38:21Z
High-throughput screening with the Eimeria tenella CDC2-related kinase2/cyclin complex EtCRK2/EtCYC3a.This article is from Microbiology , volume 158 . Abstract The poultry disease coccidiosis, caused by infection with Eimeria spp. apicomplexan parasites, is responsible for enormous economic losses to the global poultry industry. The rapid increase of resistance to therapeutic agents, as well as the expense of vaccination with live attenuated vaccines, requires the development of new effective treatments for coccidiosis. Because of their key regulatory function in the eukaryotic cell cycle, cyclin-dependent kinases (CDKs) are prominent drug targets. The Eimeria tenella CDC2-related kinase 2 (EtCRK2) is a validated drug target that can be activated in vitro by the CDK activator XlRINGO (Xenopus laevisrapid inducer of G2/M progression in oocytes). Bioinformatics analyses revealed four putative E. tenella cyclins (EtCYCs) that are closely related to cyclins found in the human apicomplexan parasite Plasmodium falciparum. EtCYC3a was cloned, expressed in Escherichia coli and purified in a co;20122014-10-28T23:41:32Z
Applications of the InChI in cheminformatics with the CDK and Bioclipse.This article is from Journal of Cheminformatics , volume 5 . Abstract Background: The InChI algorithms are written in C++ and not available as Java library. Integration into software written in Java therefore requires a bridge between C and Java libraries, provided by the Java Native Interface (JNI) technology. Results: We here describe how the InChI library is used in the Bioclipse workbench and the Chemistry Development Kit (CDK) cheminformatics library. To make this possible, a JNI bridge to the InChI library was developed, JNI-InChI, allowing Java software to access the InChI algorithms. By using this bridge, the CDK project packages the InChI binaries in a module and offers easy access from Java using the CDK API. The Bioclipse project packages and offers InChI as a dynamic OSGi bundle that can easily be used by any OSGi-compliant software, in addition to the regular Java Archive and Maven bundles. Bioclipse itself uses the InChI as a key component and calculates it on the fly whe;20132014-10-27T02:14:25Z
CIA Reading Room cia-rdp62-00634a000200010059-3: CIA ELINT TRAINING PROGRAM INITIAL REPORT OF THE EAS SUB-COMMITTEE ON TRAINING 17 DECEMBER 1958Approved For Releas'2005/11/17 : CIA-RDF CONFIDENTIAL CIA ELINT TBAINING PROGRAM Initial Report of the EAC Sub-Committee on Training 17 December 1958 A. BACKGROUND: The EAC Sub-Committee on ELINT Training has held three meetings during which the following points were considered and, agreed upon: 1. Purpose of a CIA FLINT Training Program a. To prepare technical personnel for assignments to specific ELINT activities when and where required by the Agency ELINT Program. b. To acquaint non-technical personnel not partici- pating directly in the Agency ELINT Program with the capa- bilities and potential of DINT as a scientific intelligence tool. 2. Categories of personnel. needing training Intercept Operators; Data Reduction Personnel Maintenance Engineers R&D Engineers Intelligence Analysts Operations Personnel Administrators 3. Methods of training Document No. no CN, N(!E tat class. ^ DECI,AST,-,rrD Class. C"',1.r- aC: Aut: Date: a. Internal CIA courses b. On-the-job (training site and op;19582024-05-26T01:59:38Z
Flourescent Protein Tracing19622025-09-12T10:44:29Z
CIA Reading Room cia-rdp90g00993r000200150021-6: CAREER LADDERS FOR SENIOR SECRETARIESSanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 P-A =1 SON C reer adders for ior Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 Office of Communications Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 j _ j a L' _ ~, L_ -, L _ t l - L. Sanitized Copy Approved for Release 2011/05/09: CIA-RDP90GO0993R000200150021-6 F a ova GM& ofd S Rwb a Calm o. 0 S. T o 0 0 5, hokZ9o 1 000 l~? oc~Q o~o[~i CDk [ o a G?Q o]~~ ? of ll [rte. B~ G?3~o ? o Telecommunications Specialist (Technical) GS -09 Operates communications equipment, pro- cesses messages; assignment worldwide. Electronics GS -09 Installs, repairs, maintains communications Technician (Technical) equipment; assign;19812026-04-09T03:36:55Z
CIA Reading Room cia-rdp91-00772r000301760021-8: A FR: KOKUBO-KEIZAI, TSUSHIN TO: KOMMERCHESKIY, VESTNIKDeff)')V) Agencyls Fiscal Year 197L4 Budget,(TOVT'1 7 I)p.SIRNMENT rjsl!,., ONLY,F -H, 'L,r0 1% .3 0 IZAI TSUSHIN, Tokyo, 23 Jan 7,u -.ZipJPIRS/L 41832Mar 71.1.11 ,.r], -;-~ 1~ -]HKO 'AV I.M.W. ifo =mm//LOW 1"PA(lelOp kitenna for, the Tokyo-lbarrid14f.crOw e fjolay Route,Mald "'olik-'buro Nember Ass,31sses PoliticalSitur.,,tlo-a, I-py E-liyahu Drulman, 10 T)p.HEBRITJ, nov, ",*ol Haam, Aviv, 7 Feb 73,P'o 10-11, ll~.-.1J,?R's, 5&.-LIr 7 3I-ICIo 1 -za anCoin-nrixaise)rol)lllr,a, LrY--IAclvocated to '3ett.l-- I'alesLinianWit La`a,-tv, 9 pr'.-.cl -alpin, Avi%r,IIL - -ar 73,ic~ yt remi s c rrl c j- !"ireas-ellLlus - u -11j.4,y OfbY Y(Aluda Lah.ev.-3: 1 EDI0 1 T,a LviV73,Aor 731" p T~ eo, a,.! ee a r a sI-jl:) ,oTY!"ofby'')taff 7)jSC- SSC.Solua Lahav,I r10junLahav., YehudaBedouin 3i.ipj,)o:*qteis Predict New CivilianEx-oulsions in Sinai, 10 pp.KOL HAIM, Aviv, 25 Jul 73, -.-jp 10. 1.!.JPRS 7-77,7Oc t 7.1,4m,q 11,ational convention for Tokodl List,5r-op .M IIA IAM,, Tel Aviv, 1 Aug 73, p 2.ip I;19832026-03-24T11:09:31Z
github.com-sindresorhus-awesome_-_2022-02-27_08-48-06😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au;20222022-02-28T11:15:45Z
github.com-sindresorhus-awesome_-_2022-07-25_14-23-56😎 Awesome lists about all kinds of interesting topics My open source work is supported by the community Special thanks to: All your environment variables, in one place Stop struggling with scattered API keys, hacking together home-brewed tools, and avoiding access controls. Keep your team and servers in sync with Doppler. Your app, enterprise-ready. Start selling to enterprise customers with just a few lines of code. Add Single Sign-On (and more) in minutes instead of months. Strapi is the leading open-source headless CMS. It’s 100% JavaScript, fully customizable, and developer-first. Founded in 2018, OSS Capital is the first and only venture capital platform focused exclusively on supporting early-stage COSS (commercial open source) startup founders. Instant, shareable cloud PostgreSQL database Import any dataset in seconds, share with anyone with a click, try without signing up Dev environments built for the cloud Natively integrated with GitLab, GitHub, and Bitbucket, Gitpod au;20222022-07-26T01:20:50Z
Behind The Scenes and Updates On Each CaseIn this episode, I take you behind-the-scenes of each case I covered in the Court Junkie podcast, as well as go over the latest updates. You'll also hear from Pravin Varughese's mom and family friend, as well as other Court Junkies.  Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie.Music featured in this episode: - Improvisation On Friday... by Alex (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/AlexBeroza/17253 Ft: The3amAssociation - CAliformia Road by dilating_times (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/dilating_times/44880 - summertime instrumental 1 by cdk (c) copyright 2008 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter;20172023-07-08T12:41:02Z
vmmo vjmom m zzmomkqjm rkmodcnkrn rmjcoqq, od m czmvm oq gzqcjmk. tom madgzqkmmk crq odcoq rtdrdgo dgomzrcmkc mrkzr. m cdk rcq c rkqomz mkmgqcmm tjqkqkrn odcmn rqkc, gkdgo tdqcmkc gqcrzkr. g vgq-kd gmjqkd, om gzrvdc kdotq rcqkm, kqcooq gdv vmmo m oq grcmqk rgmcmkcrn. mqgc mrkdzkm, dgomcgo tdgocmc c qvd dgpnkmnz, rkmjm qcr qiq orcoqq. to qil oq aomqk, gkd rqzgtq gqcrzkm gmcod dkgmod gzrvdcr, tdjkdcr oq gdtrrkmqk corjm, gkd cdcqk tdjrgmkc dkkma.2024-08-05T20:01:20Z
Cell cycle control : mechanisms and controlxii, 402 p. : 24 cm // Includes bibliographical references and index // Cell cycle molecules and mechanisms of the budding and fission yeasts / Tim Humphrey and Amanda Pearce -- The plant cell cycle : an overview / John H. Doonan -- The C. elegans cell cycle / Sander van den Heuvel -- Developmental control of growth and cell cycle progression in drosophila / Lisa Swanhart, Jeremy Kupsco, and Robert J. Duronio -- The xenopus cell cycle : an overview / Anna Philpott and P. Renee Yew -- The mammalian cell cycle : an overview / Jane V. Harper and Gavin Brooks -- Synchronization of cell populations in G1/S and G2/M phases of the cell cycle / Jane V. Harper -- Mapping origins of DNA replication in eukaryotes / Susan A. Gerbi -- In situ assay for analyzing the chromatin binding of proteins in fission yeast / Stephen E. Kearsey ... [et al.] -- Application of magnetic beads to purify cells transiently transfected with plasmids encoding short hairpin RNAs / Peter D. Adams -- The cell cycle and v;20052020-05-25T21:59:48Z
CIA Reading Room cia-rdp70-00058r000200100098-1: PUZZLING FOREIGN POLICY OF THE U.S.FE.B. 1 51962 Approved For Release 1999/09/'-pQ1 .RDP7 United 8tates'T e ro ruby die has rdad in. hiai iodal ,which goes MO A,maxrlcan w psper. head-- haq~_ Cominunlat lined' :"Vtl~ e d ti 4!- .,stay' cra* e iA- OOMDgiW11'k .. Cdk ? bif thin M4 Ctrants: : thy; ''zi ,e4 tent to foreigh.*ld' anti the Congo Leader:' it erptains ywQ s trong atfr pe Vol" of,A oa Yet the "iJnlt d gat- ' t d f th o re e e o .policies which go along with former . Batista government this vast pone, do. Tf a c$dl 1'9 goal di et .4 Yr t 1 1e pt Victory' )endue B +dk a ltfiil Q d ve tIs at gC'tbe ' muiifng ta11i fir .. < ;thd words et etc. have speeches ' men. _~ e "l ode ?tSat~ snatchesf h p_oeeibie' 14%, Dim kTuubaff~ ~*ent-in the T?os rte 's, the l" rnm #? ant i~ic tltt~aoty.. Vital, i o s e a slat t[1gli,~ ? f i'q~M,' Cato ndgixe ex+~ e s 1$ o bf t 1+ . 'e dl 'iral o 1, + # < Uride*rstar-dstr,~ Ikrta eager ~e~ e td l t ' :thew le' n logs ,tn ezontinq otii rj~Y .# tiYea rioltcy a it izas ttt-t era:.+1e tie; era;19622023-08-06T09:52:48Z
the valaue theory of karl marx19762025-05-22T13:48:47Z
CIA Reading Room cia-rdp91-00929r000200790054-5: FR:YURKOV D.A. TO:YUR JEV V.ner. FIz Tvvrdo&,o TnIAw.. Val I I Vo U~AIPScm ftj-, - doiid ft-atcVol I!, No arcrbardcart or *l,-i '.1r:-IVIV of ALM tku Djp~.ndwwca i5fcir, .4ut A14,*,act yomation an U.0 01,16.-t-4tim Ofw1U) tbe Dapwndanov cf tho !-"to of !)&foctor) the of a ~;~3L;Ll aMth-.1-cetran at~4m, 17 7. S. VaTiln, 7. pata~c--Mr, Ytri4r. lVorlor.0 Tala, 'lol -f- No 1,40AV,&j!'JuU." vi, t~wrrzyperv- Zbw T"b rizp '101 X(YM,, Wo 7t (If FbV-Orvv-~hVol I=,reaeustum or sa"tro" In*/44810"We &OdUU*m, by 2. T&. lubevo 5 pp.MULWO We zbw Sam nal %I XXTUI, so O~ 1VA,pp U"-LVA.Amr bwt et Ptasftv M" - T*eb ftlevia& wt, ft 6S" . PanIrob ~q gr/, 6 f,2.7hc=-,cl,!cL-ic Propertiss of Cd-6b AUoyog byV. A. Yhrkov, X. 1. Alskseywmp 2 pp.RMIAN, per, Zbur Takh I= nso Val Ml; No 4,,Apr 1956,, pp 9U-912.Awr Ust, of PhysSoviet no-"cbftl I so 4~742 9154-A - "IceAug 57The lborav*loozris PropwtUt a tM AllMmft-Cd &M ft.C4# by V. Am Yaxkmp T. V. Iskmam.,4 pp.mnums per# m NVUL I Noun"# VOL Tma, so 1j,IMP pp al-ehopp5"oat 6c / 3 0', /t~~To la;19832026-04-02T13:08:43Z
Cyclin K goes with Cdk12 and Cdk13.This article is from Cell Division , volume 7 . Abstract The cyclin-dependent kinases (Cdks) regulate many cellular processes, including the cell cycle, neuronal development, transcription, and posttranscriptional processing. To perform their functions, Cdks bind to specific cyclin subunits to form a functional and active cyclin/Cdk complex. This review is focused on Cyclin K, which was originally considered an alternative subunit of Cdk9, and on its newly identified partners, Cdk12 and Cdk13. We briefly summarize research devoted to each of these proteins. We also discuss the proteins' functions in the regulation of gene expression via the phosphorylation of serine 2 in the C-terminal domain of RNA polymerase II, contributions to the maintenance of genome stability, and roles in the onset of human disease and embryo development.20122014-10-27T22:08:10Z
Macintosh Mania 12019-07-06T06:46:50Z
BRITANNICA WORLD LANGUAGE DICTIONARY19592025-08-24T15:43:03Z
ginerbreadmanginerbreadman2022-11-15T19:45:05Z
Ep 10 Part 2: Kristine Bunch's Struggle For FreedomIn Part 2 of this episode, Kristine and her newly-formed defense team fight to win back her freedom. Armed with advances in fire science, a potential Brady violation, and some shocking revelations about the State's evidence at trial, Kristine and her team fight till the very end. A special thank you to Kristine Bunch for helping me tell her story. Please consider supporting Court Junkie with as little as $3 a month via Patreon.com/CourtJunkie. Help support Court Junkie with $6 a month and get access to bonus monthly episodes.Follow me on Twitter @CourtJunkiePod or Instagram at CourtJunkie. Music featured in this episode: Like Music (cdk Mix) by cdk (c) copyright 2015 Licensed under a Creative Commons Attribution Share-Alike  (3.0) license. http://dig.ccmixter.org/files/cdk/48915 Ft: Phasenwandler Homesick (Keymix) by keytronic (c) copyright 2014 Licensed under a Creative Commons Attribution (3.0) license. http://dig.ccmixter.org/files/Keytronic/47457 Ft: Kizzylotus Paper Planes - Durd;20162023-07-08T12:43:12Z
Teaching and Learning Adolescent Psychiatry19712025-09-26T19:28:34Z
GNU GCC mipsel (CDK-patched) 2.7.2-cdk (PS1 MIPS R3000, linux)Overview GNU GCC mipsel (CDK-patched) 2.7.2-cdk — historical compiler archived for software preservation and exact-version identification (catalog id <b>gcc2.7.2-cdk</b>). Key binaries File Size Version info SHA-256 cc1 3220572 GCC: (Ubuntu 9.4.0-1ubuntu1~20.04.2) 9.4.0 90db2db7bcfe372244ca4d9785a7bfbf7613d711f69ee3bfe6c91d82a85e611d Hashes cc1 md5 1aee0a1960288da8ef15b6f5eca185e9 sha1 3a4fbfa4f5cea14fef08f04ef2351bd2ce1db3ca Full per-file hashes: manifest.json / manifest.txt in this item. How to identify this compiler Object/ident string: # GNU C version cygnus-2.7.2-970404 SN32.3.7.0004 (SonyPSX) compiled by CC. Source Package source: https://github.com/decompals/old-gcc/releases/download/0.15/gcc-2.7.2-cdk.tar.gz Notes Linux i386-hosted GCC mipsel cross compiler, CDK variant, rebuilt with patches by decompals/old-gcc. Test compile is to assembly (cc1 only). Version string derived from the decomp.me id.2026-10-29T04:58:45Z
CIA Reading Room cia-rdp91-00772r000200890017-1: A FR: JOURNAL OF PHYSIQUE ET LE RADI TO: JOURNAL FUR PRAKTISCHE CHEMIEFriu=.;-, by J. 7-van. U11CLASSIM-Dyer,'~ Journal of Phyal-quo et Le Radium. No-----------195'i7-Havy Tr 1.631/091-,127A E- C~Sci V410=10S.-iNb rDie Y90. TM trunaltion 0+---*~ 0:w r, lmdt of flwzt by U. T. Yuwmj14. Lab Igue-Frolow.. 15 pp.J. php. at :nLdlum4Hge 18, 48-P It98 15 dVth;b;r, 3,9'57.AND-tr-33MMA 58-505Sal 5P4 4~eAug 59pI irpriROF YICIHoilin~th hdo ~)y R-, Duverney,de'Physique et le Radium,16.!- 92261509270s611R-383-IqPreliininary;Ebcperiments on Radioactivities Consequentto J~xp.~osioa of Wires Containing D uterim, ByM. Bon~asFRENCH, per, Le Journal de Physique et le Radiixr,, Vol.2XVIII, No 1.0, 1957, PP 5E5-592*JP.RS for Army Rocket wid Guded Missile AAgency$7 SeP~ GOboalwaima Selector far slow Ifeutronsp by 0. GobertpD4 Tap---otp 21 pp.jrvaival dm- !I~T 10 Ruium.Val M 19501, -PP51-A-,wjuts 6.36aLqiulatlona of the Us *am Ymber of NeutronsEmitted by IndWed Flosion of u23tJ by Ifeutrowiof 11F.2 I%Vp by S. Alalse, M. Gaudin, at &I.FRMII., Oarj, Joamal 62 Rtyslque et le Radiu;19832026-03-25T23:48:15Z
CIA Reading Room cia-rdp84-00581r000300800016-0: RUSSIA AND BACK FR: ARKHIV ANATOMII, GISTOLOGII I TO: ARKHIV ANATOMII, GISTOLOGII Ivaectrm Mieroscopy ce Intemourowl !'~navocsjby S. P, Sar-jaw-t., 19 PP.W.19MAI., por,, Anntld=U.,_GistolRj;~,~&-brioluail no 29 1962s vp 112-121.JPRS 15283Set - t4ttdlclwOct. 62(3F -22-J06)0PROBLEVsS OF EVOLUTIONARY MORPHOLOGY OF THECELL IN THE LIGHT OF DATA FROM ELECTRONMICROSCOPY, BY A. N. STUDITSKIY, 45 PP.RUSSIAN, PER, ARKHIV ANATOMII,_GISTOLOGII IE2461 OLOG I I . VOL XL I I , W IT 1 )G2, PP 3-27.--JPRS 14719SCI - BIOLOGYAUG ~2 205,985MORPHOLOGY OF CARDIAC GANGLIA IN 'ME CAT.11963] flip) (figs amirted) 26refsFASEB Nianuscript m S 122-3.Order from OTS or M-A $1. 60 Tr-63-23908figs available on loan fromTrans. of.ArMly Anatomil, Gistolop i EnibxlologU(USSR)avallable)DESCRIFTOM- *Ganglia, Cells (Molqgy)~ *Nerve cells,Nermw symem, 1-leart, *Autwornic nervous system.morpbologyIn this study of die neurone of the cardiac ganglis of theprecoriffum, three di utinct types of cells were tsolateci.Type I are Idezriflod as multipolar motor neuruns. Mwpericellular apparatus of these cells consis;19722026-03-31T21:12:45Z
CIA Reading Room cia-rdp91-00403r000200500046-0: FR:BARBIERI R TO:BARDENHEUER PResearch on Vackarmoderle Reaction.Note 11. On the Maolianism of theYormatiou of lutovuul S-,alfur inPolythionic Acid9l, by Ro Barbieri*ITALIANp perlVvI 920, 1%2* 0-6?5NTO 72-12316-07BJuly 72Studleo on the Weakenrodar Reaotion.Note 1. Thiaoulphurie Acids as ProbableIntermediate Produatep by Re Barbieri.ITALIAIT, parp Ricerea Scientifica.Far&a 11, Hendleonti.Vol 2j No 1,, 19620 pp 62-67073July 72investigations of the Reaction H2StSO2Analytical Procedures for Separatingand Breaking Down Maercquantities ofNfur Componanto in Research WithS , by Ro Barbieri*ITALIAN# porp ifigalVol 30, 1960l pp 1509-1517UTO 72-11838-07BJune 72.191 ( [erawl. M2911AVIM, Gliuscme). ami" 63-129098eHiuf['MbaMj. 1. Barbieri, R*AtULYSIS OF ORGANOMETALUC CONIOUNDS. 17. Taghavint, G.DITIMONATES OF RjPbCI AND R2PbC]- f19621.10p.K-H50 K-H121 MOdf M. BaJilgo, U.K -H - 1117IV1aromer,r1 1 - a-V. Kresge-Hooker7YRm Of [U] U, y) 1960, Science Mraryv. 30, no. 12, p. 1963-1968. Associatca, Detroit, Mich.DESCMMRS: 0=1cal andysi;19832026-03-26T07:30:01Z
CIA Reading Room cia-rdp83m00914r002800040028-2: REQUEST FOR INTERVIEW - JOSEPH FROMM, U.S. NEWS & WORLD REPORTApproved For Relgrase 2007/03123: CIA-RDP83M00914R(~~C~4f~'f OEXA 82-272 MEMORANDUM FOR: Director of Central Intelligence FROM: erector, Office of External Affairs STAT SUBJECT: Request for Interview - Joseph Fromm, U.S. News & World Report 1. Action Requested: Decline an on-the-record interview with Joseph Fromm, U.S. News & World Report. 2. Background: Fromm's telephoned request is based on his impression that you would like to get your views accurately on the public record. He offers a recorded interview with a pre-publication screening opportunity. The subject would be the role of .intelligence and your role in improving it. Joseph Fromm and other reporters met with you at a breakfast meeting at Headquarters in Rpril 1981. 3. Staff Position: Too frequent on-the-record interviews are not consistent with the current low-profile policy. One leads to another. Your recent interview with David Kahn should suffice for awhile, unless you have some special reason for doing another. The DDCI;19822025-02-22T17:14:43Z
github.com-sottlmarek-DevSecOps_-_2022-11-04_12-18-33Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Report typos as issue not via PR. Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevS;20222022-11-05T16:23:36Z
Het Utrechts Archief 168793Het Utrechts Archief catalog number: 168793 Description (Dutch): Afbeelding van een gezelschap op het 4e perron van het N.S.-station Rotterdam C.S. te Rotterdam, bij het electrische treinstel nr. 461 (mat. 1936) van de N.S.N.B. Het betreft hier een gezelschap uit een extra trein voor de Handelsmaatschappij R.S. Stokvis en Zonen. Het treinstel 461 was een electrisch drierijtuigen-treinstel dat na de oorlog is samengesteld uit bakken van diverse treinstellen (Bk 607, C 613 en CDk 610).19612021-02-03T11:11:51Z
github.com-sottlmarek-DevSecOps_-_2022-01-15_03-45-55Ultimate DevSecOps library Ultimate DevSecOps library Contribution rules If you want to contribute to this library of knowledge please create proper PR (Pull Request) with description what you are adding following these set of rules: Clear description of PR (which tool, why, number of stars, maturity and topic) Keep it simple - Fill the description properly Fact over feelings or personal opinions Add source and follow the library style Avoid duplicits - one tool, one topic Try to make bigger updates then on tool link Currently open-source only Add only active projects Add only security tools Note: Currently this is an early version of the library. I recommend PR after first official release. DevSecOps library info: This library contains list of tools and methodologies accompanied with resources. The main goal is to provide to the engineers a guide through opensource DevSecOps tooling. This repository covers only cyber security in the cloud and the DevSecOps scope. Table of Contents Def;20222022-01-15T10:00:54Z
Identification of Genes Interacting with rnt-1 Through Large-Scale RNAi Screening in Caenorhabditis elegans.This article is from G3: Genes|Genomes|Genetics , volume 3 . Abstract Although many critical roles of the RUNX family proteins have already been identified, little attention has been given to how these proteins interact with other factors. Elucidating RUNX protein interactions will help extend our understanding of their roles in normal development and tumorigenesis. In this study, we performed large-scale RNAi screening to identify genes that genetically interact with rnt-1, the sole homolog of RUNX protein in the nematode Caenorhabditis elegans. To this end, we took advantage of the fact that C. elegans can survive a severe loss of RNT-1 function with only mild phenotypes, and we looked for genes that caused a synthetic phenotype in the rnt-1 mutant background. We identified seven genes, three of which (cdk-8, cic-1, and sur-2) are involved in transcription, two of which (pgp-2 and cct-5) are involved in stress response, and two of which (D2045.7 and W09D10.4) are involved in signalin;20132014-10-28T00:42:20Z
Shoreline City Council Regular Meeting - December 2, 2024# Shoreline City Council Regular Meeting - December 2, 2024 The Shoreline City Council met on Monday, December 2, 2024, at 7:00 p.m. in the Council Chamber at Shoreline City Hall. The meeting focused on two major study items: the adoption of Ordinance No. 1026 updating the 2024 Comprehensive Plan and Ordinance No. 1027 updating the Zoning Map and Development Code to implement the plan. The council heard extensive public comment, discussed staff presentations, and set the stage for action at the December 16 meeting. ### Consent Calendar - **Approved unanimously (6-0):** The consent calendar included approval of special meeting minutes of November 4, 2024, regular meeting minutes of November 18, 2024, and authorization for the City Manager to execute change orders increasing the contract with CDK Construction Inc. by $850,000 to a maximum of $7,912,540 for the Ballinger Maintenance Facility Project. ### Public Comments & Testimony - **Jill Chapman**, Shoreline resident, expressed concern;20242026-09-03T10:16:24Z
Plant WEE1 kinase is cell cycle regulated and removed at mitosis via the 26S proteasome machinery.This article is from Journal of Experimental Botany , volume 64 . Abstract In yeasts and animals, premature entry into mitosis is prevented by the inhibitory phosphorylation of cyclin-dependent kinase (CDK) by WEE1 kinase, and, at mitosis, WEE1 protein is removed through the action of the 26S proteasome. Although in higher plants WEE1 function has been confirmed in the DNA replication checkpoint, Arabidopsis wee1 insertion mutants grow normally, and a role for the protein in the G2/M transition during an unperturbed plant cell cycle is yet to be confirmed. Here data are presented showing that the inhibitory effect of WEE1 on CDK activity in tobacco BY-2 cell cultures is cell cycle regulated independently of the DNA replication checkpoint: it is high during S-phase but drops as cells traverse G2 and enter mitosis. To investigate this mechanism further, a yeast two-hybrid screen was undertaken to identify proteins interacting with Arabidopsis WEE1. Three F-box proteins and a subunit of t;20132014-10-23T22:24:00Z
Crazy Bytes 4 [REPACKED]First, I'd like to thank the original uploader for this archive which contains some rare gems. Like some others, I had difficulty accessing the files easily. This isn't intended to stop on anyone's toes, but rather make it more readily accessible. If you are seeking the original, untouched archive go here:  https://archive.org/details/CrazyBytes044CD If you simply want the software, continue on. The original text encoding on the password was difficult to work with.  Now, everything has been zipped without passwords and all original file timestamps have been preserved. It is not necessary to run the menu or other included software to access the files. There are 6 .RAR files which will not fully extract because of CRC errors. While they can partially extract, they're likely corrupted or missing files.  These corrupted RARs are included for consistency. The rars are in the zip of their respective folders. Unzip to see find the rar and it's password. If you'd like to try extracting the ;2022-01-21T22:02:32Z
A functional role for Smad7 in sustaining colon cancer cell growth and survival.This article is from Cell Death & Disease , volume 5 . Abstract Initially identified as an inhibitor of transforming growth factor (TGF)-β mainly owing to its ability to bind TGF-β receptor type I and abrogate TGF-β-driven signaling, Smad7 can interact with additional intracellular proteins and regulate TGF-β-independent pathways, thus having a key role in the control of neoplastic processes in various organs. Genome-wide association studies have shown that common alleles of Smad7 influence the risk of colorectal cancer (CRC), even though the contribution of Smad7 in colon carcinogenesis is not fully understood. In this study, we assessed the expression and role of Smad7 in human and mouse models of sporadic CRC. We document a significant increase of Smad7 in human CRC relative to the surrounding nontumor tissues and show that silencing of Smad7 inhibits the growth of CRC cell lines both in vitro and in vivo after transplantation into immunodeficient mice. Knockdown of Smad7 result;20142014-10-24T02:06:36Z
CIA Reading Room cia-rdp91-00929r000100090020-0: FR:KURTA G. TO:KUGAKOV M.M.Retaxmion Phenomew for Attenwalm of Sxvdin Ductop by G. K=txp.GERMM, per, A~M Vol )as 1961, pp 112-117.NASA TT P-9277Sci-Mectrmay 65U.S. GOVERNMENT ONLY28(4190mTransplantation of Himan Carcitwom.9 by Raw Kurtzabn,10 pp?)=WAN, perp Ki. usch.., Vol Uls, 1926o pp 1166-1168.inScientific - Medicine CTS/DIX // .2 P401Proceocs lor Yonufactur-ling a Cb--ese ?rwuct of GrGratGd Hl&~i-Fat Chaese, by 2. 24 Tlxalsmaa,W, J. Kurt--lial3,, 6 pp.amm, potperrit 949,6i6i 30 Aug -1956.sLA 6o-149aI f- -1 -7,SciROSTE.Tmals B. 1.KURUKLISP G. A.Stanki I instrument# Vol. 17, xo. 6, 11figures wo 3 tableav 2600 words- 1946.Deep Dry Cyaniding of Cutting- Toole.Brutcher Trans, Order No* 1914s, $4-55amom Lai to latruall"Is 3*MQWbt,-Nw 73cateshoWalow contsm As foblize 40""*1. rA* 4UNft Of & IPYT*V"* &*SUQW(""I) ft sbo AOL".' coutaft of the sx*itStan a" on ow ant" Tore"sumaby T. gulmas *t RuJAPAUMS, Fifirs MUM TakwLELS it Val LisU64v pp 463oMaw MIN X0scl - S/wMay 66The !~!chanlce c-f Beending of the SbRP.-, of incUne;19832026-03-25T15:12:02Z
CIA Reading Room cia-rdp91-00772r000100750011-3: A FR: LITVINUV, I. TO: LIVANOV, H. A.44 Atmat of byI A A Ogg * I* Ao L4tVi*iOV* 41Ira, .A&SOltwolaku yena 00.14tsa Valk VI 1,0 kto 41,0TITO i&-$17anITVI I~y d others. Some data on the structureI i ~ 0l fFE,,le fi~,el,, , xprecipitation.rudy gllaly.g,~, ~is.'Obs. 230:60-4 (1968)9LL/5~82!~J~r-, (hl 7799))-77S~ aphy, by L. D. ]Atvinov,MAe~ko,~ *prcx 208 pp.~j6k a. 1970.I I I' -ge-m-w-aNS, TS Bum-w/piamIm Pm;ssci Proptilsim and fus3m398,593I'll ;tat crthirv 71~4nv::zzl 1,ardact!vivo,it 4c~ E-31, W1TIP7r T 57.7-tttl-4.t Sttvctv" mad Propsniospy, i4res4cs of the sio 0 Al 0 -40rp.o4IT M4046366th W~ UW Ar!,!LStgi3p.Part 1"!"a astSupJIM j ppNMHAlm a t .'Ot.4mv ~by 14tvinm 1, 14 pp*t Ali Oi 0 0 June011&PL,~:Trticiesl/Pan.. 0-16-311s v ii;. F. j;;Ol I szl~dk.ov,IV4L~iy #,PL/Jr;U T-21244S c i - 41, i.6,piIPUO 1547 6; c 4 3I&VOAOck Atm:9? ppe4toescow, ilo9vp9110rmc~ 11 luitetrically Active Uq-urities onu4~rxtat'iwi ui~ c-ermiduu, by -".* S. c.creii~,Yu, I Li~v'inov11ok Al. HaUL. ~."ISSRS1 Vol liql, '-'v, 21,At; frkV-01Jarl, 1!,W:~L--7;19832026-03-31T12:29:08Z
CIA Reading Room cia-rdp83m00914r002800070042-3: MARTIN CRAMER S PROPOSED INTELLIGENCE MUSEUMApproved For Release 2007104113: CIA-RDP83M00914R002800070042-3 ER 82-4873/2 s OEXA 82-1129/1 ' L' ` ~ ~` ~~'~ `~ ' ~~.~ ~~ 24 May 1982 MEMORANDUM FOR: Director of Central Intelligence FROM: erector, ice of External Affairs SUBJECT: Martin Cramer's Proposed Intelligence ~~useum 1. Action Requested: None; for information only: STAT 2 . STAT as promote t e eve opment STAT an in a igence museum or many years. e wrote you on 16 April 1982 asking for support for his long sought intelligence museum. He specifically asked for help in procuring a Federal site or facility, identifying CIA officers to assist him, support of requests for exhibit materials, and advice on approaching people and foundations for assistance. The notion of an intelligence museum has been considered by succes- sive DCI's since 1969 (see chronology). Cramer's proposal first came to CIA in 1977. After careful study it was determined that it would be in- appropriate far CIA officially to sanction and support such a venture;20162026-10-05T22:58:02Z
DTIC ADA453395: Suppression of Prostate Cancer by PTEN and p18INK4cThe Rb pathway suppresses tumorigenesis by constraining G1 cell cycle progression. Functional inactivation or reduction of this pathway is a common event found in many types of human tumors. To test how the Rb pathway interacts with other cellular pathways in tumor suppression, we characterized mice with combined mutations in the CDK inhibitor p18 (exp Ink4c) and the lipid phosphatase PTEN, which regulates cell growth and survival. The p18(exp -/-) ; PTEN (exp +/-) double mutant mice develop prostate cancer in the anterior and dorsolateral lobes and thyroid C-cell tumors with nearly complete penetrance, and pituitary tumors in both the anterior and intermediate lobes. AKT/PKB, an oncoprotein and downstream substrate of PTEN, was activated and accumulated at the plasma membrane in PTEN (exp +/-) cells, and further activated and accumulated in the nucleus in p18 (exp -/-) ; PTEN (exp +/-) tumor cells, suggesting a tissue- and genetic background-dependent haploinsufficiency of Pten in tum;20062018-06-05T18:22:11Z
DTIC ADA398199: Regulation of Ubiquitin Mediated Proteolysis of G1 Cyclins and the CDK Inhibitor p27 by the Cullin Gene Family in Normal Tumorigenic Human Breast CellsUbiquitin-mediated proteolysis of cyclins, cyclin-dependent kinase inhibitors and certain other substrates, including proteins whose degradation is necessary for progression through mitosis, provide a molecular basis for unidirectional progression through the eukaryotic cell cycle. Aberrations in the ubiquitin-mediated destruction pathways, and particularly in the destruction of the Dl cyclin, have been implicated in human breast cancer. A cascade of enzymes leads to ubiquitination of substrate: El enzyme (ubiquitin activating); E2 enzyme (ubiquitin conjugating), and E3 enzyme (ubiquitin ligase). This last class of enzyme is large, and it performs the functions of targeting substrate and catalyzing formation of the polvubiquitin chains that mark substrate for destruction. We have found that all three members of the yeast cullin family are capable of performing the ubiquitination activity of E3 enzyme. All three yeast cullins undergo covalent modification with Rub1 protein, presumably t;20012018-05-05T21:00:08Z
Inhibition of Post-Transcriptional RNA Processing by CDK Inhibitors and Its Implication in Anti-Viral Therapy.This article is from PLoS ONE , volume 9 . Abstract Cyclin-dependent kinases (CDKs) are key regulators of the cell cycle and RNA polymerase II mediated transcription. Several pharmacological CDK inhibitors are currently in clinical trials as potential cancer therapeutics and some of them also exhibit antiviral effects. Olomoucine II and roscovitine, purine-based inhibitors of CDKs, were described as effective antiviral agents that inhibit replication of a broad range of wild type human viruses. Olomoucine II and roscovitine show high selectivity for CDK7 and CDK9, with important functions in the regulation of RNA polymerase II transcription. RNA polymerase II is necessary for viral transcription and following replication in cells. We analyzed the effect of inhibition of CDKs by olomoucine II on gene expression from viral promoters and compared its effect to widely-used roscovitine. We found that both roscovitine and olomoucine II blocked the phosphorylation of RNA polymerase II C-termi;20142014-10-23T20:50:01Z
Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks.This article is from BMC Systems Biology , volume 6 . Abstract Background: High-throughput measurement technologies produce data sets that have the potential to elucidate the biological impact of disease, drug treatment, and environmental agents on humans. The scientific community faces an ongoing challenge in the analysis of these rich data sources to more accurately characterize biological processes that have been perturbed at the mechanistic level. Here, a new approach is built on previous methodologies in which high-throughput data was interpreted using prior biological knowledge of cause and effect relationships. These relationships are structured into network models that describe specific biological processes, such as inflammatory signaling or cell cycle progression. This enables quantitative assessment of network perturbation in response to a given stimulus. Results: Four complementary methods were devised to quantify treatment-induced activity changes in processes described by ;20122014-10-25T01:34:45Z

LibGen

AuthorTitlePublishedmd5